Toshio Ohta

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. ncbi request reprint Functional relation between caffeine- and muscarine-sensitive Ca2+ stores and no Ca2+ releasing action of cyclic adenosine diphosphate-ribose in guinea-pig adrenal chromaffin cells
    Toshio Ohta
    Laboratory of Pharmacology, Department of Biomedical Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Neurosci Lett 326:167-70. 2002
  2. doi request reprint Novel gating and sensitizing mechanism of capsaicin receptor (TRPV1): tonic inhibitory regulation of extracellular sodium through the external protonation sites on TRPV1
    Toshio Ohta
    Laboratory of Pharmacology, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Biol Chem 283:9377-87. 2008
  3. ncbi request reprint Novel agonistic action of mustard oil on recombinant and endogenous porcine transient receptor potential V1 (pTRPV1) channels
    Toshio Ohta
    Laboratory of Pharmacology, Department of Biochemical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Biochem Pharmacol 73:1646-56. 2007
  4. pmc Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5-HT receptors in rat primary sensory neurons
    Toshio Ohta
    Laboratory of Pharmacology, Department of Biochemical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Physiol 576:809-22. 2006
  5. ncbi request reprint Molecular cloning, functional characterization of the porcine transient receptor potential V1 (pTRPV1) and pharmacological comparison with endogenous pTRPV1
    Toshio Ohta
    Laboratory of Pharmacology, Department of Biochemical Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Biochem Pharmacol 71:173-87. 2005
  6. ncbi request reprint P2X2 receptors are essential for [Ca2+]i increases in response to ATP in cultured rat myenteric neurons
    Toshio Ohta
    Laboratory of Pharmacology, Dept of Biomedical Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Am J Physiol Gastrointest Liver Physiol 289:G935-48. 2005
  7. ncbi request reprint Evidence for paracrine modulation of voltage-dependent calcium channels by amperometric analysis in cultured porcine adrenal chromaffin cells
    Toshio Ohta
    Laboratory of Pharmacology, Department of Biomedical Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 0600818, Japan
    Brain Res 1030:183-92. 2004
  8. doi request reprint Involvement of transient receptor potential vanilloid subtype 1 in analgesic action of methylsalicylate
    Toshio Ohta
    Department of Biomedical Sciences, Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Mol Pharmacol 75:307-17. 2009
  9. ncbi request reprint Ca(2+)-dependent K(+) current and exocytosis in responses to caffeine and muscarine in voltage-clamped guinea-pig adrenal chromaffin cells
    T Ohta
    Laboratory of Pharmacology, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Neurochem 78:1243-55. 2001
  10. ncbi request reprint Effects of inhibitors for tyrosine kinase and non-selective cation channel on capacitative Ca(2+) entry in rat ileal smooth muscle
    T Ohta
    Laboratory of Pharmacology Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, North 18, West 9, Sapporo, Japan
    Eur J Pharmacol 387:211-20. 2000

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Functional relation between caffeine- and muscarine-sensitive Ca2+ stores and no Ca2+ releasing action of cyclic adenosine diphosphate-ribose in guinea-pig adrenal chromaffin cells
    Toshio Ohta
    Laboratory of Pharmacology, Department of Biomedical Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Neurosci Lett 326:167-70. 2002
    ....
  2. doi request reprint Novel gating and sensitizing mechanism of capsaicin receptor (TRPV1): tonic inhibitory regulation of extracellular sodium through the external protonation sites on TRPV1
    Toshio Ohta
    Laboratory of Pharmacology, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Biol Chem 283:9377-87. 2008
    ....
  3. ncbi request reprint Novel agonistic action of mustard oil on recombinant and endogenous porcine transient receptor potential V1 (pTRPV1) channels
    Toshio Ohta
    Laboratory of Pharmacology, Department of Biochemical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Biochem Pharmacol 73:1646-56. 2007
    ..These results provide an insight into the TRPV1-mediated effects of MO on inflammation and hyperalgesia...
  4. pmc Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5-HT receptors in rat primary sensory neurons
    Toshio Ohta
    Laboratory of Pharmacology, Department of Biochemical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Physiol 576:809-22. 2006
    ..Under inflammatory conditions, the increases of the biosynthesis of these 5-HT receptors may lead to further potentiation of TRPV1 functions, resulting in the generation of inflammatory hyperalgesia in vivo...
  5. ncbi request reprint Molecular cloning, functional characterization of the porcine transient receptor potential V1 (pTRPV1) and pharmacological comparison with endogenous pTRPV1
    Toshio Ohta
    Laboratory of Pharmacology, Department of Biochemical Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Biochem Pharmacol 71:173-87. 2005
    ..Similar pharmacological profiles were observed in cultured porcine dorsal root ganglion neurons. We discuss putative amino acid residues related to pharmacological differences among mammalian TRPV1 homologues...
  6. ncbi request reprint P2X2 receptors are essential for [Ca2+]i increases in response to ATP in cultured rat myenteric neurons
    Toshio Ohta
    Laboratory of Pharmacology, Dept of Biomedical Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Am J Physiol Gastrointest Liver Physiol 289:G935-48. 2005
    ..A small part of the ATP-induced [Ca2+]i increase may be also mediated via a P2Y receptor-related mechanism...
  7. ncbi request reprint Evidence for paracrine modulation of voltage-dependent calcium channels by amperometric analysis in cultured porcine adrenal chromaffin cells
    Toshio Ohta
    Laboratory of Pharmacology, Department of Biomedical Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 0600818, Japan
    Brain Res 1030:183-92. 2004
    ....
  8. doi request reprint Involvement of transient receptor potential vanilloid subtype 1 in analgesic action of methylsalicylate
    Toshio Ohta
    Department of Biomedical Sciences, Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Mol Pharmacol 75:307-17. 2009
    ..The present data indicate that MS has both stimulatory and inhibitory actions on TRPV1 channels and suggest that the latter action may partly underlie the analgesic effects of MS independent of inhibition of cyclooxygenases in vivo...
  9. ncbi request reprint Ca(2+)-dependent K(+) current and exocytosis in responses to caffeine and muscarine in voltage-clamped guinea-pig adrenal chromaffin cells
    T Ohta
    Laboratory of Pharmacology, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Neurochem 78:1243-55. 2001
    ..There seems to be a spatial difference between [Ca(2+)](i) increased by Ca(2+) release from caffeine-sensitive stores and that released from muscarine (inositol 1,4,5-trisphosphate)-sensitive ones...
  10. ncbi request reprint Effects of inhibitors for tyrosine kinase and non-selective cation channel on capacitative Ca(2+) entry in rat ileal smooth muscle
    T Ohta
    Laboratory of Pharmacology Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, North 18, West 9, Sapporo, Japan
    Eur J Pharmacol 387:211-20. 2000
    ..SK&F 96365, but not tetrandrine, seems to selectively inhibit the contractile responses to capacitative Ca(2+) entry in rat ileal smooth muscles...
  11. ncbi request reprint Characteristics of cytosolic Ca2+ elevation induced by muscarinic receptor activation in single adrenal chromaffin cells of the guinea pig
    T Ohta
    Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Cell Calcium 20:303-14. 1996
    ..Voltage-dependent Ca(2+)-channels may function as one of the Ca2+ entry pathways activated by muscarinic receptor in guinea pig adrenal chromaffin cells...
  12. ncbi request reprint Redox regulation of PI3K/Akt and p53 in bovine aortic endothelial cells exposed to hydrogen peroxide
    Koichi Niwa
    Laboratory of Biofluid Dynamics, Research Institute for Electronic Science, Hokkaido University, Sapporo 060 0812, Japan
    Antioxid Redox Signal 5:713-22. 2003
    ..These results suggest that H(2)O(2) induces Ca(2+)-dependent apoptosis and Ca(2+)-independent survival signals such as redox-regulated activation of PI3K/Akt, which is partly mediated by the activation of growth factor receptors in BAEC...
  13. ncbi request reprint Inhibitory effects of opioids on voltage-dependent Ca(2+) channels and catecholamine secretion in cultured porcine adrenal chromaffin cells
    Go Kitamura
    Laboratory of Pharmacology, Department of Biomedical Science, Hokkaido University, Sapporo 0600818, Japan
    Brain Res 942:11-22. 2002
    ..These results suggest that porcine adrenal chromaffin cells possess mu-, delta- and kappa-opioid receptors and activation of opioid receptors mainly inhibits N-type VDCCs via pertussis toxin-sensitive G-proteins...
  14. doi request reprint Voltage-gated channel properties of epithelial cells in porcine vomeronasal organ
    Tetsuya Ishida
    Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Neurosci Lett 441:277-81. 2008
    ..It is also suggested that porcine VSNs detecting pheromones generate action potentials through these channels...
  15. pmc Involvement of adenosine in depression of synaptic transmission during hypercapnia in isolated spinal cord of neonatal rats
    Ken Ichi Otsuguro
    Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Physiol 574:835-47. 2006
    ..The inhibition of adenosine kinase activity is suggested to cause the accumulation of extracellular adenosine during hypercapnia...
  16. doi request reprint Lipopolysaccharides enhance the action of bradykinin in enteric neurons via secretion of interleukin-1beta from enteric glial cells
    Matsuka Murakami
    Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Neurosci Res 87:2095-104. 2009
    ..The alteration of the regulatory effect of glial cells may be the cause of the changes in neural function in the enteric nervous system in inflammatory bowel disease...
  17. pmc Inhibitory effects of caffeine on secretagogue-induced catecholamine secretion from adrenal chromaffin cells of the guinea-pig
    Y Nakazato
    Department of Pharmacology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Br J Pharmacol 111:935-41. 1994
    ....
  18. doi request reprint Endogenously released 5-HT inhibits A and C fiber-evoked synaptic transmission in the rat spinal cord by the facilitation of GABA/glycine and 5-HT release via 5-HT(2A) and 5-HT(3) receptors
    Takeyuki Iwasaki
    Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Eur J Pharmacol 702:149-57. 2013
    ..5-HT3 receptors may be involved in the facilitation of 5-HT release via a positive feedback process...
  19. ncbi request reprint Two distinct inhibitory actions of steroids on cholinoceptor-mediated secretion of catecholamine from guinea-pig adrenal medullary cells
    Kazuki Yonekubo
    Laboratory of Pharmacology, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Neurosci Lett 337:89-92. 2003
    ....
  20. ncbi request reprint Ca2+ store-independent augmentation of [Ca2+]i responses to G-protein coupled receptor activation in recombinantly TRPC5-expressed rat pheochromocytoma (PC12) cells
    Toshio Ohta
    Laboratory of Pharmacology, Department of Biomedical Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Neurosci Lett 358:161-4. 2004
    ..These results suggest that TRPC5 channels expressed in PC12 cells function as ROCs activated by G-protein/phospholipase C coupled receptors, but not as SOCs...
  21. ncbi request reprint Involvement of mitochondrial Na+-Ca2+ exchange in intracellular Ca2+ increase induced by ATP in PC12 cells
    Kouji Maruyama
    Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Sapporo 060 0818, Japan
    Brain Res 1013:40-50. 2004
    ....
  22. ncbi request reprint Characteristics of ATP-induced catecholamine secretion from adrenal chromaffin cells of the guinea-pig
    T Asano
    Laboratory of Pharmacology, Hokkaido University, Sapporo, Japan
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 112:101-8. 1995
    ..This effect may be accomplished by increasing the entry of extracellular Ca2+, but not by mobilizing intracellular Ca2+ stores in adrenal chromaffin cells of the guinea-pig...
  23. ncbi request reprint Lipid raft disruption prevents apoptosis induced by 2-chloro-2'-deoxyadenosine (Cladribine) in leukemia cell lines
    Eriko Takahashi
    Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 jo Nishi 9 chome, Sapporo, Japan
    Leuk Res 30:1555-61. 2006
    ..On the other hand, they had no effects on the cellular uptake of 2CdA. These results indicated that lipid rafts partly contributed to 2CdA-induced apoptosis by regulating Ca(2+) influx via the plasma membrane...
  24. ncbi request reprint Involvement of prostaglandin E(2) derived from enteric glial cells in the action of bradykinin in cultured rat myenteric neurons
    M Murakami
    Laboratory of Pharmacology, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, N18W9, Sapporo 060 0818, Japan
    Neuroscience 145:642-53. 2007
    ..It is suggested that a neuron-glial interaction plays an important role in the effect of BK in the rat myenteric plexus...
  25. ncbi request reprint Modulation of calcium current by ATP in guinea-pig adrenal chromaffin cells
    K Otsuguro
    Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060, Japan
    Pflugers Arch 431:402-7. 1996
    ..In addition, ATP seems to modulate Ca2+ channels via the pathway related to G-protein. Adenine nucleotides and adenosine may play a role in controlling secretory activity in guinea-pig adrenal chromaffin cells...
  26. ncbi request reprint Effects of opioid receptor and alpha2-adrenoceptor agonists on slow ventral root potentials and on capsaicin and formalin tests in neonatal rats
    Ken Ichi Otsuguro
    Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Sapporo 060 0818, Japan
    Brain Res Dev Brain Res 158:50-8. 2005
    ....
  27. ncbi request reprint Involvement of voltage-dependent Ca2+ channels in cytosolic Ca2+ increase induced by deprivation of extracellular cations in adrenal chromaffin cells of the guinea pig
    T Ohta
    Laboratory of Pharmacology, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 0600818
    Brain Res 814:99-111. 1998
    ....
  28. ncbi request reprint Release of dopamine and ATP from PC12 cells treated with dexamethasone, reserpine and bafilomycin A1
    Y Kasai
    Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Vet Med Sci 63:367-72. 2001
    ..Similar to dopamine uptake into secretory vesicles, the H+-gradient across the vesicular membrane developed by vacuolar ATPase may play an important role in the vesicular uptake of ATP...
  29. pmc Roles of purines in synaptic modulation evoked by hypercapnia in isolated spinal cord of neonatal rat in vitro
    K Otsuguro
    Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Br J Pharmacol 156:1167-77. 2009
    ..In this study, we examined the effects of various drugs affecting purine turnover on the responses to hypercapnia in the spinal cord...
  30. pmc Characteristics of 5-HT-containing chemoreceptor cells of the chicken aortic body
    S Ito
    Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Physiol 515:49-59. 1999
    ..5. These results suggest that epithelioid cells containing 5-HT act as chemoreceptor cells in the chicken aortic body, having voltage-dependent Na+, K+, and L- and N-type Ca2+ channels, and oxygen-sensitive K+ channels...
  31. ncbi request reprint Zinc modulates primary afferent fiber-evoked responses of ventral roots in neonatal rat spinal cord in vitro
    K Otsuguro
    Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Neuroscience 138:281-91. 2006
    ..The release of glutamate from interneurons may play an important role in Zn(2+)-induced potentiation of slow ventral root potential in the spinal cord of the neonatal rat...
  32. ncbi request reprint Estradiol-17beta stimulates the renewal of spermatogonial stem cells in males
    T Miura
    Faculty of Fisheries, Hokkaido University, Hakodate, 041 8611, Japan
    Biochem Biophys Res Commun 264:230-4. 1999
    ..These results clearly show that estrogen is an indispensable "male hormone" in the early spermatogenetic cycle...
  33. ncbi request reprint Calcium channel current facilitation in porcine adrenal chromaffin cells
    N Kitamura
    Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University, North 18th West 9th, Sapporo 060, Japan
    Pflugers Arch 435:781-8. 1998
    ..These results suggest that, in porcine chromaffin cells, there is a omega-conotoxin GVIA-sensitive N-type Ca2+ channel that is under the inhibitory control of a G protein, which can be relieved by a conditioning pulse...
  34. ncbi request reprint Vasopressin-induced contraction in the rat basilar artery in vitro
    E Katori
    Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University, 060-0818, Sapporo, Japan
    Eur J Pharmacol 416:113-21. 2001
    ....
  35. ncbi request reprint Measurement of intracellular Na+ concentration by a Na+-sensitive fluorescent dye, sodium-binding benzofuran isophthalate, in porcine adrenal chromaffin cells--usage of palytoxin as a Na+ ionophore
    S Ito
    Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Neurosci Methods 75:21-7. 1997
    ..Palytoxin has an advantage of calibrating ([Na+]in) in a shorter time than dose gramicidin because of its powerful ionophoretic activity...
  36. pmc Heterogeneity of neuronal nicotinic acetylcholine receptors in 5-HT-containing chemoreceptor cells of the chicken aorta
    S Ito
    Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Br J Pharmacol 132:1934-40. 2001
    ..It is suggested that neuronal nicotinic ACh receptors, sensitive and insensitive to alpha - BTX, are present on the chemoreceptor cells of the chicken aorta, the activation of which causes the release of 5-HT...
  37. ncbi request reprint p38 MAPK and Ca2+ contribute to hydrogen peroxide-induced increase of permeability in vascular endothelial cells but ERK does not
    K Niwa
    Laboratory of Biofluid Dynamics, Research Institute for Electronic Science, Hokkaido University, West 6, North 12, Kita ku, Sapporo, 060 0812, Japan
    Free Radic Res 35:519-27. 2001
    ..These results indicate that the activation of p38 MAPK and the increase of [Ca2+]i are essential for the H2O2-induced increase of endothelial permeability and that ERK is not...
  38. ncbi request reprint Changes in intracellular Na+ concentration evoked by nicotinic receptor activation in the guinea-pig adrenal chromaffin cells
    S Ito
    Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Neurosci Lett 238:111-4. 1997
    ....
  39. ncbi request reprint Amino acid sequence of squid troponin C
    T Ojima
    Laboratory of Biochemistry and Biotechnology, Graduate School of Fisheries Science, Hokkaido University, Hakodate, 041 8611, Hokkaido, Japan
    Comp Biochem Physiol B Biochem Mol Biol 129:787-96. 2001
    ..In the sequence of the central D/E-helix region of squid and scallop TnCs, a deletion of three amino acids was required to maximize the homology with the other TnCs...
  40. pmc Endogenous 5-HT outflow from chicken aorta by 5-HT uptake inhibitors and amphetamine derivatives
    Dugar Delgermurun
    Laboratory of Pharmacology, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    J Vet Med Sci 78:71-6. 2016
    ..These results suggest that the 5-HT uptake system of 5-HT-containing chemoreceptor cells in the chicken thoracic aorta has characteristics similar to those of 5-HT-containing neurons in the mammalian central nervous system (CNS). ..
  41. doi request reprint Histamine potentiates acid-induced responses mediating transient receptor potential V1 in mouse primary sensory neurons
    Y Kajihara
    Laboratory of Pharmacology, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Neuroscience 166:292-304. 2010
    ..The present results suggest that histamine sensitizes acid-induced responses through TRPV1 activation via H1R coupled with PLC/PKC pathways, the action of which may be involved in the generation of inflammatory pain...
  42. pmc Evolution of Heat Sensors Drove Shifts in Thermosensation between Xenopus Species Adapted to Different Thermal Niches
    Shigeru Saito
    From the Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Aichi 444 8787, Japan, the Department of Physiological Sciences, Sokendai The Graduate University for Advanced Studies, Okazaki, Aichi 444 8787, Japan, and
    J Biol Chem 291:11446-59. 2016
    ..These combined subtle amino acid substitutions in peripheral thermal sensors potentially serve as a driving force for the evolution of thermal and chemical sensation. ..
  43. ncbi request reprint Roles of protein kinase C delta in the accumulation of P53 and the induction of apoptosis in H2O2-treated bovine endothelial cells
    Koichi Niwa
    Laboratory of Biofluid Dynamics, Research Institute for Electronic Science, Hokkaido University, Sapporo 060 0812, Japan
    Free Radic Res 36:1147-53. 2002
    ..These results suggest that PKC delta contributes to the accumulation of p53 and that Ca2+ plays a role in downstream signals of p53 leading to apoptosis in H2O2-treated BAEC...
  44. ncbi request reprint Relaxant mechanisms of parathyroid hormone in rat mesenteric artery
    Toshio Ohta
    Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Cardiovasc Pharmacol 40:554-63. 2002
    ....
  45. ncbi request reprint Inhibitory effects of cortical steroids and adrenocorticotropic hormone on catecholamine secretion in guinea-pig perfused adrenal glands
    K Yonekubo
    Laboratory of Pharmacology, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Auton Autacoid Pharmacol 22:93-101. 2002
    ..6 These results suggest that steroids affect nicotinic and muscarinic ACh receptor-mediated responses through distinct mechanisms, and that cortisol released from the adrenal cortex inhibits CA secretion from the adrenal medulla...
  46. ncbi request reprint Interleukin-1beta enhances the action of bradykinin in rat myenteric neurons through up-regulation of glial B1 receptor expression
    M Murakami
    Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, N18W9, Sapporo 060 0818, Japan
    Neuroscience 151:222-31. 2008
    ..The alteration of phenotypes of glial cells may be the cause of the changes in neural function in the enteric nervous system in IBD...
  47. ncbi request reprint Gastric vasodilator and motor responses to splanchnic stimulation and tachykinins in the dog
    S Ito
    Department of Pharmacology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Gen Pharmacol 24:291-8. 1993
    ..6. It is concluded that splanchnic nerve stimulation produced cholinergic and SPergic vasodilation after ganglionic blockade in the dog stomach...
  48. ncbi request reprint Acellular and cellular hemoglobin solutions as vasoconstrictive factor
    K Nakai
    Hokkaido Red Cross Blood Center, Sapporo, Japan
    Artif Cells Blood Substit Immobil Biotechnol 22:559-64. 1994
    ..These findings indicate that acellular Hb solutions are more potent inhibitors than cellular Hb solutions by a factor of about 100, and that the encapsulation of Hb is a preferable method to mimic the red cell...
  49. pmc Gastric vasodilatation and vasoactive intestinal peptide output in response to vagal stimulation in the dog
    S Ito
    Department of Pharmacology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    J Physiol 404:669-82. 1988
    ..6. It is concluded that release of VIP in response to stimulation of the vagal innervation to the stomach in the dog is primarily vasodilating in action...
  50. ncbi request reprint Purification and properties of a new Brevibacterium sterolicum cholesterol oxidase produced by E. coli MM294/pnH10
    Kinya Fujishiro
    Research and Development Section, Kyowa Medex Co, Ltd, Sumitomo Irifune Building, 2 1 1 Irifune, Chuo Ku, Tokyo 104 0042, Japan
    FEMS Microbiol Lett 215:243-8. 2002
    ..sterolicum nov. sp. ATCC21387. The new enzyme, designated cholesterol oxidase II, was distinguished by its high affinity toward cholesterol (K(m)=30 microM)...