Takashi Yokoo

Summary

Affiliation: Jikei University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Reduction of lysosomal storage in murine mucopolysaccharidosis type VII by transplantation of normal and genetically modified macrophages
    T Ohashi
    Department of Gene Therapy, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan
    Blood 95:3631-3. 2000
  2. ncbi request reprint Prophylaxis of antibody-induced acute glomerulonephritis with genetically modified bone marrow-derived vehicle cells
    T Yokoo
    Department of Internal Medicine II, Jikei University School of Medicine, Tokyo, Japan
    Hum Gene Ther 10:2673-8. 1999
  3. pmc Generation of interspecies limited chimeric nephrons using a conditional nephron progenitor cell replacement system.
    S Yamanaka
    Nat Commun 8:1719. 2017
  4. pmc Potential use of stem cells for kidney regeneration
    Takashi Yokoo
    Project Laboratory for Kidney Regeneration, Institute of DNA Medicine, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, 105 8461, Japan
    Int J Nephrol 2011:591731. 2011
  5. ncbi request reprint Xenobiotic kidney organogenesis from human mesenchymal stem cells using a growing rodent embryo
    Takashi Yokoo
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, Japan 105 8461
    J Am Soc Nephrol 17:1026-34. 2006
  6. ncbi request reprint Xenobiotic kidney organogenesis: a new avenue for renal transplantation
    Takashi Yokoo
    Project Laboratory for Kidney Regeneration, Institute of DNA Medicine, Tokyo Japan
    J Nephrol 22:312-7. 2009
  7. doi request reprint Stem cells for kidney repair: useful tool for acute renal failure?
    Takashi Yokoo
    Project Laboratory for Kidney Regeneration, Division of Nephrology and Hypertension, Department of Internal Medicine, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan
    Kidney Int 74:847-9. 2008
  8. doi request reprint Kidney organogenesis and regeneration: a new era in the treatment of chronic renal failure?
    Takashi Yokoo
    Project Laboratory for Kidney Regeneration, Institute of DNA Medicine, The Jikei University School of Medicine, 3 25 8, Nishi Shimbashi, Tokyo, 105 8461, Japan
    Clin Exp Nephrol 12:326-31. 2008
  9. doi request reprint Generation of a transplantable erythropoietin-producer derived from human mesenchymal stem cells
    Takashi Yokoo
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Transplantation 85:1654-8. 2008
  10. doi request reprint Kidney regeneration by xeno-embryonic nephrogenesis
    Takashi Yokoo
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3 25 8 Nishishimbashi Minato ku, Tokyo 105 8461, Japan
    Med Mol Morphol 41:5-13. 2008

Detail Information

Publications86

  1. ncbi request reprint Reduction of lysosomal storage in murine mucopolysaccharidosis type VII by transplantation of normal and genetically modified macrophages
    T Ohashi
    Department of Gene Therapy, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan
    Blood 95:3631-3. 2000
    ..These observations suggest that macrophage transplantation is a promising method for treatment of murine MPS VII without myeloablation, and macrophages may be good target cells for ex vivo gene therapy for MPS VII...
  2. ncbi request reprint Prophylaxis of antibody-induced acute glomerulonephritis with genetically modified bone marrow-derived vehicle cells
    T Yokoo
    Department of Internal Medicine II, Jikei University School of Medicine, Tokyo, Japan
    Hum Gene Ther 10:2673-8. 1999
    ..This success may strengthen the rationale for gene therapy in the treatment of inflammatory diseases such as glomerulonephritis...
  3. pmc Generation of interspecies limited chimeric nephrons using a conditional nephron progenitor cell replacement system.
    S Yamanaka
    Nat Commun 8:1719. 2017
    ..Thus, this technique enables in vivo differentiation from progenitor cells into nephrons, providing insights into nephrogenesis and organ regeneration...
  4. pmc Potential use of stem cells for kidney regeneration
    Takashi Yokoo
    Project Laboratory for Kidney Regeneration, Institute of DNA Medicine, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, 105 8461, Japan
    Int J Nephrol 2011:591731. 2011
    ..In this manuscript, current advances in renal stem cell research are reviewed and their usefulness for kidney regeneration discussed. We also reviewed the current knowledge of the emerging field of renal stem cell biology...
  5. ncbi request reprint Xenobiotic kidney organogenesis from human mesenchymal stem cells using a growing rodent embryo
    Takashi Yokoo
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, Japan 105 8461
    J Am Soc Nephrol 17:1026-34. 2006
    ..1 versus 0.3 +/- 0.2 mg, respectively), suggesting that the neo-kidney may produce urine. Taken together, these findings suggest that hMSC can differentiate into a mature renal structure with the potential to replace lost kidney function...
  6. ncbi request reprint Xenobiotic kidney organogenesis: a new avenue for renal transplantation
    Takashi Yokoo
    Project Laboratory for Kidney Regeneration, Institute of DNA Medicine, Tokyo Japan
    J Nephrol 22:312-7. 2009
    ..Here we review the challenges faced in developing a whole functional kidney de novo and discuss the obstacles which must be overcome before clinical use is possible...
  7. doi request reprint Stem cells for kidney repair: useful tool for acute renal failure?
    Takashi Yokoo
    Project Laboratory for Kidney Regeneration, Division of Nephrology and Hypertension, Department of Internal Medicine, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan
    Kidney Int 74:847-9. 2008
    ..Although these cells have the potential to differentiate into endothelial-lineage cell types, their therapeutic benefit to the ischemic kidney is mainly via the production of renoprotective factors...
  8. doi request reprint Kidney organogenesis and regeneration: a new era in the treatment of chronic renal failure?
    Takashi Yokoo
    Project Laboratory for Kidney Regeneration, Institute of DNA Medicine, The Jikei University School of Medicine, 3 25 8, Nishi Shimbashi, Tokyo, 105 8461, Japan
    Clin Exp Nephrol 12:326-31. 2008
    ..We review recent progress in the field of regenerative nephrology, focusing on the de novo establishment of a whole kidney...
  9. doi request reprint Generation of a transplantable erythropoietin-producer derived from human mesenchymal stem cells
    Takashi Yokoo
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Transplantation 85:1654-8. 2008
    ..Together these results confirmed the generation of a stem cell-derived organoid that is capable of producing EPO and sensitive to physiological regulation...
  10. doi request reprint Kidney regeneration by xeno-embryonic nephrogenesis
    Takashi Yokoo
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3 25 8 Nishishimbashi Minato ku, Tokyo 105 8461, Japan
    Med Mol Morphol 41:5-13. 2008
    ....
  11. ncbi request reprint Stem cells and kidney organogenesis
    Takashi Yokoo
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, Japan
    Front Biosci 13:2814-32. 2008
    ..This article reviews the current understanding of kidney organogenesis and kidney stem cells, and discusses the potential of kidney organogenesis as a therapeutic strategy for renal failure...
  12. ncbi request reprint Emphysematous cystitis complication in a patient undergoing hemodialysis
    Takashi Yokoo
    Department of Internal Medicine, Tokyu Hospital, Tokyo, Japan
    Clin Exp Nephrol 11:247-50. 2007
    ..Not anuric but rather oliguric diabetic patients, even after long-term hemodialysis, are the patients at risk for emphysematous cystitis...
  13. pmc Human mesenchymal stem cells in rodent whole-embryo culture are reprogrammed to contribute to kidney tissues
    Takashi Yokoo
    Department of Internal Medicine and Gene Therapy and Pediatrics, Institute of DNA Medicine, Jikei University School of Medicine, 3 25 8, Nishi Shimbashi, Minato ku, Tokyo 105 8461, Japan
    Proc Natl Acad Sci U S A 102:3296-300. 2005
    ..We show that a combination of whole-embryo culture, followed by organ culture, encourages exogenous human mesenchymal stem cells to differentiate and contribute to functional complex structures of the new kidney...
  14. ncbi request reprint Stem cell gene therapy for chronic renal failure
    T Yokoo
    Division of Nephrology and Hypertension, Department of Internal Medicine, Institute of DNA Medicine, Jikei University School of Medicine, 3 25 8, Nishi Shimbashi, Minato ku, Tokyo, 105 8461 Japan
    Curr Gene Ther 3:387-94. 2003
    ..This article reviews the recent investigation on this tailor-made stem cell gene therapy for chronic renal failure and discusses the potential of this novel strategy and the major practical challenges of its clinical application...
  15. ncbi request reprint Gene delivery using human cord blood-derived CD34+cells into inflamed glomeruli in NOD/SCID mice
    Takashi Yokoo
    Division of Nephrology and Hypertension, Department of Internal Medicine, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan
    Kidney Int 64:102-9. 2003
    ..In this regard, umbilical cord blood may be a useful alternative and, therefore, we focused on their suitability as a source of hematopoietic stem cells for transplantation-based therapy for glomerulonephritis...
  16. ncbi request reprint Transplantation-based gene therapy for inflammatory diseases: focus on glomerulonephritis
    T Yokoo
    Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, Japan
    Curr Gene Ther 1:227-35. 2001
    ..This article focuses on the glomerulonephritis as a model of local inflammation and reviews recent investigations on transplantation-based gene therapy for inflammatory diseases...
  17. ncbi request reprint Inflamed glomeruli-specific gene activation that uses recombinant adenovirus with the Cre/loxP system
    T Yokoo
    Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 12:2330-7. 2001
    ..These results suggested that only the v-cells recruited in the glomeruli could be switched on and activate foreign genes...
  18. ncbi request reprint Genetically modified bone marrow continuously supplies anti-inflammatory cells and suppresses renal injury in mouse Goodpasture syndrome
    T Yokoo
    Department of Internal Medicine, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan
    Blood 98:57-64. 2001
    ..These results suggest that reconstitution of bone marrow for continuous supply of anti-inflammatory cells may be a useful strategy for the treatment of chronic inflammation...
  19. doi request reprint Clinicopathological characteristics of patients with immunoglobulin A nephropathy showing acute exacerbations after favorable long-term clinical courses
    Mai Tanaka
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo, Japan
    Clin Exp Nephrol 20:226-34. 2016
    ..Sometimes, acute and progressive proteinuria increases occur in patients with IgA nephropathy (IgAN) after favorable long-term clinical courses of >10 years, but their clinical and histological characteristics are not well understood...
  20. ncbi request reprint Widespread and highly persistent gene transfer to the CNS by retrovirus vector in utero: implication for gene therapy to Krabbe disease
    Jin Song Shen
    Department of Gene Therapy, Institute of DNA Medicine, The Jikei University School of Medicine, Tokyo, Japan
    J Gene Med 7:540-51. 2005
    ..In this study, in order to obtain permanent gene transduction, we investigated the feasibility of retrovirus-mediated in utero gene transduction...
  21. doi request reprint The effect of metanephros transplantation on blood pressure in anephric rats with induced acute hypotension
    Shinya Yokote
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Nephrol Dial Transplant 27:3449-55. 2012
    ..The aim of the present study was to determine the metabolic function of transplanted metanephroi with particular reference to maintaining blood pressure...
  22. ncbi request reprint Recurrence and graft loss after renal transplantation in adults with IgA vasculitis
    Mayuko Kawabe
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3 25 8, Nishi Shimbashi, Minato ku, 105 8461, Tokyo, Japan
    Clin Exp Nephrol . 2016
    ..5-60 %, leading to graft loss in 0-50 % of these patients. However, limited data are available on recurrence and graft loss after renal transplantation...
  23. doi request reprint Successful treatment of recurrent Henoch-Schönlein purpura nephritis in a renal allograft with tonsillectomy and steroid pulse therapy
    Takafumi Yamakawa
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Nephrology (Carlton) 21:53-6. 2016
    ..Further studies are needed to elucidate the efficacy and mechanisms of tonsillectomy with recurrent HSPN in kidney transplant patients. ..
  24. doi request reprint Rare case of nephrocalcinosis in the distal tubules caused by hereditary renal hypouricaemia 3 months after kidney transplantation
    Yusuke Okabayashi
    Division of Nephrology and Hypertension, Department of Internal Medicine
    Nephrology (Carlton) 21:67-71. 2016
    ..This is the first report of nephrocalcinosis in the distal tubules as a diagnostic clue to hereditary renal hypouricaemia. We also review the related literature. ..
  25. doi request reprint 33 Years of Peritoneal Dialysis-Associated Peritonitis: A Single-Center Study in Japan
    Masatsugu Nakao
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Ther Apher Dial 20:60-5. 2016
    ..Furthermore, changes in microorganisms, antimicrobial therapies, patient education and improved PD system devices have presumably affected the reduction in the duration of peritonitis. ..
  26. doi request reprint Clinical and pathological features of donor/recipient body weight mismatch after kidney transplantation
    Takafumi Yamakawa
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Nephrology (Carlton) 20:36-9. 2015
    ..Previous studies have shown that a donor/recipient body weight mismatch affects long-term graft survival and graft function after kidney transplantation. However, the mechanisms are not fully understood...
  27. doi request reprint Xenotransplanted embryonic kidney provides a niche for endogenous mesenchymal stem cell differentiation into erythropoietin-producing tissue
    Kei Matsumoto
    Project Laboratory for Kidney Regeneration, Institute of DNA Medicine, The Jikei University School of Medicine, Minato ku, Tokyo, Japan
    Stem Cells 30:1228-35. 2012
    ..Our findings may alleviate adverse effects due to long-lasting immunosuppression and help mitigate ethical concerns...
  28. doi request reprint Metanephros transplantation inhibits the progression of vascular calcification in rats with adenine-induced renal failure
    Shinya Yokote
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Nephron Exp Nephrol 120:e32-40. 2012
    ..The aim of the present study was to determine the metabolic function of transplanted metanephroi in rats with chronic renal failure (CRF), with particular reference to secondary hyperparathyroidism and vascular calcification...
  29. doi request reprint A thermoreversible polymer mediates controlled release of glial cell line-derived neurotrophic factor to enhance kidney regeneration
    Yousof Gheisari
    Project Laboratory for Kidney Regeneration, Institute of DNA Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Artif Organs 34:642-7. 2010
    ..These findings suggest that the GDNF-polymer can be used as a diffuser of GDNF for kidney organogenesis...
  30. pmc Possible prevention of uremic nausea by vitamin D receptor activators in non-dialysis patients with stage 5 chronic kidney disease
    Masato Ikeda
    Division of Nephrology and Hypertension, The Jikei University School of Medicine Katsushika Medical Center, 6 41 2 Katsushika ku, Tokyo, 125 8506, Japan
    Clin Exp Nephrol . 2016
    ..The objective of this study was to explore whether VDRA administration during the predialysis period is associated with a reduced prevalence of uremic nausea just prior to beginning dialysis...
  31. ncbi request reprint Reduction of proteinuria by therapeutic intervention improves the renal outcome of elderly patients with IgA nephropathy
    Yusuke Okabayashi
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo, 105 8641, Japan
    Clin Exp Nephrol 20:910-917. 2016
    ..The number of elderly patients with IgA nephropathy (IgAN) is increasing in parallel with the increased longevity in the general population. However, information is limited regarding the characteristics of such patients...
  32. doi request reprint Risk factors for encapsulating peritoneal sclerosis: analysis of a 36-year experience in a University Hospital
    Masatsugu Nakao
    Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Nephrology (Carlton) . 2016
    ..Encapsulating peritoneal sclerosis (EPS) is a rare but serious complication that occurs in peritoneal dialysis (PD) therapy. The present study aimed to identify the risk factors, especially peritonitis and biocompatible PD fluid...
  33. doi request reprint The prognostic values of caveolin-1 immunoreactivity in peritubular capillaries in patients with kidney transplantation
    Yasuyuki Nakada
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Clin Transplant 30:1417-1424. 2016
    ..1; P=.0324). CAV-1 immunoreactivity in PTCs may serve as a prognostic marker for kidney allograft survival...
  34. doi request reprint Acute T cell-mediated rejection accompanied by C4d-negative acute antibody-mediated rejection and cell debris in tubulus: A case report
    Tsuyoshi Takamura
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Nephrology (Carlton) 20:70-4. 2015
    ..This case report demonstrates the difficulty in the diagnosis of, and therapy for, the complicated pathological findings of ACR, AMR and suspicion of a UTI...
  35. doi request reprint Glomerular Density in Biopsy-Proven Hypertensive Nephrosclerosis
    Kotaro Haruhara
    Department of Internal Medicine, Division of Nephrology and Hypertension, The Jikei University School of Medicine, Minato ku, Tokyo, Japan
    Am J Hypertens 28:1164-71. 2015
    ..However, the significance of the nephron number estimated from a renal biopsy in patients with hypertensive nephrosclerosis (HNS) has not yet been elucidated...
  36. doi request reprint A refractory case of subclinical antibody-mediated rejection due to anti-HLA-DQ antibody in a kidney transplant patient
    Toshinari Fujimoto
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Nephrology (Carlton) 20:81-5. 2015
    ..8 mg/dL. This case report demonstrates the difficulty of treating AMR due to the presence of anti-DQ DSAbs and the necessity for subsequent therapies in refractory cases...
  37. doi request reprint Successful treatment of BK virus nephropathy using therapeutic drug monitoring of mycophenolic acid
    Akimitsu Kobayashi
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Nephrology (Carlton) 19:37-41. 2014
    ..This case report demonstrates the usefulness of MPA AUC0-12 for more accurate adjustment of immunosuppressive therapy and the difficulty of pathological differentiation of BKVN and acute cellular rejection. ..
  38. doi request reprint Functional development of a transplanted embryonic kidney: effect of transplantation site
    Kei Matsumoto
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Minato ku, Tokyo, Japan
    J Nephrol 25:50-5. 2012
    ..Thus, we determined the optimal transplantation site for the metanephros in terms of retaining its ability to produce renin and erythropoietin (EPO)...
  39. doi request reprint Integration of human mesenchymal stem cells into the Wolffian duct in chicken embryos
    Akira Fukui
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 385:330-5. 2009
    ..These results suggest that chicken Pax2-expressing hMSCs can be competent to differentiate into the Wolffian duct cells by the influence of chicken local signals...
  40. pmc Tonsillectomy reduces recurrence of IgA nephropathy in mesangial hypercellularity type categorized by the Oxford classification
    Keita Hirano
    Division of Nephrology, Department of Internal Medicine, Ashikaga Red Cross Hospital, 284 1 Yobe cho, Ashikaga, Tochigi, 326 0843, Japan
    Clin Exp Nephrol 20:425-32. 2016
    ..In patients with IgA nephropathy (IgAN), recurrence after steroid pulse therapy is associated with reduced renal survival. However, the predictors of recurrence have not yet been clarified...
  41. doi request reprint Probable C4d-negative accelerated acute antibody-mediated rejection due to non-HLA antibodies
    Takahito Niikura
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Nephrology (Carlton) 20:75-8. 2015
    ..56 mg/dL, found no evidence of rejection. This case, presented with a review of relevant literature, demonstrates that probable C4d-negative accelerated acute AMR can result from non-HLA antibodies...
  42. pmc Urine excretion strategy for stem cell-generated embryonic kidneys
    Shinya Yokote
    Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Minato ku, Tokyo 105 8461, Japan
    Proc Natl Acad Sci U S A 112:12980-5. 2015
    ....
  43. ncbi request reprint Stem cells in kidney regeneration
    Shinya Yokote
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei, University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo 105 8461, Japan
    Curr Med Chem 19:6009-17. 2012
    ..In this review, we describe current advances in stem cell research for kidney tissue repair and de novo organ regeneration...
  44. pmc Adipose tissue-derived mesenchymal stem cells in long-term dialysis patients display downregulation of PCAF expression and poor angiogenesis activation
    Shuichiro Yamanaka
    Division of Regenerative Medicine, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 9:e102311. 2014
    ..Furthermore, PCAF, HIF-1α, and VEGF expression were not upregulated by hypoxic stimulation of KD-MSCs. These results suggest that the hypoxic response may be blunted in MSCs from ESKD patients. ..
  45. doi request reprint Plasma cell-rich rejection accompanied by acute antibody-mediated rejection in a patient with ABO-incompatible kidney transplantation
    Maiko Furuya
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Nephrology (Carlton) 19:31-4. 2014
    ..We also include a review of the related literature. ..
  46. doi request reprint Acute vascular rejection during antituberculosis therapy in a kidney transplant patient
    Yasuyuki Nakada
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Nephrology (Carlton) 19:27-30. 2014
    ..7 mg/dL on April 1 2013). The present case report demonstrates the difficulties associated with management of TAC-based regimens in kidney transplant patients undergoing antituberculosis therapy. We also review the relevant literature. ..
  47. doi request reprint Intra-arterial catheter system to repeatedly deliver mesenchymal stem cells in a rat renal failure model
    Yuichi Katsuoka
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo, 105 8461, Japan
    Clin Exp Nephrol 20:169-77. 2016
    ....
  48. doi request reprint Subclinical antibody-mediated rejection due to anti-human-leukocyte-antigen-DR53 antibody accompanied by plasma cell-rich acute rejection in a patient with cadaveric kidney transplantation
    Ai Katsuma
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo
    Nephrology (Carlton) 21:31-4. 2016
    ....
  49. pmc Serum uric acid and the incidence of CKD and hypertension
    Satoru Kuriyama
    Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8, Nishi Shinbashi, Minato ku, Tokyo, 105 8461, Japan
    Clin Exp Nephrol 19:1127-34. 2015
    ..Uric acid (UA) levels correlate positively with the prevalence of chronic kidney disease (CKD) and/or hypertension. We tested the hypothesis that UA may also have a link to a new incidence of CKD and hypertension...
  50. doi request reprint Change in glomerular volume and its clinicopathological impact after kidney transplantation
    Akimitsu Kobayashi
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Nephrology (Carlton) 20:31-5. 2015
    ..Although the glomerular volume in baseline biopsies predicts late allograft function, the relationship between allograft function and the annual changes in glomerular volume after kidney transplantation are unclear...
  51. doi request reprint Renal histopathological findings in relation to ambulatory blood pressure in chronic kidney disease patients
    Kotaro Haruhara
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Hypertens Res 38:116-22. 2015
    ..These results suggest that interstitial fibrosis/tubular atrophy is the most relevant renal histopathological parameter associated with abnormalities in ambulatory blood pressure, including nocturnal hypertension, in this population...
  52. pmc De novo kidney regeneration with stem cells
    Shinya Yokote
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo 105 8461, Japan
    J Biomed Biotechnol 2012:453519. 2012
    ..In addition, we describe the hurdles that must be overcome and possible applications of this approach in kidney regeneration...
  53. ncbi request reprint [A case of acute kidney injury during warfarin therapy]
    Shinichiro Nishio
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Nihon Jinzo Gakkai Shi 55:966-71. 2013
    ..The present case, therefore, suggests that a warfarin overdose is a potential risk factor for acute kidney injury in the presence of coexisting glomerular injury...
  54. doi request reprint A case of idiopathic membranoproliferative glomerulonephritis with a transient glomerular deposition of nephritis-associated plasmin receptor antigen
    Masahiro Okabe
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo, 105 8461, Japan
    Clin Exp Nephrol 16:337-41. 2012
    ..Despite the use of a corticosteroid, hypocomplementemia persisted for more than 1 year. It was therefore suggested that a streptococcal infection may have influenced the development of glomerular injury in this idiopathic case of MPGN...
  55. doi request reprint Organogenesis for kidney regeneration
    Shinya Yokote
    Project Laboratory for Kidney Regeneration, Department of Internal Medicine, Institute of DNA Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Curr Opin Organ Transplant 18:186-90. 2013
    ....
  56. ncbi request reprint Diffuse tubulointerstitial nephritis accompanied by renal crystal formation in an HIV-infected patient undergoing highly active antiretroviral therapy
    Go Kanzaki
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Japan
    Intern Med 51:1543-8. 2012
    ..Therefore, the possibility of HARRT-induced nephrotoxicity should be considered in HIV-infected patients, even though the activity of HIV is controlled by such therapies...
  57. doi request reprint Fluctuation in Serum Sodium Levels Related to Ipragliflozin Administration in a Patient with Diabetic Nephropathy and Sequela of Traumatic Brain Injury
    Hideo Okonogi
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Japan
    Intern Med 55:1887-91. 2016
    ..NaCl and fludrocortisone were initiated again, and the laboratory data improved. We herein report a case of serum sodium fluctuation related to ipragliflozin administration. ..
  58. pmc Associations among serum trimethylamine-N-oxide (TMAO) levels, kidney function and infarcted coronary artery number in patients undergoing cardiovascular surgery: a cross-sectional study
    Aki Mafune
    Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan
    Clin Exp Nephrol 20:731-739. 2016
    ..We aimed to clarify whether TMAO levels are associated with the number of infarcted coronary arteries as a measure of the severity of atherosclerosis, with adjustment using a priori-defined covariates such as kidney function...
  59. doi request reprint Hypermethylation of the CaSR and VDR genes in the parathyroid glands in chronic kidney disease rats with high-phosphate diet
    Taketo Uchiyama
    Department of Anatomy, The Jikei University School of Medicine, Tokyo, Japan
    Hum Cell 29:155-61. 2016
    ..Consequently, our data suggest that mechanisms, other than DNA hypermethylation, were responsible for the reduction in mRNA and protein levels of CaSR and VDR in PTGs of CKD HP rats. ..
  60. doi request reprint Factors associated with a vicious cycle involving a low nephron number, hypertension and chronic kidney disease
    Go Kanzaki
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Hypertens Res 38:633-41. 2015
    ..Such a vicious cycle may induce HTN and/or CKD via the common mechanisms of renal hemodynamic maladaptation. ..
  61. pmc The Different Association between Serum Ferritin and Mortality in Hemodialysis and Peritoneal Dialysis Patients Using Japanese Nationwide Dialysis Registry
    Yukio Maruyama
    Division of Nephrology and Hypertension, Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 10:e0143430. 2015
    ..However, associations between serum ferritin and mortality are unclear and there have been no investigations among patients undergoing peritoneal dialysis (PD)...
  62. pmc The role of a low glomerular density and being overweight in the etiology of proteinuria in CKD patients without known glomerular diseases
    Hidekazu Okamoto
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo, 105 8461, Japan
    Clin Exp Nephrol 18:911-7. 2014
    ..The pathogenesis and pathophysiology of these CKD patients have not been sufficiently elucidated...
  63. pmc Unilateral ureteral obstruction attenuates intrarenal angiotensin II generation induced by podocyte injury
    Masahiro Okabe
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan
    Am J Physiol Renal Physiol 308:F932-7. 2015
    ..Thus, our study indicates that the major source of increased renal ANG II in podocyte injury is filtered angiotensinogen. ..
  64. doi request reprint Diffuse tubulointerstitial nephritis associated with ANCA-negative pauci-immune glomerulonephritis
    Go Kanzaki
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Clin Exp Nephrol 16:480-4. 2012
    ..No disorders known to be associated with TIN were detected. The pathogenesis involved in this unusual presentation of a concomitant occurrence of TIN and pauci-immune GN is currently unclear...
  65. ncbi request reprint Inhibition of endogenous BMP in the glomerulus leads to mesangial matrix expansion
    Yoichi Miyazaki
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 340:681-8. 2006
    ..This phenotype is similar to the fibronectin nephropathy. These results suggest that endogenous BMP can have an important role in regulating glomerular structural homeostasis...
  66. ncbi request reprint [Novel approaches for therapeutic kidney regeneration]
    Takashi Yokoo
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University, School of Medicine
    Nihon Rinsho 65:1529-37. 2007
    ....
  67. ncbi request reprint In vitro and pathological investigations of MODY5 with the R276X-HNF1beta (TCF2) mutation
    Kei Fujimoto
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Endocr J 54:757-64. 2007
    ..Analysis with light and electron microscopy on biopsied kidney specimens suggested that the origin of the cysts might be glomeruli but the primary lesion could be tubules...
  68. doi request reprint A case of slowly progressive scleroderma kidney
    Masahiro Okabe
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3 25 8 Nishi shimbashi, Minato ku, Tokyo 105 8461, Japan
    Clin Exp Nephrol 15:430-3. 2011
    ..Unlike typical SRC, however, the larger renal arteries seemed to be unaffected. These histological findings were probably responsible for the "slowly progressive" renal impairment over the years without causing typical SRC...
  69. pmc Proton Pump Inhibitor Use and Magnesium Concentrations in Hemodialysis Patients: A Cross-Sectional Study
    Akio Nakashima
    Division of Nephrology and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 10:e0143656. 2015
    ..05; 95% CI: 1.14-3.69; P = 0.017). PPI use is associated with an increased risk of hypomagnesemia in hemodialysis patients. Future prospective studies are needed to explore magnesium replacement in PPI users on hemodialysis. ..
  70. pmc Generation of a felinized swine endothelial cell line by expression of feline decay-accelerating factor
    Luna Izuhara
    Division of Regenerative Medicine, The Jikei University School of Medicine, Tokyo, Japan
    PLoS ONE 10:e0117682. 2015
    ..Our results suggest that a "felinized" pig kidney can be generated for the treatment of CKD in cats in the future. ..
  71. pmc Dialysate temperature adjustment as an effective treatment for baroreflex failure syndrome in hemodialysis patient
    Natsumi Tanabe
    Jikei University Hospital, 3 25 8, Nishishimbashi, Minato ku, Tokyo 105 0003, Japan
    BMC Nephrol 15:151. 2014
    ..We experienced a case of hemodialysis patient who had difficulty in controlling blood pressure during dialysis because of his baroreflex failure syndrome and successfully controlled his blood pressure by adjusting dialysate temperature...
  72. doi request reprint Monitoring of body water composition by the simultaneous use of bioelectrical impedance analysis and Crit-Line(®) during hemodialysis
    Naoki Sugano
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo, 105 8461, Japan
    Clin Exp Nephrol 18:944-51. 2014
    ..Crit-Line(®) (CL), on the other hand, assesses intravascular water (IVW) volume. We evaluate continuous changes in body water composition during hemodialysis (HD) with concurrent use of BIA and CL...
  73. ncbi request reprint Inflamed site-specific delivery of bone marrow-derived cells carrying IL-1Ra
    Takashi Yokoo
    Division of Nephrology and Hypertension, Department of Internal Medicine, Institute of DNA Medicine, Jikei University School of Medicine, 3 25 8, Nishi Shimbashi, Minato ku, Tokyo, 105 8461 Japan
    Nephrol Dial Transplant 17:91-3. 2002
    ..These data suggested that our novel system may be used as a therapeutic intervention for glomerulonephritis...
  74. doi request reprint Effect of aliskiren in chronic kidney disease patients with refractory hypertension undergoing hemodialysis: a randomized controlled multicenter study
    Satoru Kuriyama
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo, 105 8461, Japan
    Clin Exp Nephrol 18:821-30. 2014
    ..The purpose of this study was to evaluate the effect of the DRI, aliskiren, in patients with therapy-resistant hypertension undergoing hemodialysis (HD)...
  75. pmc A multicenter randomized controlled trial of tonsillectomy combined with steroid pulse therapy in patients with immunoglobulin A nephropathy
    Tetsuya Kawamura
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Nephrol Dial Transplant 29:1546-53. 2014
    ..The study aim was, for the first time, to conduct a multicenter randomized controlled trial to evaluate the effect of tonsillectomy in patients with IgA nephropathy (IgAN)...
  76. doi request reprint Comparison of multipotency and molecular profile of MSCs between CKD and healthy rats
    Akifumi Yamada
    Project Laboratory for Kidney Regeneration, Institute of DNA Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Hum Cell 27:59-67. 2014
    ..However, long-term exposure to uremic toxin and the differences in gene expression of MSCs derived from bone marrow or adipose tissue may affect renal regeneration. ..
  77. doi request reprint A higher serum alkaline phosphatase is associated with the incidence of hip fracture and mortality among patients receiving hemodialysis in Japan
    Yukio Maruyama
    Division of Nephrology and Hypertension, The Jikei University School of Medicine, Tokyo, Japan
    Nephrol Dial Transplant 29:1532-8. 2014
    ..However, unlike calcium, phosphate or parathyroid hormone, the relationship between serum ALP and patient outcome receiving hemodialysis (HD) in Japan is unknown...
  78. ncbi request reprint Mechanistic view of renal protective action of calcium channel blockade
    Naoki Sugano
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3 19 18 Nishi shinbashi, Minato ku, Tokyo 105 8471, Japan
    Curr Hypertens Rev 9:187-92. 2013
    ..It requires more extensive studies to clarify whether the ostensibly beneficial actions of these calcium channel blockers are available in a clinical setting. ..
  79. pmc Keap1 inhibition attenuates glomerulosclerosis
    Yoichi Miyazaki
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
    Nephrol Dial Transplant 29:783-91. 2014
    ..Podocyte injury triggers the progressive deterioration of glomerular damage toward glomerulosclerosis. We examined whether modulation of the Keap1-Nrf2 system has an impact on this process...
  80. doi request reprint A case of BK virus nephropathy and cytomegalovirus infection concurrent with plasma cell-rich acute rejection
    Aki Mafune
    Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Clin Transplant 26:49-53. 2012
    ..However, in this report, we describe the successful management of BKN and cytomegalovirus infection concurrent with plasma cell-rich acute rejection...
  81. pmc Successful treatment of adult IgA nephropathy with nephrotic-level proteinuria by combination therapy including long-term coadministration of mizoribine
    Hideo Okonogi
    Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Sendai, Japan
    Case Rep Nephrol Urol 2:53-8. 2012
    ..In this report, we describe the pathological findings and successful treatment course, and discuss the potential effects of long-term coadministration of mizoribine for adult IgAN treatment...
  82. doi request reprint Kidney regeneration using developing xenoembryo
    Akira Fukui
    Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan
    Curr Opin Organ Transplant 20:160-4. 2015
    ..The principle of the methodology, recent advances, and limitations and challenges associated with kidney regeneration are outlined...
  83. pmc Homozygous deletions of UGT2B17 modifies effects of smoking on TP53-mutations and relapse of head and neck carcinoma
    Aki Mafune
    Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo, Japan
    BMC Cancer 15:205. 2015
    ..Thus, we examined Japanese patients with HNSCC to explore if UGT2B17-deletion and/or p16 (+) modify effects of smoking on TP53-mutations and affect relapse...
  84. doi request reprint Relationship between renal function and the risk of recurrent atrial fibrillation following catheter ablation
    Michifumi Tokuda
    Department of Cardiology, Jikei University School of Medicine, 3 25 8, Nishi Shinbashi, Minato ku, Tokyo 105 8461, Japan
    Heart 97:137-42. 2011
    ..Although several clinical variables are associated with the recurrence of atrial fibrillation (AF) following catheter ablation, the influence of renal function remains to be determined...
  85. ncbi request reprint Enhanced erythropoiesis mediated by activation of the renin-angiotensin system via angiotensin II type 1a receptor
    Hideki Kato
    Center for Tsukuba Advanced Research Alliance TARA, University of Tsukuba, Tsukuba, Ibaraki, Japan
    FASEB J 19:2023-5. 2005
    ..These results provide clear genetic evidence that activated RAS enhances erythropoiesis through the AT1a receptor of kidney cells and that this effect is mediated by the elevation of plasma erythropoietin levels in vivo...
  86. ncbi request reprint [Regenerative medicine for kidney: Bone marrow stem cell transplantation for glomerulonephritis]
    Takashi Yokoo
    Nihon Naika Gakkai Zasshi 92:149-54. 2003