Hiroyuki Kohno

Summary

Affiliation: Kanazawa Medical University
Country: Japan

Publications

  1. ncbi request reprint Modifying effect of tuna orbital oil rich in docosahexaenoic acid and vitamin D3 on azoxymethane-induced colonic aberrant crypt foci in rats
    H Kohno
    Department of Serology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Oncol Rep 7:1069-74. 2000
  2. pmc Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    BMC Cancer 5:46. 2005
  3. ncbi request reprint Dietary supplementation with silymarin inhibits 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 rats
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
    Clin Cancer Res 11:4962-7. 2005
  4. ncbi request reprint Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats
    Hiroyuki Kohno
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Cancer Sci 95:481-6. 2004
  5. ncbi request reprint Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPARgamma expression and alteration of lipid composition
    Hiroyuki Kohno
    First Departments of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Int J Cancer 110:896-901. 2004
  6. ncbi request reprint Lack of modifying effects of 4-ter t-octylphenol and benzyl butyl phthalate on 3,2-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in rats
    Hiroyuki Kohno
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Cancer Sci 95:300-5. 2004
  7. ncbi request reprint Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Cancer Sci 96:69-76. 2005
  8. ncbi request reprint Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 118:2936-42. 2006
  9. ncbi request reprint A specific inducible nitric oxide synthase inhibitor, ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 121:506-13. 2007
  10. ncbi request reprint Tumor-initiating potency of a novel heterocyclic amine, aminophenylnorharman in mouse colonic carcinogenesis model
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Int J Cancer 121:1659-64. 2007

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Modifying effect of tuna orbital oil rich in docosahexaenoic acid and vitamin D3 on azoxymethane-induced colonic aberrant crypt foci in rats
    H Kohno
    Department of Serology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Oncol Rep 7:1069-74. 2000
    ....
  2. pmc Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    BMC Cancer 5:46. 2005
    ....
  3. ncbi request reprint Dietary supplementation with silymarin inhibits 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 rats
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
    Clin Cancer Res 11:4962-7. 2005
    ..Here, we investigated the modifying effects of dietary feeding with a naturally occurring polyphenolic antioxidant flavonoid silymarin on 3,2'-dimethyl-4-aminobiphenyl (DMAB)-induced prostatic carcinogenesis in male F344 rats...
  4. ncbi request reprint Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats
    Hiroyuki Kohno
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Cancer Sci 95:481-6. 2004
    ....
  5. ncbi request reprint Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPARgamma expression and alteration of lipid composition
    Hiroyuki Kohno
    First Departments of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Int J Cancer 110:896-901. 2004
    ....
  6. ncbi request reprint Lack of modifying effects of 4-ter t-octylphenol and benzyl butyl phthalate on 3,2-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in rats
    Hiroyuki Kohno
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Cancer Sci 95:300-5. 2004
    ..These results might suggest that dietary feeding of the estrogenic compounds tOP and BBP did not modulate DMAB-induced prostatic carcinogenesis in rats...
  7. ncbi request reprint Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Cancer Sci 96:69-76. 2005
    ....
  8. ncbi request reprint Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 118:2936-42. 2006
    ..Our findings may suggest that certain prenyloxycoumarins, such as auraptene and collinin, could serve as an effective agent against colitis-related colon cancer development in rodents...
  9. ncbi request reprint A specific inducible nitric oxide synthase inhibitor, ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 121:506-13. 2007
    ..Our findings may suggest that ONO-1714 could therefore serve as an effective agent for suppression of colitis-related colon cancer development in the Apc(Min/+) mice...
  10. ncbi request reprint Tumor-initiating potency of a novel heterocyclic amine, aminophenylnorharman in mouse colonic carcinogenesis model
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Int J Cancer 121:1659-64. 2007
    ..These findings indicate that APNH has an initiating activity in inflamed mouse colon and the APNH-DNA adduct formation correlates with its tumorigenic potential...
  11. ncbi request reprint Dietary conjugated linolenic acid inhibits azoxymethane-induced colonic aberrant crypt foci in rats
    Hiroyuki Kohno
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Jpn J Cancer Res 93:133-42. 2002
    ..These findings might suggest possible chemopreventive activity of CLN in the early phase of colon tumorigenesis through modulation of cryptal cell proliferation activity and/or apoptosis...
  12. ncbi request reprint Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
    Clin Cancer Res 13:2519-25. 2007
    ..Inflammation influences carcinogenesis. In the current study, we investigated whether ursodeoxycholic acid (UDCA) can inhibit colitis-related mouse colon carcinogenesis and compared it with the effects of sulfasalazine...
  13. ncbi request reprint A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate
    Takuji Tanaka
    The First Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293
    Cancer Sci 94:965-73. 2003
    ....
  14. ncbi request reprint 9trans,11trans conjugated linoleic acid inhibits the development of azoxymethane-induced colonic aberrant crypt foci in rats
    Yumiko Yasui
    Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
    Nutr Cancer 59:82-91. 2007
    ..Our findings thus provide some novel insight into the chemopreventive effect of 9t,11t-CLA against preinitiation as well as postinitiation stages of colorectal carcinogenesis...
  15. ncbi request reprint Catalpa seed oil rich in 9t,11t,13c-conjugated linolenic acid suppresses the development of colonic aberrant crypt foci induced by azoxymethane in rats
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Oncol Rep 16:989-96. 2006
    ..These findings suggest the possible chemopreventive activity of CPO in the early phase of colon carcinogenesis...
  16. ncbi request reprint Diet supplemented with citrus unshiu segment membrane suppresses chemically induced colonic preneoplastic lesions and fatty liver in male db/db mice
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
    Int J Cancer 120:252-8. 2007
    ....
  17. ncbi request reprint Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cycloox
    Takuji Tanaka
    The Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Carcinogenesis 26:229-38. 2005
    ..The findings suggest that DSS exerts powerful tumor-promoting effects on PhIP-initiated colon carcinogenesis in mice and this mouse model is useful for investigating environment-related colon carcinogenesis within a short-term period...
  18. ncbi request reprint Preventive effects of extract of leaves of ginkgo (Ginkgo biloba) and its component bilobalide on azoxymethane-induced colonic aberrant crypt foci in rats
    Rikako Suzuki
    The First Department of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Cancer Lett 210:159-69. 2004
    ..These findings might suggest possible chemopreventive ability of EGb or bilobalide, through alterations in cryptal cell proliferation activity and drug metabolizing enzymes' activities, in colon tumorigenesis...
  19. ncbi request reprint Citrus auraptene suppresses azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db mice
    Kei Hayashi
    Department of Surgical Oncology, Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Oshikawaa 020 0903, Japan
    Nutr Cancer 58:75-84. 2007
    ....
  20. ncbi request reprint Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats
    Hiroyuki Kohno
    First Department of Pathology, Kanazawa Medical University, Ishikawa, Japan
    Int J Cancer 101:461-8. 2002
    ....
  21. ncbi request reprint A lipophilic statin, pitavastatin, suppresses inflammation-associated mouse colon carcinogenesis
    Yumiko Yasui
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 121:2331-9. 2007
    ..Our findings thus show that pitavastatin is effective in inhibiting colitis-related colon carcinogenesis through modulation of mucosal inflammation, oxidative/nitrosative stress, and cell proliferation...
  22. ncbi request reprint A novel geranylated derivative, ethyl 3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate, synthesized from ferulic acid suppresses carcinogenesis and inducible nitric oxide synthase in rat tongue
    Takuji Tanaka
    Department of Pathology, Kanazawa Medical University, Ishikawa, Japan
    Oncology 64:166-75. 2003
    ....
  23. ncbi request reprint Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc(Min/+) mice: inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms
    Takuji Tanaka
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 118:25-34. 2006
    ..The findings also suggest that strong oxidative/nitrosative stress caused by DSS-induced inflammation may contribute to the colonic neoplasms development...
  24. ncbi request reprint Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Carcinogenesis 27:162-9. 2006
    ..These differences may have been directly influenced by the response to nitrosation stress due to the inflammation caused by DSS...
  25. ncbi request reprint Dietary beta-cryptoxanthin inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice
    Katsuhito Miyazawa
    Department of Urogenital Surgery, Kanazawa Medical University, Ishikawa 920 0293, Japan
    Oncol Rep 17:297-304. 2007
    ..These findings suggest that beta-cryptoxanthin is able to prevent OH-BBN-induced bladder carcinogenesis in mice...
  26. ncbi request reprint An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Carcinogenesis 27:619-30. 2006
    ....
  27. ncbi request reprint Suppressive effect of 1,4-phenylene diisothiocyanate on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice
    Shigeyuki Sugie
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 117:524-30. 2005
    ..These results suggest that dietary DITC could be a preventive agent against BBN-induced bladder carcinogenesis in mice when fed during the initiation phase...
  28. ncbi request reprint Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats
    Rikako Suzuki
    The First Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Biofactors 22:111-4. 2004
    ..These findings might suggest that citrus nobiletin has chemopreventive ability against AOM-induced rat colon carcinogenesis...
  29. ncbi request reprint Aqueous and ethanolic extract fractions from the Brazilian propolis suppress azoxymethane-induced aberrant crypt foci in rats
    Yumiko Yasui
    Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
    Oncol Rep 20:493-9. 2008
    ..Our findings suggest that AEP and EEP possess a chemopreventive ability in the early phase of colon carcinogenesis through the modulation of cell proliferation...
  30. ncbi request reprint Lack of modifying effects of 4-n-octylphenol on 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in rats
    Hiroyuki Kohno
    Department of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Ecotoxicol Environ Saf 51:210-5. 2002
    ..These results might suggest that dietary feeding of the weak estrogenic compound 4-n-octylphenol did not have modulating effects on DMAB-induced rat prostatic carcinogenesis...
  31. ncbi request reprint Dietary protocatechuic acid during the progression phase exerts chemopreventive effects on chemically induced rat tongue carcinogenesis
    Rikako Suzuki
    The First Departments of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Asian Pac J Cancer Prev 4:319-26. 2003
    ..001) during progression phase. Our results suggest that dietary PCA inhibits progression of 4-NQO-induced oral carcinogenesis, and such inhibition might be related to suppression of cell proliferation by PCA...
  32. ncbi request reprint Effect of alpha-naphthyl isothiocyanate on 2-amino-3-methylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in rats
    Shigeyuki Sugie
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 115:346-50. 2005
    ..These results imply that the isothiocyanate compound ANIT shows potent inhibitory effects on mammary carcinogenesis induced by PhIP in female SD rats when administered during the initiation stage...
  33. ncbi request reprint Inhibitory effects of estrogenic compounds, 4-nonylphenol and genistein, on 7,12-dimethylbenz[a]anthracene-induced ovarian carcinogenesis in rats
    Takuji Tanaka
    The First Department of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Ecotoxicol Environ Saf 52:38-45. 2002
    ..These results might suggest that dietary feeding of estrogenic compounds either synthetic (4-NP) or natural (GS) could act as an inhibitor of DMBA-induced rat ovarian carcinogenesis...
  34. ncbi request reprint A bitter diterpenoid furanolactone columbin from Calumbae Radix inhibits azoxymethane-induced rat colon carcinogenesis
    Hiroyuki Kohno
    Department of Pathology, Kanazawa Medical University, Uchinada, 920 0293, Ishikawa, Japan
    Cancer Lett 183:131-9. 2002
    ....
  35. ncbi request reprint Modifying effects of dietary capsaicin and rotenone on 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis
    Takuji Tanaka
    Department of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Carcinogenesis 23:1361-7. 2002
    ..Neurosci., 3, 1301-1306, 2000), suggesting that additional studies to confirm the safety of rotenone are warranted...
  36. ncbi request reprint Lack of modifying effects of an estrogenic compound atrazine on 7,12-dimethylbenz(a)anthracene-induced ovarian carcinogenesis in rats
    Takuji Tanaka
    The First Department of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Cancer Lett 210:129-37. 2004
    ..These results might suggest dietary feeding of a EDC atrazine did not affect DMBA-induced rat ovarian carcinogenesis...
  37. ncbi request reprint Preventive effects of chrysin on the development of azoxymethane-induced colonic aberrant crypt foci in rats
    Shingo Miyamoto
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Oncol Rep 15:1169-73. 2006
    ..These findings might suggest a possible chemopreventive activity of chrysin in the early step of colon tumorigenesis through modulation of cryptal cell proliferation activity and apoptosis...
  38. ncbi request reprint Chemoprevention of Colon Carcinogenesis by Dietary Non-nutritive Compounds
    Takuji Tanaka
    First Department of Pathology, Kanazawa Medical University, Ishikawa 920 0293, Japan
    Asian Pac J Cancer Prev 2:165-177. 2001
    ..This article will introduce our recent studies in our search for chemopreventive effects of flavonoids (diosmin and hesperidin) and other phytochemicals in edible plants on rat colon carcinogenesis...
  39. ncbi request reprint Sequential observations on the occurrence of preneoplastic and neoplastic lesions in mouse colon treated with azoxymethane and dextran sodium sulfate
    Rikako Suzuki
    Research Fellow of the Japan Society for the Promotion of Science, Chiyoda ku, Tokyo 102 8471, Japan
    Cancer Sci 95:721-7. 2004
    ..Our results suggest that combined treatment of mice with AOM and DSS generates neoplasms in the colonic mucosa via dysplastic lesions induced by nitrosative stress...
  40. ncbi request reprint Mild inflammation accelerates colon carcinogenesis in Mlh1-deficient mice
    Kazuki Taniguchi
    Surgical Oncology, Tokyo Medical and Dental University, Tokyo, Japan
    Oncology 71:124-30. 2006
    ..The interaction between inflammation and mismatch repair deficiency, however, remains unclear. The aim of this study was to determine the effect of inflammation on colorectal carcinogenesis in Mlh1-deficient mice...
  41. ncbi request reprint Dihydrochalcones: evaluation as novel radical scavenging antioxidants
    Yoshimasa Nakamura
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Agric Food Chem 51:3309-12. 2003
    ..A hydroxyl group at the 2'-position of the dihydrochalcone A ring, newly formed by reduction of the flavanone C ring, is an essential pharmacophore for its radical scavenging potential...
  42. ncbi request reprint Inhibitory effects of troglitazone, a peroxisome proliferator-activated receptor gamma ligand, in rat tongue carcinogenesis initiated with 4-nitroquinoline 1-oxide
    Koujiro Yoshida
    Department of Tumor Pathology, Gifu University School of Medicine, Gifu 500 8705, Japan
    Cancer Sci 94:365-71. 2003
    ..This study warrants further investigation on the use of PPAR gamma ligands as a novel preventive approach for oral malignancy...
  43. ncbi request reprint Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARgamma ligand, troglitazone, on colon cancer cells
    Masashi Hosokawa
    Graduate School of Fisheries Sciences, Hokkaido University, 3 1 1 Minato, Hakodate, Hakodate, Hokkaido 041 8611, Japan
    Biochim Biophys Acta 1675:113-9. 2004
    ..These findings indicate that fucoxanthin may act as a chemopreventive and/or chemotherapeutic carotenoid in colon cancer cells by modulating cell viability in combination with troglitazone...
  44. ncbi request reprint Dietary silymarin suppresses 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats
    Yoshitame Yanaida
    Department of Laboratory Sciences, School of Health Sciences, Faculty of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa 920 0942, Japan
    Carcinogenesis 23:787-94. 2002
    ..p.m.) during the promotion phase of 4-NQO-induced rat tumorigenesis exerts chemopreventive ability against tongue squamous cell carcinoma through modification of phase II enzymes activity, cell proliferation, and/or PGE(2) content...
  45. ncbi request reprint Dietary garcinol inhibits 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats
    Koujiro Yoshida
    Department of Oral and Maxillofacial Surgery, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu 500 8705, Japan
    Cancer Lett 221:29-39. 2005
    ....
  46. ncbi request reprint Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARgamma in human colon cancer Caco-2 cells
    Yumiko Yasui
    Graduate School of Fisheries Sciences, Hokkaido University, 3 1 1 Minato, Hakodate, Hokkaido 041 8611, Japan
    Prostaglandins Leukot Essent Fatty Acids 73:113-9. 2005
    ..These results suggest that BGO-FFA rich in 9c,11t,13t-CLN may induce apoptosis in Caco-2 cells through up-regulation of GADD45, p53 and PPARgamma...
  47. ncbi request reprint Lack of enhancing effects of degraded lambda-carrageenan on the development of beta-catenin-accumulated crypts in male DBA/2J mice initiated with azoxymethane
    Kazuya Hata
    BMR Laboratories, Sunplanet Co, Ltd, 4388 Hagiwara, Kamiishidu, Yoro gun, Gifu 503 1602, Japan
    Cancer Lett 238:69-75. 2006
    ..Our results may indicate no enhancing or promoting effects of degraded lambda-carrageenan on colon carcinogenesis in mice initiated with AOM...
  48. ncbi request reprint An acyclic retinoid, NIK-333, inhibits N-diethylnitrosamine-induced rat hepatocarcinogenesis through suppression of TGF-alpha expression and cell proliferation
    Masataka Kagawa
    Pharmaceutical Research Laboratories, Nikken Chemicals Co Ltd, 1 346 Kitabukuro cho, Omiya ku, Saitama shi, Saitama 330 0835, Japan
    Carcinogenesis 25:979-85. 2004
    ..01). Our results suggest that NIK-333 inhibits DEN-induced hepatocarcinogenesis through suppression of TGF-alpha expression and cell proliferation...
  49. ncbi request reprint Extract of Kurosu, a vinegar from unpolished rice, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats
    Yumi Shimoji
    Research Center, Tamanoi Vinegar, CO, Ltd, Nara, Japan
    Nutr Cancer 49:170-3. 2004
    ..05), compared with those in the AOM alone group. These findings suggest that EK may be effective for inhibiting colon carcinogenesis...
  50. ncbi request reprint beta-Catenin-accumulated crypts in the colonic mucosa of juvenile ApcMin/+ mice
    Kazuya Hata
    BMR Laboratories, Sunplanet Co, Ltd, 4388 Hagiwara, Kamiishidu, Yourou, Gifu 503 1602, Japan
    Cancer Lett 239:123-8. 2006
    ..Also, a few microadenomas were detected in Apc(Min/+) mice of 5-week old. Our results may indicate need of further investigation of the colorectal mucosa of Apc(Min/+) mice for examining colorectal carcinogenesis using Apc(Min/+) mice...
  51. ncbi request reprint Prevention of rat hepatocarcinogenesis by acyclic retinoid is accompanied by reduction in emergence of both TGF-alpha-expressing oval-like cells and activated hepatic stellate cells
    Tetsuro Sano
    Pharmaceutical Research Laboratories, Nikken Chemicals Co, Saitama, Japan
    Nutr Cancer 51:197-206. 2005
    ..These results suggest that NIK-333 is a promising drug for the chemoprevention of HCC by uniquely suppressing the early events of hepatocarcinogenesis, that is, development of both oval-like cells and fibrogenesis...
  52. ncbi request reprint Indole-3-carbinol inhibits the growth of human colon carcinoma cells but enhances the tumor multiplicity and volume of azoxymethane-induced rat colon carcinogenesis
    Masumi Suzui
    Tumor Pathology Division, Faculty of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    Int J Oncol 27:1391-9. 2005
    ..Therefore, the present study may provide further evidence for the ambivalent modulatory activity of I3C and this information may be useful when including I3C in cancer chemoprevention and/or extensive clinical therapy trials...
  53. ncbi request reprint Differences between right- and left-sided colon cancer in patient characteristics, cancer morphology and histology
    Toru Nawa
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Gastroenterol Hepatol 23:418-23. 2008
    ..Recently, the clinical and biological differences between right- and left-sided colon cancers have been widely debated. However, close analyses of these clinical differences, based on large-scale studies, have been scarcely reported...
  54. ncbi request reprint Mechanism of inhibition of small intestinal motility by restraint stress differs from that with norepinephrine treatment in rats
    Fumitake Tsukada
    Department of Radiopharmacy, Tohoku Pharmaceutical University, Sendai, Japan
    Biol Pharm Bull 25:122-4. 2002
    ..Considering these results, it is reasonable to assume that the mechanisms of inhibition of small intestinal motility due to restraint stress and norepinephrine treatment are different...
  55. ncbi request reprint Growth inhibition and apoptosis induction by all-trans-conjugated linolenic acids on human colon cancer cells
    Yumiko Yasui
    Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041 8611, Japan
    Anticancer Res 26:1855-60. 2006
    ..These results suggest that beta-eleostearic and beta-calendic acids have signaling pathways different from those of alpha-eleostearic and alpha-calendic acids and exhibit high potency for reducing the cell viability of Caco-2...
  56. ncbi request reprint Effects of polyamines on histone polymerization
    Naoko Sato
    Department of Radiopharmacy, Tohoku Pharmaceutical University, Sendai, Miyagi, Japan
    J Protein Chem 22:303-7. 2003
    ..Also, we propose that histone cross-linking by TGase may be responsible for the changes in DNA function such as transcription and replication and that TGase may be involved in cell growth and differentiation...
  57. ncbi request reprint Docosahexaenoic acid-containing phosphatidylethanolamine enhances HL-60 cell differentiation by regulation of c-jun and c-myc expression
    Hideki Ishigamori
    Graduate School of Fisheries Sciences, Hokkaido University, Hokkaido, Japan
    Mol Cell Biochem 275:127-33. 2005
    ..Thus, 18:1/DHA-PE might enhance dbcAMP-induced HL-60 cell differentiation and growth inhibition by regulation of c-jun and c-myc mRNA and their products...
  58. ncbi request reprint Inhibitory and promotive effects of polyamines on transglutaminase-induced protein polymerization
    Naoko Sato
    Department of Radiopharmacy, Tohoku Pharmaceutical University, 4 4 1, Komatsushima, Aoba ku, Sendai, Miyagi 981 8558, Japan
    Protein Pept Lett 10:396-403. 2003
    ..On the other hand, polymerization of N,N-dimethylcasein was increased by spermine (SPM) and SPD. These results suggested polyamines played two distinct roles as inhibitor and promoter for TGase-catalyzed protein polymerization...
  59. ncbi request reprint Stool decay-accelerating factor as a marker for monitoring the disease activity during leukocyte apheresis therapy in patients with refractory ulcerative colitis
    Hiroyuki Kohno
    Department of Medicine and Medical Science Medicine 1, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Gastroenterol Hepatol 20:73-8. 2005
    ..In the present study, we evaluated the usefulness of stool DAF as a marker for monitoring disease activity in patients with steroid-resistant active UC being treated with leukocyte apheresis performed with a centrifugal cell separator...
  60. ncbi request reprint Potent inhibitory effect of trans9, trans11 isomer of conjugated linoleic acid on the growth of human colon cancer cells
    Fumiaki Beppu
    Laboratory of Biofunctional Material Chemistry, Division of Marine Bioscience, Graduate School of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041 8611, Japan
    J Nutr Biochem 17:830-6. 2006
    ..These results suggest that decreased expression of Bcl-2 by t9t11-CLA might increase the sensitivity of cells to lipid peroxidation and to programmed cell death, apoptosis...