Kazuo Tamura

Summary

Affiliation: Fukuoka University
Country: Japan

Publications

  1. ncbi request reprint Phase I study of the combination of irinotecan hydrochloride, carboplatin, and dexamethasone for the treatment of relapsed or refractory malignant lymphoma
    Junji Suzumiya
    Department of Internal Medicine, Fukuoka University, School of Medicine, Nanakuma 7 45 1, Jonan ku, Fukuoka 814 0180, Japan
    Int J Hematol 79:266-70. 2004
  2. doi request reprint Efficacy and safety of micafungin, an echinocandin antifungal agent, on invasive fungal infections in patients with hematological disorders
    Kazuo Tamura
    Department of Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan
    Leuk Lymphoma 50:92-100. 2009
  3. ncbi request reprint Efficacy and safety of febuxostat for prevention of tumor lysis syndrome in patients with malignant tumors receiving chemotherapy: a phase III, randomized, multi-center trial comparing febuxostat and allopurinol
    Kazuo Tamura
    General Medical Research Center, Fukuoka University, Fukuoka, Fukuoka, Japan
    Int J Clin Oncol 21:996-1003. 2016
  4. ncbi request reprint Breakthrough chemotherapy-induced nausea and vomiting: report of a nationwide survey by the CINV Study Group of Japan
    Kazuo Tamura
    General Medical Research Center, Fukuoka University, 7 45 1, Nanakuma, Jonan ku, Fukuoka shi, Fukuoka, 814 0180, Japan
    Int J Clin Oncol . 2016
  5. doi request reprint Recombinant human soluble thrombomodulin (thrombomodulin alfa) to treat disseminated intravascular coagulation in solid tumors: results of a one-arm prospective trial
    Kazuo Tamura
    Division of Medical Oncology, Hematology and Infectious Diseases, Department of Medicine, Fukuoka University Hospital, 7 45 1, Nanakuma, Jonan ku, Fukuoka, Fukuoka, 814 0180, Japan
    Int J Clin Oncol 20:821-8. 2015
  6. doi request reprint Testing the effectiveness of antiemetic guidelines: results of a prospective registry by the CINV Study Group of Japan
    Kazuo Tamura
    Division of Medical Oncology, Hematology and Infectious Diseases, Department of Medicine, School of Medicine, Fukuoka University, 7 45 1, Nanakuma, Jonan ku, Fukuoka, Fukuoko, 814 0180, Japan
    Int J Clin Oncol 20:855-65. 2015
  7. doi request reprint Efficacy and safety of tazobactam/piperacillin as an empirical treatment for the patients of adult and child with febrile neutropenia in Japan
    Kazuo Tamura
    Division of Medical Oncology, Hematology and Infectious Diseases, Department of Internal Medicine, Fukuoka University Hospital, Japan Electronic address
    J Infect Chemother 21:654-62. 2015
  8. ncbi request reprint Cefepime or carbapenem treatment for febrile neutropenia as a single agent is as effective as a combination of 4th-generation cephalosporin + aminoglycosides: comparative study
    K Tamura
    Fukuoka University Hospital, Fukuoka, Japan
    Am J Hematol 71:248-55. 2002
  9. ncbi request reprint Randomized trial of cefepime monotherapy or cefepime in combination with amikacin as empirical therapy for febrile neutropenia
    K Tamura
    Fukuoka University Hospital, Fukuoka, 814 0180, Japan
    Clin Infect Dis 39:S15-24. 2004
  10. ncbi request reprint Initial empirical antimicrobial therapy: duration and subsequent modifications
    K Tamura
    Fukuoka University Hospital, Fukuoka, Japan
    Clin Infect Dis 39:S59-64. 2004

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint Phase I study of the combination of irinotecan hydrochloride, carboplatin, and dexamethasone for the treatment of relapsed or refractory malignant lymphoma
    Junji Suzumiya
    Department of Internal Medicine, Fukuoka University, School of Medicine, Nanakuma 7 45 1, Jonan ku, Fukuoka 814 0180, Japan
    Int J Hematol 79:266-70. 2004
    ..The overall response rate was 36%. We conclude that the combination therapy of CPT-11, carboplatin, and dexamthasone is effective as salvage therapy but that the duration of response is too short...
  2. doi request reprint Efficacy and safety of micafungin, an echinocandin antifungal agent, on invasive fungal infections in patients with hematological disorders
    Kazuo Tamura
    Department of Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan
    Leuk Lymphoma 50:92-100. 2009
    ..1% (39/277), but most of them were mild and reversible. These data indicate the usefulness of micafungin as a novel therapeutic drug for both empirical and targeted therapy for IFIs...
  3. ncbi request reprint Efficacy and safety of febuxostat for prevention of tumor lysis syndrome in patients with malignant tumors receiving chemotherapy: a phase III, randomized, multi-center trial comparing febuxostat and allopurinol
    Kazuo Tamura
    General Medical Research Center, Fukuoka University, Fukuoka, Fukuoka, Japan
    Int J Clin Oncol 21:996-1003. 2016
    ....
  4. ncbi request reprint Breakthrough chemotherapy-induced nausea and vomiting: report of a nationwide survey by the CINV Study Group of Japan
    Kazuo Tamura
    General Medical Research Center, Fukuoka University, 7 45 1, Nanakuma, Jonan ku, Fukuoka shi, Fukuoka, 814 0180, Japan
    Int J Clin Oncol . 2016
    ..However, almost half the patients experienced breakthrough CINV. We analyzed the survey results in relationship to the management of patients with breakthrough CINV...
  5. doi request reprint Recombinant human soluble thrombomodulin (thrombomodulin alfa) to treat disseminated intravascular coagulation in solid tumors: results of a one-arm prospective trial
    Kazuo Tamura
    Division of Medical Oncology, Hematology and Infectious Diseases, Department of Medicine, Fukuoka University Hospital, 7 45 1, Nanakuma, Jonan ku, Fukuoka, Fukuoka, 814 0180, Japan
    Int J Clin Oncol 20:821-8. 2015
    ..Recombinant human soluble thrombomodulin (thrombomodulin alfa, TM-α) is a new anticoagulant developed in Japan. We conducted a prospective study that evaluated the efficacy and safety of TM-α in patients with DIC-ST...
  6. doi request reprint Testing the effectiveness of antiemetic guidelines: results of a prospective registry by the CINV Study Group of Japan
    Kazuo Tamura
    Division of Medical Oncology, Hematology and Infectious Diseases, Department of Medicine, School of Medicine, Fukuoka University, 7 45 1, Nanakuma, Jonan ku, Fukuoka, Fukuoko, 814 0180, Japan
    Int J Clin Oncol 20:855-65. 2015
    ..Guidelines recommend a combination of two prophylactic antiemetics for moderately emetogenic chemotherapy (MEC) and three for highly emetogenic chemotherapy (HEC) and certain MEC regimens...
  7. doi request reprint Efficacy and safety of tazobactam/piperacillin as an empirical treatment for the patients of adult and child with febrile neutropenia in Japan
    Kazuo Tamura
    Division of Medical Oncology, Hematology and Infectious Diseases, Department of Internal Medicine, Fukuoka University Hospital, Japan Electronic address
    J Infect Chemother 21:654-62. 2015
    ..As for pediatric patients, given the limited number of cases studied, further investigation is needed (Clinical trial number: Japic CTI-121728)...
  8. ncbi request reprint Cefepime or carbapenem treatment for febrile neutropenia as a single agent is as effective as a combination of 4th-generation cephalosporin + aminoglycosides: comparative study
    K Tamura
    Fukuoka University Hospital, Fukuoka, Japan
    Am J Hematol 71:248-55. 2002
    ..These results indicate that cefepime or a carbapenem alone is as effective as a combination of cefepime and an aminoglycoside for treating FN...
  9. ncbi request reprint Randomized trial of cefepime monotherapy or cefepime in combination with amikacin as empirical therapy for febrile neutropenia
    K Tamura
    Fukuoka University Hospital, Fukuoka, 814 0180, Japan
    Clin Infect Dis 39:S15-24. 2004
    ..Overall, cefepime monotherapy is as effective as dual therapy for the initial treatment of febrile neutropenic patients. Further study is warranted for patients with severe neutropenia and leukemia who may benefit from dual therapy...
  10. ncbi request reprint Initial empirical antimicrobial therapy: duration and subsequent modifications
    K Tamura
    Fukuoka University Hospital, Fukuoka, Japan
    Clin Infect Dis 39:S59-64. 2004
    ..For patients initially receiving dual therapy, the cephalosporin or carbapenem can be changed as with monotherapy, whereas the initial aminoglycoside should be changed to another aminoglycoside or intravenous ciprofloxacin...
  11. ncbi request reprint Clinical guidelines for the management of neutropenic patients with unexplained fever in Japan: validation by the Japan Febrile Neutropenia Study Group
    Kazuo Tamura
    The First Department of Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan
    Int J Antimicrob Agents 26:S123-7; discussion S133-40. 2005
    ....
  12. ncbi request reprint Retrospective analysis of cord blood transplantation on 62 adult patients with advanced hematological malignancies
    Kazuo Tamura
    Department of Internal Medicine, Fukuoka University Hospital, Japan
    Fukuoka Igaku Zasshi 97:175-82. 2006
    ..It is of importance that the appropriate indication for CBT should be discussed between transplant experts and patients and their families in each case...
  13. doi request reprint Rituximab in combination with CHOP chemotherapy for the treatment of diffuse large B cell lymphoma in Japan: a retrospective analysis of 1,057 cases from Kyushu Lymphoma Study Group
    Ritsuko Seki
    Division of Hematology and Oncology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Int J Hematol 91:258-66. 2010
    ..104), compared with no radiation group (P < 0.001). Results of this large-scale, multicenter study confirm that rituximab plus CHOP provided a greater survival benefit than CHOP alone...
  14. doi request reprint Population pharmacokinetic study of a test dose oral busulfan in Japanese adult patients undergoing hematopoietic stem cell transplantation
    Yasushi Takamatsu
    Division of Medical Oncology, Hematology and Infectious Disease, Department of Medicine, Fukuoka University, Nanakuma 7 45 1, Jonan ku, Fukuoka, 814 0180, Japan
    Cancer Chemother Pharmacol 65:1203-7. 2010
    ..The aim of this study is to determine the population pharmacokinetics of oral busulfan in Japanese adults...
  15. doi request reprint Addition of rituximab to cyclophosphamide, doxorubicin, vincristine, and prednisolone therapy has a high risk of developing interstitial pneumonia in patients with non-Hodgkin lymphoma
    Hiroo Katsuya
    Department of Medical Oncology and Hematology, Fukuoka University Hospital, Fukuoka, Japan
    Leuk Lymphoma 50:1818-23. 2009
    ..Patients with lymphoma who were treated by R-CHOP regimen, might be considered as PCP prophylactic, especially if the number of lymphocytes is low at the beginning of chemotherapy...
  16. ncbi request reprint [Extranodal NK/T-cell lymphoma arising from soft tissue of the left forearm]
    Naoko Kunami
    Division of Oncology, Hematology and Infectious Disease, Department of Internal Medicine, Fukuoka University
    Rinsho Ketsueki 51:422-6. 2010
    ..The patient currently remains alive and well without progression 2 years after amputation. When evaluating panniculitis, which is difficult to cure, ENKL should be considered in the differential diagnosis and treated appropriately...
  17. doi request reprint Expression and role of GLUT-1, MCT-1, and MCT-4 in malignant pleural mesothelioma
    Ai Mogi
    Department of Pathology, Fukuoka University School of Medicine and Hospital, 7 45 1 Nanakuma, Jonan ku, Fukuoka, 814 0180, Japan
    Virchows Arch 462:83-93. 2013
    ..Taken together, these results indicate that combined application of GLUT-1, MCT-1, and MCT-4 immunohistochemistry might be useful in differentiating MPM from RMH and suggest that MCT-1plays an important biological role...
  18. doi request reprint Targeting Bcl-2 family proteins in adult T-cell leukemia/lymphoma: in vitro and in vivo effects of the novel Bcl-2 family inhibitor ABT-737
    Kenji Ishitsuka
    Department of Internal Medicine, Division of Medical Oncology, Hematology and Infectious Disease, Fukuoka University, 7 45 1 Nanakuma, Jonan, Fukuoka 814 0180, Japan
    Cancer Lett 317:218-25. 2012
    ..These results suggest that the use of an agent targeting anti-apoptotic bcl-2 family proteins, either alone or in combination with other conventional drugs, represents a novel promising approach for ATLL...
  19. doi request reprint Prognostic index for acute- and lymphoma-type adult T-cell leukemia/lymphoma
    Hiroo Katsuya
    Department of Internal Medicine, Fukuoka University, Jonan, Fukuoka, Japan
    J Clin Oncol 30:1635-40. 2012
    ..The aim of this study was to develop a prognostic index (PI) for acute- and lymphoma-type ATL (ATL-PI)...
  20. doi request reprint Bortezomib, doxorubicin and intermediate-dose dexamethasone (iPAD) therapy for relapsed or refractory multiple myeloma: a multicenter phase 2 study
    Yasushi Takamatsu
    Division of Medical Oncology, Hematology and Infectious Diseases, Department of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Int J Hematol 98:179-85. 2013
    ..We conclude that iPAD therapy is feasible, and shows efficacy by inducing high response rates and long response duration. ..
  21. doi request reprint A patient with acute myeloid leukemia who developed fatal pneumonia caused by carbapenem-resistant Bacillus cereus
    Hiroo Katsuya
    The Department of Medicine, Division of Medical Oncology, Infectious Disease, and Endocrinology, School of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    J Infect Chemother 15:39-41. 2009
    ..This is the first report of fulminant infection caused by carbapenem-resistant B. cereus in a neutropenic patient. B. cereus should be kept in mind as a target of empirical treatment when neutropenic patients develop pneumonia...
  22. doi request reprint Paclitaxel as a first-line chemotherapy for Japanese women with advanced or recurrent breast cancer: a multi-institutional practice-based study by the Kyushu Breast Cancer Study Group (KBC-SG)
    Mikimasa Ishikawa
    Department of Surgery, Kyushu Koseinenkin Hospital, Fukuoka, Japan
    Breast Cancer 17:131-5. 2010
    ..A non-anthracycline-based novel therapy is necessary to improve the survival and reduce the toxicity...
  23. ncbi request reprint Individual dose adjustment of oral busulfan using a test dose in hematopoietic stem cell transplantation
    Yasushi Takamatsu
    First Department of Internal Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    Int J Hematol 86:261-8. 2007
    ....
  24. doi request reprint Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (III)
    Daisuke Nakano
    Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka, 814 0180, Japan
    J Nat Med 67:894-903. 2013
    ..Extracts from the aerial parts of Annona reticulata and A. squamosa showed the most potent inhibitory activity and three aporphine alkaloids were isolated from their extracts as the active principles by activity-guided fractionation...
  25. doi request reprint Importance of inducible multidrug resistance 1 expression in HL-60 cells resistant to gemtuzumab ozogamicin
    Taichi Matsumoto
    Division of Medical Oncology, Hematology and Infectious Disease, Department of Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan
    Leuk Lymphoma 53:1399-405. 2012
    ..If the cells are positive then MEK1/2 inhibitors may be effective in overcoming resistance to GO...
  26. doi request reprint THP-COP regimen for the treatment of peripheral T-cell lymphoma and adult T-cell leukemia/lymphoma: a multicenter phase II study
    Yasushi Takamatsu
    Division of Medical Oncology, Hematology and Infectious Disease, Department of Medicine, Fukuoka University, Jonan ku, Fukuoka, Japan
    Eur J Haematol 84:391-7. 2010
    ..The aim of this study is to confirm the efficacy of THP-COP in the treatment of T-cell lymphoma...
  27. doi request reprint Presence of both heterogeneous vancomycin-intermediate resistance and β-lactam antibiotic-induced vancomycin resistance phenotypes is associated with the outcome in methicillin-resistant Staphylococcus aureus bloodstream infection
    Tohru Takata
    Division of Oncology, Department of Medicine, Fukuoka University School of Medicine, Fukuoka University School ofMedicine, Fukuoka, Japan
    Scand J Infect Dis 45:203-12. 2013
    ..The aim of this study was to determine the impact of the combination of hVISA and BIVR phenotypes on the clinical outcome in MRSA bacteremia...
  28. ncbi request reprint Cladribine treatment in two-hour intravenous infusion for previously-treated low grade B-cell lymphoma: a pilot study
    Yasushi Takamatsu
    Division of Medical Oncology, Hematology and Infectious Disease, Department of Medicine, Fukuoka University Hospital, Jonan ku, Fukuoka, Japan
    J Clin Exp Hematop 49:69-75. 2009
    ..Cladribine can be administered in 2-hour infusion in an outpatient clinic and is therefore quite convenient for patients...
  29. doi request reprint Am80 inhibits stromal cell-derived factor-1-induced chemotaxis in T-cell acute lymphoblastic leukemia cells
    Taichi Matsumoto
    Division of Medical Oncology and Hematology and Infectious Disease, Department of Internal Medicine, Fukuoka University, Nanakuma, Fukuoka, Japan
    Leuk Lymphoma 51:507-14. 2010
    ..Am80 may be an effective drug to inhibit the extramedullary infiltration of T-ALL cells...
  30. doi request reprint Treatment and survival among 1594 patients with ATL
    Hiroo Katsuya
    Division of Medical Oncology, Hematology and Infectious Diseases, Department of Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan
    Blood 126:2570-7. 2015
    ..Of note, one-quarter of patients who could undergo transplantation experienced long survival. It is also noted that the prognosis of the smoldering type was worse than expected. ..
  31. doi request reprint A phase I study of bortezomib in combination with doxorubicin and intermediate-dose dexamethasone (iPAD therapy) for relapsed or refractory multiple myeloma
    Yasushi Takamatsu
    Division of Medical Oncology, Hematology and Infectious Diseases, Department of Medicine, Fukuoka University, Fukuoka, 814 0180, Japan
    Int J Hematol 92:503-9. 2010
    ..It is concluded that bortezomib at the dose of 1.0 mg/m² is recommended in combination with doxorubicin and intermediate-dose dexamethasone...
  32. doi request reprint Prognostic impact of immunohistochemical biomarkers in diffuse large B-cell lymphoma in the rituximab era
    Ritsuko Seki
    Division of Hematology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan
    Cancer Sci 100:1842-7. 2009
    ..001) and also in the R-CHOP group (P < 0.001). Results of improved survival with rituximab addition indicate that the relevance of previously recognized prognostic factors should be re-evaluated...
  33. doi request reprint Clinicopathological characteristics and rituximab addition to cytotoxic therapies in patients with rheumatoid arthritis and methotrexate-associated large B lymphoproliferative disorders
    Kozue Yamada
    Department of Pathology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    Histopathology 67:70-80. 2015
    ..To analyse the clinicopathological characteristics and prognosis of 40 rheumatoid arthritis (RA) patients with methotrexate (MTX)-associated large B cell lymphoproliferative disorders (MTX-BLPD)...
  34. doi request reprint Colitis mimicking graft-versus-host disease during treatment with the anti-CCR4 monoclonal antibody, mogamulizumab
    Kenji Ishitsuka
    Division of Oncology, Hematology and Infectious Diseases, Department of Internal Medicine, Fukuoka University, 7 45 1 Nanakuma Jonan, Fukuoka, 814 0180, Japan
    Int J Hematol 102:493-7. 2015
    ..Special attention should be paid to the risk of unique immune-related adverse events induced by mogamulizumab...
  35. doi request reprint Safety and pharmacokinetic evaluation of repeated intravenous administration of palonosetron 0.75 mg in patients receiving highly or moderately emetogenic chemotherapy
    Yosuke Ikari
    Division of Medical Oncology, Hematology and Infectious Diseases, Department of Internal Medicine, School of Medicine, Fukuoka University, Nanakuma, Jyonan ku, Fukuoka, Japan
    Support Care Cancer 22:1959-64. 2014
    ..The aims of this study were to evaluate the safety, efficacy, and pharmacokinetics of repeated doses of palonosetron 0.75 mg on days 1 and 3 in Japanese patients who received highly or moderately emetogenic chemotherapy...
  36. doi request reprint Simultaneous determination of cytosine arabinoside and its metabolite, uracil arabinoside, in human plasma using hydrophilic interaction liquid chromatography with UV detection
    Masanobu Uchiyama
    Department of Pharmacy, Fukuoka University Hospital, Fukuoka, Japan
    Biomed Chromatogr 27:818-20. 2013
    ..This method was used to determine the plasma concentrations of Ara-C and Ara-U in a patient treated with high-dose Ara-C therapy for end-stage renal failure...
  37. doi request reprint Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (II): apoptosis of antiproliferactive principle (24,25-dihydrowithanolide D) against ATL cell lines and structure-activity relationships with witha
    Daisuke Nakano
    Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka, 814 0180, Japan
    J Nat Med 67:415-20. 2013
    ..Furthermore, 24,25-dihydrowithanolide D (13) was identified as the most potent inhibitor, showing selective toxicity against ATL cell lines by inducing apoptotic cell death...
  38. ncbi request reprint Oncogene associated cDNA microarray analysis shows PRAME gene expression is a marker for response to anthracycline containing chemotherapy in patients with diffuse large B-cell lymphoma
    Riko Kawano
    First Department of Internal Medicine, School of Medicine, Fukuoka University
    J Clin Exp Hematop 49:1-7. 2009
    ..0373). Our results therefore indicate that PRAME expression in DLBCL correlates with response to anthracycline containing chemotherapy...
  39. ncbi request reprint Antitumor effects of CRM197, a specific inhibitor of HB-EGF, in T-cell acute lymphoblastic leukemia
    Naoko Kunami
    Department of Internal Medicine, Faculty of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Anticancer Res 31:2483-8. 2011
    ..CRM197 induced apoptosis, and furthermore, the combination of CRM197 plus doxorubicin enhanced cytotoxicity in a T-ALL cell line. These results suggest that HB-EGF is a promising therapeutic target for T-ALL...
  40. doi request reprint Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (V): coumarins and alkaloids from Boenninghausenia japonica and Ruta graveolens
    Daisuke Nakano
    Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka, 814 0180, Japan
    J Nat Med 71:170-180. 2017
    ..Following 27, compound 28 showed potent activity. These results therefore suggested that the presence of a 3-dimethylallyl moiety was important to the antiproliferative activity of these coumarin analogs...
  41. doi request reprint Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (IV): phenanthroindolizidine alkaloids from Tylophora tanakae leaves
    Daisuke Nakano
    Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka, 814 0180, Japan
    J Nat Med 69:397-401. 2015
    ..In contrast, the presence of a 2-methoxy moiety, a 7-methoxy moiety, or an N-oxide moiety appears to reduce the potency of the antiproliferative activity against HTLV-1-infected T cells. ..
  42. doi request reprint Interferon-α and zidovudine for relapsed/refractory adult T cell leukemia/lymphoma: case reports of Japanese patients
    Kenji Ishitsuka
    Division of Medical Oncology, Hematology and Infectious Disease, Fukuoka University, 7 45 1 Nanakuma Jonan, Fukuoka 814 0180, Japan
    Int J Hematol 92:762-4. 2010
    ..It is impossible to draw any definitive conclusion from this small study; however, IFN/AZT showed clear anti-ATL effects for refractory/relapsed ATL patients. This report would contribute for developing future ATL treatment in Japan...
  43. pmc Objective evaluation of oxaliplatin-induced vascular pain secondary to peripheral vein administration
    Yoichiro Yoshida
    Department of Gastroenterological Surgery, Fukuoka University Faculty of Medicine, 7 45 1 Nanakuma, Jonan ku, Fukuoka, 814 0180 Japan
    Springerplus 5:1872. 2016
    ..PainVision PS-2100 (PV) is a medical device that was designed to objectively and quantitatively assess patient nociception and perception...
  44. ncbi request reprint Thrombocytopenia in association with splenomegaly during granulocyte-colony-stimulating factor treatment in mice is not caused by hypersplenism and is resolved spontaneously
    Yasushi Takamatsu
    First Department of Internal Medicine, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    Transfusion 47:41-9. 2007
    ..Because splenic pooling of PLTs caused thrombocytopenia in patients with splenomegaly and splenic enlargement was observed in G-CSF-treated donors, it was hypothesized that hypersplenism might cause G-CSF-induced thrombocytopenia...
  45. pmc A phase II study of bortezomib in patients with relapsed or refractory aggressive adult T-cell leukemia/lymphoma
    Kenji Ishitsuka
    Division of Oncology, Hematology and Infectious Diseases, Fukuoka University, Fukuoka, Japan
    Cancer Sci 106:1219-23. 2015
    ....
  46. ncbi request reprint 5-Fluorouracil Chemotherapy for Dihydropyrimidine Dehydrogenase-deficient Patients: Potential of the Dose-escalation Method
    Yoichiro Yoshida
    Department of Gastroenterological Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    Anticancer Res 35:4881-7. 2015
    ..Dihydropyrimidine dehydrogenase (DPD) degrades approximately 85% of administered 5-fluorouracil (5-FU). With a reported high mortality rate, chemotherapy is generally contraindicated for patients with DPD deficiency...
  47. ncbi request reprint RARalpha is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells
    Shiro Jimi
    Central Laboratory of Pathology and Morphology, School of Medicine, Fukuoka University, Fukuoka 814 0180, Japan
    Int J Oncol 31:397-404. 2007
    ..0137). Our results indicate that Am-80-induced cell-type non-specific growth inhibition is mediated by TGF-beta2, where the total mass of RARalpha could be an important regulatory factor in hematologic malignant cells...
  48. doi request reprint Dose escalation study of epirubicin and docetaxel in patients with advanced or recurrent breast cancer
    Ichiro Ichinose
    Department of Medicine, Fukuoka University School of Medicine, Fukuoka, Japan
    Chemotherapy 54:379-85. 2008
    ..To develop a combination of epirubicin (EPI) and docetaxel (DTX) in Japan, dose escalation and pharmacokinetic studies were performed in patients with advanced or recurrent breast cancer...
  49. doi request reprint Pleural malignant mesothelioma with invasive micropapillary component and its association with pulmonary metastasis
    Ai Mogi
    Departments of Pathology, Fukuoka University Hospital, Fukuoka, Japan
    Pathol Int 59:874-9. 2009
    ..This component can predict more aggressive lymphatic spread, similar to that of carcinomas in other organs with micropapillary pattern...
  50. doi request reprint Simple and sensitive HPLC method for the fluorometric determination of methotrexate and its major metabolites in human plasma by post-column photochemical reaction
    Masanobu Uchiyama
    Department of Pharmacy, Fukuoka University Hospital, Fukuoka, Japan
    Biomed Chromatogr 26:76-80. 2012
    ..The within- and between-day variations for MTX, 7-OH-MTX and DAMPA were reliable (each was lower than 6.3%). This method was also used to monitor the concentrations of MTX and its metabolites in a patient on MTX therapy...
  51. ncbi request reprint Primary colorectal T-cell lymphoma
    Mitsuo Okada
    First Department of Internal Medicine, Fukuoka University, Fukuoka, Japan
    J Gastroenterol 38:376-84. 2003
    ..To our knowledge, this is the first case report of primary colorectal T-cell lymphoma with cytotoxic/suppressor T-cell phenotype...
  52. ncbi request reprint Epstein-Barr virus infection and gene promoter hypermethylation in rheumatoid arthritis patients with methotrexate-associated B cell lymphoproliferative disorders
    Kozue Ejima-Yamada
    Division of Medical Oncology, Hematology and Infectious Disease, Department of Pathology, Faculty of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka, 814 0180, Japan
    Virchows Arch . 2016
    ....
  53. doi request reprint Mature T/NK-cell lymphoproliferative disease and Epstein-Barr virus infection are more frequent in patients with rheumatoid arthritis treated with methotrexate
    Seiji Kondo
    Department of Hematology, Clinical Research Center, National Hospital Organization Kyushu Medical Center, 1 8 1 Jigyohama, Chuo Ku, Fukuoka, Japan
    Virchows Arch 462:399-407. 2013
    ..EBV infection may play a role in the pathogenesis of T/NK-cell LPD, as well as B-cell LPD and Hodgkin lymphoma in MTX-treated RA patients...
  54. ncbi request reprint Promise of combining a Bcl-2 family inhibitor with bortezomib or SAHA for adult T-cell leukemia/lymphoma
    Naoko Kunami
    Department of Internal Medicine, Division of Medical Oncology, Hematology and Infectious Diseases, Fukuoka University, Jonan, Fukuoka, Japan
    Anticancer Res 34:5287-94. 2014
    ..Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy of peripheral T-lymphocytes and its prognosis still remains very poor...
  55. doi request reprint Methicillin-resistant Staphylococcus aureus bloodstream infections in a Japanese University Hospital between 1987 and 2004
    Tohru Takata
    Department of Oncology, Hematology, and Infectious Diseases, Fukuoka University School of Medicine, Fukuoka, Japan
    J Infect Chemother 18:199-206. 2012
    ..75; 95% confidence interval, 1.17-2.64). These data indicated that SCCmec type II MRSA isolates were responsible for the increased MRSA bloodstream infections for inpatients during the 18-year study period in the hospital...
  56. ncbi request reprint Analysis of Candida glabrata strains with reduced sensitivity to micafungin in vitro isolated from a patient with persistent Candidemia
    Takahiko Ishikawa
    Department of Medicine, School of Medicine, Fukuoka University, Fukuoka 814 0181, Japan
    Jpn J Infect Dis 63:332-7. 2010
    ..Taken together, this low affinity of MCF for the enzymes is likely to cause the reduced sensitivities. These data further indicate that MCF could induce acquired MCF-resistant strains during clinical use...
  57. ncbi request reprint An evaluation of busulfan pharmacokinetics in patients undergoing hematopoietic stem cell transplantation
    Yasushi Takamatsu
    First Department of Internal Medicine, Fukuoka University School of Medicine, Nanakuma 7 45 1, Jonan ku, Fukuoka 814 0180, Japan
    Jpn J Clin Oncol 35:400-3. 2005
    ..However, there are no data available for Japanese patients...
  58. ncbi request reprint Attenuated antibody reaction for the primary antigen but not for the recall antigen of influenza vaccination in patients with non-Hodgkin B-cell lymphoma after the administration of rituximab-CHOP
    Tohru Takata
    Division of Oncology, Hematology, and Infectious Diseases, Department of Medicine, Fukuoka University School of Medicine
    J Clin Exp Hematop 49:9-13. 2009
    ..014). This study showed that vaccination against influenza virus generated an appreciable humoral response to recall antigens in NHL patients treated with R-CHOP therapy, but not to the primary antigen...
  59. ncbi request reprint Osteosarcoma of the patella mimicking giant cell tumor: imaging features with histopathological correlation
    Mikiko Aoki
    Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Anticancer Res 34:2541-5. 2014
    ..Our case highlights the difficulty in the diagnosis of patellar osteosarcoma and the importance of performing a biopsy before definitive treatment. ..
  60. ncbi request reprint Adjuvant therapy for breast cancer in Kyushu
    Shinichi Wakamatsu
    Department of Internal Medicine, School of Medicine, Fukuoka University Hospital, 7 45 1 Nanakuma, Jonan ku, Fukuoke City 814 0810, Japan
    Breast Cancer 13:308-12. 2006
    ..Therefore, the Kyushu Breast Cancer Study Group (KBC-SG) started registering newly diagnosed breast cancer patients who were to receive adjuvant therapy...
  61. ncbi request reprint Imatinib mesylate inhibits cell invasion of malignant peripheral nerve sheath tumor induced by platelet-derived growth factor-BB
    Mikiko Aoki
    Department of Pathology, Fukuoka University School of Medicine, Fukuoka, Japan
    Lab Invest 87:767-79. 2007
    ..The results provide the ground for further assessment of the therapeutic potential of imatinib in suppressing the invasion and growth of MPNST...
  62. doi request reprint Screening of promising chemotherapeutic candidates against human adult T-cell leukemia/lymphoma from plants: active principles from Physalis pruinosa and structure-activity relationships with withanolides
    Daisuke Nakano
    Fukuoka University, Jonan ku, Fukuoka, Japan
    J Nat Med 65:559-67. 2011
    ..The presence of a 5β,6β-epoxy function is suggested to be essential for the activity, and the most active principle showed selective toxicity to HTLV-1-infected T-cell lines...
  63. doi request reprint Retrospective Analysis of Treatment Outcomes and Geriatric Assessment in Elderly Malignant Lymphoma Patients
    Yoshiko Naito
    Department of Medical Oncology, Hematology and Infectious Diseases, Fukuoka University
    J Clin Exp Hematop 56:43-9. 2016
    ..005), and cognitive impairment (P = 0.0488). In cases of DLBCL, survival was affected by comorbidity score ≥ 5 (P = 0.0016). High comorbidity score was strongly associated with survival in both NHL and DLBCL. ..
  64. ncbi request reprint Rapid and sensitive HPLC method for the simultaneous determination of paraquat and diquat in human serum
    Shuuji Hara
    Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
    Anal Sci 23:523-6. 2007
    ..3 and 2.2%, respectively. This technique was also utilized to determine the paraquat and diquat serum levels in a patient who had ingested herbicide (Prigrox L) containing paraquat and diquat...
  65. doi request reprint Administration of chemotherapy via the median cubital vein without implantable central venous access ports: port-free chemotherapy for metastatic colorectal cancer patients
    Yoichiro Yoshida
    Department of Gastroenterological Surgery, Fukuoka University Faculty of Medicine, 7 45 1 Nanakuma, Jonan ku, Fukuoka, 814 0180, Japan
    Int J Clin Oncol 20:332-7. 2015
    ..In this study, the safety and efficacy of CV-port-free chemotherapy administration via the median cubital vein was assessed in metastatic colorectal cancer patients...
  66. doi request reprint Multicenter phase II study of mogamulizumab (KW-0761), a defucosylated anti-cc chemokine receptor 4 antibody, in patients with relapsed peripheral T-cell lymphoma and cutaneous T-cell lymphoma
    Michinori Ogura
    Michinori Ogura, Nagoya Daini Red Cross Hospital Takashi Ishida and Hiroshi Inagaki, Nagoya City University Graduate School of Medical Sciences Kazuhito Yamamoto, Aichi Cancer Center Ryuzo Ueda, Aichi Medical University School of Medicine, Nagoya Kiyohiko Hatake, Japanese Foundation for Cancer Research Kensei Tobinai, National Cancer Center Hospital Shiro Akinaga, Kyowa Hakko Kirin, Tokyo Masafumi Taniwaki, Kyoto Prefectural University of Medicine, Kyoto Kiyoshi Ando, Tokai University School of Medicine, Kanagawa Katsuya Fujimoto, Hokkaido University Graduate School of Medicine, Sapporo Toshihiro Miyamoto, Kyushu University Graduate School of Medical Sciences Naokuni Uike, National Hospital Organization Kyushu Cancer Center Kazuo Tamura, Fukuoka University, Fukuoka Mitsune Tanimoto, Okayama University Hospital, Okayama Kunihiro Tsukasaki, Nagasaki University Graduate School of Biomedical Science Masao Tomonaga, Japanese Red Cross Nagasaki Atomic Bomb Hospital, Nagasaki Kenichi Ishizawa, Tohoku University Hospital, Sendai and Junji Suzumiya, Shimane University Hospital, Izumo, Japan
    J Clin Oncol 32:1157-63. 2014
    ..This multicenter phase II study evaluated the efficacy and safety of mogamulizumab in patients with relapsed PTCL and cutaneous T-cell lymphoma (CTCL)...
  67. ncbi request reprint Bone marrow necrosis in a patient with acute promyelocytic leukemia during re-induction therapy with arsenic trioxide
    Kenji Ishitsuka
    1st Department of Internal Medicine, Fukuoka University, Fukuoka, Japan
    Eur J Haematol 72:280-4. 2004
    ..9 microm and 3.2 h, respectively, in the therapeutic range. This is the first case of bone marrow necrosis after standard-dose As2O3 therapy...
  68. ncbi request reprint [Clinical management for febrile neutropenia]
    Kazuo Tamura
    First Department of Internal Medicine, School of Medicine, Fukuoka University
    Kansenshogaku Zasshi 80:358-65. 2006
  69. ncbi request reprint Beta-cell function is a major contributor to oral glucose disposition in obese Japanese students
    Takashi Asano
    Medical Health Center, Fukuoka University, Fukuoka, Japan
    Endocr J 54:903-10. 2007
    ..In conclusion, our study showed that both insulin sensitivity and impaired beta-cell function are associated with impaired glucose metabolism, and that beta-cell function may be more important in determining glucose disposal...
  70. ncbi request reprint Treatment of adult T-cell leukemia/lymphoma: past, present, and future
    Kenji Ishitsuka
    Internal Medicine, Division of Hematology and Oncology, Fukuoka University, Fukuoka, Japan
    Eur J Haematol 80:185-96. 2008
    ..Further studies are required to confirm the clinical benefits of these novel therapeutics. This article reviews the current status and future directions of ATLL treatment...
  71. pmc Evaluation of regional cerebral glucose metabolism in patients with malignant lymphoma of the body using statistical image analysis
    Masanari Nonokuma
    Department of Radiology, Fukuoka University Hospital, Fukuoka, Japan
    Ann Nucl Med 28:950-60. 2014
    ..Post-therapeutic changes in cerebral glucose metabolism were also evaluated...
  72. doi request reprint Human T-cell leukaemia virus type I and adult T-cell leukaemia-lymphoma
    Kenji Ishitsuka
    Division of Oncology, Hematology and Infectious Diseases, Department of Internal Medicine, Fukuoka University, Fukuoka, Japan Electronic address
    Lancet Oncol 15:e517-26. 2014
    ....
  73. ncbi request reprint [Pilot study-previously treated advanced non-small cell lung cancer]
    Shigetoshi Shirahama
    First Dept of Internal Medicine, School of Medicine, Fukuoka University
    Gan To Kagaku Ryoho 31:2133-7. 2004
    ..Severe non-hematological toxicity was uncommon; grade 1 neuropathy in 2 patients. This regimen had good clinical efficacy with low toxicity in outpatients with advanced NSCLC...
  74. ncbi request reprint Epstein-Barr virus genome level, T-cell clonality and the prognosis of angioimmunoblastic T-cell lymphoma
    Riko Kawano
    Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Haematologica 90:1192-6. 2005
    ..AILT is characterized by the presence of increased numbers of Epstein-Barr virus (EBV) infected cells. The aim of this study was to clarify the correlation between clonality, EBV and prognosis...
  75. ncbi request reprint [Legionnaires' disease asssociated with meningitis and cerebellar ataxia]
    Takahiko Ishikawa
    The First Department of Internal Medicine, Fukuoka Univsity, School of Medicine, Fukuoka
    Nihon Naika Gakkai Zasshi 95:2289-91. 2006
  76. ncbi request reprint Lack of common NOD2 variants in Japanese patients with Crohn's disease
    Nagamu Inoue
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Gastroenterology 123:86-91. 2002
    ..Here, we have evaluated the 3 NOD2 variants in Japanese patients to determine whether the gene is also associated with susceptibility to CD in a non-Western population...
  77. ncbi request reprint Pregnancy complicated with pure red cell aplasia: a case report
    Yasuo Makino
    Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, Japan
    J Perinat Med 31:530-4. 2003
    ..The neonate was a normal female infant without anemia (hemoglobin 17.9 g/dl) and the 1 minute Apgar score was 8. Her hemoglobin level rose to 12.1 g/dl spontaneously two weeks after delivery...
  78. ncbi request reprint Emmprin, a cell surface inducer of matrix metalloproteinases (MMPs), is expressed in T-cell lymphomas
    Kazuki Nabeshima
    Department of Pathology, Fukuoka University School of Medicine, Fukuoka, Japan
    J Pathol 202:341-51. 2004
    ..In conclusion, emmprin is overexpressed by T-lymphoma cells, when compared with normal counterparts, and facilitates MMP-2 production via interactions with fibroblasts, which could play a role in stromal invasion by lymphoma cells...
  79. ncbi request reprint [High dose ara-C therapy induced bradycardia in an acute myeloid leukemia patient with inv (16)(p13q22)]
    Midori Kumagawa
    Blood Transfusion Unit of Fukuoka University Hospital, First Department of Internal Medicine, School of Medicine, Fukuoka University
    Rinsho Ketsueki 44:404-6. 2003
    ..After achieving informed consent, we gave her another course of high dose ara-C, which once again resulted in a decreased heart rate. This suggests that the administration of high dose ara-C could cause bradycardia...
  80. ncbi request reprint [A successful treatment of progressive necrotizing myositis caused by Aeromonas veronii biotype sobria]
    Ai Masuya
    First Department of Internal Medicine, Fukuoka University School of Medicine
    Kansenshogaku Zasshi 77:991-5. 2003
    ..It is to note that even though the patient's neutrophil count is zero, he or she should be treated aggressively by drainaging the lesion or even amputation of the involved extremities in combination with proper antibiotics...
  81. ncbi request reprint [Registration of hematological disorders by the Kyushu Hematology Organization for Treatment (K-HOT) Study Group]
    Riko Kawano
    Fukuoka University Hospital
    Rinsho Ketsueki 45:478-80. 2004
    ..The annual incidence of MM is estimated to be much higher than that previously reported. It is also confirmed that ATL is still one of the frequently encountered lymphoid malignancies in the Kyushu district...
  82. ncbi request reprint Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathway
    Kenji Ishitsuka
    Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Oncogene 24:5888-96. 2005
    ....
  83. ncbi request reprint Clinical guidelines for the management of cancer patients with neutropenia and unexplained fever
    Huang Xiao Jun
    Int J Antimicrob Agents 26:S128-32; discussion S133-40. 2005
  84. ncbi request reprint [Management of febrile neutropenic patients]
    Tohru Takata
    First Dept of Internal Medicine, Fukuoka University School of Medicine
    Gan To Kagaku Ryoho 33:13-8. 2006
    ..After 48 hours of observation on the treatment, antifungals are then started depending on the results of culture and serological tests. Chemoprophylaxis should be considered for patients at high risk...
  85. ncbi request reprint [Concept and clinical study of sepsis]
    Kazuo Tamura
    Nihon Naika Gakkai Zasshi 94:2620-8. 2005
  86. ncbi request reprint Efficacy and toxicity of vinorelbine with doxorubicin/cyclophosphamide combination chemotherapy in a phase I-II study for advanced or recurrent breast cancer patients
    Toshiaki Saeki
    Department of Surgery, National Shikoku Cancer Center Hospital, Matsuyama
    Breast Cancer 13:159-65. 2006
    ..To evaluate the efficacy and toxicity of vinorelbine (VNB) with doxorubicin/cyclophosphamide (AC) combination chemotherapy, a phase I-II study was carried out in patients with advanced or recurrent breast cancer...
  87. ncbi request reprint Efficacy of intravenous ciprofloxacin in patients with febrile neutropenia refractory to initial therapy
    Hitoshi Matsuoka
    Koga General Hospital, Miyazaki, Japan
    Leuk Lymphoma 47:1618-23. 2006
    ..These findings indicate that addition of intravenous ciprofloxacin is effective against FN refractory to initial antibiotic therapy and has acceptable toxicity...
  88. ncbi request reprint [Adjuvant doxorubicin and cyclophosphamide followed by weekly paclitaxel for Japanese women with node-positive breast cancer: a multi-institutional feasibility study in a variety of practice settings in Kyushu]
    Keisei Anan
    Dept of Surgery, Kitakyushu Municipal Medical Center
    Gan To Kagaku Ryoho 33:1417-22. 2006
    ..8%) treatment discontinuations, including two allergic reactions to paclitaxel. AC followed by wT can be administered safely in the community at doses of 50 mg/m(2), 500 mg/m(2), and 80 mg/m(2), respectively,with minimal toxicity...
  89. ncbi request reprint [Antibiotic therapy for patients with neutropenia]
    Kazuo Tamura
    Nihon Naika Gakkai Zasshi 95:2202-7. 2006
  90. ncbi request reprint Dosage of capecitabine and cyclophosphamide combination therapy in patients with metastatic breast cancer
    Shinji Ohno
    Department of Breast Oncology, National Kyushu Cancer Center Hospital, 3 1 1 Notame, Minami Ku, Fukuoka 811 1395, Japan
    Anticancer Res 27:1009-13. 2007
    ..Capecitabine and cyclophosphamide are orally administered and have preclinical synergy and non-overlapping toxicities...
  91. ncbi request reprint Therapeutic potential of arsenic trioxide with or without interferon-alpha for relapsed/refractory adult T-cell leukemia/lymphoma
    Kenji Ishitsuka
    Haematologica 92:719-20. 2007
    ..Further studies are needed to clarify the role of As2O3 and its usefulness when combined with IFN for the treatment of ATLL...
  92. ncbi request reprint [Febrile neutropenia]
    Kazuo Tamura
    Rinsho Ketsueki 48:273-84. 2007
  93. ncbi request reprint VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study JCOG9801
    Kunihiro Tsukasaki
    Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan
    J Clin Oncol 25:5458-64. 2007
    ..To test the superiority of VCAP-AMP-VECP over biweekly cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), we conducted a randomized controlled trial exclusively for ATLL...
  94. ncbi request reprint [Adjuvant epirubicin and cyclophosphamide followed by weekly paclitaxel for Japanese women with node-positive breast cancer: a multi-institutional feasibility study]
    Michiyo Saimura
    Dept of Surgery, Kitakyushu Municipal Medical Center
    Gan To Kagaku Ryoho 35:1519-23. 2008
    ..EC followed by wPTX can be safely performed with a little toxicity at doses of 75/90 mg/m(2), 600 mg/m(2) and 80 mg/m(2), respectively...
  95. ncbi request reprint Primary central nervous system lymphoma: the clinical features and treatment of 22 cases
    Takao Shibata
    First Department of Internal Medicine, Fukuoka University School of Medicine
    Intern Med 41:283-9. 2002
    ..To clarify the efficacy of chemotherapy after radiation therapy in immunocompetent patients with primary central nervous system lymphoma (PCNSL)...
  96. ncbi request reprint IL18 polymorphism is associated with an increased risk of Crohn's disease
    Kazuo Tamura
    Laboratory of Hereditary Tumor, Institute for Advanced Medical Sciences, Hyogo College of Medicine, 1 1, Mukogawa cho, Nishinomiya 663 8501, Japan
    J Gastroenterol 37:111-6. 2002
    ..Cytokine genes are thought to be important in inflammatory bowel disease. Recently, interleukin 18, cloned as a novel proinflammatory cytokine, has been implicated in inflammatory bowel disease, especially Crohn's disease...
  97. ncbi request reprint Phase II study of cladribine (2-chlorodeoxyadenosine) in relapsed or refractory adult T-cell leukemia-lymphoma
    Kensei Tobinai
    Hematology Division, National Cancer Center Hospital, Tokyo, Japan
    Int J Hematol 77:512-7. 2003
    ..In conclusion, cladribine is not worthy of further investigation for the treatment of ATL...
  98. ncbi request reprint [Infection control for the treatment of hematological malignancies: a survey of the Kyushu Hematology Organization for Treatment Study Group (K-HOT)]
    Kenji Ishitsuka
    First Department of Internal Medicine, Fukuoka University
    Rinsho Ketsueki 44:483-90. 2003
    ..For allogeneic SCT, the cumulative dose of immunoglobulin significantly varied from institutions to institutions. The benefit of this study is the ability to recognize practical management patterns for infection control...
  99. ncbi request reprint [Familial tumor syndrome and ectopic hormone-producing tumors]
    Kazuo Tamura
    Laboratory of Hereditary Tumor, Institute for Advanced Medical Sciences, Hyogo College of Medicine
    Nihon Rinsho 62:851-63. 2004
    ..At this opportunity, we interpret for these three disorders...
  100. ncbi request reprint A historical perspective on familial cancer: results and vision of the Polyposis Center Project
    Joji Utsunomiya
    Familial Cancer Center, The Cancer Institute Hospital, Tokyo, Japan
    Int J Clin Oncol 9:215-31. 2004
  101. ncbi request reprint Mechanism of carcinogenesis in familial tumors
    Kazuo Tamura
    Laboratory of Hereditary Tumor, Institute for Advanced Medical Sciences, Hyogo College of Medicine, 1 1 Mukogawa cho, 663 8501, Nishinomiya, Japan
    Int J Clin Oncol 9:232-45. 2004
    ..Germline mutation of DNA mismatch repair genes causes hereditary nonpolyposis colorectal cancer. The tumor phenotype from patients with hereditary nonpolyposis colorectal cancer is demonstrated to be microsatellite instability positive...