Francis W Muregi

Summary

Affiliation: Hamamatsu University School of Medicine
Country: Japan

Publications

  1. doi Plasmodium berghei: efficacy of 5-fluoroorotate in combination with commonly used antimalarial drugs in a mouse model
    Francis W Muregi
    Department of Infectious Diseases, Hamamatsu University School of Medicine, 1 20 1, Handayama, Higashi ku, Hamamatsu, Shizuoka 431 3192, Japan
    Exp Parasitol 121:376-80. 2009
  2. ncbi Antimalarial activity of methanolic extracts from plants used in Kenyan ethnomedicine and their interactions with chloroquine (CQ) against a CQ-tolerant rodent parasite, in mice
    Francis W Muregi
    Department of Parasitology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Japan
    J Ethnopharmacol 111:190-5. 2007
  3. ncbi In Vivo antimalarial activity of aqueous extracts from Kenyan medicinal plants and their chloroquine (CQ) potentiation effects against a blood-induced CQ-resistant rodent parasite in mice
    Francis W Muregi
    Department of Parasitology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Phytother Res 21:337-43. 2007
  4. doi Plasmodium berghei: lack of antimalarial activity of an analogue of folate precursor, 2,4-diamino-6-hydroxymethylpteridine in a mouse model
    Francis W Muregi
    Department of Parasitology, Hamamatsu University School of Medicine, Higashi ku, Hamamatsu 431 3192, Japan
    Exp Parasitol 120:286-9. 2008
  5. ncbi Novel rational drug design strategies with potential to revolutionize malaria chemotherapy
    F W Muregi
    Department of Infectious Diseases, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashiku, Hamamatsu 431 3192, Japan
    Curr Med Chem 18:113-43. 2011
  6. ncbi Antimalarial drugs and their useful therapeutic lives: rational drug design lessons from pleiotropic action of quinolines and artemisinins
    Francis W Muregi
    Department of Infectious Diseases, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashiku, Hamamatsu 431 3192, Japan
    Curr Drug Discov Technol 7:280-316. 2010
  7. ncbi Chloroquine efficacy in Plasmodium berghei NK65-infected ICR mice, with reference to the influence of initial parasite load and starting day of drug administration on the outcome of treatment
    Akira Ishih
    Department of Parasitology, Hamamatsu University School of Medicine, Japan
    Southeast Asian J Trop Med Public Health 37:13-7. 2006
  8. ncbi Possible involvement of IFN-gamma in early mortality of Plasmodium berghei NK65-infected BALB/c mice after febrifugine treatment
    Akira Ishih
    Department of Parasitology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Southeast Asian J Trop Med Public Health 39:949-58. 2008
  9. pmc Resistance of a rodent malaria parasite to a thymidylate synthase inhibitor induces an apoptotic parasite death and imposes a huge cost of fitness
    Francis W Muregi
    Department of Infectious Diseases, Hamamatsu University School of Medicine, Hamamatsu, Japan
    PLoS ONE 6:e21251. 2011

Detail Information

Publications10

  1. doi Plasmodium berghei: efficacy of 5-fluoroorotate in combination with commonly used antimalarial drugs in a mouse model
    Francis W Muregi
    Department of Infectious Diseases, Hamamatsu University School of Medicine, 1 20 1, Handayama, Higashi ku, Hamamatsu, Shizuoka 431 3192, Japan
    Exp Parasitol 121:376-80. 2009
    ..Drugs in a synergistic combination may exert less resistance selection pressure, thus FOA-PYR and FOA-DAP-ART warrant further evaluation with an ultimate object of possible clinical use against drug-resistant malaria...
  2. ncbi Antimalarial activity of methanolic extracts from plants used in Kenyan ethnomedicine and their interactions with chloroquine (CQ) against a CQ-tolerant rodent parasite, in mice
    Francis W Muregi
    Department of Parasitology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Japan
    J Ethnopharmacol 111:190-5. 2007
    ....
  3. ncbi In Vivo antimalarial activity of aqueous extracts from Kenyan medicinal plants and their chloroquine (CQ) potentiation effects against a blood-induced CQ-resistant rodent parasite in mice
    Francis W Muregi
    Department of Parasitology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Phytother Res 21:337-43. 2007
    ..Plants, which showed significant antimalarial activity including V. lasiopus, T. asiatica and R. prinoides, should further be evaluated in the search for novel agents against drug-resistant malaria...
  4. doi Plasmodium berghei: lack of antimalarial activity of an analogue of folate precursor, 2,4-diamino-6-hydroxymethylpteridine in a mouse model
    Francis W Muregi
    Department of Parasitology, Hamamatsu University School of Medicine, Higashi ku, Hamamatsu 431 3192, Japan
    Exp Parasitol 120:286-9. 2008
    ..05). Our findings do not seem to support the hypothesis of selective de novo metabolism of DAP to AMP by the malarial parasite...
  5. ncbi Novel rational drug design strategies with potential to revolutionize malaria chemotherapy
    F W Muregi
    Department of Infectious Diseases, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashiku, Hamamatsu 431 3192, Japan
    Curr Med Chem 18:113-43. 2011
    ..We thus explore malaria apoptosis machinery as a novel drug target, and also discuss the potential of hybrid molecules as well as prodrugs and double prodrugs in malaria chemotherapy...
  6. ncbi Antimalarial drugs and their useful therapeutic lives: rational drug design lessons from pleiotropic action of quinolines and artemisinins
    Francis W Muregi
    Department of Infectious Diseases, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashiku, Hamamatsu 431 3192, Japan
    Curr Drug Discov Technol 7:280-316. 2010
    ..This review relates the pleiotropic action of CQ and ART with their long UTLs, and discusses their relevance in rational drug development strategies. Novel targets with potential to yield drugs with long UTLs are also explored...
  7. ncbi Chloroquine efficacy in Plasmodium berghei NK65-infected ICR mice, with reference to the influence of initial parasite load and starting day of drug administration on the outcome of treatment
    Akira Ishih
    Department of Parasitology, Hamamatsu University School of Medicine, Japan
    Southeast Asian J Trop Med Public Health 37:13-7. 2006
    ..The present results indicate that in in vivo antimalarial drug-assay systems, several factors, sush as initial parasite load and starting time of treatment may influence the drug response in the host...
  8. ncbi Possible involvement of IFN-gamma in early mortality of Plasmodium berghei NK65-infected BALB/c mice after febrifugine treatment
    Akira Ishih
    Department of Parasitology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Southeast Asian J Trop Med Public Health 39:949-58. 2008
    ..The results of the present study suggest that although IFN-gamma is significant for protective immunity in mice with malaria infection, it may play an adverse role post-medication, causing earlier mortality of treated BALB/c mice...
  9. pmc Resistance of a rodent malaria parasite to a thymidylate synthase inhibitor induces an apoptotic parasite death and imposes a huge cost of fitness
    Francis W Muregi
    Department of Infectious Diseases, Hamamatsu University School of Medicine, Hamamatsu, Japan
    PLoS ONE 6:e21251. 2011
    ..The greatest impediment to effective malaria control is drug resistance in Plasmodium falciparum, and thus understanding how resistance impacts on the parasite's fitness and pathogenicity may aid in malaria control strategy...