Yukihiko Kawasaki

Summary

Affiliation: Fukushima Medical University
Country: Japan

Publications

  1. ncbi request reprint Tonsillectomy with methylprednisolone pulse therapy as rescue treatment for steroid-resistant IgA nephropathy in children
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Tohoku J Exp Med 218:11-6. 2009
  2. ncbi request reprint Henoch-Schönlein purpura nephritis in childhood: pathogenesis, prognostic factors and treatment
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Japan
    Fukushima J Med Sci 59:15-26. 2013
  3. doi request reprint Differences in clinical findings, pathology, and outcomes between C3 glomerulonephritis and membranoproliferative glomerulonephritis
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima City, Fukushima, 960 1295, Japan
    Pediatr Nephrol 31:1091-9. 2016
  4. doi request reprint The basic data for residents aged 16 years or older who received a comprehensive health check examinations in 2011-2012 as a part of the Fukushima Health Management Survey after the great East Japan earthquake
    Yukihiko Kawasaki
    Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University Department of Pediatrics, Japan
    Fukushima J Med Sci 60:159-69. 2014
  5. ncbi request reprint Accumulation of macrophages expressing myeloid-related protein 8 associated with the progression of sclerotic changes in children with IgA nephropathy
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Tohoku J Exp Med 218:49-55. 2009
  6. ncbi request reprint The pathogenesis and treatment of IgA nephropathy
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima 960 1295, Japan
    Fukushima J Med Sci 54:43-60. 2008
  7. ncbi request reprint Efficacy of single dose of oral mizoribine pulse therapy two times per week for frequently relapsing nephrotic syndrome
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima Japan
    J Nephrol 20:52-6. 2007
  8. doi request reprint Serum KL-6 levels as a biomarker of lung injury in respiratory syncytial virus bronchiolitis
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Hikariga oka, Fukushima City, Fukushima, Japan
    J Med Virol 81:2104-8. 2009
  9. pmc Mizoribine: a new approach in the treatment of renal disease
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima City, Fukushima 960 1295, Japan
    Clin Dev Immunol 2009:681482. 2009
  10. ncbi request reprint A 12-year-old girl with hemolytic uremic syndrome as initial symptom of systemic lupus erythematosus and a literature review
    Y Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Am J Nephrol 22:576-80. 2002

Collaborators

Detail Information

Publications94

  1. ncbi request reprint Tonsillectomy with methylprednisolone pulse therapy as rescue treatment for steroid-resistant IgA nephropathy in children
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Tohoku J Exp Med 218:11-6. 2009
    ..Our findings suggest that tonsillectomy pulse therapy may be effective as rescue treatment for steroid-resistant IgA nephropathy in childhood...
  2. ncbi request reprint Henoch-Schönlein purpura nephritis in childhood: pathogenesis, prognostic factors and treatment
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Japan
    Fukushima J Med Sci 59:15-26. 2013
    ..Nevertheless, detailed investigation into the pathogenesis of HSPN and double-blind randomized control studies on children with HSPN are still necessary...
  3. doi request reprint Differences in clinical findings, pathology, and outcomes between C3 glomerulonephritis and membranoproliferative glomerulonephritis
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima City, Fukushima, 960 1295, Japan
    Pediatr Nephrol 31:1091-9. 2016
    ....
  4. doi request reprint The basic data for residents aged 16 years or older who received a comprehensive health check examinations in 2011-2012 as a part of the Fukushima Health Management Survey after the great East Japan earthquake
    Yukihiko Kawasaki
    Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University Department of Pediatrics, Japan
    Fukushima J Med Sci 60:159-69. 2014
    ..This report describes the results for residents aged 16 years or older who received the health check examinations and evaluates the data obtained from 2011 and 2012...
  5. ncbi request reprint Accumulation of macrophages expressing myeloid-related protein 8 associated with the progression of sclerotic changes in children with IgA nephropathy
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Tohoku J Exp Med 218:49-55. 2009
    ..Our results suggest that renal macrophages expressing MRP8 may be involved in the progression of sclerotic changes in children with IgAN...
  6. ncbi request reprint The pathogenesis and treatment of IgA nephropathy
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima 960 1295, Japan
    Fukushima J Med Sci 54:43-60. 2008
    ..Furthermore the detail investigations into the pathogenesis of IgAN and double-blind randomized control studies on children with IgAN will be necessary...
  7. ncbi request reprint Efficacy of single dose of oral mizoribine pulse therapy two times per week for frequently relapsing nephrotic syndrome
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima Japan
    J Nephrol 20:52-6. 2007
    ..None of patients had severe adverse effects, such as uricacidemia, leukopenia, liver dysfunction or alopecia. Oral mizoribine pulse therapy consisting of a single dose two days a week may be effective and safe in some FRNS patients...
  8. doi request reprint Serum KL-6 levels as a biomarker of lung injury in respiratory syncytial virus bronchiolitis
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Hikariga oka, Fukushima City, Fukushima, Japan
    J Med Virol 81:2104-8. 2009
    ..These findings suggest that serum KL-6 is associated with the severity of RSV bronchiolitis and that it may be a useful biomarker for the severity of RSV bronchiolitis...
  9. pmc Mizoribine: a new approach in the treatment of renal disease
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima City, Fukushima 960 1295, Japan
    Clin Dev Immunol 2009:681482. 2009
    ....
  10. ncbi request reprint A 12-year-old girl with hemolytic uremic syndrome as initial symptom of systemic lupus erythematosus and a literature review
    Y Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Am J Nephrol 22:576-80. 2002
    ..These findings suggest that SLE should be suspected in any HUS patient presenting with hemolytic anemia, thrombocytopenia, acute renal failure and hypocomplementemia, and the therapeutic response and prognosis for SLE with HUS are good...
  11. doi request reprint The incidence and severity of Henoch-Schönlein purpura nephritis over a 22-year period in Fukushima Prefecture, Japan
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima City, Fukushima, 960 1295, Japan
    Int Urol Nephrol 42:1023-9. 2010
    ..To evaluate the incidence and the severity of HSPN, we examined the epidemiology and clinical manifestations of HSPN in Fukushima Prefecture over a 22-year period...
  12. doi request reprint Methylprednisolone pulse plus mizoribine in children with Henoch-Schoenlein purpura nephritis
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima, Fukushima, 960 1295, Japan
    Clin Rheumatol 30:529-35. 2011
    ..Our study suggests that MUPM is effective in ameliorating the proteinuria and the histological severity of HSPN in patients with <50% crescents but is not so effective for HSPN in patients with >50% crescents...
  13. doi request reprint Serum SP-D levels as a biomarker of lung injury in respiratory syncytial virus bronchiolitis
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
    Pediatr Pulmonol 46:18-22. 2011
    ..These findings suggest that serum SP-D is associated with the severity of RSV bronchiolitis and that it may be a useful biomarker for the severity of RSV bronchiolitis...
  14. ncbi request reprint The role of FB21 as a marker of glomerular endothelial cell injury
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, 960 1295, Japan
    Fukushima J Med Sci 52:35-43. 2006
    ..These results suggest that FB21 can be used as a specific marker for glomerular endothelial cell injury in various types of glomerulonephritis...
  15. doi request reprint The pathogenesis and treatment of pediatric Henoch-Schönlein purpura nephritis
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima, Fukushima 960 1295, Japan
    Clin Exp Nephrol 15:648-57. 2011
    ..Nevertheless, detailed investigations of the pathogenesis of HSPN and double-blind randomized control studies on children with HSPN are still necessary...
  16. doi request reprint Mechanism of onset and exacerbation of chronic glomerulonephritis and its treatment
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Pediatr Int 53:795-806. 2011
    ..In future, detailed investigations into the pathogenesis of CGN and double-blind randomized control studies on children with IgAN or HSPN will be necessary...
  17. doi request reprint The role of serum myeloid-related protein 8/14 complex in Henoch-Schönlein purpura nephritis
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima 960 1295, Japan
    Pediatr Nephrol 27:65-71. 2012
    ..Our findings suggest that serum MRP8/14 complex levels might be associated with the severity of renal injury and endothelial cell dysfunction in HSPN patients...
  18. ncbi request reprint Myeloid-related protein 8 expression on macrophages is a useful prognostic marker for renal dysfunction in children with MPGN type 1
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Japan
    Am J Kidney Dis 45:510-8. 2005
    ....
  19. ncbi request reprint FB21, a monoclonal antibody that reacts with a sialic-acid-dependent carbohydrate epitope, is a marker for glomerular endothelial cell injury
    Yukihiko Kawasaki
    Department of Pediatrics Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
    Am J Kidney Dis 44:239-49. 2004
    ..We evaluated FB21 staining in fetal kidneys and kidneys of children and adults with normal kidneys and glomerulonephritis and investigated whether FB21 can be used as a marker for endothelial cell injury...
  20. doi request reprint Renal expression of alpha-smooth muscle actin and c-Met in children with Henoch-Schönlein purpura nephritis
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima City, Fukushima 960 1295, Japan
    Pediatr Nephrol 23:913-9. 2008
    ..Our findings suggest that the expression of renal alpha-SMA may be associated with progression of renal injury in HSPN...
  21. ncbi request reprint Development of glomerular endothelial cells, podocytes and mesangial cells in the human fetus and infant
    Kei Takano
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Tohoku J Exp Med 212:81-90. 2007
    ..In conclusion, maturation of endothelial cells starts at 25 weeks and is completed by 35 weeks of gestation. Epithelial cells and mesangial cells first appear during the S stage...
  22. doi request reprint Uteroglobulin-related protein 1 and severity of respiratory syncytial virus infection in children admitted to hospital
    Koichi Hashimoto
    Department of Pediatrics, School of Medicine, Fukushima Medical University, Fukushima, Japan
    J Med Virol 83:1086-92. 2011
    ..Furthermore, there was no relationship between severity of RSV infection and genotype or serum UGRP1 concentration. These results suggest that UGRP1 does not have a major role in the development of severe RSV infection...
  23. ncbi request reprint Efficacy of tonsillectomy pulse therapy versus multiple-drug therapy for IgA nephropathy
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima City, Fukushima, 960 1295, Japan
    Pediatr Nephrol 21:1701-6. 2006
    ....
  24. ncbi request reprint Evaluation of T helper-1/-2 balance on the basis of IgG subclasses and serum cytokines in children with glomerulonephritis
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Japan
    Am J Kidney Dis 44:42-9. 2004
    ....
  25. ncbi request reprint Efficacy of multidrug therapy combined with mizoribine in children with diffuse IgA nephropathy in comparison with multidrug therapy without mizoribine and with methylprednisolone pulse therapy
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima University School of Medicine, Fukushima, Japan
    Am J Nephrol 24:576-81. 2004
    ....
  26. ncbi request reprint Efficacy of steroid pulse, plasmapheresis, and mizoribine in a patient with focal segmental glomerulosclerosis
    Tomoko Imaizumi
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima City, Fukushima, 960 1295, Japan
    Pediatr Nephrol 22:1215-8. 2007
    ..We report that steroid pulse and MZB combined with PP may be an effective treatment in a patient with FSGS complicated by CyA-induced leukoencephalopathy...
  27. ncbi request reprint Efficacy of tonsillectomy plus methylprednisolone pulse therapy for a child with Henoch-Schoenlein purpura nephritis
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Japan
    Tohoku J Exp Med 211:291-5. 2007
    ..Tonsillectomy plus methylprednisolone pulse is effective and useful therapy for some children with recurrent purpura and persistent nephropathy...
  28. ncbi request reprint Oral mizoribine pulse therapy for patients with steroid-resistant and frequently relapsing steroid-dependent nephrotic syndrome
    Yukihiko Kawasaki
    Department of Pediatrics, School of Medicine, Fukushima Medical University, 1 Hikariga oka, Fukushima City, Fukushima 960 1295, Japan
    Nephrol Dial Transplant 20:2243-7. 2005
    ..We investigated the efficacy of oral mizoribine pulse therapy (mizoribine-pulse) for cyclosporin (CyA)-dependent, steroid-resistant nephrotic syndrome (SRNS) and frequently relapsing, steroid-dependent nephrotic syndrome (FR-SDNS)...
  29. doi request reprint Effect of Evacuation on Body Weight After the Great East Japan Earthquake
    Tetsuya Ohira
    Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan Department of Epidemiology, Fukushima Medical University School of Medicine, Fukushima, Japan Electronic address
    Am J Prev Med 50:553-60. 2016
    ..This study assessed the hypothesis that mean body weight and the proportion of overweight/obese individuals would increase among evacuees after versus before the disaster...
  30. ncbi request reprint Efficacy of methylprednisolone and urokinase pulse therapy for severe Henoch-Schönlein nephritis
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Pediatrics 111:785-9. 2003
    ..To evaluate the efficacy of methylprednisolone and urokinase pulse therapy (MUPT) for severe Henoch-Schönlein nephritis, we examined the clinical manifestation and prognosis of patients with MUPT on long-term observation...
  31. doi request reprint The trend of drug-resistant Streptococcus pneumoniae from nasopharynx of children
    Ayumi Matsumoto
    Department of Pediatrics, Fukushima Medical University, Fukushima 960 1295, Japan
    J Infect Chemother 16:255-9. 2010
    ..These results might suggest that amoxicillin was not a safe alternative to prevent the emergence of resistant strains. We need to reassess a beneficial approach for the treatment of pediatric outpatients...
  32. pmc Genetic diversity of coxsackievirus A16 associated with hand, foot, and mouth disease epidemics in Japan from 1983 to 2003
    Mitsuaki Hosoya
    Department of Pediatrics, Fukushima Medical University School of Medicine, Hikarigaoka 1, Fukushima 960 1295, Japan
    J Clin Microbiol 45:112-20. 2007
    ..We concluded that repeated outbreaks of CV-A16-related HFMD in Japan were caused, in part, by the introduction of genetically changed CV-A16 strains, which might be transmitted overseas...
  33. ncbi request reprint Efficacy of prednisolone and mizoribine therapy for diffuse IgA nephropathy
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
    Am J Nephrol 24:147-53. 2004
    ..There have been only a few studies concerning oral prednisolone and mizoribine therapy for diffuse IgA nephritis (IgAN). We evaluated the efficacy of prednisolone and mizoribine therapy for diffuse IgAN...
  34. ncbi request reprint The leukotriene B4 receptor antagonist ONO-4057 inhibits mesangioproliferative changes in anti-Thy-1 nephritis
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima City, Fukushima 960 1295, Japan
    Nephrol Dial Transplant 20:2697-703. 2005
    ..This study was conducted to evaluate the role of LTB4 in glomerulonephritis, and to examine whether ONO-4057 moderated anti-Thy-1 nephritis...
  35. doi request reprint Rituximab and low-dose cyclosporine combination therapy for steroid-resistant focal segmental glomerulosclerosis
    Kazuhide Suyama
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
    Pediatr Int 58:219-23. 2016
    ..We investigated the efficacy of rituximab and low-dose cyclosporine combination therapy for focal segmental glomerulosclerosis (FSGS) in children with steroid-resistant nephrotic syndrome (SRNS)...
  36. doi request reprint Respiratory syncytial virus shedding by children hospitalized with lower respiratory tract infection
    Aya Takeyama
    Department of Pediatrics, Soma General Hospital, Fukushima, Japan
    J Med Virol 88:938-46. 2016
    ..To prevent nosocomial RSV infections in hospital wards, healthcare workers must take appropriate infection control measures and provide adequate guidance on hand washing to the family of the patient...
  37. doi request reprint Role of vascular endothelial growth factor and angiopoietin 1 in renal injury in hemolytic uremic syndrome
    Shinichiro Ohara
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Am J Nephrol 36:516-23. 2012
    ..In order to clarify the role of vascular endothelial growth factor (VEGF) and angiopoietin 1 (Ang-1) in the renal recovery from HUS, we produced a model of mild HUS and examined the renal recovery process...
  38. doi request reprint Rhinovirus load and disease severity in children with lower respiratory tract infections
    Aya Takeyama
    Department of Pediatrics, Soma General Hospital, Fukushima, Japan
    J Med Virol 84:1135-42. 2012
    ..By contrast, in the patients ≥11 months of age, viral load may contribute to the development of disease severity...
  39. ncbi request reprint Renal effects of Coxsackie B4 virus in hyper-IgA mice
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima City, Fukushima 960 1295, Japan
    J Am Soc Nephrol 17:2760-9. 2006
    ..These results suggest that CB4 provokes exacerbation of renal pathologic findings in HIGA mice via endothelial injury, IFN-gamma production, and dysfunction of the mesangial pathway...
  40. ncbi request reprint Plasmapheresis therapy for rapidly progressive Henoch-Schönlein nephritis
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, 960 1295, Fukushima City, Fukushima, Japan
    Pediatr Nephrol 19:920-3. 2004
    ..Although this case series is without controls, our treatment protocol may be of benefit to children with rapidly progressive HSPN...
  41. ncbi request reprint IgA nephropathy in a patient with dominant dystrophic epidermolysis bullosa
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Tohoku J Exp Med 214:297-301. 2008
    ..These findings suggest that repeated skin infections might have contributed to the pathogenesis of IgA nephropathy in this patient...
  42. doi request reprint Molecular epidemiology of norovirus gastroenteritis in Soma, Japan, 2001-2003
    Noriko Onishi
    Department of Pediatrics, Fukushima Medical University School of Medicine, and Public Soma General Hospital, Fukushima, Japan
    Pediatr Int 50:65-9. 2008
    ..The aim of the present paper was to investigate the molecular epidemiology of norovirus gastroenteritis in Japan using polymerase chain reaction (PCR) and subsequent phylogenetic analysis...
  43. ncbi request reprint Girl with garland-pattern poststreptococcal acute glomerulonephritis presenting with renal failure and nephrotic syndrome
    Kazuhide Suyama
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
    Pediatr Int 49:115-7. 2007
  44. ncbi request reprint Detection of enteroviruses in renal biopsies from patients with immunoglobulin A nephropathy
    Ai Takahashi
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Pediatr Nephrol 20:1578-82. 2005
    ..05). Our findings suggest that enteroviral infection may have the possibility of becoming one of the factors involved in the mechanism of onset or evolution of IgAN...
  45. pmc Characteristics of viruses derived from nude mice with persistent measles virus infection
    Yusaku Abe
    Department of Pediatrics, Fukushima Medical University, Fukusjima, Japan
    J Virol 87:4170-5. 2013
    ..This study indicated that MV in a nude mouse model of persistent infection exhibited characteristics of the SSPE virus. This model may prove useful in elucidating the pathogenic mechanism of SSPE and developing potential therapeutics...
  46. doi request reprint Successful therapy with tonsillectomy for severe ISKDC grade VI Henoch-Schönlein purpura nephritis and persistent nephrotic syndrome
    Shinichiro Ohara
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima, Fukushima 960 1295, Japan
    Clin Exp Nephrol 15:749-53. 2011
    ..A regimen of methylprednisolone and urokinase pulse therapy plus PP with tonsillectomy may be an effective and useful therapy for some children with severe HSPN children of ISKDC grade VI and persistent nephrotic syndrome...
  47. ncbi request reprint Non-antibiotic treatment for pediatric outpatients with common cold inhibits the emergence of drug resistant pneumococci
    Ayumi Matsumoto
    Department of Pediatrics, Fukushima Medical University, Fukushima, Japan
    Fukushima J Med Sci 56:28-37. 2010
    ..Our study suggests that the treatment without antibiotics reduces the drug-resistant S. pneumoniae. Controlled antibiotic use in children might prevent children from carrying the antibiotic resistant S. pneumoniae...
  48. ncbi request reprint A 10-year-old girl with IgA nephropathy who 5 years later developed the characteristic features of Henoch-Schönlein purpura nephritis
    Mina Chishiki
    Department of Pediatrics, Fukushima Medical University, Fukushima, Japan
    Fukushima J Med Sci 56:157-61. 2010
    ....
  49. doi request reprint Efficacy of cyclosporine therapy for systemic lupus erythematosus in childhood
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Japan
    Pediatr Int 50:257-9. 2008
  50. ncbi request reprint Long-term efficacy of low-density lipoprotein apheresis for focal and segmental glomerulosclerosis
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima City, Fukushima 960 1295, Japan
    Pediatr Nephrol 22:889-92. 2007
    ..The patient has been in remission from FSGS for 12 years since LDL-A. These findings suggest that LDL-A may be useful in maintaining long-term remission from pediatric FSGS...
  51. ncbi request reprint Mizoribine oral pulse therapy for steroid-dependent nephrotic syndrome
    Yukihiko Kawasaki
    Department of Pediatrics, School of Medicine, Fukushima Medical University, 1 Hikariga oka, Fukushima 960 1295, Fukushima City, Japan
    Pediatr Nephrol 20:96-8. 2005
    ..5 microg/ml for about 10 h (from 3 h after the first dose of MZB to 2 h after the final dose). Thus, our results suggest that this regimen may be effective for patients with steroid-dependent NS...
  52. doi request reprint Incidence and prognosis of systemic lupus erythematosus in a 35 year period in Fukushima, Japan
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Pediatr Int 57:650-5. 2015
    ..We examined the epidemiology, clinical manifestations, and prognosis of pediatric systemic lupus erythematosus (SLE) in Fukushima Prefecture, Japan over a 35 year period...
  53. ncbi request reprint Glomerulonephritis associated with chronic infection from long-term central venous catheterization
    Shinichiro Ohara
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Japan
    Pediatr Nephrol 21:427-9. 2006
    ..For clinicians using long-term central venous access for parenteral feeding, rapid catheter exchange is necessary for patients with fever of unknown origin...
  54. ncbi request reprint Epstein-Barr virus-associated hemophagocytic syndrome in a patient with lupus nephritis
    Masato Isome
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikarigaoka, 960 1295 Fukushima City, Fukushima, Japan
    Pediatr Nephrol 20:226-8. 2005
    ..In our patient, the onset of reactive HPS might be related to immunosuppressive treatment during the course of lupus nephritis...
  55. doi request reprint DSCG reduces RSV-induced illness in RSV-infected mice
    Koichi Hashimoto
    Department of Pediatrics, School of Medicine, Fukushima Medical University, Fukushima, Japan
    J Med Virol 81:354-61. 2009
    ..These findings indicate that DSCG may be an effective agent for the prevention of RSV induced disease and the relief of symptoms of RSV infection...
  56. ncbi request reprint Predicting the prognosis of renal dysfunction by renal expression of alpha-smooth muscle actin in children with MPGN type 1
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
    Am J Kidney Dis 42:1131-8. 2003
    ....
  57. ncbi request reprint Efficacy of methylprednisolone and urokinase pulse therapy combined with or without cyclophosphamide in severe Henoch-Schoenlein nephritis: a clinical and histopathological study
    Yukihiko Kawasaki
    Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima City, Fukushima 960 1295, Japan
    Nephrol Dial Transplant 19:858-64. 2004
    ..We evaluated the efficacy of methylprednisolone and urokinase pulse therapy combined with cyclophosphamide for patients with HSPN of at least grade IVb...
  58. pmc Life as an evacuee after the Fukushima Daiichi nuclear power plant accident is a cause of polycythemia: the Fukushima Health Management Survey
    Akira Sakai
    Department of Radiation Life Sciences, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    BMC Public Health 14:1318. 2014
    ....
  59. pmc Evacuation after the Fukushima Daiichi Nuclear Power Plant Accident Is a Cause of Diabetes: Results from the Fukushima Health Management Survey
    Hiroaki Satoh
    Department of Nephrology, Hypertension, Diabetology, Endocrinology, and Metabolism, Fukushima Medical University, Fukushima 960 1295, Japan Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima 960 1295, Japan
    J Diabetes Res 2015:627390. 2015
    ..In conclusion, this is the first study to demonstrate that evacuation is associated with the incidence of diabetes. This information may be used to guide follow-up recommendations for evacuees. ..
  60. doi request reprint Increased prevalence of atrial fibrillation after the Great East Japan Earthquake: Results from the Fukushima Health Management Survey
    Hitoshi Suzuki
    Department of Arrhythmia and Cardiac Pacing, Fukushima Medical University, Fukushima, Japan Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Japan Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan Electronic address
    Int J Cardiol 198:102-5. 2015
    ..This study assessed the hypothesis that the prevalence of atrial fibrillation (AF) increased among residents in the evacuation zone of Fukushima prefecture after the Great East Japan Earthquake...
  61. pmc Influenza viral load and peramivir kinetics after single administration and proposal of regimens for peramivir administration against resistant variants
    Masatoki Sato
    Department of Pediatrics, Fukushima Medical University, Fukushima, Japan
    Antimicrob Agents Chemother 59:1643-9. 2015
    ..In severe cases caused by resistant variants, better inhibitory effectiveness and less frequent adverse events are expected by divided administration rather than once-daily administration with an increased dosage. ..
  62. doi request reprint Clinical and epidemiologic factors related to subsequent wheezing after virus-induced lower respiratory tract infections in hospitalized pediatric patients younger than 3 years
    Aya Takeyama
    Department of Pediatrics, Soma General Hospital, 142 Tubogasaku Niinuma, Soma City, Fukushima, 976 0011, Japan
    Eur J Pediatr 173:959-66. 2014
    ..Patients with wheezing and RV-positive aspirates at the time of admission were more likely to develop subsequent wheezing during the following 3 years...
  63. doi request reprint Efficacy of recombinant human soluble thrombomodulin for childhood hemolytic uremic syndrome
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Pediatr Int 55:e139-42. 2013
    ..The patients did not require dialysis therapy. The present results suggest that rhTM may be a safe and effective treatment for DIC complicated with HUS in children. ..
  64. doi request reprint Incidence and index of severity of hemolytic uremic syndrome in a 26 year period in Fukushima Prefecture, Japan
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Pediatr Int 56:77-82. 2014
    ..This study therefore investigated the epidemiology and prognosis of HUS in Fukushima Prefecture over a 26 year period...
  65. doi request reprint Development of common variable immunodeficiency in IgA- and IgG2-deficient patients with systemic lupus erythematosus
    Kazuhide Suyama
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima City, Fukushima, 960 1295, Japan
    Pediatr Nephrol 27:489-92. 2012
    ..There have been few reports on children who developed common variable immunodeficiency (CVID) in association with immunoglobulin A (IgA) and IgG2 deficiencies and systemic lupus erythematosus (SLE)...
  66. doi request reprint Human influenza virus infection and apoptosis induction in human vascular endothelial cells
    Makoto Sumikoshi
    Department of Pediatrics, School of Medicine, Fukushima Medical University, Fukushima, Japan
    J Med Virol 80:1072-8. 2008
    ..These results demonstrated that human influenza virus can infect and replicate in human vascular endothelial cells and induce apoptosis therein...
  67. ncbi request reprint IgA deficiency and membranous glomerulonephritis presenting as nephrotic syndrome
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, 960 1295, Fukushima City, Fukushima, Japan
    Pediatr Nephrol 20:662-4. 2005
    ..In conclusion, our treatment with corticosteroid, ACEI and ARB reduced proteinuria and was effective for our case with selective IgA deficiency and MGN...
  68. ncbi request reprint A case of Henoch-Schoenlein purpura nephritis recurring after 3 years remission
    Yumiko Ushijima
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga oka, Fukushima City, Fukushima, Japan
    Fukushima J Med Sci 56:50-6. 2010
    ..Our case is unique in respect of the recurrence at more than 3 years after the complete resolution of initial symptoms, suggesting that careful followup is required in spite of improved renal symptoms in cases of HSP...
  69. ncbi request reprint [Nephritis induced by viral infection: Pathogenesis, pathophysiology, and therapy]
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine
    Nihon Rinsho 64:576-80. 2006
  70. doi request reprint Mizoribine attenuates renal injury and macrophage infiltration in patients with severe lupus nephritis
    Hiroshi Tanaka
    Department of Pediatrics, Hirosaki University Hospital, Hirosaki, 036 8563, Japan
    Clin Rheumatol 29:1049-54. 2010
    ..9 cells per glomerulus, respectively; p < 0.05). Although this was a preliminary study in a small number of subjects, these histological observations may further confirm the beneficial effects of MZR for selected patients with DPLN...
  71. doi request reprint The efficacy of recombinant human soluble thrombomodulin for the treatment of shiga toxin-associated hemolytic uremic syndrome model mice
    Kazuhide Suyama
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
    Nephrol Dial Transplant 30:969-77. 2015
    ..In order to clarify the efficacy of rhTM for the treatment of typical hemolytic uremic syndrome (t-HUS), we examined changes in renal damage in t-HUS mice treated with rhTM or vehicle alone...
  72. doi request reprint Resistance factors for the treatment of immunoglobulin A nephropathy with diffuse mesangial proliferation
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Nephrology (Carlton) 19:384-91. 2014
    ..We, therefore, evaluated the risk factors for non-responsiveness to treatment in cases of severe IgAN...
  73. doi request reprint Mumps virus-associated acute encephalopathy: case report and review of the literature
    Masahiro Watanabe
    Department of Pediatrics, Fukushima Medical University, Fukushima, Japan
    J Child Neurol 28:243-5. 2013
    ..In terms of the clinical course and cytokine as well as chemokine profiles, the pathogenesis in our case was different from that of mumps meningoencephalitis but was similar to that of influenza virus-associated acute encephalopathy...
  74. ncbi request reprint A challenge to appropriate antibiotic use in children with respiratory infections: a 5-year single-institution experience
    Ayumi Matsumoto
    Department of Pediatrics, Fukushima Medical University, Fukushima, Japan
    Fukushima J Med Sci 57:33-45. 2011
    ..In this report, we summarize our research and suggest better treatment options for pediatric patients with respiratory infections...
  75. ncbi request reprint Prediction of relapse by plasma lipoprotein(a) concentration in children with steroid-sensitive nephrotic syndrome
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
    Nephron 92:807-11. 2002
    ..To clarify whether plasma lipoproteins, including Lp(a), can predict relapse pattern in the first years after diagnosis of nephrotic syndrome (NS), we evaluated them in patients with steroid-sensitive NS...
  76. ncbi request reprint The emergence of drug-resistant Streptococcus pneumoniae and host risk factors for carriage of drug-resistant genes in northeastern Japan
    Ayumi Matsumoto
    Department of Pediatrics, Fukushima Medical University, Fukushima 960 1295, Japan
    Jpn J Infect Dis 60:10-3. 2007
    ..01). The controlled use of antibiotics might be an important factor in preventing the emergence of S. pneumoniae with antibiotic-resistant genes...
  77. doi request reprint RSV replication is attenuated by counteracting expression of the suppressor of cytokine signaling (SOCS) molecules
    Koichi Hashimoto
    Department of Microbiology, School of Medicine, Fukushima Medical University, Fukushima 960 1295, Japan
    Virology 391:162-70. 2009
    ..These results suggest that RSV infection escapes the innate antiviral response by inducing SOCS1, SOCS3 or CIS expression in epithelial cells...
  78. ncbi request reprint Genetic diversity of enterovirus 71 associated with hand, foot and mouth disease epidemics in Japan from 1983 to 2003
    Mitsuaki Hosoya
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Pediatr Infect Dis J 25:691-4. 2006
    ..The surveillance data indicate that EV71 infection follows an epidemic mode of transmission, causing large outbreaks and then becoming quiescent for a few years...
  79. ncbi request reprint Oral disodium cromoglycate and ketotifen for a patient with eosinophilic gastroenteritis, food allergy and protein-losing enteropathy
    Junzo Suzuki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
    Asian Pac J Allergy Immunol 21:193-7. 2003
    ..Therefore, oral DSCG and ketotifen therapy might be considered as treatment option in patients with eosinophilic gastroenteritis and protein-losing enteropathy caused by food allergy...
  80. ncbi request reprint Uninephrectomy induces progressive glomerulosclerosis and apoptosis in anti-Thy1 glomerulonephritis
    Nobuko Sakai
    Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960 1295, Japan
    Pathol Int 55:19-26. 2005
    ..It is suggested that apoptosis and extracellular matrix accumulation play an important role in the development of glomerulosclerosis...
  81. ncbi request reprint Role of serum neutralizing antibody in reinfection of respiratory syncytial virus
    Yukihiko Kawasaki
    Department of Pediatrics, Soma General Hospital, Fukushima, Japan
    Pediatr Int 46:126-9. 2004
    ..To clarify the role of serum antibody in respiratory syncytial virus (RSV) reinfection, the authors conducted a follow-up study of patients with primary RSV infection...
  82. ncbi request reprint Agmatine suppresses mesangial cell proliferation by modulating polyamine metabolism
    Shigehiko Eto
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Tohoku J Exp Med 210:145-51. 2006
    ..Suppressed proliferation of the agmatine-treated human MC is not due to increased cell death. These results suggest that agmatine is a promising drug candidate for the treatment of human mesangial proliferative glomerulonephritis...
  83. ncbi request reprint Possible pathologenic role of interleukin-5 and eosino cationic protein in Henoch-Schönlein purpura nephritis
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
    Pediatr Int 47:512-7. 2005
    ..In order to identify the pathogenesis of nephritis, laboratory findings and serum cytokines between Henoch-Schönlein purpura (HSP) patients without nephritis and with nephritis were investigated...
  84. ncbi request reprint Leukocytapheresis with leukocyte removal filter for severe ulcerative colitis in childhood
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    J Pediatr Gastroenterol Nutr 39:422-5. 2004
  85. doi request reprint Functional polymorphism of the promoter region of the prostacyclin synthase gene and severity of RSV infection in hospitalized children
    Koichi Hashimoto
    School of Medicine, Fukushima Medical University, Fukushima, Japan
    J Med Virol 80:2015-22. 2008
    ..A functional polymorphism in the promoter region of the PGIS gene is associated with both significant differences in urinary PGI(2) concentrations during RSV LRTI, and severity of RSV infection in previously healthy infants...
  86. ncbi request reprint Serum regulated upon activation, normal T cell expressed and presumably secreted concentrations and eosinophils in respiratory syncytial virus infection
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
    Pediatr Int 48:257-60. 2006
    ..To do this, the authors evaluated eosinophil counts and chemokines including regulated upon activation, normal T cell expressed and presumably secreted (RANTES) in children with RSV, adenoviral, and influenza virus infections...
  87. doi request reprint Glucocorticoid receptor expression and cortisol level in cord blood of term infants
    Takashi Imamura
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan
    J Matern Fetal Neonatal Med 24:1312-6. 2011
    ..To examine the expression levels of glucocorticoid receptor (GR) isoforms in peripheral blood mononuclear cells (PBMCs) and serum cortisol levels in cord blood from term infants...
  88. ncbi request reprint Thin basement membrane disease with membranoproliferative glomerulonephritis in a 13-year-old girl
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan
    Pediatr Int 44:321-3. 2002
  89. ncbi request reprint Correlation between serum interleukin 6 and C-reactive protein concentrations in patients with adenoviral respiratory infection
    Yukihiko Kawasaki
    Department of Pediatrics, Soma General Hospital, Soma City, Japan
    Pediatr Infect Dis J 21:370-4. 2002
    ....
  90. ncbi request reprint Laboratory characteristics of acute encephalopathy with multiple organ dysfunctions
    Hiroyuki Morita
    Department of Pediatrics, Fukushima Medical University School of Medicine, Hikarigaoka 1, Fukushima 960 1295, Japan
    Brain Dev 27:477-82. 2005
    ....
  91. ncbi request reprint [Secondary nephrotic syndrome induced by infection]
    Yukihiko Kawasaki
    Department of Pediatrics, Fukushima Medical University School of Medicine
    Nihon Rinsho 62:1925-9. 2004
    ..Some of patients with these viral infections present nephrotic syndrome. There were a few reports on secondary nephrotic syndrome induced by cytomegalovirus, Epstein-Barr virus and parvovirus B19...
  92. ncbi request reprint Cytochrome c and tumor necrosis factor-alpha values in serum and cerebrospinal fluid of patients with influenza-associated encephalopathy
    Mitsuaki Hosoya
    Department of Pediatrics, Fukushima Medical University School of Medicine, Tokyo, Japan
    Pediatr Infect Dis J 24:467-70. 2005
    ..In the convalescent phase, cerebrospinal fluid cytochrome c values increased remarkably in patients with subsequent brain atrophy...
  93. ncbi request reprint [Antimicrobial resistance in Streptococcus pneumoniae and Haemophilus influenzae isolated from nasopharynx in children]
    Ayumi Matsumoto
    Department of Pediatrics, Soma General Hospital
    Kansenshogaku Zasshi 78:482-9. 2004
    ..To prevent the resistant bacteria from disseminating we should re-consider how to use the antimicobial agents and nurse the young children...
  94. ncbi request reprint [A study on measles epidemic in Sukagawa area, Fukushima Prefecture from 2002 to 2003]
    Shigehiko Etoh
    Department of Pediatrics, Public Iwase Hospital
    Kansenshogaku Zasshi 80:103-7. 2006
    ....