Yasuhiro Suzuki

Summary

Affiliation: Hamamatsu University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint [Evaluation for antithrombotic agents by a thrombotic model in animals]
    Yasuhiro Suzuki
    Department of Pharmacology, Hamamatsu University School of Medicine, Shizuoka, Japan
    Yakugaku Zasshi 132:1019-24. 2012
  2. ncbi request reprint Antithrombotic effect of geniposide and genipin in the mouse thrombosis model
    Y Suzuki
    Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Planta Med 67:807-10. 2001
  3. ncbi request reprint Novel situations of endothelial injury in stroke--mechanisms of stroke and strategy of drug development: intracranial bleeding associated with the treatment of ischemic stroke: thrombolytic treatment of ischemia-affected endothelial cells with tissue-type
    Yasuhiro Suzuki
    Department of Pharmacology, Hamamatsu University School of Medicine, Shizuoka 431 3192, Japan
    J Pharmacol Sci 116:25-9. 2011
  4. ncbi request reprint Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery
    Yasuhiro Suzuki
    Department of Pharmacology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu City, Shizuoka 431 3192, Japan
    Life Sci 73:1289-98. 2003
  5. ncbi request reprint A novel guinea pig model with cyclic flow reductions following thrombotic cerebral ischemia
    Yasuhiro Suzuki
    Department of Pharmacology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Brain Res Brain Res Protoc 10:55-9. 2002
  6. ncbi request reprint SM-20220, a Na(+)/H(+) exchanger inhibitor: effects on ischemic brain damage through edema and neutrophil accumulation in a rat middle cerebral artery occlusion model
    Yasuhiro Suzuki
    Department of Pharmacology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Brain Res 945:242-8. 2002
  7. ncbi request reprint Role of tissue-type plasminogen activator in ischemic stroke
    Yasuhiro Suzuki
    Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    J Pharmacol Sci 113:203-7. 2010
  8. ncbi request reprint Dietary supplementation with fermented soybeans suppresses intimal thickening
    Yasuhiro Suzuki
    Department of Pharmacology, Hamamatsu University School of Medicine, Shizuoka, Japan
    Nutrition 19:261-4. 2003
  9. ncbi request reprint Essential role of endogenous tissue plasminogen activator through matrix metalloproteinase 9 induction and expression on heparin-produced cerebral hemorrhage after cerebral ischemia in mice
    Bing Qiao Zhao
    Department of Pharmacology, Hamamatsu University School of Medicine, Japan
    Blood 103:2610-6. 2004
  10. ncbi request reprint A novel MCA occlusion model of photothrombotic ischemia with cyclic flow reductions: development of cerebral hemorrhage induced by heparin
    Bing Qiao Zhao
    Department of Pharmacology, Hamamatsu University School of Medicine, 1 20 1 Handayama, 431 3192, Hamamatsu, Japan
    Brain Res Brain Res Protoc 9:85-92. 2002

Collaborators

Detail Information

Publications25

  1. ncbi request reprint [Evaluation for antithrombotic agents by a thrombotic model in animals]
    Yasuhiro Suzuki
    Department of Pharmacology, Hamamatsu University School of Medicine, Shizuoka, Japan
    Yakugaku Zasshi 132:1019-24. 2012
    ..This implies that the t-PA/LRP/MMP-3 pathway may be a suitable target for developing strategies to improve the therapeutic efficacy of t-PA in acute ischemic stroke...
  2. ncbi request reprint Antithrombotic effect of geniposide and genipin in the mouse thrombosis model
    Y Suzuki
    Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Planta Med 67:807-10. 2001
    ..We conclude that geniposide showed an antithrombotic effect in vivo due to the suppression of platelet aggregation. PLA(2) inhibition by geniposide is one possible anti-platelet mechanism...
  3. ncbi request reprint Novel situations of endothelial injury in stroke--mechanisms of stroke and strategy of drug development: intracranial bleeding associated with the treatment of ischemic stroke: thrombolytic treatment of ischemia-affected endothelial cells with tissue-type
    Yasuhiro Suzuki
    Department of Pharmacology, Hamamatsu University School of Medicine, Shizuoka 431 3192, Japan
    J Pharmacol Sci 116:25-9. 2011
    ..This implies that the t-PA / LRP / MMP-3 pathway may be a suitable target for developing strategies to improve the therapeutic efficacy of t-PA in acute ischemic stroke...
  4. ncbi request reprint Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery
    Yasuhiro Suzuki
    Department of Pharmacology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu City, Shizuoka 431 3192, Japan
    Life Sci 73:1289-98. 2003
    ..These effects may partially be attributable to NK, which showed enhanced thrombolysis near the vessel wall...
  5. ncbi request reprint A novel guinea pig model with cyclic flow reductions following thrombotic cerebral ischemia
    Yasuhiro Suzuki
    Department of Pharmacology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Brain Res Brain Res Protoc 10:55-9. 2002
    ..These results show that this model is unique with respect to its development of MCA cyclic flow reductions, and may be suitable for investigating mechanisms and therapeutic reagents of CFRs in the MCA...
  6. ncbi request reprint SM-20220, a Na(+)/H(+) exchanger inhibitor: effects on ischemic brain damage through edema and neutrophil accumulation in a rat middle cerebral artery occlusion model
    Yasuhiro Suzuki
    Department of Pharmacology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Brain Res 945:242-8. 2002
    ..The NHE in neutrophils may enhance the progress of cerebral damage following cerebral ischemia-reperfusion...
  7. ncbi request reprint Role of tissue-type plasminogen activator in ischemic stroke
    Yasuhiro Suzuki
    Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    J Pharmacol Sci 113:203-7. 2010
    ..Thus, t-PA causes ICH via MMP-3 induction in endothelial cells, which is regulated through the LRP/NF-kappaB pathway, and could be targeted to improve the therapeutic efficacy of t-PA for acute ischemic stroke...
  8. ncbi request reprint Dietary supplementation with fermented soybeans suppresses intimal thickening
    Yasuhiro Suzuki
    Department of Pharmacology, Hamamatsu University School of Medicine, Shizuoka, Japan
    Nutrition 19:261-4. 2003
    ..These findings suggest that natto extracts, because of their thrombolytic activity, suppress intimal thickening after vascular injury as a result of the inhibition of mural thrombi formation...
  9. ncbi request reprint Essential role of endogenous tissue plasminogen activator through matrix metalloproteinase 9 induction and expression on heparin-produced cerebral hemorrhage after cerebral ischemia in mice
    Bing Qiao Zhao
    Department of Pharmacology, Hamamatsu University School of Medicine, Japan
    Blood 103:2610-6. 2004
    ..Targeting tPA, MMP 9, or both may provide a new approach for preventing cerebral hemorrhage associated with antithrombotic therapy for stroke in humans...
  10. ncbi request reprint A novel MCA occlusion model of photothrombotic ischemia with cyclic flow reductions: development of cerebral hemorrhage induced by heparin
    Bing Qiao Zhao
    Department of Pharmacology, Hamamatsu University School of Medicine, 1 20 1 Handayama, 431 3192, Hamamatsu, Japan
    Brain Res Brain Res Protoc 9:85-92. 2002
    ..Thus it is different from permanent or ischemia/reperfusion MCA occlusion in rodents and may be suitable for studying hemorrhagic risks associated with the use of antithrombotic agents...
  11. doi request reprint Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related protein
    Yasuhiro Suzuki
    Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu, Japan, Japan
    Blood 114:3352-8. 2009
    ..These findings indicate that t-PA deteriorates ICB via MMP-3 induction in endothelial cells, which is regulated through the LRP/nuclear factor-kappaB pathway...
  12. ncbi request reprint Tissue-type plasminogen activator has paradoxical roles in focal cerebral ischemic injury by thrombotic middle cerebral artery occlusion with mild or severe photochemical damage in mice
    Nobuo Nagai
    Department of Physiology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Cereb Blood Flow Metab 22:648-51. 2002
    ....
  13. ncbi request reprint Na+/H+ exchanger inhibitor, SM-20220, is protective against excitotoxicity in cultured cortical neurons
    Yuji Matsumoto
    Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Stroke 35:185-90. 2004
    ....
  14. doi request reprint Involvement of platelet activation by P2Y12 receptor in the development of transplant arteriosclerosis in mice
    Kenichi Yashiro
    Department of Pharmacology, Hamamatsu University School of Medicine, Higashi ku, Hamamatsu City, Shizuoka, Japan
    Transplantation 87:660-7. 2009
    ..We, therefore, investigated this question using P2Y12 receptor knockout (KO) mice, in which platelets cannot be aggregated by adenosine diphosphate stimulation...
  15. ncbi request reprint Inhibitory effects of total flavones of Hippophae Rhamnoides L on thrombosis in mouse femoral artery and in vitro platelet aggregation
    Jiayi Cheng
    Department of Pharmacology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Life Sci 72:2263-71. 2003
    ..3 micro M). The results of the present study, in which TFH prevented in-vivo thrombogenesis, probably due to inhibition of platelet aggregation, suggest a possible clinical approach for the prevention of thrombosis...
  16. doi request reprint Combination of reactive oxygen species and tissue-type plasminogen activator enhances the induction of gelatinase B in brain endothelial cells
    Kosuke Harada
    Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Int J Neurosci 122:53-9. 2012
    ..In conclusion, ROS enhanced t-PA-mediated MMP-9 production in brain endothelial cells; this MMP-9 production was decreased by the addition of edaravone, which inhibited the NF-κB pathway, specifically by enhancing I-κB degradation...
  17. ncbi request reprint Genistein, an isoflavone included in soy, inhibits thrombotic vessel occlusion in the mouse femoral artery and in vitro platelet aggregation
    Kazunao Kondo
    Department of Pharmacology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Shizuoka, Japan
    Eur J Pharmacol 455:53-7. 2002
    ..01). In conclusion, genistein prevented in vivo thrombogenesis and suppressed in vitro platelet aggregation. These results suggest that dietary supplementation of soy may prevent the progression of thrombosis and atherosclerosis...
  18. ncbi request reprint Hypercholesterolemia induces regression in neointimal thickening due to apoptosis of vascular smooth muscle cells in the hamster endothelial injury model
    Akihisa Matsuda
    Department of Pharmacology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Cardiovasc Res 53:512-23. 2002
    ..Thus, we investigated the roles of hypercholesterolemia in vascular remodeling following endothelial injury in the hamster femoral artery...
  19. ncbi request reprint Ability of NMDA and non-NMDA receptor antagonists to inhibit cerebral ischemic damage in aged rats
    Yasuhiro Suzuki
    Department of Pharmacology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Brain Res 964:116-20. 2003
    ..Our observations indicate that NMDA and AMPA receptor antagonists are less effective in aged, than in young, rats and that cerebral damage by receptor agonists depends on the type of receptor, such as NMDA and AMPA...
  20. ncbi request reprint Molecular characterization of 8-methoxyfluoroquinolone resistance in a clinical isolate of methicillin-resistant Staphylococcus aureus
    Toshinobu Horii
    Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Chemotherapy 53:104-9. 2007
    ..aureus, although in vitro studies have shown that mutations in both DNA gyrase and topoisomerase IV were required for gatifloxacin resistance in S. aureus...
  21. ncbi request reprint Detection of mutations in quinolone resistance-determining regions in levofloxacin- and methicillin-resistant Staphylococcus aureus: effects of the mutations on fluoroquinolone MICs
    Toshinobu Horii
    Department of Laboratory Medicine, Hamamatsu University School of Medicine, 1 20 1 Handa yama, Hamamatsu 431 3192, Japan
    Diagn Microbiol Infect Dis 46:139-45. 2003
    ....
  22. ncbi request reprint Characterization of a holin (HolNU3-1) in methicillin-resistant Staphylococcus aureus host
    Toshinobu Horii
    Department of Laboratory Medicine and Group of Infection Control Research, Hamamatsu University School of Medicine, 1 20 1 Handa yama, Hamamatsu 431 3192, Japan
    FEMS Immunol Med Microbiol 34:307-10. 2002
    ..We suggest that this diversity is important in the identification of the evolution of clinical isolates of S. aureus...
  23. pmc Recombinant tissue-type plasminogen activator transiently enhances blood-brain barrier permeability during cerebral ischemia through vascular endothelial growth factor-mediated endothelial endocytosis in mice
    Yasuhiro Suzuki
    School of Pharmaceutical Sciences, Ohu University, Koriyama, Japan
    J Cereb Blood Flow Metab 35:2021-31. 2015
    ..Therefore, inhibition of VEGF induction may have beneficial effects after thrombolytic therapy with rt-PA treatment after stroke. ..
  24. pmc A Review of the Mechanisms of Blood-Brain Barrier Permeability by Tissue-Type Plasminogen Activator Treatment for Cerebral Ischemia
    Yasuhiro Suzuki
    Department of Pharmacology, Hamamatsu University School of MedicineHamamatsu, Japan School of Pharmaceutical Sciences, Ohu UniversityKoriyama, Japan
    Front Cell Neurosci 10:2. 2016
    ....
  25. ncbi request reprint Antibacterial activities of beta-lactamase inhibitors associated with morphological changes of cell wall in Helicobacter pylori
    Toshinobu Horii
    Department of Laboratory Medicine, Hamamatsu University School of Medicine, 1 20 1 Handa yama, Hamamatsu 431 3192, Japan
    Helicobacter 7:39-45. 2002
    ..Here we describe the relationship between viability and cell profiles of H. pylori exposed to beta-lactamase inhibitors and some antibiotics in a short-time course...