Hitoshi Suzuki

Summary

Affiliation: Japan Advanced Institute of Science and Technology
Country: Japan

Publications

  1. pmc Endogenous Multiple Exon Skipping and Back-Splicing at the DMD Mutation Hotspot
    Hitoshi Suzuki
    School of Materials Science, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa 923 1292, Japan
    Int J Mol Sci 17:. 2016
  2. pmc Computational extraction of a neural molecular network through alternative splicing
    Shafiul Alam
    School of Materials Science, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa 923 1292, Japan
    BMC Res Notes 7:934. 2014
  3. pmc A view of pre-mRNA splicing from RNase R resistant RNAs
    Hitoshi Suzuki
    Center for Nano Materials and Technology, Japan Advanced Institute of Science and Technology, 1 1 Asahidai, Nomi, Ishikawa 923 1292, Japan
    Int J Mol Sci 15:9331-42. 2014
  4. doi request reprint Nested introns in an intron: evidence of multi-step splicing in a large intron of the human dystrophin pre-mRNA
    Hitoshi Suzuki
    School of Materials Science, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa 923 1292, Japan
    FEBS Lett 587:555-61. 2013
  5. pmc Alternative splicing produces structural and functional changes in CUGBP2
    Hitoshi Suzuki
    Center for Nano Materials and Technology, Japan Advanced Institute of Science and Technology, Ishikawa 923 1292, Japan
    BMC Biochem 13:6. 2012
  6. ncbi request reprint Localization of c-mos mRNA around the animal pole in the zebrafish oocyte with Zor-1/Zorba
    Hitoshi Suzuki
    Center for Nano Materials and Technology, Japan Advanced Institute of Science and Technology, Ishikawa, Japan
    Biosci Trends 3:96-104. 2009
  7. pmc Comprehensive analysis of alternative splicing and functionality in neuronal differentiation of P19 cells
    Hitoshi Suzuki
    Center for Nano Materials and Technology, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa, Japan
    PLoS ONE 6:e16880. 2011
  8. doi request reprint Retinoic acid treatment and cell aggregation independently regulate alternative splicing in P19 cells during neural differentiation
    A H M Khurshid Alam
    School of Materials Science, Japan Advanced Institute of Science and Technology, Ishikawa, Japan
    Cell Biol Int 34:631-43. 2010
  9. doi request reprint Functional gene expression analysis of tissue-specific isoforms of Mef2c
    Yoshiharu Sekiyama
    School of Materials Science, Japan Advanced Institute of Science and Technology, 1 1 Asahidai, Nomi, Ishikawa, 923 1292, Japan
    Cell Mol Neurobiol 32:129-39. 2012
  10. doi request reprint Alternative splicing of Mef2c promoted by Fox-1 during neural differentiation in P19 cells
    Nor Hakimah Ab Hakim
    Center for Nano Materials Technology, Japan Advanced Institute of Science and Technology, 1 1 Asahidai, Nomi, Ishikawa 923 1211, JapanGraduate School of Materials Science, Japan Advanced Institute of Science and Technology, 1 1 Asahidai, Nomi, Ishikawa 923 1211, Japan
    Genes Cells 15:255-67. 2010

Collaborators

Detail Information

Publications14

  1. pmc Endogenous Multiple Exon Skipping and Back-Splicing at the DMD Mutation Hotspot
    Hitoshi Suzuki
    School of Materials Science, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa 923 1292, Japan
    Int J Mol Sci 17:. 2016
    ....
  2. pmc Computational extraction of a neural molecular network through alternative splicing
    Shafiul Alam
    School of Materials Science, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa 923 1292, Japan
    BMC Res Notes 7:934. 2014
    ....
  3. pmc A view of pre-mRNA splicing from RNase R resistant RNAs
    Hitoshi Suzuki
    Center for Nano Materials and Technology, Japan Advanced Institute of Science and Technology, 1 1 Asahidai, Nomi, Ishikawa 923 1292, Japan
    Int J Mol Sci 15:9331-42. 2014
    ..Moreover, circRNA might function as microRNA sponges. There is an enormous variety of endogenous circRNAs, which are generally synthesized in cells and tissues. ..
  4. doi request reprint Nested introns in an intron: evidence of multi-step splicing in a large intron of the human dystrophin pre-mRNA
    Hitoshi Suzuki
    School of Materials Science, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa 923 1292, Japan
    FEBS Lett 587:555-61. 2013
    ..Nested splicing events, which bring the authentic 5' and 3' splice sites into close proximity, could be one of the splicing mechanisms for the extremely large introns...
  5. pmc Alternative splicing produces structural and functional changes in CUGBP2
    Hitoshi Suzuki
    Center for Nano Materials and Technology, Japan Advanced Institute of Science and Technology, Ishikawa 923 1292, Japan
    BMC Biochem 13:6. 2012
    ..These RNA-binding proteins contain two RNA recognition motif (RRM) domains at the N-terminus and another RRM at the C-terminus. CUGBP2 is a member of this family of proteins that possesses several alternatively spliced exons...
  6. ncbi request reprint Localization of c-mos mRNA around the animal pole in the zebrafish oocyte with Zor-1/Zorba
    Hitoshi Suzuki
    Center for Nano Materials and Technology, Japan Advanced Institute of Science and Technology, Ishikawa, Japan
    Biosci Trends 3:96-104. 2009
    ..Interestingly, we found c-mos mRNA is located in the animal cortex of zebrafish oocyte, where Zor-1 protein exists. Taken together, these results suggest that the animal cortex is the central core of oocyte maturation in zebrafish...
  7. pmc Comprehensive analysis of alternative splicing and functionality in neuronal differentiation of P19 cells
    Hitoshi Suzuki
    Center for Nano Materials and Technology, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa, Japan
    PLoS ONE 6:e16880. 2011
    ..Many alternative isoforms are expressed in a spatio-temporal manner, and function in diverse processes, including in the neural system...
  8. doi request reprint Retinoic acid treatment and cell aggregation independently regulate alternative splicing in P19 cells during neural differentiation
    A H M Khurshid Alam
    School of Materials Science, Japan Advanced Institute of Science and Technology, Ishikawa, Japan
    Cell Biol Int 34:631-43. 2010
    ..Taken together, our results suggest that RA treatment and cell aggregation independently regulate the alternative splicing mechanism in the early stage of P19 cells during neural differentiation...
  9. doi request reprint Functional gene expression analysis of tissue-specific isoforms of Mef2c
    Yoshiharu Sekiyama
    School of Materials Science, Japan Advanced Institute of Science and Technology, 1 1 Asahidai, Nomi, Ishikawa, 923 1292, Japan
    Cell Mol Neurobiol 32:129-39. 2012
    ..The results showed significant gene expression changes due to overexpression of Mef2c isoforms in both an isoforms-dependent and -independent manner...
  10. doi request reprint Alternative splicing of Mef2c promoted by Fox-1 during neural differentiation in P19 cells
    Nor Hakimah Ab Hakim
    Center for Nano Materials Technology, Japan Advanced Institute of Science and Technology, 1 1 Asahidai, Nomi, Ishikawa 923 1211, JapanGraduate School of Materials Science, Japan Advanced Institute of Science and Technology, 1 1 Asahidai, Nomi, Ishikawa 923 1211, Japan
    Genes Cells 15:255-67. 2010
    ..Taken together, our results suggest that Fox-1, expressed specifically in the neural cell stage, promoted Mef2c exon β inclusion via the GCAUG. ..
  11. doi request reprint Expression analysis of Fgf8a &Fgf8b in early stage of P19 cells during neural differentiation
    A H M Khurshid Alam
    School of Materials Science, Japan Advanced Institute of Science and Technology, Japan
    Cell Biol Int 33:1032-7. 2009
    ..Increased Fgf8b mRNA expression was cellular-aggregation dependent. The results demonstrated that cellular-aggregation-induced Fgf8b, but not Fgf8a, may play a pivotal role in early neural differentiation of P19 cells...
  12. doi request reprint Changing blue fluorescent protein to green fluorescent protein using chemical RNA editing as a novel strategy in genetic restoration
    Luyen T Vu
    School of Materials Science, Japan Advanced Institute of Science and Technology JAIST, 1 1 Asahidai, Nomi City, Ishikawa, 923 1292, Japan
    Chem Biol Drug Des 86:1242-52. 2015
    ..Thus, we successfully used non-enzymatic site-directed deamination for genetic restoration in vitro. In the near future, in vivo studies that include cultured cells and model animals will be conducted to treat genetic disorders. ..
  13. doi request reprint Chemical RNA Editing for Genetic Restoration: The Relationship between the Structure and Deamination Efficiency of Carboxyvinyldeoxyuridine Oligodeoxynucleotides
    Luyen Thi Vu
    School of Materials Science, Japan Advanced Institute of Science and Technology JAIST, 1 1 Asahidai, Nomi City, Ishikawa, 923 1292, Japan
    Chem Biol Drug Des 87:583-93. 2016
    ..We showed that the optimal deamination efficiency was achieved with ODNs having a complementary sequence length slightly more than 14 nt and a hairpin length of 9 nt. ..
  14. doi request reprint Alternative splicing regulation of APP exon 7 by RBFox proteins
    Shafiul Alam
    School of Materials Science, Japan Advanced Institute of Science and Technology, 1 1 Asahidai, Nomi, Ishikawa 923 1292, Japan Electronic address
    Neurochem Int 78:7-17. 2014
    ..Overall, RBFox proteins may shift APP from exon 7 containing isoforms, APP770 and APP751, toward the exon 7 lacking isoform, APP695, which is predominant in neural tissues. ..