Hiroyuki Oshiumi

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. doi request reprint DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo 060 8638, Japan Electronic address
    Cell Rep 11:1193-207. 2015
  2. pmc A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita ku, Sapporo, Japan
    PLoS Pathog 9:e1003533. 2013
  3. ncbi request reprint [Innate immune responses against viral infection and its suppression by viral proteins]
    Hiroyuki Oshiumi
    Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Yakugaku Zasshi 133:323-8. 2013
  4. ncbi request reprint [Innate immune response to RNA virus infection]
    Hiroyuki Oshiumi
    Graduate School of Medicine, Hokkaido University
    Uirusu 61:153-61. 2011
  5. doi request reprint Ubiquitin-mediated modulation of the cytoplasmic viral RNA sensor RIG-I
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku Sapporo 060 8638, Japan
    J Biochem 151:5-11. 2012
  6. doi request reprint The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku Sapporo 060 8638, Japan
    Cell Host Microbe 8:496-509. 2010
  7. doi request reprint Oligomerized TICAM-1 (TRIF) in the cytoplasm recruits nuclear BS69 to enhance NF-kappaB activation and type I IFN induction
    Hiromi Takaki
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita ku, Sapporo, Japan
    Eur J Immunol 39:3469-76. 2009
  8. pmc A molecular mechanism for Toll-IL-1 receptor domain-containing adaptor molecule-1-mediated IRF-3 activation
    Megumi Tatematsu
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Biol Chem 285:20128-36. 2010
  9. doi request reprint The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Immunol 187:5320-7. 2011
  10. pmc DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling
    Moeko Miyashita
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Mol Cell Biol 31:3802-19. 2011

Collaborators

Detail Information

Publications52

  1. doi request reprint DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo 060 8638, Japan Electronic address
    Cell Rep 11:1193-207. 2015
    ..Our results define DDX60 as a sentinel for cytoplasmic antiviral response, which is counteracted by virus-mediated EGF receptor activation. ..
  2. pmc A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita ku, Sapporo, Japan
    PLoS Pathog 9:e1003533. 2013
    ..In conclusion, our results establish that Riplet-mediated K63-linked polyubiquitination released RIG-I RD autorepression, which allowed the access of positive factors to the RIG-I protein...
  3. ncbi request reprint [Innate immune responses against viral infection and its suppression by viral proteins]
    Hiroyuki Oshiumi
    Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Yakugaku Zasshi 133:323-8. 2013
    ....
  4. ncbi request reprint [Innate immune response to RNA virus infection]
    Hiroyuki Oshiumi
    Graduate School of Medicine, Hokkaido University
    Uirusu 61:153-61. 2011
    ..In addition, HCV NS3-4A protein cleaves IPS-1 to inhibit the signal. Molecular mechanism of how viral RNA is recognized by innate immune system will make great progress on our understanding of how virus escapes from host immune system...
  5. doi request reprint Ubiquitin-mediated modulation of the cytoplasmic viral RNA sensor RIG-I
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku Sapporo 060 8638, Japan
    J Biochem 151:5-11. 2012
    ..The splice variant of RIG-I encodes a protein that lacks the first CARD of RIG-I, and the variant RIG-I protein is not ubiquitinated by TRIM25. Therefore, ubiquitin is the key regulator of the cytoplasmic viral RNA sensor RIG-I...
  6. doi request reprint The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku Sapporo 060 8638, Japan
    Cell Host Microbe 8:496-509. 2010
    ..These data indicate that Riplet is essential for regulating RIG-I-mediated innate immune response against RNA virus infection in vivo...
  7. doi request reprint Oligomerized TICAM-1 (TRIF) in the cytoplasm recruits nuclear BS69 to enhance NF-kappaB activation and type I IFN induction
    Hiromi Takaki
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita ku, Sapporo, Japan
    Eur J Immunol 39:3469-76. 2009
    ....
  8. pmc A molecular mechanism for Toll-IL-1 receptor domain-containing adaptor molecule-1-mediated IRF-3 activation
    Megumi Tatematsu
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Biol Chem 285:20128-36. 2010
    ..Upon stimulation of TLR3/4, TICAM-1 oligomerizes through the TIR domain and the C-terminal region, which may break the intramolecular association and induce a conformational change that allows TBK1 access to TICAM-1...
  9. doi request reprint The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Immunol 187:5320-7. 2011
    ..These data indicate that the TLR3/TICAM-1 pathway functions are dominant in host protection and innate immune responses against PV infection...
  10. pmc DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling
    Moeko Miyashita
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Mol Cell Biol 31:3802-19. 2011
    ..Expression of DDX60 promotes the binding of RIG-I to double-stranded RNA. Taken together, our analyses indicate that DDX60 is a novel antiviral helicase promoting RIG-I-like receptor-mediated signaling...
  11. doi request reprint MAVS-dependent IRF3/7 bypass of interferon β-induction restricts the response to measles infection in CD150Tg mouse bone marrow-derived dendritic cells
    Hiromi Takaki
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita ku, Sapporo 060 8638, Japan
    Mol Immunol 57:100-10. 2014
    ..We also showed the importance of IL-10-producing CD4(+) T cells induced by MV-infected BMDCs in vitro, which may account for immune modulation due to the functional aberration of DCs...
  12. doi request reprint Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway
    Miwa Sasai
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita ku, Sapporo, Japan
    Mol Immunol 47:1283-91. 2010
    ..TRAF2/6 may participate in TICAM-1-mediated IFN-beta induction besides TRAF3...
  13. doi request reprint DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Eur J Immunol 40:940-8. 2010
    ..Forced expression of DDX3 augmented virus-mediated IFN-beta induction and host cell protection against virus infection. Hence, DDX3 is an antiviral IPS-1 enhancer...
  14. doi request reprint IPS-1 is essential for type III IFN production by hepatocytes and dendritic cells in response to hepatitis C virus infection
    Masaaki Okamoto
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Immunol 192:2770-7. 2014
    ..Our study indicated that IPS-1-dependent pathway plays a crucial role in type III IFN production by CD8(+) DCs and hepatocytes in response to HCV, leading to cytoplasmic antiviral protein expressions. ..
  15. doi request reprint The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model
    Hiromi Takaki
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita ku, Sapporo 060 8638, Japan
    J Immunol 191:4740-7. 2013
    ..Induction of type I IFN in these DC subsets was abolished by the MyD88 inhibitory peptide. Thus, production of type I IFN occurs via the MyD88-dependent and MAVS-independent signaling pathway during MV infection. ..
  16. pmc Development of mouse hepatocyte lines permissive for hepatitis C virus (HCV)
    Hussein Hassan Aly
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
    PLoS ONE 6:e21284. 2011
    ..This is the first report on the entry and replication of HCV infectious particles in mouse hepatocytes. These mouse hepatocyte lines will facilitate establishing a mouse HCV infection model with multifarious applications...
  17. pmc Homo-oligomerization is essential for Toll/interleukin-1 receptor domain-containing adaptor molecule-1-mediated NF-kappaB and interferon regulatory factor-3 activation
    Kenji Funami
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Biol Chem 283:18283-91. 2008
    ..Thus, full activation and formation of TICAM-1 signalosomes requires oligomerization induced at two different sites and RIP1 binding...
  18. pmc Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    PLoS ONE 5:e14258. 2010
    ..The results enable us to conclude that HCV infection is promoted by modulating the dual function of DDX3...
  19. doi request reprint Multi-step regulation of interferon induction by hepatitis C virus
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita, Sapporo 060 8638, Japan
    Arch Immunol Ther Exp (Warsz) 61:127-38. 2013
    ..We discuss the mechanisms that abolish type I and type III IFN production in HCV-infected cells, which may contribute to understanding the mechanism of virus persistence and resistance to the IFN therapy...
  20. doi request reprint Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Biol Chem 284:807-17. 2009
    ..We infer that a variety of RIG-I-ubiquitinating molecular complexes sustain RIG-I activation to modulate RNA virus replication in the cytoplasm...
  21. doi request reprint INAM plays a critical role in IFN-γ production by NK cells interacting with polyinosinic-polycytidylic acid-stimulated accessory cells
    Jun Kasamatsu
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo 060 8638, Japan
    J Immunol 193:5199-207. 2014
    ..INAM could therefore be a novel target molecule for cancer immunotherapy against IFN-γ-suppressible metastasis. ..
  22. doi request reprint Strain-to-strain difference of V protein of measles virus affects MDA5-mediated IFN-β-inducing potential
    Hiromi Takaki
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita ku, Sapporo 060 8638, Japan
    Mol Immunol 48:497-504. 2011
    ..Ultimately, measles vaccine strains have two modes of IFN-β-induction for their attenuation: V protein mutation and production of defective interference (DI) RNA...
  23. pmc Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors
    Hiroaki Shime
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita ku, Sapporo 060 8638, Japan
    Proc Natl Acad Sci U S A 109:2066-71. 2012
    ....
  24. pmc Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation
    Takashi Ebihara
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo 060 8638, Japan
    J Exp Med 207:2675-87. 2010
    ..We identify a new pathway for mDC-NK contact-mediated NK activation that is governed by a TLR signal-derived membrane molecule...
  25. pmc Interferon-stimulated gene of 20 kDa protein (ISG20) degrades RNA of Hepatitis B virus to impede the replication of HBV in vitro and in vivo
    Chean Ring Leong
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo, 060 8638 Japan
    Oncotarget 7:68179-68193. 2016
    ..Taken together, ISG20 acts as an innate anti-HBV effector that selectively degrades HBV RNA and blocks replication of infectious HBV particles. ISG20 would be a critical effector for ameliorating chronic HBV infection in the IFN therapy...
  26. pmc Double-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells
    Jun Kasamatsu
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo, 060 8638, Japan
    BMC Immunol 17:9. 2016
    ..Trem genes belong to a rapidly expanding family of receptors that include activating and inhibitory paired-isoforms...
  27. doi request reprint A MAVS/TICAM-1-independent interferon-inducing pathway contributes to regulation of hepatitis B virus replication in the mouse hydrodynamic injection model
    Chean Ring Leong
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    J Innate Immun 7:47-58. 2015
    ..Taken together, we show that the RNA-sensing pathways do not participate in the regulation of HBV replication in a mouse model; meanwhile MyD88 is implicated in the HBV clearance...
  28. doi request reprint Phylogenetic and expression analysis of lamprey toll-like receptors
    Jun Kasamatsu
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita ku, Sapporo 060 8638, Japan
    Dev Comp Immunol 34:855-65. 2010
    ..This is the first report to describe the TLR repertoire and IFN system in one of the most primitive vertebrates, the lamprey...
  29. doi request reprint Functional evolution of the TICAM-1 pathway for extrinsic RNA sensing
    Tsukasa Seya
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Immunol Rev 227:44-53. 2009
    ..In this review, we discuss the fundamentals of the extrinsic dsRNA recognition system, which has evolved to induce cellular effectors to cope with dsRNA virus infection across different vertebrate species...
  30. ncbi request reprint Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses
    Aya Matsuo
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Immunol 181:3474-85. 2008
    ..TLR22 may be a functional substitute of human cell-surface TLR3 and serve as a surveillant for infection with dsRNA virus to alert the immune system for antiviral protection in fish...
  31. pmc Cell type-specific subcellular localization of phospho-TBK1 in response to cytoplasmic viral DNA
    Takayuki Suzuki
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
    PLoS ONE 8:e83639. 2013
    ..Taken together, our data elucidated the cell type-specific subcellular localization of p-TBK1 and a cell type-specific role of IPS-1 in TBK1 activation in response to cytoplasmic viral DNA. ..
  32. pmc Biphasic function of TLR3 adjuvant on tumor and spleen dendritic cells promotes tumor T cell infiltration and regression in a vaccine therapy
    Masahiro Azuma
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita ku, Sapporo, Japan
    Oncoimmunology 5:e1188244. 2016
    ..Collectively, Poly(I:C) tunes up proper maturation of CD8α(+) DC to establish TLR3-mediated IL-12 function and cross-presentation in spleen and lymphocyte-attractive antitumor microenvironment in tumor. ..
  33. doi request reprint STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation
    Ken Takashima
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo, 060 8638, Japan
    Biochem Biophys Res Commun 478:1764-71. 2016
    ..Our data show that STING induces tumor cytotoxicity by NK cells through tumor and host immune cell network to contribute to innate surveillance and suppression of tumors in vivo. ..
  34. doi request reprint Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-2
    Kenji Funami
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo 060 8638, Japan and
    J Immunol 195:4456-65. 2015
    ..D91A/E92A of TICAM-2 selectively associates the TLR4-dependent TICAM-2 assembling, but not cytosolic TICAM-2 self-aggregation, to activate TICAM-1. ..
  35. doi request reprint Myeloid-derived suppressor cells confer tumor-suppressive functions on natural killer cells via polyinosinic:polycytidylic acid treatment in mouse tumor models
    Hiroaki Shime
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    J Innate Immun 6:293-305. 2014
    ..The results infer that MDSC is a target of poly I:C to prime NK cells, which exert antitumor activity to NK-sensitive tumor cells...
  36. doi request reprint Pattern recognition receptors of innate immunity and their application to tumor immunotherapy
    Tsukasa Seya
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Cancer Sci 101:313-20. 2010
    ..In addition, we describe the mechanism by which DC-dependent natural killer activation is triggered for the induction of antitumor immunity...
  37. pmc Interferon (IFN) and Cellular Immune Response Evoked in RNA-Pattern Sensing During Infection with Hepatitis C Virus (HCV)
    Masato Nakai
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita ku, Sapporo 060 8638, Japan
    Sensors (Basel) 15:27160-73. 2015
    ..Here we summarize our view on the mechanism by which DCs mature to induce NK and CTL in a status of HCV infection. ..
  38. doi request reprint PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo
    Ryo Takemura
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan Department of Hematology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Cancer Immunol Res 3:902-14. 2015
    ....
  39. doi request reprint Regulator of complement activation (RCA) gene cluster in Xenopus tropicalis
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita ku, Sapporo, Japan
    Immunogenetics 61:371-84. 2009
    ..Taken together, frog possesses a RCA locus, but the constitution of the ARC proteins differs from that of the amniotes with a unique self-resemblance...
  40. ncbi request reprint Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA
    Kenji Funami
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    J Immunol 179:6867-72. 2007
    ..Thus, the spatiotemporal mobilization of TICAM-1 in response to dsRNA and the formation of the TICAM-1 speckles containing RIP1 and NAP1 are important for the activation of the TLR3-TICAM-1 pathway...
  41. ncbi request reprint TICAM-1 and TICAM-2: toll-like receptor adapters that participate in induction of type 1 interferons
    Tsukasa Seya
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka 537 8511, Japan
    Int J Biochem Cell Biol 37:524-9. 2005
    ..Our results reveal the details of MyD88-independent pathways which separately recruit the distinct adapters downstream of TLR3 and TLR4 and variations of the TLR output are in part regulated by the two additional adapters in DCs...
  42. pmc The dataset of proteins specifically interacted with activated TICAM-1
    Kenji Funami
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo 060 8638, Japan
    Data Brief 8:697-9. 2016
    ..Among 53 proteins, 14-3-3-zeta specifically interacts with oligomerized TICAM-1 to corroborate TICAM-1 signalosome. ..
  43. doi request reprint Dendritic cell subsets involved in type I IFN induction in mouse measles virus infection models
    Hiromi Takaki
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo 060 8638, Japan Electronic address
    Int J Biochem Cell Biol 53:329-33. 2014
    ....
  44. doi request reprint Toll-IL-1-receptor-containing adaptor molecule-1: a signaling adaptor linking innate immunity to adaptive immunity
    Misako Matsumoto
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Prog Mol Biol Transl Sci 117:487-510. 2013
    ..Hence, TICAM-1 signaling appears to link innate immunity to adaptive immunity. In this review, we summarize the current knowledge on TICAM-1 and discuss its role in virus infection and antitumor immunity...
  45. pmc An embryo-specific expressing TGF-β family protein, growth-differentiation factor 3 (GDF3), augments progression of B16 melanoma
    Nobuyuki Ehira
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku Sapporo 060 8638, Japan
    J Exp Clin Cancer Res 29:135. 2010
    ..Finally, our results support the view that GDF3 has the ability to induce progression of CD24-inducible melanoma in mice...
  46. pmc Pan-vertebrate toll-like receptors during evolution
    Hiroyuki Oshiumi
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Curr Genomics 9:488-93. 2008
    ..In this review, we summarize the similarities and differences of the TLR family in various vertebrates and introduce these unique TLRs for a possible application to the field of clinical practices for cancer or virus infection...
  47. doi request reprint Evolution of the DEAD box helicase family in chicken: chickens have no DHX9 ortholog
    Haruko Sato
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo 060 8638
    Microbiol Immunol 59:633-40. 2015
    ..DHX9 may generally compensate for the function of RIG-I and deficiency of DHX9 possibly participates in exacerbations of viral infection such as influenza in chickens. ..
  48. ncbi request reprint [Immunobiological response against RNA virus infection]
    Tsukasa Seya
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University
    Uirusu 63:135-42. 2013
    ..In this review, we focus on the potential role of hepatitis C virus (HCV) RNA in modulating the inflammatory milieu around mDCs and evoking antiviral immunity to drive specific cellular effectors against the virus. ..
  49. doi request reprint Antiviral responses induced by the TLR3 pathway
    Misako Matsumoto
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Rev Med Virol 21:67-77. 2011
    ..Here, we review the current knowledge on the role of TLR3 during viral infection, and the current understanding of the TLR3-signalling cascade that operates via the adaptor protein TICAM-1 (also called TRIF)...
  50. pmc Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair
    Kyoko Nakamura
    Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    PLoS Genet 6:e1000828. 2010
    ..We propose that the BRCA1-CtIP complex plays a role in the nuclease-mediated elimination of oligonucleotides covalently bound to polypeptides from DSBs, thereby facilitating subsequent DSB repair...
  51. doi request reprint Links between recognition and degradation of cytoplasmic viral RNA in innate immune response
    Hiroyuki Oshiumi
    Laboratory for Biologics Development, Research Center for Zoonosis Control, GI CoRE Global Station for Zoonosis Control, Hokkaido University, Sapporo, Japan
    Rev Med Virol 26:90-101. 2016
    ..These observations imply that viral RNA degradation and recognition are linked to each other. In this review, I discuss the links between recognition and degradation of viral RNA...
  52. ncbi request reprint Combinational recognition of bacterial lipoproteins and peptidoglycan by chicken Toll-like receptor 2 subfamily
    Megumi Higuchi
    Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Dev Comp Immunol 32:147-55. 2008
    ..These results suggest that chTLR2 subfamily members discriminate between their ligands by combinational events...