S Ikehara

Summary

Affiliation: Kansai Medical University
Country: Japan

Publications

  1. ncbi request reprint Pluripotent hemopoietic stem cells in mice and humans
    S Ikehara
    First Department of Pathology, Transplantation Center, Kansai Medical University, Moriguchi, Osaka, Japan
    Proc Soc Exp Biol Med 223:149-55. 2000
  2. ncbi request reprint A novel strategy for allogeneic stem cell transplantation: perfusion method plus intra-bone marrow injection of stem cells
    Susumu Ikehara
    Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    Exp Hematol 31:1142-6. 2003
  3. pmc Stem cell transplantation increases antioxidant effects in diabetic mice
    Ming Li
    Department of Stem Cell Disorders, Kansai Medical University, Moriguchi City, Osaka, Japan
    Int J Biol Sci 8:1335-44. 2012
  4. pmc Bone-marrow-derived mesenchymal stem cells for organ repair
    Ming Li
    Department of Stem Cell Disorders, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
    Stem Cells Int 2013:132642. 2013
  5. pmc Bone marrow stem cell as a potential treatment for diabetes
    Ming Li
    Department of Stem Cell Disorders, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
    J Diabetes Res 2013:329596. 2013
  6. ncbi request reprint Treatment of autoimmune diseases by hematopoietic stem cell transplantation
    S Ikehara
    First Department of Pathology, Transplantation Center, Kansai Medical University, Osaka, Japan
    Exp Hematol 29:661-9. 2001
  7. ncbi request reprint Bone marrow transplantation: a new strategy for intractable diseases
    Susumu Ikehara
    First Department of Pathology, Transplantation Center, Regeneration Research Center for Intractable Diseases, Kansai Medical University, Moriguchi City, Osaka, Japan
    Drugs Today (Barc) 38:103-11. 2002
  8. ncbi request reprint New strategies for BMT, organ transplantation, and regeneration therapy
    Susumu Ikehara
    First Department of Pathology, Transplantation Center, Regeneration Research Center for Intractable Diseases, Kansai Medical University, Osaka 570 8506, USA
    Hematology 8:77-81. 2003
  9. ncbi request reprint Treatment of autoimmune diseases in mice by a new method for allogeneic bone marrow transplantation
    Susumu Ikehara
    First Department of Pathology, Transplantation Center, Regeneration Research Center for Intractable Diseases, Kansai Medical University, Moriguchi City, Osaka, Japan
    Ther Apher Dial 7:292-7. 2003
  10. ncbi request reprint A new concept of stem cell disorders and their new therapy
    Susumu Ikehara
    First Department of Pathology, Transplantation Center, Regeneration Research Center for Intractable Diseases, Center for Cancer Therapy, Kansai Medical University, Moriguchi City, Osaka, Japan
    J Hematother Stem Cell Res 12:643-53. 2003

Collaborators

Detail Information

Publications134 found, 100 shown here

  1. ncbi request reprint Pluripotent hemopoietic stem cells in mice and humans
    S Ikehara
    First Department of Pathology, Transplantation Center, Kansai Medical University, Moriguchi, Osaka, Japan
    Proc Soc Exp Biol Med 223:149-55. 2000
    ..In humans, we also show that c-kit<low P-HSCs can differentiate into c-kit(low) cells, then c-kit+ cells in vitro...
  2. ncbi request reprint A novel strategy for allogeneic stem cell transplantation: perfusion method plus intra-bone marrow injection of stem cells
    Susumu Ikehara
    Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    Exp Hematol 31:1142-6. 2003
    ..In this article, we discuss why this new method (PM+IBM-BMT) may become a valuable strategy for allogeneic stem cell (both P-HSC and MSC) transplantation...
  3. pmc Stem cell transplantation increases antioxidant effects in diabetic mice
    Ming Li
    Department of Stem Cell Disorders, Kansai Medical University, Moriguchi City, Osaka, Japan
    Int J Biol Sci 8:1335-44. 2012
    ..Thus IBM-BMT+TT unregulated the expression of HO-1, peNOS and pAKT, while decreasing iNOS levels in the kidney of db/db mice. This was associated with an improvement in renal function...
  4. pmc Bone-marrow-derived mesenchymal stem cells for organ repair
    Ming Li
    Department of Stem Cell Disorders, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
    Stem Cells Int 2013:132642. 2013
    ..In this paper, we focus on the role of BM-derived MSCs in organ repair...
  5. pmc Bone marrow stem cell as a potential treatment for diabetes
    Ming Li
    Department of Stem Cell Disorders, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
    J Diabetes Res 2013:329596. 2013
    ..TSCs include the bone-marrow-, liver-, and pancreas-derived stem cells. In this review, we focus on treatment using bone marrow stem cells for type 1 and 2 DM...
  6. ncbi request reprint Treatment of autoimmune diseases by hematopoietic stem cell transplantation
    S Ikehara
    First Department of Pathology, Transplantation Center, Kansai Medical University, Osaka, Japan
    Exp Hematol 29:661-9. 2001
    ..We identified the mechanisms underlying the components of this approach and have found that stromal cells play a crucial role in successful BMT. In this review, the conditions essential for successful allogeneic BMT are discussed...
  7. ncbi request reprint Bone marrow transplantation: a new strategy for intractable diseases
    Susumu Ikehara
    First Department of Pathology, Transplantation Center, Regeneration Research Center for Intractable Diseases, Kansai Medical University, Moriguchi City, Osaka, Japan
    Drugs Today (Barc) 38:103-11. 2002
    ..since it can efficiently reconstitute the recipient with both donor-derived hemopoietic stem cells and mesenchymal stem cells...
  8. ncbi request reprint New strategies for BMT, organ transplantation, and regeneration therapy
    Susumu Ikehara
    First Department of Pathology, Transplantation Center, Regeneration Research Center for Intractable Diseases, Kansai Medical University, Osaka 570 8506, USA
    Hematology 8:77-81. 2003
    ..We believe that this new method will become a powerful strategy for the treatment of various intractable diseases, including age-associated diseases such as osteoporosis...
  9. ncbi request reprint Treatment of autoimmune diseases in mice by a new method for allogeneic bone marrow transplantation
    Susumu Ikehara
    First Department of Pathology, Transplantation Center, Regeneration Research Center for Intractable Diseases, Kansai Medical University, Moriguchi City, Osaka, Japan
    Ther Apher Dial 7:292-7. 2003
    ..In addition, this strategy was found to be applicable for the transplantation of organs. We believe that these strategies for BMT and organ transplantation herald a new era in transplantation...
  10. ncbi request reprint A new concept of stem cell disorders and their new therapy
    Susumu Ikehara
    First Department of Pathology, Transplantation Center, Regeneration Research Center for Intractable Diseases, Center for Cancer Therapy, Kansai Medical University, Moriguchi City, Osaka, Japan
    J Hematother Stem Cell Res 12:643-53. 2003
    ..In this review, we show that this new method may become a powerful strategy for the treatment of various intractable diseases...
  11. ncbi request reprint Neural cell adhesion molecule contributes to hemopoiesis-supporting capacity of stromal cell lines
    Xiaoli Wang
    First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    Stem Cells 23:1389-99. 2005
    ..Our findings clearly indicate that NCAM functions on the maintenance of HSCs...
  12. ncbi request reprint Intra-bone marrow-bone marrow transplantation: a new strategy for treatment of stem cell disorders
    Susumu Ikehara
    First Department of Pathology, Transplantation Center, Regeneration Research Center for Intractable Diseases, and Center for Cancer Therapy, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    Ann N Y Acad Sci 1051:626-34. 2005
    ..We believe that this strategy heralds a revolution in the field of transplantation and regenerative therapy...
  13. ncbi request reprint Innovative BMT methods for intractable diseases
    Susumu Ikehara
    First Department of Pathology, Transplantation Center, Regeneration Research Center for Intractable Diseases, Center for Cancer Therapy, Kansai Medical University, Moriguchi City, Osaka 570 8506, Japan
    Immunol Res 38:251-60. 2007
    ..We believe that this strategy heralds a revolution in the field of transplantation (BMT and organ allografts) and regeneration therapy...
  14. doi request reprint A novel method of bone marrow transplantation (BMT) for intractable autoimmune diseases
    Susumu Ikehara
    First Department of Pathology, Transplantation Center, Regeneration Research Center for Intractable Diseases, Center for Cancer Therapy, Kansai Medical University, Moriguchi City, Osaka 570 8506, Japan
    J Autoimmun 30:108-15. 2008
    ..0 Gy x 2, which is equivalent to one shot of 8 Gy (a sublethal dose). We believe that this strategy heralds a revolution in the field of transplantation (BMT and organ transplantation) and regeneration therapy...
  15. doi request reprint Stem cell transplantation for autoimmune diseases: what can we learn from experimental models?
    Susumu Ikehara
    First Department of Pathology, Transplantation Center, Regeneration Research Center for Intractable Diseases, Center for Cancer Therapy, Kansai Medical University, Moriguchi City, Osaka, Japan
    Autoimmunity 41:563-9. 2008
    ..We believe that this strategy heralds a revolution in the field of transplantation (BMT and organ allografts) and regeneration therapy...
  16. doi request reprint The future of stem cell transplantation in autoimmune disease
    Susumu Ikehara
    First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 85506, Japan
    Clin Rev Allergy Immunol 38:292-7. 2010
    ..In this review article, we provide evidence that IBM-BMT heralds a revolution in the field of transplantation and regeneration medicine...
  17. doi request reprint A new bone marrow transplantation method for stem cell disorders
    Susumu Ikehara
    First Department of Pathology, Transplantation Center, Kansai Medical University, Moriguchi City, Japan
    Ann N Y Acad Sci 1173:774-80. 2009
    ..We believe that the advent of IBM-BMT and our proposed concept herald a revolution in the field of transplantation (BMT and organ transplantation) and regeneration medicine...
  18. doi request reprint Thymus transplantation for treatment of cancer: lessons from murine models
    Susumu Ikehara
    Department of Stem Cell Disorders, Kansai Medical University, Osaka, Japan
    Expert Rev Clin Immunol 7:205-11. 2011
    ....
  19. doi request reprint A novel BMT technique for treatment of various currently intractable diseases
    Susumu Ikehara
    Department of Stem Cell Disorders, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka, Japan
    Best Pract Res Clin Haematol 24:477-83. 2011
    ..We believe that the development of this technique will herald a revolution in the field of BMT, regeneration medicine and also organ transplantation...
  20. ncbi request reprint Intra-bone marrow injection of allogeneic bone marrow cells: a powerful new strategy for treatment of intractable autoimmune diseases in MRL/lpr mice
    T Kushida
    First Department of Pathology, Transplantation Center, Kansai Medical University, Moriguchi City, Osaka, Japan
    Blood 97:3292-9. 2001
    ..This strategy would therefore be suitable for human therapy...
  21. ncbi request reprint Major histocompatibility complex restriction between hematopoietic stem cells and stromal cells in vitro
    K Sugiura
    First Department of Pathology, Transplantation Center, Moriguchi-City, Japan
    Stem Cells 19:46-58. 2001
    ..The enhancement of cytokine expression was also observed when stromal cells and HSCs were MHC-matched. These results suggest that signaling via the MHC molecules augments stromal cell activity and elicits the MHC restriction...
  22. ncbi request reprint Successful allogeneic bone marrow transplantation (BMT) by injection of bone marrow cells via portal vein: stromal cells as BMT-facilitating cells
    T X Fan
    First Department of Pathology, Transplantation Center, Kansai Medical University, Osaka, Japan
    Stem Cells 19:144-50. 2001
    ..It is likely that donor stromal cells and HSCs trapped in the liver migrate into the recipient BM and spleen, where they form CFU-BM and CFU-S, respectively...
  23. ncbi request reprint A novel strategy for organ allografts using sublethal (7 Gy) irradiation followed by injection of donor bone marrow cells via portal vein
    T Jin
    First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi City, Osaka 570-8506, Japan
    Transplantation 71:1725-31. 2001
    ..The major mechanism underlying the persistent tolerance induced by this strategy seems to be because of clonal deletion. This simple and safe strategy would be of great advantage for human organ transplantation...
  24. doi request reprint Allogeneic intra-BM-BMT plus adult thymus transplantation from same donor has benefits for long-term survival even after sublethal irradiation or low-dose BM cell injection
    T Nishida
    Department of Pathology, Kansai Medical University, Moriguchi, Osaka, Japan
    Bone Marrow Transplant 43:829-37. 2009
    ..These results suggest that IBM-BMT plus ATT is effective in reconstituting the recipients with donor-derived cells even after SubLI or LDBMCI...
  25. ncbi request reprint A new method for tolerance induction: busulfan administration followed by intravenous injection of neuraminidase-treated donor bone marrow
    T Nagahama
    The First Department of Pathology, Kansai Medical University, Osaka, Japan
    Stem Cells 19:425-35. 2001
    ..Therefore, this "single-day protocol" would be of great advantage for human organ transplantation...
  26. ncbi request reprint Tolerance induction across Mls and minor histocompatibility complex by inhibiting activation of T helper type 1 in early period
    K Sugiura
    First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi City, Osaka 570-8506, Japan
    Immunol Lett 77:25-30. 2001
    ..These data suggest that CY, when administered 2 days after the p.v. injection, induces persistent tolerance by inhibiting T helper type 1 (Th1) activity in the early period but not the Th1 activity in the later periods...
  27. doi request reprint The combination method using magnetic beads and a magnet helps sustain the number of donor BM cells after intra-BM injection, resulting in rapid hematopoietic recovery
    C Shima
    First Department of Pathology, Kansai Medical University, Osaka, Japan
    Bone Marrow Transplant 45:993-9. 2010
    ..These results suggest that the IBM-BMT using the combination of magnetic beads and a magnet is superior to the conventional IBM-BMT...
  28. pmc Prevention of graft-versus-host disease by intrabone marrow injection of donor T cells: involvement of bone marrow stromal cells
    T Miyake
    First Department of Pathology, and Department of Surgery, Kansai Medical University, Osaka, Japan
    Clin Exp Immunol 152:153-62. 2008
    ..v.-DLI. Thus, the prevention of GVHD observed in the recipients of IBM-BMT + IBM-DLI was attributable to the increased production of immunosuppressive cytokines from BMSCs after interaction with host reactive T cells (in DLI)...
  29. pmc Distinct mechanisms of neonatal tolerance induced by dendritic cells and thymic B cells
    M Inaba
    Department of Pathology, Kansai Medical University, Osaka, Japan
    J Exp Med 173:549-59. 1991
    ..Therefore, different types of bone marrow-derived APC have different capacities for inducing tolerance, and the active cell types (dendritic cells and CD5+ thymic B cells) can act by distinct mechanisms...
  30. ncbi request reprint New method for thyroid transplantation across major histocompatibility complex barriers using allogeneic bone marrow transplantation
    S Lee
    First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi City, Osaka 570-8506, Japan
    Transplantation 72:1144-9. 2001
    ..CONCLUSIONS: Using both BU and Neu treatments, we have succeeded in inducing long-term tolerance and preventing the rejection of thyroid allografts by the single-day protocol...
  31. ncbi request reprint Major histocompatibility complex restriction between hematopoietic stem cells and stromal cells in vivo
    F Hashimoto
    First Department of Pathology, Kansai Medical University, Osaka, Japan
    Blood 89:49-54. 1997
    ..These findings strongly suggest that an MHC restriction exists between HSCs and stromal cells...
  32. ncbi request reprint Crucial role of donor-derived stromal cells in successful treatment for intractable autoimmune diseases in mrl/lpr mice by bmt via portal vein
    T Kushida
    First Department of Pathology, Transplantation Center, Kansai Medical University, Moriguchi City, Osaka, Japan
    Stem Cells 19:226-35. 2001
    ..This new strategy to facilitate the early recovery of hemopoiesis would therefore be of great advantage in human application...
  33. ncbi request reprint The characteristics of hematopoietic stem cells from autoimmune-prone mice and the role of neural cell adhesion molecules in abnormal proliferation of these cells in MRL/lpr mice
    Xiaoli Wang
    First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    Haematologica 92:300-7. 2007
    ..1 In order to understand how autoimmune diseases develop, we investigated the distinct qualitative differences between hematopoietic stem cells (HSC) from normal and autoimmune-prone mice...
  34. ncbi request reprint Induction of immune-mediated hearing loss in SCID mice by injection of MRL/lpr mouse spleen cells
    H Iwai
    Department of Otorhinolaryngology, Kansai Medical University, Moriguchi, Osaka, Japan
    Hear Res 117:173-7. 1998
    ..These findings suggest that cell-mediated immunity is involved in the development of SHL and cochlear pathology...
  35. ncbi request reprint Prevention of accelerated presbycusis by bone marrow transplantation in senescence-accelerated mice
    H Iwai
    Department of Otorhinolaryngology, Kansai Medical University, Moriguchi, Osaka, Japan
    Bone Marrow Transplant 28:323-8. 2001
    ....
  36. pmc Treatment of autoimmune diseases in MRL/lpr mice by allogenic bone marrow transplantation plus adult thymus transplantation
    N Hosaka
    First Department of Pathology, Kansai Medical University, Moriguchi, Osaka, Japan
    Clin Exp Immunol 147:555-63. 2007
    ..Finally, the autoimmune diseases in MRL/lpr mice could be cured by BMT with TT. These results indicate that the combination of BMT plus TT can overcome the chimeric resistance and treat the autoimmune diseases in MRL/lpr mice...
  37. doi request reprint Transplantation of newborn thymus plus hematopoietic stem cells can rescue supralethally irradiated mice
    T Ryu
    First Department of Pathology, Kansai Medical University, Moriguchi, Osaka, Japan
    Bone Marrow Transplant 41:659-66. 2008
    ..These findings suggest that NLCs plus NT transplantation can rescue SLI mice most effectively, and that high production of IL-7 in NT plays a crucial role with induction of CD4(+) T cells...
  38. pmc High mortality rate of (NZW x BXSB)F1 mice induced by administration of lipopolysaccharide attributes to high production of tumour necrosis factor-alpha by increased numbers of dendritic cells
    N Koike-Kiriyama
    First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
    Clin Exp Immunol 154:285-93. 2008
    ..The results also suggest that not only the quantity of endotoxin, but also the host conditions, the facility to translate signal from TLR, and so on, could reflect the degree of bacterial infections and prognosis...
  39. pmc The Wistar Bonn Kobori rat, a unique animal model for autoimmune pancreatitis with extrapancreatic exocrinopathy
    Y Sakaguchi
    First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
    Clin Exp Immunol 152:1-12. 2008
    ..We also show that these autoimmune diseases can be prevented by a newly devised strategy of bone marrow transplantation (BMT) in which bone marrow cells are injected directly into the bone marrow cavity: intrabone marrow-BMT...
  40. ncbi request reprint Optimal protocol for total body irradiation for allogeneic bone marrow transplantation in mice
    Y Z Cui
    First Department of Pathology, Kansai Medical University, Moriguchi, Osaka, Japan
    Bone Marrow Transplant 30:843-9. 2002
    ..In all the combinations, the highest survival rate was achieved in the recipients irradiated with (6+6) or (6.5+6.5) Gy with a 4 h interval. In the surviving mice, the hematolymphoid tissues had been fully reconstituted with donor cells...
  41. ncbi request reprint Changes in markers, receptors and adhesion molecules expressed on murine hemopoietic stem cells after a single injection of 5-fluorouracil
    N Nishio
    First Department of Pathology, Kansai Medical University, Osaka, Japan
    Stem Cells 14:584-91. 1996
    ..However, there is no change in the expression of adhesion molecules (VLA-4, LFA-1 and CD44) on the P-HSC...
  42. ncbi request reprint Treatment of streptozotocin-induced diabetes mellitus in mice by intra-bone marrow bone marrow transplantation plus portal vein injection of beta cells induced from bone marrow cells
    M Li
    First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
    Int J Hematol 86:438-45. 2007
    ..Hyperglycemia was normalized by 5 days after the treatment and remained normal for more than 45 days. This strategy might be applicable to patients with type I diabetes mellitus...
  43. ncbi request reprint A CD1a+/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells
    T Ito
    First Department of Internal Medicine, First Department of Pathology, Kansai Medical University, Osaka, Japan
    J Immunol 163:1409-19. 1999
    ..Furthermore, CD14+ monocytes only expressed E-cadherin, but lacked the other LC markers after culture in these cytokines. Therefore, CD1a+/CD11c+ DCs are the direct precursors of LCs in peripheral blood...
  44. ncbi request reprint Differential regulation of human blood dendritic cell subsets by IFNs
    T Ito
    First Department of Internal Medicine, Kansai Medical University, Osaka, Japan
    J Immunol 166:2961-9. 2001
    ..The IL-3-primed CD11c(-) DCs activated T cells to produce IL-10, IFN-gamma, and IL-4. Thus, CD11c(+) and CD11c(-) DC subsets play distinct roles in the cytokine network, especially their responses to IFNs...
  45. ncbi request reprint Proteasome inhibitor 1 enhances paclitaxel-induced apoptosis in human lung adenocarcinoma cell line
    H Oyaizu
    First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka 570-8506, Japan
    Oncol Rep 8:825-9. 2001
    ..Furthermore, augmented apoptosis is related to NF-kappaB activation. Based on these findings, we propose that the combination of paclitaxel with PS1 could be a new strategy for cancer treatment...
  46. ncbi request reprint Comparative immunobiology of thymic DC mRNA in autoimmune-prone mice
    T Okada
    First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi, Osaka 570 8506, Japan
    J Autoimmun 28:41-5. 2007
    ..We submit that these results highlight the possibility of a selective defect in thymic DCs which will be a pivotal step in loss of tolerance, and suggest that future studies focus on adoptive cell transfer involving this population...
  47. ncbi request reprint Induction of tolerance in quadruple chimeric mice
    Tian xue Fan
    Department of Pathology, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
    Stem Cells 22:683-95. 2004
    ....
  48. ncbi request reprint Bone marrow transplantation as a strategy for the treatment of autoimmune hearing loss in MRL/Mp-lpr/lpr mice
    Hiroshi Iwai
    Department of Otolaryngology, Rakusai New Town Hospital, Kansai Medical University, Kyoto, Japan
    J Neuroimmunol 168:76-82. 2005
    ....
  49. doi request reprint Long-term maintenance of donor-derived hematopoiesis by intra-bone marrow-bone marrow transplantation
    Mariko Omae
    First Department of Pathology, Kansai Medical University, Osaka, Japan
    Stem Cells Dev 17:291-302. 2008
    ..v.-BMT. These findings clearly show that IBM-BMT efficiently promotes the longterm maintenance of donor-derived hematopoiesis...
  50. doi request reprint Facilitation of hematopoietic recovery by bone grafts with intra-bone marrow-bone marrow transplantation
    Changye Song
    First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka, Japan
    Immunobiology 213:455-68. 2008
    ..Moreover, the analyses of thymic sections using confocal microscopy revealed that donor BM stromal cells had migrated into the thymus. Thus, the co-administration of donor bones has great advantages for allogeneic BMT in adult mice...
  51. pmc Successful pancreatic allografts in combination with bone marrow transplantation in mice
    H Iwai
    1st Department of Pathology, Kansai Medical College, Osaka, Japan
    Immunology 62:457-62. 1987
    ..These findings suggest that pancreatic allografts combined with bone marrow transplantation may become a viable strategy for the treatment of patients with diabetes or patients who have undergone pancreatectomy...
  52. pmc Attenuation of lpr-graft-versus-host disease (GVHD) in MRL/lpr spleen cell-injected SCID mice by in vivo treatment with anti-V beta 8.1,2 monoclonal antibody
    N Hosaka
    First Department of Pathology, Kansai Medical University, Osaka, Japan
    Clin Exp Immunol 96:500-7. 1994
    ..1,2+ T cells, and contribute to the development of lpr-GVHD...
  53. ncbi request reprint Stimulatory effects of hepatocyte growth factor on hemopoiesis of SCF/c-kit system-deficient mice
    C Z Yu
    First Department of Pathology, Kansai Medical University, Osaka, Japan
    Stem Cells 16:66-77. 1998
    ..RBC, WBC, and platelet counts also increased. These results suggest that the SCF/c-kit system is not essential to hemopoiesis but that a compensatory system such as the HGF/c-met system functions in the SCF/c-kit system-deficient mice...
  54. ncbi request reprint Pathology of ALY mice: congenital immunodeficiency with lymph node and Peyer's patch defects
    R Yasumizu
    First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
    Immunobiology 202:213-25. 2000
    ..By contrast, the NK activity is normal. Taken together, the ALY mouse is an invaluable model to elucidate the immunological networks between the lymphoid structures (lymph nodes, Peyer's patches, lymphoid follicles, etc.) and functions...
  55. ncbi request reprint Intra-bone marrow injection of dendritic cells for treatment of malignant tumor in mice
    N Koike-Kiriyama
    First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
    J Exp Clin Cancer Res 26:337-42. 2007
    ..DCs derived from tumor-bearing mice had some effects on the suppression of tumor growth but they were less effective than DCs from untreated mice...
  56. ncbi request reprint Simultaneous injection of bone marrow cells and stromal cells into bone marrow accelerates hematopoiesis in vivo
    Yuming Zhang
    First Department of Pathology, Kansai Medical University, Moriguchi, Japan
    Stem Cells 22:1256-62. 2004
    ....
  57. ncbi request reprint Treatment of senile osteoporosis in SAMP6 mice by intra-bone marrow injection of allogeneic bone marrow cells
    Keizo Takada
    First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    Stem Cells 24:399-405. 2006
    ..These findings indicate that not only the hemopoietic system but also the bone marrow microenvironment were normalized after IBM-BMT, resulting in an amelioration of the imbalance between bone absorption and formation...
  58. ncbi request reprint Transfer of accelerated presbycusis by transplantation of bone marrow cells from senescence-accelerated mice
    Susumu Baba
    Department of Otolaryngology, Kansai Medical University, 10 15 Fumizonocho, Moriguchi City, Osaka 570 8507, Japan
    Brain Res 1120:93-9. 2006
    ..Further studies into the relationship between the inner ear cells and BMCs are required...
  59. doi request reprint Caspase inhibitor ZVAD-fmk facilitates engraftment of donor hematopoietic stem cells in intra-bone marrow-bone marrow transplantation
    Yuichiro Imai
    First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
    Stem Cells Dev 19:461-8. 2010
    ..These results suggest that ZVAD-fmk can suppress apoptosis of hematopoietic stem cells and/or immature progenitor cells of the donor bone marrow cells, thereby accelerating the donor hematopoiesis...
  60. ncbi request reprint Protection of T cells from radiation-induced apoptosis by Cepharanthin
    H Oyaizu
    First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
    Int Immunopharmacol 1:2091-9. 2001
    ..These results suggest that CE inhibits the signal transduction pathway of apoptosis induced by radiation, regardless of the expression of Bcl-2 or Bax...
  61. pmc Dehydroxymethylepoxyquinomicin (DHMEQ) can suppress tumour necrosis factor-α production in lipopolysaccharide-injected mice, resulting in rescuing mice from death in vivo
    T Shimo
    Department of Pediatrics, Kansai Medical University, Moriguchi City, Osaka, Japan
    Clin Exp Immunol 166:299-306. 2011
    ..The serum levels of TNF-α in the mice that received both LPS and DHMEQ were suppressed compared to the mice that received only LPS. These results suggest that DHMEQ can be utilized for the prevention and treatment of endotoxin shock...
  62. ncbi request reprint Comparison of bone marrow cells harvested from various bones of cynomolgus monkeys at various ages by perfusion or aspiration methods: a preclinical study for human BMT
    Taketoshi Kushida
    First Department of Pathology, Transplantation Center, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    Stem Cells 20:155-62. 2002
    ..These findings suggest, even in humans, that the perfusion method is better than the aspiration method, and that the best site for collection of BMCs is the humerus...
  63. ncbi request reprint Choroidal neovascularization is provided by bone marrow cells
    Minoru Tomita
    First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
    Stem Cells 22:21-6. 2004
    ....
  64. doi request reprint Administration of granulocyte colony-stimulating factor to recipients followed by intra-bone marrow-bone marrow transplantation accelerates acceptance of allogeneic bone marrow cells in mice
    Yasuhiro Suzuki
    First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    Immunobiology 213:427-35. 2008
    ..The combination of G-CSF pretreatment and IBM-BMT can produce the rapid recovery of donor-derived hematopoiesis and suppress graft rejection. This method would lighten the burden on patients in allogeneic BMT...
  65. doi request reprint Prolonged survival in mice with advanced tumors treated with syngeneic or allogeneic intra-bone marrow-bone marrow transplantation plus fetal thymus transplantation
    Naoki Hosaka
    First Department of Pathology, Kansai Medical University, Moriguchi, Osaka, 570 8506, Japan
    Cancer Immunol Immunother 59:1121-30. 2010
    ..These results suggest that BMT + TT, particularly Allo-BMT + Allo-TT or 3rd-party TT, is most effective in prolonging survival as a result of the restoration of T cell function in hosts with advanced tumors...
  66. doi request reprint Adult bone marrow cells can differentiate into hemopoietic cells and endothelial cells but not into other lineage cells in normal growth and normal life
    Seiji Yanai
    First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    Int J Hematol 91:213-8. 2010
    ..These results suggest that adult BMCs can differentiate into not only hemopoietic cells but also vascular endothelial cells, but cannot differentiate into other lineage cells in normal growth and normal life...
  67. pmc Bone marrow transplantation therapy using resistant donors for retrovirus-induced leukaemia in mice
    H Iwai
    Department of Otorhinolaryngology, Kansai Medical University, Osaka, Japan
    Clin Exp Immunol 95:135-40. 1994
    ....
  68. ncbi request reprint Involvement of PLAGL2 in activation of iron deficient- and hypoxia-induced gene expression in mouse cell lines
    T Furukawa
    Department of Hygiene, Kansai Medical University, Osaka 570 8506, Japan
    Oncogene 20:4718-27. 2001
    ..We propose that PLAGL2 is involved in the cell cycle arrest and apoptosis of tumor cells by regulating iron depletion- or hypoxia-inducible gene expression...
  69. ncbi request reprint Analyses of dendritic cell subsets in pregnancy
    T Yoshimura
    First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
    Am J Reprod Immunol 50:137-45. 2003
    ....
  70. ncbi request reprint Prevention of senile osteoporosis in SAMP6 mice by intrabone marrow injection of allogeneic bone marrow cells
    Naoya Ichioka
    First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
    Stem Cells 20:542-51. 2002
    ....
  71. ncbi request reprint Macrophage colony-stimulating factor (M-CSF), as well as granulocyte colony-stimulating factor (G-CSF), accelerates neovascularization
    Keizo Minamino
    First Department of Pathology, Kansai Medical University, Moriguchi, Osaka 570 8507, Japan
    Stem Cells 23:347-54. 2005
    ..Both M-CSF and G-CSF augmented the differentiation of BMCs into endothelial cells of blood vessels through vascular endothelial cell growth factor (VEGF), resulting in early recovery of blood flow in the ischemic limbs...
  72. ncbi request reprint A new strategy for treatment of malignant tumor: intra-bone marrow-bone marrow transplantation plus CD4- donor lymphocyte infusion
    Yasuhiro Suzuki
    First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka 570 8506, Japan
    Stem Cells 23:365-70. 2005
    ..These results suggest that IBM-BMT plus DLI (the depletion or reduction of a certain cell population like CD4(+) T cells) could be helpful to suppress both GvHD and tumor growth...
  73. ncbi request reprint Prevention of graft-versus-host disease by intra-bone marrow injection of donor T cells
    Junichi Fukui
    First Department of Pathology, Kansai Medical University, Fumizono cho, Moriguchi City, Osaka, Japan
    Stem Cells 25:1595-601. 2007
    ..Thus, IBM-BMT plus IBM-DLI seem to preferentially induce Tregs and Th2, resulting in the prevention of GvHD. Disclosure of potential conflicts of interest is found at the end of this article...
  74. doi request reprint Analysis of tolerance induction using triple chimeric mice: major histocompatibility complex-disparate thymus, hemopoietic cells, and microenvironment
    Wenhao Cui
    Department of Pathology, Kansai Medical University, Moriguchi, Osaka, Japan
    Transplantation 85:1151-8. 2008
    ..We have previously shown that fetal thymus transplantation (TT) with BMT is effective for elderly recipients in mice...
  75. doi request reprint Activation of rat nucleus pulposus cells by coculture with whole bone marrow cells collected by the perfusion method
    Masayuki Umeda
    Department of Orthopedic Surgery, Kansai Medical University, Moriguchi City, Osaka, Japan
    J Orthop Res 27:222-8. 2009
    ..In conclusion, we suggest that fresh whole BMCs harvested by the perfusion method are more effective for increasing the proliferative and matrix synthesis capacity of nucleus pulposus cells...
  76. pmc Adult thymus transplantation with allogeneic intra-bone marrow-bone marrow transplantation from same donor induces high thymopoiesis, mild graft-versus-host reaction and strong graft-versus-tumour effects
    Takashi Miyake
    First Department of Pathology, Kansai Medical University, Moriguchi, Osaka, Japan
    Immunology 126:552-64. 2009
    ..Allogeneic IBM-BMT + ATT thus can induce high thymopoiesis, preserving strong GVT effects without severe GVHR...
  77. doi request reprint Presence of donor-derived thymic epithelial cells in [B6-->MRL/lpr] mice after allogeneic intra-bone marrow-bone marrow transplantation (IBM-BMT)
    Takashi Takaki
    First Department of Pathology, Kansai Medical University, Moriguchi, Osaka, Japan
    J Autoimmun 31:408-15. 2008
    ..These findings suggest that BMCs contain the precursors of functional TECs, and that they can differentiate into TECs, thereby correcting thymic function...
  78. ncbi request reprint Synergistic effects of injection of bone marrow cells into both portal vein and bone marrow on tolerance induction in transplantation of allogeneic pancreatic islets
    K Ikebukuro
    First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    Bone Marrow Transplant 38:657-64. 2006
    ..PV+IBM)-BMT was found to be the most effective in inducing the acceptance of allogeneic PIs. These results suggest that allogeneic PI-transplantation in conjunction with (PV+IBM)-BMT could become a viable strategy...
  79. ncbi request reprint Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function
    A Hashimoto
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
    J Immunol 165:1738-42. 2000
    ..In contrast, T cell development and TCR-mediated proliferation were normal. Taken together, PLC-gamma 2 is a critical component of BCR signaling pathways and is required to promote B cell development...
  80. ncbi request reprint New strategies for allogeneic BMT
    S Ikehara
    First Department of Pathology, Transplantation Center, Regeneration Research Center for Intractable Diseases, Kansai Medical University, Moriguchi City, Osaka, Japan
    Bone Marrow Transplant 32:S73-5. 2003
    ..We believe that these strategies for allo BMT and organ allografts herald a new era in transplantation, and that they would be helpful in allogeneic HSCT of autoimmune diseases...
  81. ncbi request reprint Treatment of streptozotocin-induced diabetes mellitus by transplantation of islet cells plus bone marrow cells via portal vein in rats
    Kazuya Ikebukuro
    First Department of Pathology, Kansai Medical University, Osaka 570 8506, Japan
    Transplantation 73:512-8. 2002
    ..v.) injection of donor BMCs (9 Gy + PV + i.v.)...
  82. ncbi request reprint New strategies for BMT and organ transplantation
    Susumu Ikehara
    First Department of Pathology, Regeneration Research Center for Intractable Diseases, Kansai Medical University, Moriguchi City, Osaka, Japan
    Int J Hematol 76:161-4. 2002
    ..We believe that these strategies for BMT and organ transplantation herald a new era in transplantation...
  83. ncbi request reprint Enhancement of allogeneic hematopoietic stem cell engraftment and prevention of GVHD by intra-bone marrow bone marrow transplantation plus donor lymphocyte infusion
    Koichi Nakamura
    First Department of Pathology, Kansai Medical University, Osaka, Japan
    Stem Cells 22:125-34. 2004
    ..These findings suggest that IBM-BMT in conjunction with DLI will be a valuable strategy for allogeneic BMT in humans...
  84. ncbi request reprint Long-term survival of bone marrow-derived retinal nerve cells in the retina
    Keizo Minamino
    First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
    Neuroreport 16:1255-9. 2005
    ..Moreover, we still detected bone marrow stem cell-derived retinal nerve cells in the retina 1 year after injection in the retina...
  85. ncbi request reprint Long-term observation after simultaneous lung and intra-bone marrow-bone marrow transplantation
    Hiroyuki Kaneda
    First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
    J Heart Lung Transplant 24:1415-23. 2005
    ..We demonstrate that IBM-BMT can be used to induce tolerance even in simultaneous lung transplantations in rats without administering any immunosuppressants...
  86. ncbi request reprint Allogeneic intrabone marrow-bone marrow transplantation plus donor lymphocyte infusion suppresses growth of colon cancer cells implanted in skin and liver of rats
    Yasushi Koike
    First Department of Pathology, Kansai Medical University, 10 15 Moriguchi, Osaka, Japan
    Stem Cells 25:385-91. 2007
    ..Allogeneic IBM-BMT + DLI using CD4(-) cells via the portal vein significantly prolonged the survival. These results suggest that allogeneic IBM-BMT + DLI using CD4(-) cells could become a new strategy for the treatment of solid tumors...
  87. ncbi request reprint Induction of senile osteoporosis in normal mice by intra-bone marrow-bone marrow transplantation from osteoporosis-prone mice
    Yusuke Ueda
    First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    Stem Cells 25:1356-63. 2007
    ..quot; Disclosure of potential conflicts of interest is found at the end of this article...
  88. ncbi request reprint Extensive studies on perfusion method plus intra-bone marrow-bone marrow transplantation using cynomolgus monkeys
    Muneo Inaba
    First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
    Stem Cells 25:2098-103. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  89. ncbi request reprint Effect of hepatocyte growth factor on long term hematopoiesis of human progenitor cells in transgenic-severe combined immunodeficiency mice
    Kikuya Sugiura
    Department of Advanced Pathobiology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai City, Osaka, Japan
    Cytokine 37:218-26. 2007
    ..The results also imply that HGF acts on HSCs/HPCs as a synergistic proliferative factor combined with SCF. We have demonstrated the advantage of the human cytokine-producing animal in the maintenance of human HSCs...
  90. ncbi request reprint Granulocyte-colony stimulating factor increases donor mesenchymal stem cells in bone marrow and their mobilization into peripheral circulation but does not repair dystrophic heart after bone marrow transplantation
    Kimiko Tatsumi
    The Department of Pediatrics, Kansai Medical University, Moriguchi, Japan
    Circ J 72:1351-8. 2008
    ..Hereditary disordered cardiac muscle could be replaced with intact cardiomyocytes derived from genetically intact bone marrow (BM)-derived stem cells...
  91. doi request reprint Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis
    Shizuo Ohnishi
    Department of Neurology, Kansai Medical University, Moriguchi City, Osaka, Japan
    Brain Res 1296:216-24. 2009
    ..These results suggest that the replacement with normal hematopoietic cells improved the neural cell environment, thereby slowing the progression of the disease...
  92. doi request reprint Transformation potential of bone marrow stromal cells into undifferentiated high-grade pleomorphic sarcoma
    Qing Li
    First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
    J Cancer Res Clin Oncol 136:829-38. 2010
    ..In the present study, we investigated what types of tumor cells are inducible from BM adherent cells by chemical carcinogens...
  93. ncbi request reprint Successful allogeneic bone marrow transplantation. Crucial roles of stromal cells in prevention of graft rejection
    S Ikehara
    First Department of Pathology, Transplantation Center, Kansai Medical University, Moriguchi City, Japan
    Acta Haematol 105:172-8. 2001
    ..In this paper, we show how stromal cells play crucial roles in overcoming chimerism-resistant allo BMT...
  94. doi request reprint Prevention of corticosteroid-induced osteonecrosis in rabbits by intra-bone marrow injection of autologous bone marrow cells
    T Asada
    Department of Orthopaedic Surgery, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    Rheumatology (Oxford) 47:591-6. 2008
    ..Femoral head osteonecrosis (ON) is a serious complication of steroid administration. We evaluated bone marrow transplantation (BMT) for preventing corticosteroid-induced ON...
  95. ncbi request reprint Long-term immunologic induction of donor-specific tolerance to skin allografts by bone marrow transplant in rabbits
    Yi Biao Wang
    Department of Plastic and Reconstructive Surgery, Kansai Medical University, Moriguchi City, Osaka, Japan
    Plast Reconstr Surg 111:291-7; discussion 298-9. 2003
    ..The results demonstrate that induction of allograft tolerance can be achieved by bone marrow transplantation in a rabbit model. This protocol deserves further study in other large animal models...
  96. ncbi request reprint Successful allogeneic leg transplantation in rats in conjunction with intra-bone marrow injection of donor bone marrow cells
    Takashi Esumi
    First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
    Transplantation 76:1543-8. 2003
    ..Furthermore, the prior injection of fludarabine can reduce the irradiation dose to the sublethal level (4.5 Gy x 2). Therefore, we hypothesize that IBM-BMT plus fludarabine is applicable to allogeneic leg transplantation in rats...
  97. ncbi request reprint Bone marrow cells as an origin of immune-mediated hearing loss
    Hiroshi Iwai
    Department of Otorhinolaryngology, Kansai Medical University Osaka, Moriguchi, Japan
    Acta Otolaryngol 124:8-12. 2004
    ....
  98. ncbi request reprint Lumican expression is associated with the formation of mesenchyme-like elements in salivary pleomorphic adenomas
    Kimihide Kusafuka
    Department of Transplantation for Regeneration Therapy, Sponsored by Otsuka Pharmaceutical Co, Ltd, Kansai Medical University, 10 15 Fumizono cho, Moriguchi, Osaka 570 8506, Japan
    J Pathol 203:953-60. 2004
    ....
  99. ncbi request reprint Mobilization of bone marrow cells by G-CSF rescues mice from cisplatin-induced renal failure, and M-CSF enhances the effects of G-CSF
    Masayoshi Iwasaki
    First Department of Pathology, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
    J Am Soc Nephrol 16:658-66. 2005
    ..These results suggest that bone marrow cells mobilized by G-CSF accelerate the improvement in renal functions and prevent the renal tubular injury induced by cisplatin and that M-CSF enhances the effects of G-CSF...
  100. ncbi request reprint Treatment of streptozotocin-induced diabetes mellitus in rats by transplantation of islet cells from two major histocompatibility complex disparate rats in combination with intra bone marrow injection of allogeneic bone marrow cells
    Mitsuru Taira
    First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    Transplantation 79:680-7. 2005
    ....