Tadahito Shimada

Summary

Affiliation: Dokkyo University School of Medicine
Country: Japan

Publications

  1. ncbi Polaprezinc down-regulates proinflammatory cytokine-induced nuclear factor-kappaB activiation and interleukin-8 expression in gastric epithelial cells
    T Shimada
    Second Department of Internal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    J Pharmacol Exp Ther 291:345-52. 1999
  2. ncbi Hepatocyte growth factor protects gastric epithelial cells against ceramide-induced apoptosis through induction of cyclooxygenase-2
    T Shimada
    Department of Gastroenterology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Life Sci 68:539-46. 2000
  3. pmc Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells
    T Shimada
    Department of Gastroenterology, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Gut 50:658-64. 2002
  4. ncbi Regulation of TFF3 expression by homeodomain protein CDX2
    Tadahito Shimada
    Department of Gastroenterology, Dokkyo Medical University, Mibu, Tochigi 321 0293, Japan
    Regul Pept 140:81-7. 2007
  5. ncbi Peroxisome proliferator-activated receptor gamma (PPARgamma) regulates trefoil factor family 2 (TFF2) expression in gastric epithelial cells
    Tadahito Shimada
    Department of Gastroenterology, Dokkyo Medical University, Mibu, Tochigi 321 0293, Japan
    Int J Biochem Cell Biol 39:626-37. 2007
  6. ncbi PPARgamma mediates NSAIDs-induced upregulation of TFF2 expression in gastric epithelial cells
    Tadahito Shimada
    Department of Gastroenterology and Institute for Medical Science, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    FEBS Lett 558:33-8. 2004
  7. ncbi Up-regulation of TFF expression by PPARgamma ligands in gastric epithelial cells
    T Shimada
    Department of Gastroenterology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Aliment Pharmacol Ther 18:119-25. 2003
  8. ncbi Up-regulation of TFF1 (pS2) expression by TNF-alpha in gastric epithelial cells
    Takero Koike
    Department of Gastroenterology and Institute for Medical Science, Dokkyo Medical University, Mibu, Tochigi, Japan
    J Gastroenterol Hepatol 22:936-42. 2007
  9. ncbi Central thyrotropin-releasing hormone increases hepatic cyclic AMP through vagal-cholinergic and prostaglandin-dependent pathways in rats
    Masashi Yoneda
    Department of Gastroenterology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Tochigi 321 0293, Japan
    Peptides 26:1573-9. 2005
  10. ncbi Thyrotropin-releasing hormone in the dorsal vagal complex stimulates pancreatic blood flow in rats
    Masashi Yoneda
    Department of Gastroenterology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Tochigi 321 0293, Japan
    Regul Pept 131:74-81. 2005

Collaborators

Detail Information

Publications29

  1. ncbi Polaprezinc down-regulates proinflammatory cytokine-induced nuclear factor-kappaB activiation and interleukin-8 expression in gastric epithelial cells
    T Shimada
    Second Department of Internal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    J Pharmacol Exp Ther 291:345-52. 1999
    ..Collectively, these results suggest that polaprezinc is a novel type of anti-inflammatory agent that down-regulates inflammatory responses of gastric mucosal cells...
  2. ncbi Hepatocyte growth factor protects gastric epithelial cells against ceramide-induced apoptosis through induction of cyclooxygenase-2
    T Shimada
    Department of Gastroenterology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Life Sci 68:539-46. 2000
    ..Thus, these results indicate that COX-2 is involved in the survival signaling from HGF in gastric epithelial cells, and suggest a role for physiologically-induced COX-2 in the protection of the cells from apoptosis...
  3. pmc Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells
    T Shimada
    Department of Gastroenterology, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Gut 50:658-64. 2002
    ..Involvement of peroxisome proliferator activated receptor gamma (PPARgamma) in the growth response of colon cancer cells has been suggested...
  4. ncbi Regulation of TFF3 expression by homeodomain protein CDX2
    Tadahito Shimada
    Department of Gastroenterology, Dokkyo Medical University, Mibu, Tochigi 321 0293, Japan
    Regul Pept 140:81-7. 2007
    ..These results suggest that CDX2 plays a key role in the expression of TFF3 in the intestine and perhaps in intestinal metaplasia of the stomach...
  5. ncbi Peroxisome proliferator-activated receptor gamma (PPARgamma) regulates trefoil factor family 2 (TFF2) expression in gastric epithelial cells
    Tadahito Shimada
    Department of Gastroenterology, Dokkyo Medical University, Mibu, Tochigi 321 0293, Japan
    Int J Biochem Cell Biol 39:626-37. 2007
    ..Since TFF2 is a critical gastroprotective agent, PPARgamma may be involved in the gastric mucosal defense through regulating TFF2 expression in humans...
  6. ncbi PPARgamma mediates NSAIDs-induced upregulation of TFF2 expression in gastric epithelial cells
    Tadahito Shimada
    Department of Gastroenterology and Institute for Medical Science, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    FEBS Lett 558:33-8. 2004
    ..This mechanism may be important in reducing the extent of gastric mucosal injury caused by the administration of non-steroidal anti-inflammatory drugs (NSAIDs)...
  7. ncbi Up-regulation of TFF expression by PPARgamma ligands in gastric epithelial cells
    T Shimada
    Department of Gastroenterology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Aliment Pharmacol Ther 18:119-25. 2003
    ....
  8. ncbi Up-regulation of TFF1 (pS2) expression by TNF-alpha in gastric epithelial cells
    Takero Koike
    Department of Gastroenterology and Institute for Medical Science, Dokkyo Medical University, Mibu, Tochigi, Japan
    J Gastroenterol Hepatol 22:936-42. 2007
    ..However, the regulatory mechanisms of TFF1 expression are not fully understood. The aim of this study was to investigate the effect of TNF-alpha, a representative proinflammatory cytokine, on TFF1 expression...
  9. ncbi Central thyrotropin-releasing hormone increases hepatic cyclic AMP through vagal-cholinergic and prostaglandin-dependent pathways in rats
    Masashi Yoneda
    Department of Gastroenterology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Tochigi 321 0293, Japan
    Peptides 26:1573-9. 2005
    ....
  10. ncbi Thyrotropin-releasing hormone in the dorsal vagal complex stimulates pancreatic blood flow in rats
    Masashi Yoneda
    Department of Gastroenterology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Tochigi 321 0293, Japan
    Regul Pept 131:74-81. 2005
    ....
  11. ncbi Protective effect of central thyrotropin-releasing hormone analog on cerulein-induced acute pancreatitis in rats
    Masashi Yoneda
    Department of Gastroenterology, Dokkyo University School of Medicine Kitakobayashi 880, Mibu, Tochigi 321 0293, Japan
    Regul Pept 125:119-24. 2005
    ..These results indicate that the TRH analog acts in the central nervous system to protect against acute pancreatitis through vagal and nitric oxide-dependent pathways...
  12. ncbi [Strategy to manage low dose aspirin-induced gastrointestinal injury]
    Hideyuki Hiraishi
    Department of Gastroenterology, Dokkyo Medical University
    Nihon Rinsho 69:369-75. 2011
    ..Herein, we focus on the strategy to manage aspirin-induced peptic ulcerations and their complications, based on the scientific evidence...
  13. ncbi Intraportal nicotine infusion in rats decreases hepatic blood flow through endothelin-1 and both endothelin A and endothelin B receptors
    Takashi Hashimoto
    Department of Gastroenterology, Dokkyo University School of Medicne, Kitakobayashi 880, Mibu, Tochigi 321 0293, Japan
    Toxicol Appl Pharmacol 196:1-10. 2004
    ..These findings suggest that nicotine inhibits hepatic circulation through ET-1, and ET(A) and ET(B) receptor...
  14. doi Frequency of nonsteroidal anti-inflammatory drug-associated ulcers
    Hideyuki Hiraishi
    Department of Gastroenterology, Dokkyo Medical University, Mibu, Tochigi, 321 0293, Japan
    Clin J Gastroenterol 5:171-6. 2012
    ..It is hoped that accumulation of evidence on gastrointestinal risk will allow many patients to rationally avoid gastrointestinal complications while receiving the benefits of NSAIDs and low-dose aspirin. ..
  15. doi Proton pump inhibitors and recurrent bleeding in peptic ulcer disease
    Akihiro Tajima
    Department of Gastroenterology, Dokkyo Medical University, Koshigaya Hospital, Koshigaya, Japan
    J Gastroenterol Hepatol 23:S237-41. 2008
    ..The metabolism of PPIs is dependent upon P450 2C19 genotypes and the clinical usefulness of genotypic analysis remains to be determined...
  16. ncbi [Role of Helicobacter pylori eradication in the prevention of peptic ulcer in NSAID users]
    Tadahito Shimada
    Department of Gastroenterology, Dokkyo Medical University
    Nihon Rinsho 65:1824-9. 2007
    ..However, H. pylori eradication should be considered in patients receiving long -term PPI maintenance treatment to prevent the development of corpus gastritis and gastric atrophy...
  17. ncbi [Guidelines in the management of Helicobacter pylori infection in Japan--in comparison with the guidelines published in other countries]
    Tadahito Shimada
    Department of Gastroenterology, Dokkyo University School of Medicine
    Nihon Rinsho 61:7-12. 2003
    ..Considering the high prevalence of gastric carcinomas in Japan. H. pylori eradication for the prevention of gastric carcinomas should be discussed urgently...
  18. ncbi [Diagnosis of Hlicobacter pylori infection by PCR]
    Tadahito Shimada
    Department of Gastroenterology, Dokkyo University School of Medicine
    Nihon Rinsho 60:319-23. 2002
  19. ncbi [Duodenal ulcer is one of the diseases for which H. pylori eradication is recommended]
    Tadahito Shimada
    Department of Gastroenterology, Dokkyo University School of Medicine
    Nihon Rinsho 63:264-8. 2005
  20. ncbi Comparison between endoscopic papillary balloon dilatation and endoscopic sphincterotomy for the treatment of common bile duct stones
    Hidetaka Watanabe
    Department of Gastroenterology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321 0293, Japan
    J Gastroenterol 42:56-62. 2007
    ....
  21. ncbi Brain-gut axis of the liver: the role of central neuropeptides
    Masashi Yoneda
    Department of Gastroenterology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321 0293, Japan
    J Gastroenterol 37:151-6. 2002
  22. ncbi [Iron deficiency anemia and H. pylori]
    Tadahito Shimada
    Department of Gastroenterology, Dokkyo Medical University
    Nihon Rinsho 66:584-9. 2008
    ..Uptake of iron by H. pylori is also suggested. Further properly designed trials are needed to confirm a causal relationship between H. pylori and IDA...
  23. ncbi [Cholyl glycine (CG)]
    Masashi Yoneda
    Department of Gastroenterology, Dokkyo University School of Medicine
    Nihon Rinsho 63:806-8. 2005
  24. ncbi [PPARgamma agonists for the diseases of gastrointestinal tract and liver]
    Tadahito Shimada
    Department of Gastroenterology, Dokkyo Medical University
    Nihon Rinsho 68:312-6. 2010
    ....
  25. ncbi [Role of proton pump inhibitor in the management of low dose aspirin related ulcerations]
    Hideyuki Hiraishi
    Department of Gastroenterology, Dokkyo Medical University
    Nihon Rinsho 68:2096-101. 2010
    ..Herein, we focus on the role of proton pump inhibitor (PPI) in the strategy to prevent and to treat aspirin-induced peptic ulcerations and their complications, based on the scientific evidence...
  26. ncbi [Helicobacter pylori vacuolating cytotoxin (VacA) and its mode of action]
    Tadahito Shimada
    Department of Gastroenterology, Dokkyo University School of Medicine
    Nihon Rinsho 60:90-5. 2002
  27. ncbi [Mechanism of gastric mucosal cell injury induced by reactive oxygen species and nitric oxide]
    Hideyuki Hiraishi
    Department of Gastroenterology, Dokkyo University School of Medicine
    Nihon Rinsho 60:130-6. 2002
  28. ncbi Peroxisome proliferator-activated receptor-gamma and esophageal cancer
    Tadahito Shimada
    J Lab Clin Med 140:4-5. 2002
  29. ncbi [Guideline for prophylaxis and treatment of NSAID-associated gastric ulcerations]
    Hideyuki Hiraishi
    Dapartment of Gastroenterology, Dokkyo Medical University
    Nihon Rinsho 65:1812-7. 2007
    ..However, long-term use of a COX-2 inhibitor may be associated with higher risk of cardiovascular events and strokes. Herein, we focus on prophylaxis and treatment of NSAID-associated gastric ulcerations...