K Oshikawa

Summary

Affiliation: Jichi Medical School
Country: Japan

Publications

  1. ncbi request reprint ST2 protein induced by inflammatory stimuli can modulate acute lung inflammation
    Katsuhisa Oshikawa
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, 3311 Minamikawachi, Kawachi gun, 329 0498, Tochigi, Japan
    Biochem Biophys Res Commun 299:18-24. 2002
  2. ncbi request reprint Serum anti-p53 autoantibodies from patients with idiopathic pulmonary fibrosis associated with lung cancer
    K Oshikawa
    Department of Pulmonary Medicine, Jichi Medical School, Tochigi, Japan
    Respir Med 94:1085-91. 2000
  3. ncbi request reprint Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation
    K Oshikawa
    Department of Pulmonary Medicine, Jichi Medical School, 311 Minamikawachi, Kawachi gun, Tochigi, 329 0498, Japan
    Am J Respir Crit Care Med 164:277-81. 2001
  4. ncbi request reprint Human lung fibroblasts inhibit macrophage inflammatory protein-1alpha production by lipopolysaccharide-stimulated macrophages
    Katsuhisa Oshikawa
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, Minamikawachi, Tochigi, Japan
    Biochem Biophys Res Commun 312:650-5. 2003
  5. ncbi request reprint Elevated soluble CD26 levels in patients with tuberculous pleurisy
    K Oshikawa
    Department of Pulmonary Medicine, Jichi Medical School, Minamikawachi, Tochigi, Japan
    Int J Tuberc Lung Dis 5:868-72. 2001
  6. ncbi request reprint Gene expression of Toll-like receptors and associated molecules induced by inflammatory stimuli in the primary alveolar macrophage
    Katsuhisa Oshikawa
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, Minamikawachi, Tochigi, Japan
    Biochem Biophys Res Commun 305:649-55. 2003
  7. ncbi request reprint Expression of ST2 in helper T lymphocytes of malignant pleural effusions
    Katsuhisa Oshikawa
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, Minamikawachi, Tochigi, Japan
    Am J Respir Crit Care Med 165:1005-9. 2002
  8. ncbi request reprint Regulation of toll-like receptor 2 and 4 gene expression in murine alveolar macrophages
    Katsuhisa Oshikawa
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, Minamikawachi, Tochigi, Japan
    Exp Lung Res 29:401-12. 2003
  9. ncbi request reprint Expression and function of the ST2 gene in a murine model of allergic airway inflammation
    K Oshikawa
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, Tochigi, Japan
    Clin Exp Allergy 32:1520-6. 2002
  10. ncbi request reprint [Cytokine production by peripheral blood mononuclear cells in bronchial asthma treated with suplatast tosilate]
    H Yamasawa
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School
    Arerugi 50:513-9. 2001

Collaborators

Detail Information

Publications26

  1. ncbi request reprint ST2 protein induced by inflammatory stimuli can modulate acute lung inflammation
    Katsuhisa Oshikawa
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, 3311 Minamikawachi, Kawachi gun, 329 0498, Tochigi, Japan
    Biochem Biophys Res Commun 299:18-24. 2002
    ..These results suggest that increases in endogenous ST2 protein in AM, which is induced by inflammatory stimuli, such as LPS and proinflammatory cytokines, may modulate acute lung inflammation...
  2. ncbi request reprint Serum anti-p53 autoantibodies from patients with idiopathic pulmonary fibrosis associated with lung cancer
    K Oshikawa
    Department of Pulmonary Medicine, Jichi Medical School, Tochigi, Japan
    Respir Med 94:1085-91. 2000
    ..2%), IPF with lung cancer (57.1%) and IPF without lung cancer (53.1%) than PE (21.7%). These results suggest that p53 mutations occur frequently and substantially in IPF, resulting in a high prevalence of lung cancer...
  3. ncbi request reprint Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation
    K Oshikawa
    Department of Pulmonary Medicine, Jichi Medical School, 311 Minamikawachi, Kawachi gun, Tochigi, 329 0498, Japan
    Am J Respir Crit Care Med 164:277-81. 2001
    ..634, p = 0.004) and Pa(CO(2)) (r = 0.516, p = 0.003). These results suggest that soluble human ST2 protein in sera may be related to Th2-mediated allergic inflammation inducing acute exacerbation in patients with atopic asthma...
  4. ncbi request reprint Human lung fibroblasts inhibit macrophage inflammatory protein-1alpha production by lipopolysaccharide-stimulated macrophages
    Katsuhisa Oshikawa
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, Minamikawachi, Tochigi, Japan
    Biochem Biophys Res Commun 312:650-5. 2003
    ....
  5. ncbi request reprint Elevated soluble CD26 levels in patients with tuberculous pleurisy
    K Oshikawa
    Department of Pulmonary Medicine, Jichi Medical School, Minamikawachi, Tochigi, Japan
    Int J Tuberc Lung Dis 5:868-72. 2001
    ..We therefore hypothesized that CD26 expression might increase in tuberculous pleural effusion, and might thus be a possible marker for detecting tuberculous pleurisy...
  6. ncbi request reprint Gene expression of Toll-like receptors and associated molecules induced by inflammatory stimuli in the primary alveolar macrophage
    Katsuhisa Oshikawa
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, Minamikawachi, Tochigi, Japan
    Biochem Biophys Res Commun 305:649-55. 2003
    ..These results indicate that the TLR2 expression upregulated in AM following bacterial respiratory infections may render AM responsive to TLR2 ligands, which may enhance innate immunity against pathogens in the lung...
  7. ncbi request reprint Expression of ST2 in helper T lymphocytes of malignant pleural effusions
    Katsuhisa Oshikawa
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, Minamikawachi, Tochigi, Japan
    Am J Respir Crit Care Med 165:1005-9. 2002
    ..These results suggest that CD4+ T cells in CA shift to Th2, which can produce soluble ST2 protein, resulting in increased concentrations of p-ST2 in malignant pleural effusion...
  8. ncbi request reprint Regulation of toll-like receptor 2 and 4 gene expression in murine alveolar macrophages
    Katsuhisa Oshikawa
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, Minamikawachi, Tochigi, Japan
    Exp Lung Res 29:401-12. 2003
    ..These results indicate that TLR2 expression up-regulated in AM in response to bacterial respiratory infections may render AM responsive to TLR2 ligands, which may accelerate the innate immunity against pathogens in the lung...
  9. ncbi request reprint Expression and function of the ST2 gene in a murine model of allergic airway inflammation
    K Oshikawa
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, Tochigi, Japan
    Clin Exp Allergy 32:1520-6. 2002
    ..However, the role, function, and kinetics of soluble ST2 expression in asthma remain unclear...
  10. ncbi request reprint [Cytokine production by peripheral blood mononuclear cells in bronchial asthma treated with suplatast tosilate]
    H Yamasawa
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School
    Arerugi 50:513-9. 2001
    ..These results suggest that supratast tosilate improves the disease status of bronchial asthma through its ability to inhibit the production Th2 cytokines, at least IL-5, in vivo...
  11. ncbi request reprint Infection of TT virus in patients with idiopathic pulmonary fibrosis
    M Bando
    Department of Medicine, Jichi Medical School, Tochigi, Japan
    Respir Med 95:935-42. 2001
    ..TTV infection influences the disease activityand prognosis of IPF in some cases. Further studies are required to elucidate the clinical significance of TTV in IPF...
  12. ncbi request reprint Particle-mediated gene transfer of murine interleukin-12 cDNA suppresses the growth of Lewis lung carcinoma
    K Oshikawa
    Department of Pulmonary Medicine, Jichi Medical School, Tochigi, Japan
    In Vivo 13:397-402. 1999
    ..These results show that in vivo delivery of IL-12 cDNA into skin by the Helios gene gun device can have a useful routine application for cancer therapy research...
  13. ncbi request reprint Glucose-6-phosphate dehydrogenase in rat lung alveolar epithelial cells. An ultrastructural enzyme-cytochemical study
    S Matsubara
    Department of Obstetrics and Gynecology, Jichi Medical School, Minamikawachi machi 3311 1, Kawachi gun, Tochigi 329 0498, Japan
    Eur J Histochem 46:243-8. 2002
    ..The cytochemical controls ensured specific detection of enzyme activity. This enzyme may play a role in airway defense by delivering substances for cell proliferation and antioxidant forces, thus maintaining the airway architecture...
  14. ncbi request reprint Cavernous hemangiomas of lungs and liver in an asymptomatic girl
    Akira Kobayashi
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi Machi, Kawachi gun, Tochigi, 329 0431, Japan
    Respiration 70:647-50. 2003
    ..In pulmonary hemangiomas, some cases have an inexorable clinical course with hemoptysis, respiratory distress, and heart failure. In our case, the lesions have not remarkably progressed under observation for more than 2 years...
  15. ncbi request reprint [Effect of macrolide antibiotics on apoptosis of neutrophils--special reference to the suppressive effect on survival enhancing factor production in pulmonary epithelial cell]
    Hideaki Yamasawa
    Jpn J Antibiot 56:140-3. 2003
  16. ncbi request reprint Intrathoracic sporadic desmoid tumor with the beta-catenin gene mutation in exon 3 and activated cyclin D1
    Shunji Tajima
    Department of Medicine, Division of Pulmonary Medicine, Jichi Medical School, Tochigi, Japan
    Respiration 73:558-61. 2006
    ....
  17. ncbi request reprint Macrolides inhibit epithelial cell-mediated neutrophil survival by modulating granulocyte macrophage colony-stimulating factor release
    Hideaki Yamasawa
    Department of Medicine, Jichi Medical School, Tochigi, Japan
    Am J Respir Cell Mol Biol 30:569-75. 2004
    ..These results suggest that macrolides inhibit epithelial cell-mediated neutrophil survival by modulating GM-CSF release, which may, at least in part, explain the effectiveness of this family of drugs on DPB...
  18. ncbi request reprint Evidence that exogenous substances can be phagocytized by alveolar epithelial cells and transported into blood capillaries
    Tomoko Kato
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi Machi, Kawachi gun, Tochigi, 329 0498, Japan
    Cell Tissue Res 311:47-51. 2003
    ..These findings suggest that alveolar epithelial cells can incorporate exogenous particles, which are then transferred from the alveoli to intravascular spaces by transcytosis...
  19. ncbi request reprint Intratumoral injection of interleukin-12 plasmid DNA, either naked or in complex with cationic lipid, results in similar tumor regression in a murine model
    Fushun Shi
    Department of Surgery, University of Wisconsin Madison, Madison, Wisconsin 53792, USA
    Mol Cancer Ther 1:949-57. 2002
    ..These results indicate that direct intratumoral gene transfer with naked nonviral IL-12 DNA provides an effective and simple method for the treatment of murine tumors, suggesting an approach for clinical application...
  20. ncbi request reprint ST2 gene induced by type 2 helper T cell (Th2) and proinflammatory cytokine stimuli may modulate lung injury and fibrosis
    Shunji Tajima
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Exp Lung Res 33:81-97. 2007
    ..These findings suggest that soluble ST2 gene may increase, possibly reflecting the development of the inflammatory process and the Th2-type immune response in the fibrotic lung tissue, and may modulate a process of pulmonary fibrosis...
  21. ncbi request reprint [Thoracic actinomycosis: clinical, radiological, and pathological findings in 11 cases]
    Naoko Mato
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School
    Nihon Kokyuki Gakkai Zasshi 41:514-20. 2003
    ..These results suggest that radiological findings, such as LAA and bronchial and bronchiolar dilatation, are characteristic for TA, and can be useful in making a diagnosis of TA...
  22. ncbi request reprint The increase in serum soluble ST2 protein upon acute exacerbation of idiopathic pulmonary fibrosis
    Shunji Tajima
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, Tochigi, Japan
    Chest 124:1206-14. 2003
    ..It has been reported that the inflammatory response in idiopathic pulmonary fibrosis (IPF) is thought to be associated with proinflammatory cytokines and Th2 immune response...
  23. ncbi request reprint [Therapeutic effect of macrolide antibiotics on murine model of hematogenous pulmonary MRSA infection]
    Toyomitsu Sawai
    Jpn J Antibiot 56:54-6. 2003
  24. ncbi request reprint [Usual interstitial pneumonia associated with psoriasis vulgaris]
    Takanari Tokunaga
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School, Tochigi, Japan
    Nihon Kokyuki Gakkai Zasshi 40:692-6. 2002
    ..Surgical lung biopsy under thoracoscopy revealed usual interstitial pneumonia (UIP). The association of interstitial pneumonia with psoriasis vulgaris is rare...
  25. ncbi request reprint [Two cases of lung cancer in the third decade of life]
    Tatsuya Hosono
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School
    Nihon Kokyuki Gakkai Zasshi 42:859-64. 2004
    ..In some cases, young adults with lung cancer have been misdiagnosed as having bronchial asthma or pulmonary tuberculosis...
  26. ncbi request reprint [Mechanism of sarcoid granuloma formation--participation of cytokines and chemokines]
    Yukihiko Sugiyama
    Division of Pulmonary Medicine, Department of Medicine, Jichi Medical School
    Nihon Rinsho 60:1728-33. 2002
    ..Failure of removal of causative antigen(s) can induce prolonged existence of granuloma and irreversible fibrosis...