Yukihiro Akao

Summary

Affiliation: Gifu International Institute of Biotechnology
Country: Japan

Publications

  1. ncbi A tumour-associated DEAD-box protein, rck/p54 exhibits RNA unwinding activity toward c-myc RNAs in vitro
    Yukihiro Akao
    Department of Genetic Diagnosis, Gifu International Institute of Biotechnology, Kakamigahara, Gifu 504 0838, Japan
    Genes Cells 8:671-6. 2003
  2. pmc Anti-cancer effects of xanthones from pericarps of mangosteen
    Yukihiro Akao
    Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Int J Mol Sci 9:355-70. 2008
  3. pmc Vaticanol C, a resveratrol tetramer, activates PPARalpha and PPARbeta/delta in vitro and in vivo
    Tomoko Tsukamoto
    Department of Food Science and Nutrition, Nara Women s University, Nara, 630 8506, Japan
    Nutr Metab (Lond) 7:46. 2010
  4. pmc α-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation
    Masa Aki Shibata
    Laboratory of Anatomy and Histopathology, Faculty of Health Science, Osaka Health Science University, Osaka, Japan
    BMC Med 9:69. 2011
  5. doi Role of microRNA-143 in Fas-mediated apoptosis in human T-cell leukemia Jurkat cells
    Yukihiro Akao
    Department of Medical Oncology, Gifu International Institute of Biotechnology, Kakamigahara, Gifu 504 0838, Japan
    Leuk Res 33:1530-8. 2009
  6. ncbi Downregulation of microRNAs-143 and -145 in B-cell malignancies
    Yukihiro Akao
    Department of Medical Oncology, Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Cancer Sci 98:1914-20. 2007
  7. ncbi MicroRNAs 143 and 145 are possible common onco-microRNAs in human cancers
    Yukihiro Akao
    Gifu International Institute of Biotechnology, Gifu 504 0838, Japan
    Oncol Rep 16:845-50. 2006
  8. ncbi High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation
    Yukihiro Akao
    Gifu International Institute of Biotechnology, Kakamigahara 504 0838, Japan
    Biochem Biophys Res Commun 342:1284-90. 2006
  9. doi Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells
    Yukihiro Akao
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Bioorg Med Chem 16:2803-10. 2008
  10. ncbi Expression of the DEAD-box/RNA helicase rck/p54 in mouse tissues: implications for heterogeneous protein expression
    Yukihiro Akao
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    J Histochem Cytochem 54:955-60. 2006

Collaborators

Detail Information

Publications92

  1. ncbi A tumour-associated DEAD-box protein, rck/p54 exhibits RNA unwinding activity toward c-myc RNAs in vitro
    Yukihiro Akao
    Department of Genetic Diagnosis, Gifu International Institute of Biotechnology, Kakamigahara, Gifu 504 0838, Japan
    Genes Cells 8:671-6. 2003
    ..Our previous data suggested that rck/p54 positively affected the translation initiation of c-myc mRNA...
  2. pmc Anti-cancer effects of xanthones from pericarps of mangosteen
    Yukihiro Akao
    Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Int J Mol Sci 9:355-70. 2008
    ..These findings could provide a relevant basis for the development of xanthones as an agent for cancer prevention and the combination therapy with anti-cancer drugs...
  3. pmc Vaticanol C, a resveratrol tetramer, activates PPARalpha and PPARbeta/delta in vitro and in vivo
    Tomoko Tsukamoto
    Department of Food Science and Nutrition, Nara Women s University, Nara, 630 8506, Japan
    Nutr Metab (Lond) 7:46. 2010
    ..We previously demonstrated that resveratrol protects brain against ischemic stroke in mice through a PPARalpha-dependent mechanism. Here we report the different effects of the oligomers of resveratrol...
  4. pmc α-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation
    Masa Aki Shibata
    Laboratory of Anatomy and Histopathology, Faculty of Health Science, Osaka Health Science University, Osaka, Japan
    BMC Med 9:69. 2011
    ....
  5. doi Role of microRNA-143 in Fas-mediated apoptosis in human T-cell leukemia Jurkat cells
    Yukihiro Akao
    Department of Medical Oncology, Gifu International Institute of Biotechnology, Kakamigahara, Gifu 504 0838, Japan
    Leuk Res 33:1530-8. 2009
    ..These data suggest that the up-regulation of miR-143 could be related to the apoptosis in part by targeting ERK5, which leads to promotion of Foxo3a/FasL positive feedback loop...
  6. ncbi Downregulation of microRNAs-143 and -145 in B-cell malignancies
    Yukihiro Akao
    Department of Medical Oncology, Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Cancer Sci 98:1914-20. 2007
    ..Taken together, these findings suggest that miRs-143 and -145 may be useful as biomarkers that differentiate B-cell malignant cells from normal cells and contribute to carcinogenesis in B-cell malignancies by a newly defined mechanism...
  7. ncbi MicroRNAs 143 and 145 are possible common onco-microRNAs in human cancers
    Yukihiro Akao
    Gifu International Institute of Biotechnology, Gifu 504 0838, Japan
    Oncol Rep 16:845-50. 2006
    ..These findings indicate that the miRNAs 143 and 145 could become good tumor markers and provide an important clue in the study of the mechanism of oncogenesis involving miRNAs...
  8. ncbi High expression of sphingosine kinase 1 and S1P receptors in chemotherapy-resistant prostate cancer PC3 cells and their camptothecin-induced up-regulation
    Yukihiro Akao
    Gifu International Institute of Biotechnology, Kakamigahara 504 0838, Japan
    Biochem Biophys Res Commun 342:1284-90. 2006
    ..These findings strongly suggest that high expression and up-regulation of SPHK1 and S1P receptors protect PC3 cells from the apoptosis induced by CPT...
  9. doi Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells
    Yukihiro Akao
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Bioorg Med Chem 16:2803-10. 2008
    ..These results indicate the relevance of the combination of phytochemicals for the enhancement of the anticancer effect...
  10. ncbi Expression of the DEAD-box/RNA helicase rck/p54 in mouse tissues: implications for heterogeneous protein expression
    Yukihiro Akao
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    J Histochem Cytochem 54:955-60. 2006
    ....
  11. ncbi let-7 microRNA functions as a potential growth suppressor in human colon cancer cells
    Yukihiro Akao
    Department of Genetic Diagnosis, Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Biol Pharm Bull 29:903-6. 2006
    ..These findings suggest the involvement of let-7 miRNA in the growth of colon cancer cells. Thus, miRNAs might provide a basis for novel RNA anti-cancer agents...
  12. ncbi Human DEAD-box/RNA unwindase rck/p54 contributes to maintenance of cell growth by affecting cell cycle in cultured cells
    Yukihiro Akao
    Gifu International Institute of Biotechnology, Kakamigahara, Gifu 504 0838, Japan
    Int J Oncol 29:41-8. 2006
    ..These data suggest that rck/p54 contributes to cell growth possibly by modulating translation-initiation control of the genes involved in the cell proliferation, which is a newly defined mechanism leading to carcinogenesis...
  13. ncbi MicroRNA-143 and -145 in colon cancer
    Yukihiro Akao
    Department of Medical Oncology, Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    DNA Cell Biol 26:311-20. 2007
    ..Further, we discuss the expression of miRNA-143 and -145 in colon cancer and their roles in carcinogenesis. The available data suggest that miRNAs would be potentially useful as diagnostic and therapeutic tools...
  14. ncbi A highly bioactive lignophenol derivative from bamboo lignin exhibits a potent activity to suppress apoptosis induced by oxidative stress in human neuroblastoma SH-SY5Y cells
    Yukihiro Akao
    Gifu International Institute of Biotechnology, Kakamigahara, Gifu 504 0838, Japan
    Bioorg Med Chem 12:4791-801. 2004
    ..These data suggest that lig-8 is a promising neuroprotector, which affects the signaling pathway of neuronal cell death and that it would be of benefit to delay the progress of neurodegenerative diseases...
  15. doi Role of anti-oncomirs miR-143 and -145 in human colorectal tumors
    Y Akao
    Department of Medical Oncology, Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    Cancer Gene Ther 17:398-408. 2010
    ....
  16. ncbi Cell growth inhibitory effect of cinnamic acid derivatives from propolis on human tumor cell lines
    Yukihiro Akao
    Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Biol Pharm Bull 26:1057-9. 2003
    ..Importantly, HL60 cells were more sensitive to drupanin than were Con A-stimulated peripheral blood lymphocytes, whereas the potency of artepillin C was the opposite of that of drupanin...
  17. doi Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells
    Yasunori Fujita
    Department of Longevity and Aging Research, Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    Biochem Biophys Res Commun 377:114-9. 2008
    ....
  18. ncbi Effects of sesquiterpene lactones on melanogenesis in mouse B16 melanoma cells
    Kenji Ohguchi
    Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    Biol Pharm Bull 32:308-10. 2009
    ..These results demonstrated that the inhibitory effects of sesquiterpene lactones on melanin biosynthesis may be due to the suppression of tyrosinase expression...
  19. ncbi Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines
    Kenji Matsumoto
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    J Nat Prod 66:1124-7. 2003
    ..All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis...
  20. doi Decreased expression of microRNA-143 and -145 in human gastric cancers
    Takeshi Takagi
    Department of Medical Oncology, Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Oncology 77:12-21. 2009
    ..Downregulation of specific microRNAs (miRNAs) occurs in human tumors, which suggests a function for miRNAs in tumor suppression. We investigated the role of the miRNAs miR-143 and miR-145 in gastric cancers...
  21. doi Inhibitory effects of whisky congeners on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice
    Tomohiro Itoh
    Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    J Agric Food Chem 58:7149-57. 2010
    ..These compounds remarkably suppressed the PCA reaction. Taken together, these findings suggest that WC seemed to be beneficial to ameliorate allergic reactions...
  22. ncbi Antitumor effect of resveratrol oligomers against human cancer cell lines and the molecular mechanism of apoptosis induced by vaticanol C
    Tetsuro Ito
    Gifu International Institute of Biotechnology, Mitake, Kani gun, Gifu 505 0116, Japan
    Carcinogenesis 24:1489-97. 2003
    ..Taken together, the findings presented here indicate that Vat C induced marked apoptosis in malignant cells mainly by affecting mitochondrial membrane potential...
  23. doi Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3
    Tomohiro Itoh
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Bioorg Med Chem 17:5374-9. 2009
    ..These results suggested that strawberry would be of some ameliorative benefit for the allergic symptoms...
  24. doi Inhibitory effects of sesquiterpene lactones isolated from Eupatorium chinense L. on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice
    Tomohiro Itoh
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Bioorg Med Chem 17:3189-97. 2009
    ..The SQTLs remarkably suppressed PCA reaction in a dose-dependent manner. Thus, it was suggested that SQTLs would be a candidate as an anti-allergic agent...
  25. doi Inhibitory effects of polymethoxy flavones isolated from Citrus reticulate on degranulation in rat basophilic leukemia RBL-2H3: enhanced inhibition by their combination
    Tomohiro Itoh
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Bioorg Med Chem 16:7592-8. 2008
    ..But the inhibitory effect of degranulation by PMF-combination treatment was not associated with the suppression of Ca(2+) influx...
  26. ncbi Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells
    Kenji Matsumoto
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Bioorg Med Chem 13:6064-9. 2005
    ..These findings provide a relevant basis for the development of xanthones as an agent for cancer prevention and combination therapy with anti-cancer drugs...
  27. ncbi Inhibitory effects of flavonoid glycosides isolated from the peel of Japanese persimmon (Diospyros kaki 'Fuyu') on melanin biosynthesis
    Kenji Ohguchi
    Gifu International Institute of Biotechnology, Kakamigahara, Gifu 504 0838, Japan
    Biol Pharm Bull 33:122-4. 2010
    ..Isoquercitrin and hyperin strongly inhibited the production of melanin (IC(50): 21.7 and 18.2 microM, respectively). The inhibitory effects were found to be mediated by suppression of tyrosinase expression...
  28. ncbi Type A monoamine oxidase is the target of an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol, leading to apoptosis in SH-SY5Y cells
    Hong Yi
    Department of Neurosciences, Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    J Neurochem 96:541-9. 2006
    ..These results demonstrate a novel function of MAO-A in the binding of neurotoxins and the induction of apoptosis, which may account for neuronal cell death in neurodegenerative disorders, including Parkinson's disease...
  29. ncbi Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells
    Kenji Matsumoto
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Bioorg Med Chem 12:5799-806. 2004
    ..It was also shown that the cytotoxicity substantially correlated with deltapsim decrease. These results indicate that alpha-mangostin and its analogs would be candidates for preventive and therapeutic application for cancer treatment...
  30. ncbi Antitumor effect of stilbenoids from Vateria indica against allografted sarcoma S-180 in animal model
    Satoshi Mishima
    API Company Research Institute, Gifu, Japan
    J Exp Ther Oncol 3:283-88. 2003
    ..These results demonstrated that the ethanol extract containing various stilbenoids from the stem bark of V. indica has the potent antitumor activity...
  31. ncbi Inhibitory effects of resveratrol derivatives from dipterocarpaceae plants on tyrosinase activity
    Kenji Ohguchi
    Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Biosci Biotechnol Biochem 67:1587-9. 2003
    ..The structure-activity relationships obtained in this study suggest that the double bond in the stilbene skeleton is critical for the inhibition, and also that molecular size is important for inhibitory potency...
  32. doi Rasagiline and selegiline, inhibitors of type B monoamine oxidase, induce type A monoamine oxidase in human SH-SY5Y cells
    Keiko Inaba-Hasegawa
    Department of Neurosciences, Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    J Neural Transm (Vienna) 120:435-44. 2013
    ..These results are discussed in relation to the role of MAO-A and these MAO-B inhibitors in neuronal death and neuroprotection...
  33. ncbi Characterized mechanism of alpha-mangostin-induced cell death: caspase-independent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 cells
    Yoshihito Nakagawa
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Bioorg Med Chem 15:5620-8. 2007
    ..These findings indicate unique mechanisms of alpha-mangostin-induced apoptosis and its action as an effective chemosensitizer...
  34. doi Glutathione redox status in mitochondria and cytoplasm differentially and sequentially activates apoptosis cascade in dopamine-melanin-treated SH-SY5Y cells
    Makoto Naoi
    Department of Neurosciences, Gifu International Institute of Biotechnology, 1 1 Nakafudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Neurosci Lett 465:118-22. 2009
    ..The regulation of apoptotic processing by SH redox state is discussed in relation to degeneration of nigra-striatal DA neurons in aging and PD, where oxidative stress is increased with impaired antioxidant capacity...
  35. ncbi A potent apoptosis-inducing activity of a sesquiterpene lactone, arucanolide, in HL60 cells: a crucial role of apoptosis-inducing factor
    Yoshihito Nakagawa
    Gifu International Institute of Biotechnology, Japan
    J Pharmacol Sci 97:242-52. 2005
    ..Taken together, the findings presented here indicate that arucanolide induced marked apoptosis in HL60 cells mainly by dissipating mitochondrial membrane potential, which would trigger AIF-induced apoptosis...
  36. ncbi Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan
    Yukihiro Akao
    Gifu International Institute of Biotechnology and Department of Brain Sciences, Mitake, Gifu, Japan
    J Neurochem 82:913-23. 2002
    ..Altogether, mitochondrial PT plays a key role both in NM(R)Sal-induced cell death and the neuroprotective effect of rasagiline...
  37. doi Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation
    Tomohiro Itoh
    Gifu International Institute of Biotechnology, Bio active Substances Research, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Bioorg Med Chem 16:4500-8. 2008
    ..Although intracellular free Ca(2+) concentration ([Ca(2+)](i)) was elevated by FcepsilonRI activation, it was found that alpha- or gamma-mangostin treatment was reduced the [Ca(2+)](i) elevation by suppressed Ca(2+) influx...
  38. ncbi Negative regulation of melanogenesis by phospholipase D1 through mTOR/p70 S6 kinase 1 signaling in mouse B16 melanoma cells
    Kenji Ohguchi
    Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    J Cell Physiol 205:444-51. 2005
    ..The results obtained here provide possible evidence that PLD1 exerts a negative regulatory role in the melanogenic process through mTOR/S6K1 signaling...
  39. doi A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells
    Keitaro Kojima
    Department of Urology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, Gifu 501 1193, Japan
    Biochem Biophys Res Commun 373:423-8. 2008
    ..These results suggest that up-regulation of SIRT1 expression may play an important role in promoting cell growth and chemoresistance in androgen-refractory PC3 and DU145 cells...
  40. doi Neuromelanin selectively induces apoptosis in dopaminergic SH-SY5Y cells by deglutathionylation in mitochondria: involvement of the protein and melanin component
    Makoto Naoi
    Department of Neurosciences, Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    J Neurochem 105:2489-500. 2008
    ..The novel function of NM is discussed in relation to the pathogenesis of PD...
  41. ncbi Involvement of phospholipase D1 in melanogenesis of mouse B16 melanoma cells
    Kenji Ohguchi
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    J Biol Chem 279:3408-12. 2004
    ..These results indicated that PLD1 negatively regulated the melanogenic signaling by modulating the expression of tyrosinase in mouse B16 melanoma cells...
  42. doi MicroRNA-203 regulates melanosome transport and tyrosinase expression in melanoma cells by targeting kinesin superfamily protein 5b
    Shunsuke Noguchi
    United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan
    J Invest Dermatol 134:461-9. 2014
    ....
  43. doi MicroRNA expression profiling of NGF-treated PC12 cells revealed a critical role for miR-221 in neuronal differentiation
    Nanako Hamada
    Department of Longevity and Aging Research, Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    Neurochem Int 60:743-50. 2012
    ..Our results suggest that miR-221 plays a critical role in neuronal differentiation as well as protection against apoptosis in PC12 cells...
  44. doi Type A monoamine oxidase is associated with induction of neuroprotective Bcl-2 by rasagiline, an inhibitor of type B monoamine oxidase
    Keiko Inaba-Hasegawa
    Department of Neurosciences, Gifu International Institute of Biotechnology, 1 1 Nakafudogaoka, Kakamigahara, Gifu, 504 0838, Japan
    J Neural Transm (Vienna) 119:405-14. 2012
    ..The novel role of MAO-A in Bcl-2 induction by rasagiline is discussed with regard to the molecular mechanism underlying neuroprotection by the MAO inhibitors...
  45. pmc Identification of non-coding RNAs embracing microRNA-143/145 cluster
    Akio Iio
    Department of Medical Oncology, Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Mol Cancer 9:136. 2010
    ....
  46. pmc MicroRNA-208 modulates BMP-2-stimulated mouse preosteoblast differentiation by directly targeting V-ets erythroblastosis virus E26 oncogene homolog 1
    Tomohiro Itoh
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    J Biol Chem 285:27745-52. 2010
    ..Taken together, these results suggest that the down-regulation of miR-208 in BMP-2-stimulated osteoblast differentiation is an important part of the regulatory machinery involved in early osteogenesis...
  47. ncbi Vaticanol C-induced cell death is associated with inhibition of pro-survival signaling in HL60 human leukemia cell line
    Kenji Ohguchi
    Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    Biosci Biotechnol Biochem 69:353-6. 2005
    ..These results suggest that vaticanol C might induce apoptosis via a mechanism involving activation of Bad through disruption of pro-survival signaling pathways...
  48. pmc Chemically modified synthetic microRNA-205 inhibits the growth of melanoma cells in vitro and in vivo
    Shunsuke Noguchi
    United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan
    Mol Ther 21:1204-11. 2013
    ..These findings indicate that miR-205BP/S3 is a possible promising therapeutic modality for melanoma...
  49. ncbi Involvement of calpain in melanogenesis of mouse B16 melanoma cells
    Kenji Ohguchi
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu, Japan
    Mol Cell Biochem 275:103-7. 2005
    ..These results indicate that calpain would be involved in the melanogenic signaling by modulating the expression of tyrosinase in mouse B16 melanoma cells...
  50. ncbi Eupalinin A isolated from Eupatorium chinense L. induces autophagocytosis in human leukemia HL60 cells
    Tomohiro Itoh
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Bioorg Med Chem 16:721-31. 2008
    ....
  51. doi Mitochondria in neurodegenerative disorders: regulation of the redox state and death signaling leading to neuronal death and survival
    Makoto Naoi
    Department of Neurosciences, Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    J Neural Transm (Vienna) 116:1371-81. 2009
    ..This review discusses the new role of mitochondria in regulation of neuronal cell death of neurodegenerative disorders...
  52. ncbi Fhit protein inhibits cell growth by attenuating the signaling mediated by nuclear factor-kappaB in colon cancer cell lines
    Yoshihito Nakagawa
    Department of Medical Oncology, Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Exp Cell Res 312:2433-42. 2006
    ..These results altogether suggest that Fhit functions as an anti-oncoprotein by inhibiting the phosphorylation of IkappaB-alpha and thereby blocking NF-kappaB signaling...
  53. ncbi Intracellular glutathione regulates sesquiterpene lactone-induced conversion of autophagy to apoptosis in human leukemia HL60 cells
    Tomohiro Itoh
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Anticancer Res 29:1449-57. 2009
    ..Taken together, intracellular ROS levels, including GSH, are crucial for the susceptibility to cell death and the determination of type of eupalinin A-induced cell death...
  54. ncbi Inhibitory effects of whisky congeners on melanogenesis in mouse B16 melanoma cells
    Kenji Ohguchi
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Biosci Biotechnol Biochem 72:1107-10. 2008
    ..Our results indicate that the inhibitory effects of whisky congeners on melanogenesis is due to direct inhibition of tyrosinase activity and to suppression of tyrosinase protein levels...
  55. ncbi Ceramide accumulation is independent of camptothecin-induced apoptosis in prostate cancer LNCaP cells
    Yukihiro Akao
    Gifu International Institute of Biotechnology, Mitake cho 2193 128, Kani gun, Gifu 505 0116, Japan
    Biochem Biophys Res Commun 294:363-70. 2002
    ....
  56. ncbi Oxidative stress in mitochondria: decision to survival and death of neurons in neurodegenerative disorders
    Makoto Naoi
    Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    Mol Neurobiol 31:81-93. 2005
    ..The mechanism was proved to be the result of the modification of the 20S beta-subunit with acrolein and to the binding of other acrolein-modified proteins to the 20S beta-subunit...
  57. doi Type A monoamine oxidase regulates life and death of neurons in neurodegeneration and neuroprotection
    Makoto Naoi
    Department of Neurosciences, Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    Int Rev Neurobiol 100:85-106. 2011
    ..The roles of MAO-A in the regulation of neuronal survival and death are discussed in concern to find a novel strategy to protect neurons in age-associated neurodegenerative disorders and depression...
  58. pmc MicroRNA-141 and -200a are involved in bone morphogenetic protein-2-induced mouse pre-osteoblast differentiation by targeting distal-less homeobox 5
    Tomohiro Itoh
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    J Biol Chem 284:19272-9. 2009
    ..Thus, we have observed for the first time that miR-141 and -200a are involved in pre-osteoblast differentiation in part by regulating the expression of Dlx5...
  59. ncbi Two related cinnamic Acid derivatives from Brazilian honey bee propolis, baccharin and drupanin, induce growth inhibition in allografted sarcoma S-180 in mice
    Satoshi Mishima
    API Co Ltd, R and D, Gifu, Japan
    Biol Pharm Bull 28:1025-30. 2005
    ..Furthermore, these compounds induced a significant genotoxic effect on the tumor cells in comparison with normal splenocytes. Thus, baccharin and drupanin are potent tumor suppressive components of honeybee propolis...
  60. pmc Microvesicle-mediated RNA molecule delivery system using monocytes/macrophages
    Yukihiro Akao
    United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan
    Mol Ther 19:395-9. 2011
    ..These data suggest that some of the transfected miR-143BPs were secreted from THP-1 macrophages as MV-RNAs both in vitro and in vivo...
  61. ncbi Effects of hydroxystilbene derivatives on tyrosinase activity
    Kenji Ohguchi
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Biochem Biophys Res Commun 307:861-3. 2003
    ....
  62. ncbi Involvement of phospholipase D1 in collagen type I production of human dermal fibroblasts
    Kenji Ohguchi
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Biochem Biophys Res Commun 348:1398-402. 2006
    ..These results suggest that PLD1 plays a crucial role in collagen type I production through mTOR signaling in human dermal fibroblast...
  63. pmc Role of Intracellular and Extracellular MicroRNA-92a in Colorectal Cancer
    Nami Yamada
    United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan
    Transl Oncol 6:482-92. 2013
    ..These data suggest that intracellular and extracellular miR-92a had important roles in tumor growth and the tumor microenvironment in colorectal cancer. ..
  64. ncbi Cytotoxic benzophenone derivatives from Garcinia species display a strong apoptosis-inducing effect against human leukemia cell lines
    Kenji Matsumoto
    Gifu International Institute of Biotechnology, Kani gun, Gifu, Japan
    Biol Pharm Bull 26:569-71. 2003
    ..The growth inhibitory effects of isogarcinol and xanthochymol were more potent than that of garcinol, which is a well- known cytotoxic benzophenone derivative...
  65. ncbi Localization of sphingosine kinase-1 in mouse sperm acrosomes
    Kenji Matsumoto
    Gifu International Institute of Biotechnology, Gifu, Japan
    J Histochem Cytochem 53:243-7. 2005
    ..Furthermore, we identified the presence of the S1P receptors S1P1, S1P2, S1P3, and S1P5, in mouse spermatozoa by RT-PCR. These results suggest that S1P produced by SPHK-1 would play a role in the acrosomal reaction through S1P receptors...
  66. doi Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds
    Nanako Hamada
    Department of Longevity and Aging Research, Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Bioorg Med Chem 19:1959-65. 2011
    ....
  67. doi Preconditioning by sesquiterpene lactone enhances H2O2-induced Nrf2/ARE activation
    Ken Umemura
    Department of Longevity and Aging Research, Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Biochem Biophys Res Commun 368:948-54. 2008
    ....
  68. ncbi Lig-8, a highly bioactive lignophenol derivative from bamboo lignin, exhibits multifaceted neuroprotective activity
    Yasushi Ito
    Department of Biofunctional Molecules, Gifu Pharmaceutical University, Gifu, Japan
    CNS Drug Rev 13:296-307. 2007
    ..We believe that the elucidation of the mechanism of antiapoptotic action of lig-8 may help in finding new approaches to the treatment of neurodegenerative disorders...
  69. doi MicroRNA-143 functions as a tumor suppressor in human bladder cancer T24 cells
    Syunsuke Noguchi
    The United Graduate School of Veterinary Sciences, Gifu University, Yanagido, Gifu, Japan
    Cancer Lett 307:211-20. 2011
    ..These findings suggest that the chemically-modified synthetic miR-143 functions as a tumor suppressor in T24 cells by targeting ERK5 and/or Akt...
  70. ncbi An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic bcl-2 in human dopaminergic SH-SY5Y cells
    Yukihiro Akao
    Gifu International Institute of Biotechnology, Mitake, Kani gun, Gifu, Japan
    Neurosci Lett 326:105-8. 2002
    ..Enhanced expression of bcl-2 family indicates the ability of rasagiline to adjust the apoptotic threshold and protect degenerating neurons in PD...
  71. ncbi Gnetol as a potent tyrosinase inhibitor from genus Gnetum
    Kenji Ohguchi
    Gifu International Institute of Biotechnology, Mitake, Kani gun, Gifu 505 0116, Japan
    Biosci Biotechnol Biochem 67:663-5. 2003
    ..Gnetol (IC50, 4.5 microM) was stronger than kojic acid (IC50, 139 microM) as a standard inhibitor for murine tyrosinase activity. Moreover, gnetol significantly suppressed, melanin biosynthesis in murine B16 melanoma cells...
  72. ncbi Magnolol-induced apoptosis is mediated via the intrinsic pathway with release of AIF from mitochondria in U937 cells
    Takamichi Ikai
    Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Biol Pharm Bull 29:2498-501. 2006
    ..These findings indicated that the above-mentioned sequence of intracellular signaling events led to apoptosis in magnolol-treated U937 cells, which was caspase-independent...
  73. ncbi Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines
    Yoshihito Nakagawa
    Institute of Applied Biochemistry, Yagi Memorial Park, Mitake, Gifu, Japan
    Life Sci 70:2253-69. 2002
    ..All these findings indicate that arsenic trioxide-induced apoptosis in SW480 cells is executed by the activation of caspase 3 without mediating by mitochondria under the overproduction of reactive oxygen species...
  74. ncbi Expression of rck/p54, a DEAD-box RNA helicase, in gametogenesis and early embryogenesis of mice
    Kenji Matsumoto
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu, Japan
    Dev Dyn 233:1149-56. 2005
    ..These findings indicate that rck/p54 may play an important role in gametogenesis and early embryogenesis in mammals...
  75. ncbi Dopamine-derived endogenous N-methyl-(R)-salsolinol: its role in Parkinson's disease
    Makoto Naoi
    Department of Brain Sciences, Institute of Applied Biochemistry, Yagi Memorial Park, Mitake, 505 0116 Gifu, Japan
    Neurotoxicol Teratol 24:579-91. 2002
    ..In this article, we review the recent advance in proving our hypothesis that the dopamine-derived neurotoxin causes the selective depletion of dopamine neurons in PD...
  76. ncbi Stimulation of melanogenesis by the citrus flavonoid naringenin in mouse B16 melanoma cells
    Kenji Ohguchi
    Gifu International Institute of Biotechnology
    Biosci Biotechnol Biochem 70:1499-501. 2006
    ..Melanin contents and tyrosinase activities were strongly increased by naringenin. Naringenin was found to cause marked increases in the expression levels of melanogenic enzymes...
  77. ncbi Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria
    Masashi Tanaka
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Mitake, Japan
    J Biomed Sci 9:534-41. 2002
    ..Delivery of restriction enzymes into mitochondria is a novel strategy for gene therapy of a special form of mitochondrial diseases...
  78. ncbi Mechanism of the melanogenesis stimulation activity of (-)-cubebin in murine B16 melanoma cells
    Noriko Hirata
    School of Pharmaceutical Sciences, Kinki University, 3 4 1 Kowakae, Higashiosaka, Osaka 577 8502, Japan
    Bioorg Med Chem 15:4897-902. 2007
    ..These results suggested that cubebin increased melanogenesis in B16 cells through the enhancement of tyrosinase expression mediated by activation of p38 MAPK...
  79. ncbi Growth inhibition of stilbenoids in Welwitschiaceae and Gnetaceae through induction of apoptosis in human leukemia HL60 cells
    Ibrahim Iliya
    Gifu Pharmaceutical University, Japan
    Biol Pharm Bull 29:1490-2. 2006
    ....
  80. ncbi Arsenic trioxide-induced apoptosis and its enhancement by buthionine sulfoximine in hepatocellular carcinoma cell lines
    Mariko Kito
    Institute of Applied Biochemistry, Yagi Memorial Park, Mitake, Gifu 505 0116, Japan
    Biochem Biophys Res Commun 291:861-7. 2002
    ....
  81. pmc PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation
    Hitoshi Yoshida
    Molecular Oncology Division, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Mol Cell Biol 27:5819-34. 2007
    ..1/PML IV/p300 complex and inhibited PU.1-induced transcription. These results suggest a novel pathogenic mechanism of the PML-retinoic acid receptor alpha fusion protein in acute promyelocytic leukemia...
  82. ncbi N-trans-feruloyltyramine as a melanin biosynthesis inhibitor
    Mai Efdi
    Department of Chemistry, Faculty of Engineering, Gifu University, Japan
    Biol Pharm Bull 30:1972-4. 2007
    ..FA-induced downregulation of tyrosinase resulted in suppression of melanin biosynthesis in murine B16 melanoma cells...
  83. ncbi Crystallization and X-ray analysis of the N-terminal core domain of a tumour-associated human DEAD-box RNA helicase, rck/p54
    Tsutomu Matsui
    Department of Life Science, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    Acta Crystallogr D Biol Crystallogr 60:156-9. 2004
    ..The crystal belongs to the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a = 65.5, b = 73.1, c = 84.8 A, and diffracts X-rays to beyond 2.0 A resolution...
  84. ncbi Allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway in HL60 and U937 cells
    Talia Miron
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Nutr Biochem 19:524-35. 2008
    ..The emerging mechanistic basis for the antiproliferative function of allicin, therefore, involves the activation of the mitochondrial apoptotic pathway by GSH depletion and by changes in the intracellular redox status...
  85. ncbi Structural insight of human DEAD-box protein rck/p54 into its substrate recognition with conformational changes
    Tsutomu Matsui
    Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta cho 4259, Midori ku, Yokohama, 226 8501, Japan
    Genes Cells 11:439-52. 2006
    ..These findings altogether suggest that rck/p54 may affect the IRES-dependent translation of c-myc even in the cells...
  86. ncbi Identification of caffeoylquinic acid derivatives from Brazilian propolis as constituents involved in induction of granulocytic differentiation of HL-60 cells
    Satoshi Mishima
    Nagaragawa Research Center, API Co, Ltd, 692 3 Nagara, Gifu 502 0071, Japan
    Bioorg Med Chem 13:5814-8. 2005
    ..This is the first report demonstrating that the caffeoylquinic acid derivatives induce granulocytic differentiation of HL-60 cells...
  87. ncbi Effects of propolis on cell growth and gene expression in HL-60 cells
    Satoshi Mishima
    Nagaragawa Research Center, API Co Ltd, 692 3 Nagara, Gifu 502 0071, Japan
    J Ethnopharmacol 99:5-11. 2005
    ..Propolis-induced growth inhibition in HL-60 cells was, at least in part, due to differentiation with gene expression profiles, which are similar to those induced by all-trans retinoic acid...
  88. ncbi Neuroprotection by propargylamines in Parkinson's disease: suppression of apoptosis and induction of prosurvival genes
    Wakako Maruyama
    Laboratory of Biochemistry and Metabolism, Department of Basic Gerontology, National Institute for Longevity Sciences, Obu, Aichi 474 8522, Japan
    Neurotoxicol Teratol 24:675-82. 2002
    ..Rasagiline and related propargylamines may rescue degenerating dopamine neurons through inhibiting death signal transduction initiated by mitochondria PT...
  89. ncbi Vaticanol C, a novel resveratrol tetramer, inhibits cell growth through induction of apoptosis in colon cancer cell lines
    Tetsuro Ito
    Gifu Pharmaceutical University, Mitahora Higashi, Japan
    Biol Pharm Bull 25:147-8. 2002
    ....
  90. ncbi N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kappaB transcription factor
    Wakako Maruyama
    Department of Basic Gerontology, National Institute for Longevity Sciences, Gengo 36 3, Morioka chio, Obu Aichi 474 8522, Japan
    Neurochem Int 44:393-400. 2004
    ....
  91. ncbi Inhibitory effects of crude alpha-mangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1, 2-dimethylhydrazine in the rat
    Viengvansay Nabandith
    Tumor Pathology Division, Faculty of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    Asian Pac J Cancer Prev 5:433-8. 2004
    ..This finding that crude alpha-mangostin has potent chemopreventive effects in our short-term colon carcinogenesis bioassay system suggests that longer exposure might result in suppression of tumor development...
  92. ncbi The isolation of secondary metabolites and in vitro potent anti-cancer activity of clerodermic acid from Enicosanthum membranifolium
    Mai Efdi
    Department of Chemistry, Faculty of Engineering, Gifu University, Gifu 501 1193, Japan
    Bioorg Med Chem 15:3667-71. 2007
    ..The structures of R-(-)-mellein and salicifoline chloride were confirmed by using X-ray diffraction. Clerodermic acid was shown to induce potent apoptosis against human leukemia HL60 cells...