Atsushi Nohara

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. ncbi request reprint Cholesteryl ester transfer protein inhibitor (JTT-705) and the development of atherosclerosis in rabbits with severe hypercholesterolaemia
    Zhiping Huang
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8641, Japan
    Clin Sci (Lond) 103:587-94. 2002
  2. ncbi request reprint Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patients
    Hiroshi Mabuchi
    Dept of Internal Medicine and Molecular Genetics of Cardiovascular Disorders, Div of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Takara machi 13 1, Kanazawa, Ishikawa 920 8641, Japan
    J Atheroscler Thromb 12:111-9. 2005
  3. ncbi request reprint Retinoid X receptor heterodimer variants and cardiovascular risk factors
    Atsushi Nohara
    Departments of Lipidology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Atheroscler Thromb 16:303-18. 2009
  4. ncbi request reprint High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia
    Atsushi Nohara
    Department of Lipidology, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8641, Japan
    Arterioscler Thromb Vasc Biol 27:923-8. 2007
  5. doi request reprint Molecular genetic epidemiology of homozygous familial hypercholesterolemia in the Hokuriku district of Japan
    Hiroshi Mabuchi
    Department of Lipidology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Atherosclerosis 214:404-7. 2011
  6. doi request reprint A novel type of familial hypercholesterolemia: double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene
    Hayato Tada
    Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Atherosclerosis 219:663-6. 2011
  7. doi request reprint Comparison of effects of bezafibrate and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 and adipocytokine levels in dyslipidemic subjects with impaired glucose tolerance or type 2 diabetes mellitus: results from a crossover study
    Tohru Noguchi
    Department of Lipidology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    Atherosclerosis 217:165-70. 2011
  8. ncbi request reprint CETP (cholesteryl ester transfer protein) promoter -1337 C>T polymorphism protects against coronary atherosclerosis in Japanese patients with heterozygous familial hypercholesterolaemia
    Mutsuko Takata
    Molecular Genetics of Cardiovascular Disorders, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8641, Japan
    Clin Sci (Lond) 111:325-31. 2006
  9. doi request reprint Impact of bezafibrate and atorvastatin on lipoprotein subclass in patients with type III hyperlipoproteinemia: result from a crossover study
    Masa aki Kawashiri
    Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, and Department of Internal Medicine, KKR Hokuriku Hospital, Kanazawa, Japan
    Clin Chim Acta 412:1068-75. 2011
  10. doi request reprint Efficacy and safety of coadministration of rosuvastatin, ezetimibe, and colestimide in heterozygous familial hypercholesterolemia
    Masa aki Kawashiri
    Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, Kanazawa University, Kanazawa, Japan
    Am J Cardiol 109:364-9. 2012

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Cholesteryl ester transfer protein inhibitor (JTT-705) and the development of atherosclerosis in rabbits with severe hypercholesterolaemia
    Zhiping Huang
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8641, Japan
    Clin Sci (Lond) 103:587-94. 2002
    ....
  2. ncbi request reprint Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patients
    Hiroshi Mabuchi
    Dept of Internal Medicine and Molecular Genetics of Cardiovascular Disorders, Div of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Takara machi 13 1, Kanazawa, Ishikawa 920 8641, Japan
    J Atheroscler Thromb 12:111-9. 2005
    ..627, p = 0.0165). As atorvastatin reduces serum ubiquinol-10 as well as serum cholesterol levels in all patients, it is imperative that physicians are forewarned about the risks associated with ubiquinol-10 depletion...
  3. ncbi request reprint Retinoid X receptor heterodimer variants and cardiovascular risk factors
    Atsushi Nohara
    Departments of Lipidology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Atheroscler Thromb 16:303-18. 2009
    ....
  4. ncbi request reprint High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia
    Atsushi Nohara
    Department of Lipidology, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8641, Japan
    Arterioscler Thromb Vasc Biol 27:923-8. 2007
    ..Because several nuclear receptors play pivotal roles in lipid metabolism, we tested the hypothesis that genetic variants of nuclear receptors contribute to FCHL...
  5. doi request reprint Molecular genetic epidemiology of homozygous familial hypercholesterolemia in the Hokuriku district of Japan
    Hiroshi Mabuchi
    Department of Lipidology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Atherosclerosis 214:404-7. 2011
    ..e. LDL-receptor (LDLR), PCSK9 and apolipoprotein B (ApoB) gene. We evaluated the usefulness of DNA analysis for the diagnosis of homozygous FH (homo-FH), and studied the frequency of FH in the Hokuriku district of Japan...
  6. doi request reprint A novel type of familial hypercholesterolemia: double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene
    Hayato Tada
    Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Atherosclerosis 219:663-6. 2011
    ..Autosomal recessive hypercholesterolemia (ARH) is an extremely rare inherited hypercholesterolemia, the cause of which is mutations in low-density lipoprotein (LDL) receptor adaptor protein 1 (LDLRAP1) gene...
  7. doi request reprint Comparison of effects of bezafibrate and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 and adipocytokine levels in dyslipidemic subjects with impaired glucose tolerance or type 2 diabetes mellitus: results from a crossover study
    Tohru Noguchi
    Department of Lipidology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    Atherosclerosis 217:165-70. 2011
    ....
  8. ncbi request reprint CETP (cholesteryl ester transfer protein) promoter -1337 C>T polymorphism protects against coronary atherosclerosis in Japanese patients with heterozygous familial hypercholesterolaemia
    Mutsuko Takata
    Molecular Genetics of Cardiovascular Disorders, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8641, Japan
    Clin Sci (Lond) 111:325-31. 2006
    ..022; P=0.0256). These results indicate that the CETP promoter -1337C>T polymorphism is associated with the progression of coronary atherosclerosis in Japanese patients with FH, independent of HDL-C and triacylglycerol levels...
  9. doi request reprint Impact of bezafibrate and atorvastatin on lipoprotein subclass in patients with type III hyperlipoproteinemia: result from a crossover study
    Masa aki Kawashiri
    Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, and Department of Internal Medicine, KKR Hokuriku Hospital, Kanazawa, Japan
    Clin Chim Acta 412:1068-75. 2011
    ..We elucidated the difference between the effects of bezafibrate and atorvastatin in hypertriglyceridemia with apoE2/2 and 3/3...
  10. doi request reprint Efficacy and safety of coadministration of rosuvastatin, ezetimibe, and colestimide in heterozygous familial hypercholesterolemia
    Masa aki Kawashiri
    Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, Kanazawa University, Kanazawa, Japan
    Am J Cardiol 109:364-9. 2012
    ..In conclusion, adequate introduction of this aggressive cholesterol-lowering regimen can improve the lipid profile of FH...
  11. doi request reprint The E32K variant of PCSK9 exacerbates the phenotype of familial hypercholesterolaemia by increasing PCSK9 function and concentration in the circulation
    Tohru Noguchi
    Department of Lipidology, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8640, Japan
    Atherosclerosis 210:166-72. 2010
    ..We attempted to find gain-of-function PCSK9 mutations in Japanese subjects and determine the frequency and impacts of these mutations, especially on circulating PCSK9 and LDL-C levels...
  12. ncbi request reprint ATP-binding cassette transporter G8 M429V polymorphism as a novel genetic marker of higher cholesterol absorption in hypercholesterolaemic Japanese subjects
    Kenji Miwa
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiology, Graduate School of Medical Science, Kanazawa University, Japan
    Clin Sci (Lond) 109:183-8. 2005
    ..Future studies should investigate whether these findings have implications for the optimal cholesterol-lowering drug treatment in hypercholesterolaemic patients...
  13. doi request reprint Altered metabolism of low-density lipoprotein and very-low-density lipoprotein remnant in autosomal recessive hypercholesterolemia: results from stable isotope kinetic study in vivo
    Hayato Tada
    Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Circ Cardiovasc Genet 5:35-41. 2012
    ..However, few data exist regarding lipoprotein metabolism of ARH. Therefore, we aimed to clarify lipoprotein metabolism, especially the remnant lipoprotein fractions of ARH before and after statin therapy...
  14. ncbi request reprint The relationship of percent body fat by bioelectrical impedance analysis with blood pressure, and glucose and lipid parameters
    Junji Kobayashi
    Department of Lifestyle related Disease, Kanazawa University Graduate School of Medical Science, Takara machi 13 1, Kanazawa 920 8640, Japan
    J Atheroscler Thromb 13:221-6. 2006
    ..In both genders, BMI was the strongest determinant of serum HDL-C among age, PBF and BMI. Based on these data, we suggest that measuring PBF by BIA is superior to BMI for predicting TC, LDL-C and TG in Japanese men...
  15. doi request reprint Post-prandial remnant lipoprotein metabolism in autosomal recessive hypercholesterolaemia
    Hayato Tada
    Division of Cardiovascular Medicine Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Eur J Clin Invest 42:1094-9. 2012
    ..However, few data exist regarding the functional differences in ARH and FH particularly in terms of remnant-like particles' (RLP) metabolism...
  16. doi request reprint Novel mutations of cholesteryl ester transfer protein (CETP) gene in Japanese hyperalphalipoproteinemic subjects
    Rumiko Ohtani
    Department of Laboratory Sciences, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kodatsuno, Japan
    Clin Chim Acta 413:537-43. 2012
    ..The half of hyperalphalipoproteinemia (HALP) in Japan is caused by CETP gene mutations. Other than two prevalent mutations (D442G and Intron 14 splicing donor site +1G>A), some rare CETP mutations are found in Japanese HALP subjects...
  17. ncbi request reprint Long-term course of lipoprotein lipase (LPL) deficiency due to homozygous LPL(Arita) in a patient with recurrent pancreatitis, retained glucose tolerance, and atherosclerosis
    Masa aki Kawashiri
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Disease, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    J Clin Endocrinol Metab 90:6541-4. 2005
    ..Patients with LPL deficiency suffer from the frequent recurrence of acute pancreatitis, but the underlying mechanisms are not fully understood...
  18. doi request reprint Cholesterol efflux from J774 macrophages and Fu5AH hepatoma cells to serum is preserved in CETP-deficient patients
    Kenji Miwa
    Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Clin Chim Acta 402:19-24. 2009
    ..The role of CETP in the development of atherosclerosis is debatable, and few data exist regarding the total impact of CETP inhibition on cholesterol efflux...
  19. ncbi request reprint Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study
    Hiroshi Mabuchi
    Department of Lipidology, Kanazawa University Graduate School of Medical Science, Takara machi 13 1, Kanazawa 920 8641, Japan
    Atherosclerosis 195:e182-9. 2007
    ..These changes in plasma CoQ10 levels showed no relation to the changes in serum AST, ALT and CK levels. Further studies are needed, however, for the evaluation of CoQ10 supplementation in statin therapy...
  20. ncbi request reprint Marked aortic valve stenosis progression after receiving long-term aggressive cholesterol-lowering therapy using low-density lipoprotein apheresis in a patient with familial hypercholesterolemia
    Masayuki Tsuchida
    Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Circ J 73:963-6. 2009
    ..These findings suggest that careful attention to the progression of aortic valve stenosis is needed for extreme hypercholesterolemic patients even under optimal cholesterol-lowering therapy for the secondary prevention of CAD...
  21. ncbi request reprint Cholesterol-years score is associated with development of senile degenerative aortic stenosis in heterozygous familial hypercholesterolemia
    Tsuyoshi Nozue
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Japan
    J Atheroscler Thromb 13:323-8. 2006
    ..These results suggest that physicians should be aware that AS needs attention in older patients with heterozygous FH, especially women who have been diagnosed late in life and those who have been inadequately treated...
  22. doi request reprint Apolipoprotein B gene mutations and fatty liver in Japanese hypobetalipoproteinemia
    Shoji Katsuda
    Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University, 13 1Takara machi, Kanazawa, 920 8641 Japan
    Clin Chim Acta 399:64-8. 2009
    ..The objectives of this study were to identify apoB-defective FHBL subjects and investigate fatty liver in Japanese population...
  23. ncbi request reprint Type III hyperlipoproteinemia exaggerated by Sheehan's syndrome with advanced systemic atherosclerosis: a 28-year clinical course
    Masa aki Kawashiri
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Disease, Kanazawa, Japan
    Circ J 69:746-51. 2005
    ..These findings suggest that the continuous elevation of intermediate-density lipoprotein cholesterol for a long period contributed to the development of the atherosclerotic lesions...
  24. doi request reprint Genotypic and phenotypic features in homozygous familial hypercholesterolemia caused by proprotein convertase subtilisin/kexin type 9 (PCSK9) gain-of-function mutation
    Hiroshi Mabuchi
    Department of Lipidology, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8640, Japan Electronic address
    Atherosclerosis 236:54-61. 2014
    ..We evaluated the usefulness of FH gene analysis for diagnosing homozygous FH (homo-FH), particularly in cases caused by gain-of-function (g-o-f) mutations in PCSK9 (PCSK9 E32K)...
  25. ncbi request reprint Effects of fenofibrate therapy on plasma ubiquinol-10 and ubiquinone-10 levels in Japanese patients with hyperlipidemia and type 2 diabetes mellitus
    Akimichi Asano
    Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Pharmacotherapy 26:447-51. 2006
    ..To assess the effects of fenofibrate therapy on concentrations of plasma ubiquinol-10 and ubiquinone-10-the reduced and oxidized forms, respectively, of coenzyme Q(10)...
  26. ncbi request reprint Decreased post-prandial triglyceride response and diminished remnant lipoprotein formation in cholesteryl ester transfer protein (CETP) deficiency
    Akihiro Inazu
    Department of Laboratory Science, Graduate School of Medical Science, Kanazawa University, Kodatsuno 5 11 80, Kanazawa, Ishikawa 920 0942, Japan
    Atherosclerosis 196:953-7. 2008
    ..Subjects with CETP deficiency appeared to have low levels of TG response and diminished remnant lipoprotein formation after fat-load...
  27. ncbi request reprint Effect of walking with a pedometer on serum lipid and adiponectin levels in Japanese middle-aged men
    Junji Kobayashi
    Department of Lifestyle related Disease, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Atheroscler Thromb 13:197-201. 2006
    ..To clarify the effects of walking with a pedometer on metabolic parameters, including adiponectin (APN)...
  28. doi request reprint A novel method for determining functional LDL receptor activity in familial hypercholesterolemia: application of the CD3/CD28 assay in lymphocytes
    Hayato Tada
    Division of Cardiovascular Medicine, Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Clin Chim Acta 400:42-7. 2009
    ....
  29. ncbi request reprint Serum lipoprotein lipase mass: clinical significance of its measurement
    Junji Kobayashi
    Department of Lipidology, Kanazawa University Graduate School of Medical Science Takara machi 13 1, Kanazawa 920 8640, and Department of General Medicine, Kanazawa University Hospital, Japan
    Clin Chim Acta 378:7-12. 2007
    ..Taken together, we suggest that pre-heparin LPL mass in plasma or sera provide us with useful and important information on the development of metabolic disorders leading to atherosclerotic disease...
  30. ncbi request reprint Molecular genetic analysis of familial hypercholesterolemia: spectrum and regional difference of LDL receptor gene mutations in Japanese population
    Wenxin Yu
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8641, Japan
    Atherosclerosis 165:335-42. 2002
    ..05) compared with patients with a LDL receptor gene mutation, suggesting that besides LDL receptor, defect of other genes involved in LDL metabolism may be a cause of FH with a milder phenotypic expression in Japanese population...
  31. ncbi request reprint Dual effects on HDL metabolism by cholesteryl ester transfer protein inhibition in HepG2 cells
    Zhiping Huang
    Molecular Genetics of Cardiovascular Disorders, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8641, Japan
    Am J Physiol Endocrinol Metab 284:E1210-9. 2003
    ..Thus antisense inhibition of hepatic CETP expression manifests dual effects: namely, increased formation of HDL and suppression of catabolism of HDL-CE, probably via the SR-BI pathway...
  32. ncbi request reprint Detailed analysis of serum lipids and lipoproteins from Japanese type III hyperlipoproteinemia with apolipoprotein E2/2 phenotype
    Yasuhiro Todo
    Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa, Ishikawa 920 8640, Japan
    Clin Chim Acta 348:35-40. 2004
    ..To clarify a detailed profile of serum lipids, lipoproteins and apolipoproteins (apo) in type III hyperlipoproteinemia (HLP) with apolipoprotein E (apo E) phenotype 2/2...
  33. ncbi request reprint Identification of two novel missense mutations (p.R1221C and p.R1357W) in the ABCC6 (MRP6) gene in a Japanese patient with pseudoxanthoma elasticum (PXE)
    Yoshihiro Noji
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine The Second Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa
    Intern Med 43:1171-6. 2004
    ..The second patient was homozygous for 2542_2543delG in ABCC6 gene and heterozygous for 6 kb deletion of LDL-R gene. This case is the first report of a genetically confirmed case of double mutations both in PXE and FH loci...
  34. pmc Changes in lipoprotein lipase and endothelial lipase mass in familial hypercholesterolemia during three-drug lipid-lowering combination therapy
    Hayato Tada
    Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    Lipids Health Dis 15:66. 2016
    ..FH is usually treated by coadministration of these three drugs...
  35. pmc Extreme Contrast of Postprandial Remnant-Like Particles Formed in Abetalipoproteinemia and Homozygous Familial Hypobetalipoproteinemia
    Masa aki Kawashiri
    Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    JIMD Rep 22:85-94. 2015
    ..Familial hypobetalipoproteinemia (FHBL) and abetalipoproteinemia (ABL) are rare inherited forms of hypolipidemia. Their differential diagnosis is important for predicting of the prognosis and selecting appropriate therapy...
  36. doi request reprint Relationships of serum haptoglobin concentration with HbA1c and glycated albumin concentrations in Japanese type 2 diabetic patients
    Kaoru Suzuki
    Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa City, Japan
    Clin Chem Lab Med 47:70-4. 2009
    ..The aim of this study was to clarify the relationships of serum Hp concentration with HbA(1c) and GA concentrations...
  37. ncbi request reprint Raloxifene promotes adipocyte differentiation of 3T3-L1 cells
    Yuko Murase
    Department of Molecular Genetics of Cardiovascular Disorders, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 8640, Japan
    Eur J Pharmacol 538:1-4. 2006
    ..These findings suggest that raloxifene promotes adipocyte differentiation, providing a novel insight into the treatment of postmenopausal metabolic syndrome with hypoadiponectinemia...
  38. doi request reprint A de novo mutation of the LDL receptor gene as the cause of familial hypercholesterolemia identified using whole exome sequencing
    Hayato Tada
    Division of Cardiovascular Medicine, Kanazawa University, Graduate School of Medicine, Kanazawa, Japan Electronic address
    Clin Chim Acta 453:194-6. 2016
    ..Comprehensive genetic analysis is quite useful to make a correct diagnosis in such cases. ..
  39. doi request reprint Impact of anti-apoptotic and anti-oxidative effects of bone marrow mesenchymal stem cells with transient overexpression of heme oxygenase-1 on myocardial ischemia
    Toshinari Tsubokawa
    Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, Takara machi 13 1, Kanazawa, Ishikawa, Japan
    Am J Physiol Heart Circ Physiol 298:H1320-9. 2010
    ....
  40. ncbi request reprint Clinical efficacy and safety of rosuvastatin in Japanese patients with heterozygous familial hypercholesterolemia
    Hiroshi Mabuchi
    Kanazawa University, Ishikawa, Japan
    J Atheroscler Thromb 11:152-8. 2004
    ..Rosuvastatin produced significant beneficial changes in all lipid parameters in Japanese patients with heterozygous familial hypercholesterolemia and was well tolerated...
  41. ncbi request reprint Association of coronary artery ectasia with plasma insulin levels in Japanese men of heterozygous familial hypercholesterolemia with the low-density lipoprotein receptor gene mutation K790X
    Yuko Murase
    Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa, Ishikawa, 920 8640, Japan
    Clin Chim Acta 355:33-9. 2005
    ..Hyperinsulinemia is widely believed to be an important coronary risk factor. We investigated the effect of plasma insulin levels on the development of coronary ectasia in Japanese men with heterozygous familial hypercholesterolemia (FH)...
  42. pmc Impact of serum retinol-binding protein 4 levels on regulation of remnant-like particles triglyceride in type 2 diabetes mellitus
    Naoto Yamaaki
    Department of Internal Medicine, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8640, Japan
    J Diabetes Res 2013:143515. 2013
    ..0193) but was not a determinant of TG. Conclusions. RBP4 correlates positively with serum RLP-TG independent of fat accumulation in T2DM. RBP4 may regulate remnant metabolism independent of glycemic control in T2DM...
  43. pmc Infantile Cases of Sitosterolaemia with Novel Mutations in the ABCG5 Gene: Extreme Hypercholesterolaemia is Exacerbated by Breastfeeding
    Hayato Tada
    Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    JIMD Rep 21:115-22. 2015
    ..Their unique response to weaning from breastfeeding, as well as to use of ezetimibe, could provide insights into the metabolic basis of sterols in humans. ..
  44. doi request reprint Whole exome sequencing combined with integrated variant annotation prediction identifies asymptomatic Tangier disease with compound heterozygous mutations in ABCA1 gene
    Hayato Tada
    Division of Cardiovascular Medicine, Kanazawa University, Graduate School of Medicine, Kanazawa, Japan
    Atherosclerosis 240:324-9. 2015
    ..Here, we investigated whether WES combined with integrated variant annotation prediction could facilitate the molecular diagnosis of this rare condition...
  45. ncbi request reprint Double deletions and missense mutations in the first nucleotide-binding fold of the ATP-binding cassette transporter A1 ( ABCA1) gene in Japanese patients with Tangier disease
    Zhigang Guo
    Molecular Genetics of Cardiovascular Disorders, Vascular Medicine, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Hum Genet 47:325-9. 2002
    ..The third patient was homozygous for A3199G of exon 19 that leads to Asn935Ser, which is the same mutation found in German and Spanish families. Both Asn mutations involved Walker A motif of the first nucleotide-binding fold...
  46. ncbi request reprint Long-term treatment with pitavastatin (NK-104), a new HMG-CoA reductase inhibitor, of patients with heterozygous familial hypercholesterolemia
    Yoshihiro Noji
    Molecular Genetics of Cardiovascular Disorders The Second Department of Internal Medicine, Vascular Medicine, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Atherosclerosis 163:157-64. 2002
    ..As for the safety of pitavastatin, adverse reactions were observed in one case (4%) of subjective and objective symptoms. The effects of pitavastatin on TC and LDL-C were stable during long treatment of patients with heterozygous FH...
  47. ncbi request reprint Efficacy of colestimide coadministered with atorvastatin in japanese patients with heterozygous familial hypercholesterolemia (FH)
    Masa aki Kawashiri
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Disease, Graduate School of Kanazawa University
    Circ J 69:515-20. 2005
    ..Moreover, colestimide has excellent patient compliance because it is available in tablet form...
  48. ncbi request reprint Increased circulating matrix metalloproteinase-2 in patients with hypertrophic cardiomyopathy with systolic dysfunction
    Yoshihiro Noji
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Japan
    Circ J 68:355-60. 2004
    ..Recently, matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) were reported to be involved in ventricular remodeling, however, little is known about MMPs and TIMPs in patients with HCM...
  49. pmc Cholesteryl ester transfer protein (CETP) deficiency and CETP inhibitors
    Hiroshi Mabuchi
    Department of Lipidology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    Mol Cells 37:777-84. 2014
    ..We are expecting the final data of prospective clinical trials by CETP inhibitors in 2015. ..
  50. ncbi request reprint [Familial defective apolipoprotein B-100: FDB]
    Atsushi Nohara
    Department of Lipidology, Kanazawa University Graduate School of Medical Science
    Nihon Rinsho 65:301-8. 2007
  51. ncbi request reprint Association of estrogen receptor-alpha gene polymorphisms with coronary artery disease in patients with familial hypercholesterolemia
    Hong Lu
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Arterioscler Thromb Vasc Biol 22:817-23. 2002
    ..We conclude that -1989T/G or its linked polymorphisms in the ER-alpha gene may confer risk for CAD and that the G/G genotype may be an independent predictor for CAD in patients with familial hypercholesterolemia...
  52. ncbi request reprint The distribution of fasting and non-fasting serum triglyceride levels in Japanese population
    Junji Kobayashi
    Clin Chim Acta 374:173-5. 2006
  53. ncbi request reprint Peroxisome proliferator-activated receptor alpha induces NADPH oxidase activity in macrophages, leading to the generation of LDL with PPAR-alpha activation properties
    Elisabeth Teissier
    UR 545 INSERM Institut Pasteur de Lille and Faculté de Pharmacie, Universite de Lille II, Lille, France
    Circ Res 95:1174-82. 2004
    ..These data identify a novel mechanism of autogeneration of endogenous PPAR-alpha ligands via stimulation of NADPH oxidase activity...
  54. ncbi request reprint Reassessment of the cutoff values of waist circumference and visceral fat area for identifying Japanese subjects at risk for the metabolic syndrome
    Rie Oka
    Department of Internal Medicine, Hokuriku Central Hospital of Japan Mutual Aid Association of Public School Teachers, 123 Nodera, Oyabe, Toyama 932 8503, Japan
    Diabetes Res Clin Pract 79:474-81. 2008
    ..In conclusion, setting the cutoff points of WC and VFA lower values in women than in men for the definition of central obesity is needed to identify the subjects with MetS in Japanese, as in other Asian populations...
  55. ncbi request reprint Low plasma adiponectin levels are associated with increased hepatic lipase activity in vivo: response to Schneider et al
    Junji Kobayashi
    Diabetes Care 29:181; author reply 181-2. 2006
  56. ncbi request reprint Liver X receptor activation potentiates the lipopolysaccharide response in human macrophages
    Coralie Fontaine
    Institut Pasteur de Lille, Departement d Atherosclerose, Lille, France
    Circ Res 101:40-9. 2007
    ..These data provide evidence for an immunomodulatory function of LXRs in human macrophages via mechanisms distinct from those previously identified in mouse macrophages...