Hiroshi Ohta

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. doi In vitro and in vivo safety and efficacy studies of amphotericin B on Babesia gibsoni
    Masahiro Yamasaki
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan Electronic address
    Vet Parasitol 205:424-33. 2014
  2. doi Heat shock response of Babesia gibsoni heat shock protein 70
    Masahiro Yamasaki
    Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Parasitol 94:119-24. 2008
  3. ncbi Comparison and phylogenetic analysis of the heat shock protein 70 gene of Babesia parasites from dogs
    Masahiro Yamasaki
    Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Vet Parasitol 145:217-27. 2007
  4. ncbi Flow cytometry to evaluate the level of Babesia gibsoni parasitemia in vivo and in vitro by using the fluorescent nucleic acid stain SYTO16
    Masahiro Yamasaki
    Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Jpn J Vet Res 55:129-36. 2008
  5. doi Babesia gibsoni: detection in blood smears and formalin-fixed, paraffin-embedded tissues using deoxyribonucleic acid in situ hybridization analysis
    Masahiro Yamasaki
    Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Exp Parasitol 127:119-26. 2011
  6. doi Effects and mechanisms of action of ionophorous antibiotics valinomycin and salinomycin-Na on Babesia gibsoni in vitro
    Masahiro Yamasaki
    Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Parasitol 95:1532-8. 2009
  7. doi Detection of anti-Babesia gibsoni heat shock protein 70 antibody and anti-canine heat shock protein 70 antibody in sera from Babesia gibsoni-infected dogs
    Masahiro Yamasaki
    Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Vet Parasitol 180:215-25. 2011
  8. doi Effects and mechanisms of action of polyene macrolide antibiotic nystatin on Babesia gibsoni in vitro
    Masahiro Yamasaki
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Parasitol 97:1190-2. 2011
  9. ncbi Development and characterization of a strain of Babesia gibsoni resistant to diminazene aceturate in vitro
    Shiang Jyi Hwang
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Japan
    J Vet Med Sci 72:765-71. 2010
  10. pmc Qualitative and quantitative contrast enhanced ultrasonography of the pancreas using bolus injection and continuous infusion methods in normal dogs
    Sue Yee Lim
    Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido 060 0818, Japan
    J Vet Med Sci 75:1601-7. 2013

Collaborators

Detail Information

Publications45

  1. doi In vitro and in vivo safety and efficacy studies of amphotericin B on Babesia gibsoni
    Masahiro Yamasaki
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan Electronic address
    Vet Parasitol 205:424-33. 2014
    ..These results indicate that AmB has in vivo activity against B. gibsoni; however, it does not eliminate parasites from infected dogs and affects kidney function at a high dose. ..
  2. doi Heat shock response of Babesia gibsoni heat shock protein 70
    Masahiro Yamasaki
    Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Parasitol 94:119-24. 2008
    ..gibsoni to elevated temperatures might result in increased expression of BgHsp70 and that the exposure of the intraerythrocytic parasites to decreased temperatures might not induce the overexpression of BgHsp70...
  3. ncbi Comparison and phylogenetic analysis of the heat shock protein 70 gene of Babesia parasites from dogs
    Masahiro Yamasaki
    Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Vet Parasitol 145:217-27. 2007
    ....
  4. ncbi Flow cytometry to evaluate the level of Babesia gibsoni parasitemia in vivo and in vitro by using the fluorescent nucleic acid stain SYTO16
    Masahiro Yamasaki
    Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Jpn J Vet Res 55:129-36. 2008
    ..The present results suggest that flow cytometric detection using SYTO16 is a rapid and reliable method for monitoring parasitemia both in vive and in vitro...
  5. doi Babesia gibsoni: detection in blood smears and formalin-fixed, paraffin-embedded tissues using deoxyribonucleic acid in situ hybridization analysis
    Masahiro Yamasaki
    Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Exp Parasitol 127:119-26. 2011
    ..This suggests that in situ hybridization can be utilized to investigate both the life cycle of B. gibsoni and the pathological condition of canine babesiosis...
  6. doi Effects and mechanisms of action of ionophorous antibiotics valinomycin and salinomycin-Na on Babesia gibsoni in vitro
    Masahiro Yamasaki
    Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Parasitol 95:1532-8. 2009
    ..gibsoni in LK erythrocytes were incubated in culture media containing high potassium concentrations. This showed that the intracellular cation concentration in the parasites was not modified in those media and would remain the same...
  7. doi Detection of anti-Babesia gibsoni heat shock protein 70 antibody and anti-canine heat shock protein 70 antibody in sera from Babesia gibsoni-infected dogs
    Masahiro Yamasaki
    Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Vet Parasitol 180:215-25. 2011
    ..These results indicated that BgHsp70 was a highly immunogenic protein in canine B. gibsoni infection, and that exoerythrocytic parasites might be targets of anti-BgHsp70 antibody...
  8. doi Effects and mechanisms of action of polyene macrolide antibiotic nystatin on Babesia gibsoni in vitro
    Masahiro Yamasaki
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Parasitol 97:1190-2. 2011
    ..In conclusion, nystatin destroyed B. gibsoni by ionophorous activity but did not affect either canine erythrocytes or leukocytes in vitro...
  9. ncbi Development and characterization of a strain of Babesia gibsoni resistant to diminazene aceturate in vitro
    Shiang Jyi Hwang
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Japan
    J Vet Med Sci 72:765-71. 2010
    ..These results indicated that the DA-resistant B. gibsoni strain could have resistance not only to DA, but also to other anti-babesial drugs. In conclusion, we successfully developed a DA-resistant B. gibsoni strain in vitro...
  10. pmc Qualitative and quantitative contrast enhanced ultrasonography of the pancreas using bolus injection and continuous infusion methods in normal dogs
    Sue Yee Lim
    Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido 060 0818, Japan
    J Vet Med Sci 75:1601-7. 2013
    ..05) at continuous infusion. Prolonged continuous imaging is afforded by continuous infusion of contrast agent. Peak intensity of the pancreas was slightly diminished in continuous infusion, but offered adequate imaging subjectively. ..
  11. ncbi Involvement of mitochondrial genes of Babesia gibsoni in resistance to diminazene aceturate
    Bandula Kumara Wickramasekara Rajapakshage
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Vet Med Sci 74:1139-48. 2012
    ..These results indicated that DA did not affect mtDNA directly in DA-resistant B. gibsoni. Thus, it is suggested that mtDNA should not be deeply involved in DA resistance in B. gibsoni...
  12. ncbi Reduced transcript levels of the heat shock protein 70 gene in diminazene aceturate-resistant Babesia gibsoni variants under low concentrations of diminazene aceturate
    Shiang Jyi Hwang
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Jpn J Vet Res 58:155-64. 2010
    ..We expect that further study of the function of BgHsp70 will elucidate the mechanism of drug resistance against DA in B. gibsoni...
  13. ncbi Analysis of energy generation and glycolysis pathway in diminazene aceturate-resistant Babesia gibsoni isolate in vitro
    Bandula Kumara Wickramasekara Rajapakshage
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Jpn J Vet Res 60:51-61. 2012
    ..gibsoni isolate. Further studies on the energy metabolism of B. gibsoni are necessary to clarify the mechanism of the high energy production in the DA-resistant B. gibsoni isolate...
  14. doi Activation of microbubbles by short-pulsed ultrasound enhances the cytotoxic effect of cis-diamminedichloroplatinum (II) in a canine thyroid adenocarcinoma cell line in vitro
    Noboru Sasaki
    Laboratory of Veterinary Internal Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Kita ku, Sapporo, Japan
    Ultrasound Med Biol 38:109-18. 2012
    ..Our results suggest that short exposure duration could be potentially sufficient to induce efficient drug delivery by ultrasound targeted microbubble destruction using short-pulsed diagnostic ultrasound...
  15. ncbi Contrast-enhanced ultrasonography for characterization of canine focal liver lesions
    Kensuke Nakamura
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9 Sapporo, Hokkaido 060 0818, Japan
    Vet Radiol Ultrasound 51:79-85. 2010
    ..In the portal phase, there were no characteristic findings. Contrast-enhanced ultrasonography with Sonazoid appears to improve the characterization of canine focal and multifocal hepatic lesions...
  16. ncbi Primary splenic torsion in a Boston terrier
    Hiroshi Ohta
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
    J Vet Med Sci 71:1533-5. 2009
    ..This is the first report of splenic torsion in Boston terriers, and the usefulness of ultrasonographic and CT findings of the splenic torsion was also confirmed...
  17. doi Expression of CD4+ T cell cytokine genes in the colorectal mucosa of inflammatory colorectal polyps in miniature dachshunds
    Hiroshi Ohta
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan Electronic address
    Vet Immunol Immunopathol 155:259-63. 2013
    ..There was no significant difference in IL-4 mRNA expression among the three groups. IL-17A is thought to play important roles in the pathogenesis of ICRPs. IL-10 up-regulation could oppose the proinflammatory function of IL-17A. ..
  18. doi Repeatability and reproducibility of measurements obtained via two-dimensional speckle tracking echocardiography of the left atrium and time-left atrial area curve analysis in healthy dogs
    Tatsuyuki Osuga
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060 0818, Japan
    Am J Vet Res 74:864-9. 2013
    ..To evaluate left atrial phasic function in healthy dogs by means of 2-D speckle tracking echocardiography with time-left atrial area curve analysis and to assess repeatability and reproducibility of obtained measurements...
  19. doi Expression of apical junction complex proteins in duodenal mucosa of dogs with inflammatory bowel disease
    Hiroshi Ohta
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060 0818, Japan
    Am J Vet Res 75:746-51. 2014
    ..To determine the expression of tight junction and adherens junction proteins in duodenal mucosa samples of dogs with inflammatory bowel disease (IBD)...
  20. doi Markedly increased expression of interleukin-8 in the colorectal mucosa of inflammatory colorectal polyps in miniature dachshunds
    Yu Tamura
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Vet Immunol Immunopathol 156:32-42. 2013
    ..IL-8-positive macrophages were significantly increased in large polyps compared to controls. These results suggest that IL-8 is produced mainly by macrophages and may induce neutrophil infiltration in the colorectal area of ICRP dogs...
  21. ncbi Quantitative contrast-enhanced ultrasonography of canine spleen
    Kensuke Nakamura
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Sapporo, Hokkaido 060 0818, Japan
    Vet Radiol Ultrasound 50:104-8. 2009
    ..The findings of this quantitative study should prove useful in the evaluation of diffuse or focal splenic and renal diseases in dogs...
  22. doi Expression and subcellular localization of apical junction proteins in canine duodenal and colonic mucosa
    Hiroshi Ohta
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060 0818, Japan
    Am J Vet Res 72:1046-51. 2011
    ..To examine the expression and distribution of tight junction (TJ) and adherens junction (AJ) proteins in canine duodenal and colonic mucosa...
  23. pmc Evaluation of selected cytokine gene expression in colonic mucosa from dogs with idiopathic lymphocytic-plasmacytic colitis
    Yu Tamura
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Vet Med Sci 76:1407-10. 2014
    ..Dogs with LPC failed to express a predominant cytokine profile in inflamed colonic mucosa as opposed to human IBD. ..
  24. pmc CD4⁺ T cell cytokine gene and protein expression in duodenal mucosa of dogs with inflammatory bowel disease
    Hiroshi Ohta
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Vet Med Sci 76:409-14. 2014
    ..There was no significant difference in IL-17A, IFN-γ and IL-10 protein expression levels between groups. Thus, there is no clear evidence for the involvement of distinct Th cytokine in the pathogenesis of canine IBD...
  25. pmc Contrast-enhanced ultrasonography of the hepatic vein in normal dogs
    Keitaro Morishita
    Veterinary Teaching Hospital, Graduate School of Veterinary Medicine, Hokkaido University
    J Vet Med Sci . 2016
    ..5 sec (9-17 sec), 9 sec (7-13 sec) and 84.1% (63.0-94.4%), respectively. The coefficients of variation of these parameters in the conscious and sedated groups were 7.6-29.7% and 11.8%-14.8%, respectively...
  26. doi Contrast-enhanced ultrasonographic findings in three dogs with pancreatic insulinoma
    Kensuke Nakamura
    Veterinary Teaching Hospital, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Vet Radiol Ultrasound 56:55-62. 2015
    ..Findings from the current study indicated that contrast-enhanced ultrasound may help to increase conspicuity of pancreatic insulinomas in dogs and that enhancement characteristics may be more variable in dogs than in humans. ..
  27. doi Case report: protein-losing enteropathy caused by Mesocestoides vogae (syn. M. corti) in a dog
    Yu Tamura
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Vet Parasitol 205:412-5. 2014
    ..DNA sequence analysis showed that the genes shared 100% identity with those of reported M. vogae (syn. M. corti). This is the first reported case of protein-losing enteropathy caused by M. vogae in a dog...
  28. doi Bilateral segmental aplasia with unilateral uterine horn torsion in a Pomeranian bitch
    Kensuke Nakamura
    Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Am Anim Hosp Assoc 48:327-30. 2012
    ..To the authors' knowledge, this is the first report of uterine horn torsion in conjunction with segmental aplasia of the uterine horn in a bitch...
  29. pmc Urinary exosome-derived microRNAs reflecting the changes of renal function and histopathology in dogs
    Osamu Ichii
    Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita ku, Sapporo 060 0818, Japan
    Sci Rep 7:40340. 2017
    ..In conclusion, microRNAs reflecting the changes in renal function and histopathology in dogs were identified in this study...
  30. doi Hypercalcemia in a Dog with Chronic Ingestion of Maxacalcitol Ointment
    Kensuke Nakamura
    From the Veterinary Teaching Hospital, Department of Veterinary Clinical Sciences K N, N T, K M and Laboratory of Veterinary Internal Medicine H O, M T, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan and the Laboratory of Veterinary Small Animal Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, Iwate, Japan M Y
    J Am Anim Hosp Assoc 52:256-8. 2016
    ..The dog has been generally free of clinical signs without any treatment for over 2 yr. ..
  31. doi Expression of apical junction complex proteins in colorectal mucosa of miniature dachshunds with inflammatory colorectal polyps
    Nozomu Yokoyama
    Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
    J Vet Med Sci . 2017
    ..These results indicated that no significant alteration was detected in several tight junction or adherence junction proteins expression in the colorectal epithelium of ICRPs...
  32. doi MicroRNA expression profiling of cat and dog kidneys
    Osamu Ichii
    Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan Electronic address
    Res Vet Sci 96:299-303. 2014
    ..Further, the target mRNAs of these miRNAs were identified. These data provide veterinary medicine critical information regarding renal miRNA expression. ..
  33. doi Local overexpression of interleukin-1 family, member 6 relates to the development of tubulointerstitial lesions
    Osamu Ichii
    Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan
    Lab Invest 90:459-75. 2010
    ..Ectopic overexpression of IL-1F6 in kidneys is associated with TILs and especially with cell infiltrations and changes in epithelial morphology. We propose that local overexpression of IL-1F6 is related to the development of TILs...
  34. ncbi Restricted localization of claudin-16 at the tight junction in the thick ascending limb of Henle's loop together with claudins 3, 4, and 10 in bovine nephrons
    Hiroshi Ohta
    Laboratory of Molecular Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Japan
    J Vet Med Sci 68:453-63. 2006
    ....
  35. ncbi Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys
    Hiroshi Ohta
    Laboratory of Molecular Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Vet Med Sci 68:149-55. 2006
    ....
  36. ncbi The effects of heat on the biological activity of recombinant human bone morphogenetic protein-2
    Hiroshi Ohta
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto, 390 8621, Japan
    J Bone Miner Metab 23:420-5. 2005
    ..rhBMP-2 was rendered inactive when exposed to temperatures at or in excess of 120 degrees C...
  37. ncbi Genetic diagnosis of band 3 deficiency and sexing in bovine preimplantation embryos
    Soichi Kageyama
    Hokkaido Animal Research Center, Japan
    J Vet Med Sci 68:319-23. 2006
    ..Yamagata). These results demonstrate that our procedure is reliable and applicable to produce animals free from or homozygous for the mutant allele by breeding carrier animals...
  38. ncbi Homeostatic regulation of germinal stem cell proliferation by the GDNF/FSH pathway
    Yuko Tadokoro
    Department of Science for Laboratory Animal Experimentation, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3 1, Suita 565 0871, Japan
    Mech Dev 113:29-39. 2002
    ..These results suggest that in mammalian testes, GSC proliferation and population size are regulated homeostatically by the GDNF/FSH pathway...
  39. ncbi Generation of progeny via ICSI following enrichment of elongated spermatids from mouse testis by flow-cytometric cell sorting
    Hiroshi Ohta
    Laboratory for Genomic Reprogramming, Center for Developmental Biology, RIKEN, Chuo Ku, Kobe 650 0047, Japan
    Hum Reprod 22:1612-6. 2007
    ..Enrichment of elongated spermatids from the testis prior to ICSI may solve this problem...
  40. ncbi Functional analysis of the p53 gene in apoptosis induced by heat stress or loss of stem cell factor signaling in mouse male germ cells
    Hiroshi Ohta
    Department of Science for Laboratory Animal Experimentation, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3 1, Suita, Osaka 565 0871, Japan
    Biol Reprod 68:2249-54. 2003
    ..e., although the early stage of differentiation of spermatogonia and the meiotic prophase is dependent on p53-mediated apoptosis, the later stage of spermatids is not)...
  41. ncbi Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1
    Umashankar Singh
    Department of Development and Genetics, Evolutionary Biology Center, Uppsala University, Sweden
    Dev Dyn 234:1034-45. 2005
    ..This strongly suggested that altered expression of Car2 and Ncam1 is a downstream event in placental hyperplasia...
  42. pmc cAMP-responsive element in TATA-less core promoter is essential for haploid-specific gene expression in mouse testis
    Pranee Somboonthum
    Department of Science for Laboratory Animal Experimentation, Research Institute for Microbial Diseases, Osaka University Suita, Osaka 565 0871, Japan
    Nucleic Acids Res 33:3401-11. 2005
    ..These results indicate the presence of alternative transcriptional initiation machinery for cell-type-specific gene expression in testicular germ cells...
  43. pmc Transplantation of spermatogonial stem cells isolated from leukemic mice restores fertility without inducing leukemia
    Kazutoshi Fujita
    Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan Laboratory for Genomic Reprogramming, Center for Developmental Biology, Institute of Physical and Chemical Research RIKEN, Kobe, Japan
    J Clin Invest 115:1855-61. 2005
    ....
  44. ncbi Differentiation potential of parthenogenetic embryonic stem cells is improved by nuclear transfer
    Takafusa Hikichi
    Laboratory for Genomic Reprogramming, Center for Developmental Biology, RIKEN Kobe, Kobe, Japan
    Stem Cells 25:46-53. 2007
    ..Thus, NT could be used to improve the potential of pES cells and may enhance that of otherwise poor-quality ES cells. It also offers a new tool for studying epigenetics...
  45. ncbi Rosbin: a novel homeobox-like protein gene expressed exclusively in round spermatids
    Tohru Takahashi
    Department of Science for Laboratory Animal Experimentation, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Biol Reprod 70:1485-92. 2004
    ..ROSBIN is associated with and is most likely phosphorylated by protein kinase A. We suggest that it plays an important role in transcriptional regulation in haploid germ cells...