Keiichi Fukuda

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. ncbi request reprint Mesenchymal, but not hematopoietic, stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction in mice
    Keiichi Fukuda
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
    Kidney Int 68:1940-3. 2005
  2. ncbi request reprint Bone marrow-derived regenerated cardiomyocytes (CMG Cells) express functional adrenergic and muscarinic receptors
    Daihiko Hakuno
    Cardiopulmonary Division, Department of Internal Medicine, Institute for Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
    Circulation 105:380-6. 2002
  3. ncbi request reprint Progress in myocardial regeneration and cell transplantation
    Keiichi Fukuda
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
    Circ J 69:1431-46. 2005
  4. ncbi request reprint Stem cells as a source of regenerative cardiomyocytes
    Keiichi Fukuda
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
    Circ Res 98:1002-13. 2006
  5. doi request reprint Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad
    Narihito Nagoshi
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Cell Stem Cell 2:392-403. 2008
  6. doi request reprint Current status of myocardial regeneration and cell transplantation
    Keiichi Fukuda
    Keio University School of Medicine, Cardiology Division, Department of Internal Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Future Cardiol 1:167-75. 2005
  7. pmc Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart
    Yuichi Tomita
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
    J Cell Biol 170:1135-46. 2005
  8. pmc Cardiac innervation and sudden cardiac death
    Masaki Ieda
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Curr Cardiol Rev 5:289-95. 2009
  9. pmc Induced pluripotent stem cells in cardiovascular medicine
    Toru Egashira
    Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Stem Cells Int 2011:348960. 2011
  10. pmc Plasma concentrations of osteopontin, but not thrombin-cleaved osteopontin, are associated with the presence and severity of nephropathy and coronary artery disease in patients with type 2 diabetes mellitus
    Xiaoxiang Yan
    Department of Cardiology, Rui Jin Hospital, Jiaotong University School of Medicine, Shanghai, China
    Cardiovasc Diabetol 9:70. 2010

Collaborators

Detail Information

Publications132 found, 100 shown here

  1. ncbi request reprint Mesenchymal, but not hematopoietic, stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction in mice
    Keiichi Fukuda
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
    Kidney Int 68:1940-3. 2005
    ..EGFP(+) actinin(+) cells were observed in the ischemic myocardium, indicating that MSC had been mobilized and differentiated into cardiomyocytes. Together, these results suggest that the origin of the BM-derived cardiomyocytes is MSC...
  2. ncbi request reprint Bone marrow-derived regenerated cardiomyocytes (CMG Cells) express functional adrenergic and muscarinic receptors
    Daihiko Hakuno
    Cardiopulmonary Division, Department of Internal Medicine, Institute for Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
    Circulation 105:380-6. 2002
    ..We investigated whether these receptors are expressed in differentiated CMG cells, and if so, whether they have downstream signaling systems...
  3. ncbi request reprint Progress in myocardial regeneration and cell transplantation
    Keiichi Fukuda
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
    Circ J 69:1431-46. 2005
    ..The treatment of heart failure using cytokines to mobilize stem cells has also been explored...
  4. ncbi request reprint Stem cells as a source of regenerative cardiomyocytes
    Keiichi Fukuda
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
    Circ Res 98:1002-13. 2006
    ..An integrative study involving developmental biology, stem cell biology, and tissue engineering is required to achieve the full potential of cardiac regeneration...
  5. doi request reprint Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad
    Narihito Nagoshi
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Cell Stem Cell 2:392-403. 2008
    ..The identification of NCSCs in accessible adult tissue provides a new potential source for autologous cell therapy after nerve injury or disease...
  6. doi request reprint Current status of myocardial regeneration and cell transplantation
    Keiichi Fukuda
    Keio University School of Medicine, Cardiology Division, Department of Internal Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Future Cardiol 1:167-75. 2005
    ....
  7. pmc Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart
    Yuichi Tomita
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
    J Cell Biol 170:1135-46. 2005
    ....
  8. pmc Cardiac innervation and sudden cardiac death
    Masaki Ieda
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Curr Cardiol Rev 5:289-95. 2009
    ..The present review focuses on the regulatory mechanisms underlying cardiac innervation and the critical role of these processes in cardiac performance...
  9. pmc Induced pluripotent stem cells in cardiovascular medicine
    Toru Egashira
    Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Stem Cells Int 2011:348960. 2011
    ..Furthermore, iPS cell technology has generated new human disease models using disease-specific cells. This paper summarizes the progress of iPS cell technology in cardiovascular research...
  10. pmc Plasma concentrations of osteopontin, but not thrombin-cleaved osteopontin, are associated with the presence and severity of nephropathy and coronary artery disease in patients with type 2 diabetes mellitus
    Xiaoxiang Yan
    Department of Cardiology, Rui Jin Hospital, Jiaotong University School of Medicine, Shanghai, China
    Cardiovasc Diabetol 9:70. 2010
    ....
  11. ncbi request reprint Molecular characterization of regenerated cardiomyocytes derived from adult mesenchymal stem cells
    Keiichi Fukuda
    Institute for Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo 160 8582, Japan
    Congenit Anom (Kyoto) 42:1-9. 2002
    ..These findings demonstrated that the regenerated cardiomyocytes were capable of responding to adrenergic and muscarinic stimulation. This new cell line provides a model for the study of cardiomyocyte transplantation...
  12. ncbi request reprint Reprogramming of bone marrow mesenchymal stem cells into cardiomyocytes
    Keiichi Fukuda
    Institute for Advanced Cardiac Therapeutics, Institute of Integrated Medical Research 7S1 7S2, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    C R Biol 325:1027-38. 2002
    ..These findings indicated that cell transplantation therapy for the patients with heart failure might possibly be achieved using the regenerated cardiomyocytes from autologous bone marrow cells in the near future...
  13. ncbi request reprint Application of mesenchymal stem cells for the regeneration of cardiomyocyte and its use for cell transplantation therapy
    Keiichi Fukuda
    Institute for Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
    Hum Cell 16:83-94. 2003
    ..These findings indicated that cell transplantation therapy for the patients with heart failure might possibly be achieved using the regenerated cardiomyocytes from autologous bone marrow cells in the near future...
  14. pmc Regeneration of cardiomyocytes from bone marrow: Use of mesenchymal stem cell for cardiovascular tissue engineering
    Keiichi Fukuda
    Institute for Advanced Cardiac Therapeutics, Keio University School of Medicine, Shinanomachi, Shinjuku ku, Tokyo, Japan E mail
    Cytotechnology 41:165-75. 2003
    ..These findings indicated that cell transplantation therapy for the patients with heart failure might possibly be achieved using the regenerated cardiomyocytes from autologous bone marrow cells in the near future...
  15. doi request reprint Incidence of periprocedural myocardial infarction and cardiac biomarker testing after percutaneous coronary intervention in Japan: results from a multicenter registry
    Takahide Arai
    Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Heart Vessels 28:714-9. 2013
    ..2 % of patients after PCI. The results suggest an underuse of postprocedural biomarker testing and room for procedural quality improvement, particularly in cases of silent ischemia and nonemergent cases. ..
  16. doi request reprint Eicosapentaenoic acid suppresses adverse effects of C-reactive protein overexpression on pressure overload-induced cardiac remodeling
    Toshiyuki Nagai
    Division of Cardiology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Heart Vessels 28:404-11. 2013
    ..In conclusion, the anti-inflammatory and antioxidative properties of EPA may make it an effective therapeutic strategy for adverse cardiac remodeling associated with CRP overexpression...
  17. doi request reprint Zac1 is an essential transcription factor for cardiac morphogenesis
    Shinsuke Yuasa
    Professor and Chair, Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan
    Circ Res 106:1083-91. 2010
    ..The transcriptional networks guiding heart development remain poorly understood, despite the identification of several essential cardiac transcription factors...
  18. doi request reprint Neural crest-derived stem cells migrate and differentiate into cardiomyocytes after myocardial infarction
    Yuichi Tamura
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 31:582-9. 2011
    ..Here, we examined the migration and differentiation potential of these cells on myocardial infarction (MI)...
  19. doi request reprint Electrical superior vena cava isolation using photodynamic therapy in a canine model
    Takehiro Kimura
    Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo 160 8582, Japan
    Europace 18:294-300. 2016
    ....
  20. pmc Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents
    Hideaki Kanazawa
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Clin Invest 120:408-21. 2010
    ..Thus, CHF causes target-dependent cholinergic transdifferentiation of the cardiac SNS via gp130-signaling cytokines secreted from the failing myocardium...
  21. doi request reprint Aortic aneurysm: an independent predictor of a looped brachiocephalic trunk in patients undergoing transradial coronary angiography
    Satoshi Mogi
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
    Coron Artery Dis 24:602-5. 2013
    ..A looped brachiocephalic trunk may cause transradial coronary angiography (TRA) failure with a right radial approach. The prevalences of aortic aneurysm (AA) and a looped brachiocephalic trunk are closely related to increased age...
  22. doi request reprint Endogenous prostaglandin D2 and its metabolites protect the heart against ischemia-reperfusion injury by activating Nrf2
    Yoshinori Katsumata
    Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo 160 8582, Japan
    Hypertension 63:80-7. 2014
    ..In addition, we propose activation of peroxisome proliferator-activated receptor-γ by the dehydrated metabolite of PGD(2) (15-deoxy-Δ12,14-PGJ(2)) as another mechanism by which glucocorticoids induce cardioprotection...
  23. doi request reprint C-reactive protein overexpression exacerbates pressure overload-induced cardiac remodeling through enhanced inflammatory response
    Toshiyuki Nagai
    Division of Cardiology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertension 57:208-15. 2011
    ..In conclusion, CRP itself may have a pathogenic role in the development of pressure overload-induced cardiac remodeling, possibly through enhanced inflammation and oxidative stress...
  24. doi request reprint Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization
    Hidehiro Kaneko
    Division of Cardiology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Atherosclerosis 217:350-7. 2011
    ..We sought to examine the effect of resveratrol (3,4',5-trihydroxy-trans-stilbene), a plant-derived polyphenolic compound, on the development of abdominal aortic aneurysm (AAA)...
  25. ncbi request reprint Sema3a maintains normal heart rhythm through sympathetic innervation patterning
    Masaki Ieda
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nat Med 13:604-12. 2007
    ..We conclude that appropriate cardiac Sema3a expression is needed for sympathetic innervation patterning and is critical for heart rate control...
  26. doi request reprint Pulmonary edema predictive scoring index (PEPSI), a new index to predict risk of reperfusion pulmonary edema and improvement of hemodynamics in percutaneous transluminal pulmonary angioplasty
    Takumi Inami
    Division of Cardiology, Second Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan
    JACC Cardiovasc Interv 6:725-36. 2013
    ..This study sought to identify useful predictors for hemodynamic improvement and risk of reperfusion pulmonary edema (RPE), a major complication of this procedure...
  27. doi request reprint Wnt2 accelerates cardiac myocyte differentiation from ES-cell derived mesodermal cells via non-canonical pathway
    Takeshi Onizuka
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
    J Mol Cell Cardiol 52:650-9. 2012
    ..Therefore we conclude that Wnt2 plays strong positive stage-specific role in cardiogenesis through non-canonical Wnt pathway in murine ES cells...
  28. doi request reprint 4-hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via the Nrf2-dependent pathway
    Yan Zhang
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
    J Mol Cell Cardiol 49:576-86. 2010
    ..In summary, 4-HNE activates Nrf2-mediated gene expression and stimulates GSH biosynthesis, thereby conferring on cardiomyocytes protection against ischemia-reperfusion injury...
  29. doi request reprint Impact of periprocedural bleeding on incidence of contrast-induced acute kidney injury in patients treated with percutaneous coronary intervention
    Yohei Ohno
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
    J Am Coll Cardiol 62:1260-6. 2013
    ..This study sought to evaluate the association between contrast-induced acute kidney injury (CI-AKI) after percutaneous coronary intervention and severity of bleeding estimated from periprocedural hemoglobin (Hb) measurement...
  30. doi request reprint Ventricular fibrillation associated with J-wave manifestation following pericarditis after catheter ablation for paroxysmal atrial fibrillation
    Takehiro Kimura
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan Electronic address
    Can J Cardiol 29:1330.e1-1330.e3. 2013
    ..VF might develop in juvenile onset of AF especially in individuals with a family history of sudden cardiac death. ..
  31. doi request reprint Myocardial cell sheet therapy and cardiac function
    Jun Fujita
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
    Am J Physiol Heart Circ Physiol 303:H1169-82. 2012
    ..Innervation is also a potential issue. The future application of myocardial cell therapy with MCS for advanced HF depends on resolving these difficulties...
  32. doi request reprint Disease characterization using LQTS-specific induced pluripotent stem cells
    Toru Egashira
    Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Cardiovasc Res 95:419-29. 2012
    ..This study thus sought to better characterize ion channel cardiac disorders using induced pluripotent stem cells (iPSCs)...
  33. ncbi request reprint Overexpression of human C-reactive protein exacerbates left ventricular remodeling in diabetic cardiomyopathy
    Yoshinori Mano
    Division of Cardiology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Circ J 75:1717-27. 2011
    ..However, the effect of CRP on heart failure has not been elucidated. The effect of human CRP on cardiac dysfunction induced by diabetes mellitus (DM) using human CRP-overexpressing transgenic mice (CRP-Tg) was examined...
  34. doi request reprint Regulatory role of dendritic cells in postinfarction healing and left ventricular remodeling
    Atsushi Anzai
    Division of Cardiology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Circulation 125:1234-45. 2012
    ..We previously reported dendritic cell (DC) infiltration in the infarcted heart; however, the precise contribution of DC in postinfarction healing is unclear...
  35. doi request reprint Tumor necrosis factor-α converting enzyme is a key mediator of abdominal aortic aneurysm development
    Hidehiro Kaneko
    Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Atherosclerosis 218:470-8. 2011
    ..We sought to clarify the role of TNF-α converting enzyme (Tace), which cleaves the transmembrane precursor of TNF-α, in AAA development...
  36. ncbi request reprint Application of mesenchymal stem cell-derived cardiomyocytes as bio-pacemakers: current status and problems to be solved
    Yuichi Tomita
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Institute of Integrated Medical Research, 35 Shinanomachi, Tokyo, Japan
    Med Biol Eng Comput 45:209-20. 2007
    ..Although further innovation is required, the present findings provide evidence of the potential for bone marrow-derived cardiomyocytes to be used as bio-pacemakers...
  37. ncbi request reprint Administration of granulocyte colony-stimulating factor after myocardial infarction enhances the recruitment of hematopoietic stem cell-derived myofibroblasts and contributes to cardiac repair
    Jun Fujita
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Stem Cells 25:2750-9. 2007
    ..MI leads to the recruitment of monocytes, which differentiate into myofibroblasts in the infarct region. Administration of G-CSF promotes this recruitment and enhances cardiac protection...
  38. ncbi request reprint AAV-PGIS gene transfer improves hypoxia-induced pulmonary hypertension in mice
    Takashi Kawakami
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 363:656-61. 2007
    ..At 24 weeks, all PH mice were deceased, but 47% of AAV-hPGIS-treated mice survived. This study demonstrated that AAV-hPGIS administration was effective in treating PH and prolonging survival...
  39. doi request reprint Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart
    Jin Endo
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo 160 8582, Japan
    Circ Res 105:1118-27. 2009
    ..Aldehyde accumulation is regarded as a pathognomonic feature of oxidative stress-associated cardiovascular disease...
  40. doi request reprint Simple autogeneic feeder cell preparation for pluripotent stem cells
    Weizhen Li
    Division of Cardiology, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Stem Cell Res 6:83-9. 2011
    ..Taken together, these findings imply that AF cells can replace MEFs in the routine maintenance of primate pluripotent stem cells...
  41. doi request reprint Anatomical variations affect radial artery spasm and procedural achievement of transradial cardiac catheterization
    Yohei Numasawa
    Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Heart Vessels 29:49-57. 2014
    ..23; 95 % CI 1.01-4.73; P = 0.041) were distinct predictors of RA spasm. Anatomical variations were observed in 9.1 % of the patients, and strongly correlated with RA spasm and procedural achievement of TRCC. ..
  42. pmc Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents
    Daihiko Hakuno
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Invest 120:2292-306. 2010
    ..These findings indicate that, in contrast to chondromodulin I, periostin plays an essential role in the progression of cardiac valve complex degeneration by inducing angiogenesis and MMP production...
  43. doi request reprint In vitro pharmacologic testing using human induced pluripotent stem cell-derived cardiomyocytes
    Tomofumi Tanaka
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, School of Medicine, Keio University, Tokyo, Japan
    Biochem Biophys Res Commun 385:497-502. 2009
    ..This study shows that hiPS-CMs represent a promising in vitro model for cardiac electrophysiologic studies and drug screening...
  44. doi request reprint Three-dimensional imaging and mapping of the right and left phrenic nerves: relevance to interventional cardiovascular therapy
    Kotaro Fukumoto
    Cardiology Division, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku City, Tokyo, Japan
    Europace 15:937-43. 2013
    ..This study aimed to analyse the anatomy of the PN by performing three-dimensional (3-D) imaging and pace mapping...
  45. ncbi request reprint Storms of ventricular fibrillation responsive to isoproterenol in an idiopathic ventricular fibrillation patient demonstrating complete right bundle branch block
    Yoshiyasu Aizawa
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
    Int Heart J 54:240-2. 2013
    ..5 years. From these beneficial effects, the VF of the patient was suggested to share common arrhythmogenic characteristics to those of Brugada syndrome or J-wave associated VF. ..
  46. pmc The effectiveness of rigid pericardial endoscopy for minimally invasive minor surgeries: cell transplantation, epicardial pacemaker lead implantation, and epicardial ablation
    Takehiro Kimura
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
    J Cardiothorac Surg 7:117. 2012
    ..Techniques for cell transplantation, epicardial pacemaker lead implantation, and epicardial ablation were developed...
  47. pmc Deleterious effect of the IL-23/IL-17A axis and γδT cells on left ventricular remodeling after myocardial infarction
    Xiaoxiang Yan
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
    J Am Heart Assoc 1:e004408. 2012
    ..Left ventricular (LV) remodeling leads to chronic heart failure and is a main determinant of morbidity and mortality after myocardial infarction (MI). At the present time, therapeutic options to prevent LV remodeling are limited...
  48. ncbi request reprint Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart
    Hirotaka Yada
    Cardiopulmonary Division, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Circ Res 101:69-77. 2007
    ....
  49. ncbi request reprint Prostaglandin E2 induces hypertrophic changes and suppresses alpha-skeletal actin gene expression in rat cardiomyocytes
    Satoru Miyatake
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
    J Cardiovasc Pharmacol 50:548-54. 2007
    ..In conclusion, PGE2 induced hypertrophic changes in cardiomyocytes and attenuated alpha-skeletal actin gene expression in part via EP4...
  50. doi request reprint Neural crest-derived resident cardiac cells contribute to the restoration of adrenergic function of transplanted heart in rodent
    Yuichi Tamura
    Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan Université Paris Sud, AP HP, Service de Pneumologie, Hopital Bicetre, INSERM U999, Le Kremlin Bicetre, France International University of Health and Welfare, Mita Hospital, Tokyo, Japan
    Cardiovasc Res 109:350-7. 2016
    ..Little is known about the origin and function of the intrinsic system in the transplanted heart...
  51. ncbi request reprint Cardiomyocytes undergo cells division following myocardial infarction is a spatially and temporally restricted event in rats
    Shinsuke Yuasa
    Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Mol Cell Biochem 259:177-81. 2004
    ..In conclusion, mitogenic cardiomyocytes are present in the adult rat heart following myocardial infarction, but were spatially and temporally restricted...
  52. doi request reprint Molecular mechanisms underlying the onset of degenerative aortic valve disease
    Daihiko Hakuno
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Mol Med (Berl) 87:17-24. 2009
    ..The present review focuses on the animal models of aortic valve degeneration and recent studies on the molecular mechanisms underlying the onset of degenerative aortic valve disease...
  53. doi request reprint Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis
    Naritaka Kimura
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
    Circulation 118:1737-47. 2008
    ..CTC is an avascular tissue. We investigated the molecular mechanisms underlying the avascularity of CTC and the correlation between avascularity and CTC rupture...
  54. ncbi request reprint Selective involvement of p130Cas/Crk/Pyk2/c-Src in endothelin-1-induced JNK activation
    Hiroaki Kodama
    Cardiopulmonary Division, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Hypertension 41:1372-9. 2003
    ..Collectively, the focal adhesion-dependent p130Cas/Crk/Pyk2/c-Src-mediated pathway is selectively involved in ET-induced JNK activation in cardiomyocytes...
  55. doi request reprint G-CSF promotes the proliferation of developing cardiomyocytes in vivo and in derivation from ESCs and iPSCs
    Kenichiro Shimoji
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo 160 8582, Japan
    Cell Stem Cell 6:227-37. 2010
    ..These findings indicated that G-CSF is critically involved in cardiomyocyte proliferation during development, and may be used to boost the yield of cardiomyocytes from ESCs for their potential application to regenerative medicine...
  56. pmc The role of individual domains and the significance of shedding of ATP6AP2/(pro)renin receptor in vacuolar H(+)-ATPase biogenesis
    Kenichiro Kinouchi
    Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 8:e78603. 2013
    ..The V-ATPase assembly occurs prior to its delivery to the trans-Golgi network and hence shedding of ATP6AP2/PRR would not affect the biogenesis of active V-ATPase. ..
  57. doi request reprint Use of thrombolysis in myocardial infarction risk score to predict bleeding complications in patients with unstable angina and non-ST elevation myocardial infarction undergoing percutaneous coronary intervention
    Yohei Numasawa
    Department of Cardiology, Ashikaga Red Cross Hospital, 284 1 Yobe cho, Ashikaga shi, Tochigi, Japan
    Cardiovasc Interv Ther 28:242-9. 2013
    ..021), and the incidence of access site bleeding (1.1, 2.7, and 5.5 %, p = 0.112). The TIMI score might aid in subjectively quantifying the risk of in-hospital complication rates such as access site bleeding. ..
  58. doi request reprint Anatomical characteristics of the left atrial appendage in cardiogenic stroke with low CHADS2 scores
    Takehiro Kimura
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
    Heart Rhythm 10:921-5. 2013
    ..Strokes develop even in patients with low CHADS₂ scores, and the left atrial appendage (LAA) is the embolic source 90% of the time. We focused on the LAA morphology as a new predictor of strokes...
  59. pmc Cardiomyocyte-specific overexpression of HEXIM1 prevents right ventricular hypertrophy in hypoxia-induced pulmonary hypertension in mice
    Noritada Yoshikawa
    Department of Rheumatology and Allergy, IMSUT Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    PLoS ONE 7:e52522. 2012
    ..We conclude that P-TEFb/HEXIM1-dependent transcriptional regulation may play a pathophysiological role in RVH and be a novel therapeutic target for mitigating RVH in PAH...
  60. ncbi request reprint Genetic analysis of essential cardiac transcription factors in 256 patients with non-syndromic congenital heart defects
    Kazuki Kodo
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    Circ J 76:1703-11. 2012
    ..The genetic basis of most congenital heart defects (CHDs), especially non-syndromic and non-familial conditions, remains largely unknown...
  61. ncbi request reprint Analysis of the electrophysiological properties and arrhythmias in directly contacted skeletal and cardiac muscle cell sheets
    Yuji Itabashi
    Cardio pulmonary Division, Department of Internal Medicine, Keio University School of Medicine, 3535 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Cardiovasc Res 67:561-70. 2005
    ....
  62. ncbi request reprint Bone marrow derived cells are involved in the pathogenesis of cardiac hypertrophy in response to pressure overload
    Jin Endo
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo 160 8582, Japan
    Circulation 116:1176-84. 2007
    ..The present study investigated whether BM-derived cells contribute to the pathogenesis of cardiac hypertrophy, as well as the possible cellular mechanisms involved in such a role...
  63. ncbi request reprint SHP2-mediated signaling cascade through gp130 is essential for LIF-dependent I CaL, [Ca2+]i transient, and APD increase in cardiomyocytes
    Yoko Hagiwara
    Division of Cardiology, Department of Medicine, Keio University School of Medicine, Japan
    J Mol Cell Cardiol 43:710-6. 2007
    ..5+/-4.3%, n=12, p<0.05), but not in gp130(F759/F759) (-2.1+/-11.2%, n=7, NS). SHP2-mediated signaling cascade is essential for the LIF and IL-6+sIL-6r-dependent increase in I(CaL), [Ca(2+)](i) transient and APD...
  64. ncbi request reprint G-CSF augments small vessel and cell density in canine myocardial infarciton
    Takashi Yagi
    Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Keio J Med 57:139-49. 2008
    ..These findings suggested G-CSF prevented cardiac remodeling in canine model not by increasing the cardiomyocytes but by increasing the vessel density and cell numbers in the infarcted area...
  65. doi request reprint Nongenetic method for purifying stem cell-derived cardiomyocytes
    Fumiyuki Hattori
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
    Nat Methods 7:61-6. 2010
    ..Our approaches will aid in the future success of using PSC-derived cardiomyocytes for basic and clinical applications...
  66. doi request reprint Norepinephrine-induced nerve growth factor depletion causes cardiac sympathetic denervation in severe heart failure
    Kensuke Kimura
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Auton Neurosci 156:27-35. 2010
    ....
  67. doi request reprint Human C-reactive protein exacerbates metabolic disorders in association with adipose tissue remodelling
    Hidehiro Kaneko
    Division of Cardiology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Cardiovasc Res 91:546-55. 2011
    ..C-reactive protein (CRP) expression is increased with metabolic alterations. We sought to clarify the effect of CRP on the development of obesity-induced metabolic disorders using human CRP-overexpressing transgenic mice (CRPTG)...
  68. doi request reprint Time-lapse imaging of cell cycle dynamics during development in living cardiomyocyte
    Hisayuki Hashimoto
    Department of Cardiology, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Mol Cell Cardiol 72:241-9. 2014
    ..Our time-lapse imaging of murine heart revealed a gradual elongation of the S/G2/M phase during development in living cardiomyocytes. ..
  69. pmc G-CSF influences mouse skeletal muscle development and regeneration by stimulating myoblast proliferation
    Mie Hara
    Department of Cardiology, Keio University School of Medicine, Shinjuku, Tokyo 160 8582, Japan
    J Exp Med 208:715-27. 2011
    ..These findings indicate that G-CSF is crucial for skeletal myocyte development and regeneration and demonstrate the importance of inflammation-mediated induction of muscle regeneration...
  70. ncbi request reprint Nerve growth factor is critical for cardiac sensory innervation and rescues neuropathy in diabetic hearts
    Masaki Ieda
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Circulation 114:2351-63. 2006
    ..The present study focused on the roles of nerve growth factor (NGF) in the regulation of the cardiac sensory nervous system and analyzed the mechanism of silent myocardial ischemia in DM...
  71. doi request reprint Common marmoset embryonic stem cell can differentiate into cardiomyocytes
    Hao Chen
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 369:801-6. 2008
    ..We believe that CMESC-derived cardiomyocytes will advance preclinical studies in cardiovascular regenerative medicine...
  72. doi request reprint Left circumflex coronary artery is protected against no-reflow phenomenon following percutaneous coronary intervention for coronary artery disease
    Toshiyuki Nagai
    Department of Cardiology, National Hospital Organization, Saitama Hospital, Saitama, Japan
    Heart Vessels 28:559-65. 2013
    ..044). In conclusion, LCx as the target vessel was protective against no-reflow compared with LAD following PCI for CAD. Our results suggest that embolic protection devices may be unnecessary in CAD patients with involvement of LCx. ..
  73. doi request reprint Lung natural killer cells play a major counter-regulatory role in pulmonary vascular hyperpermeability after myocardial infarction
    Xiaoxiang Yan
    From the Department of Cardiology, Rui Jin Hospital, Medical School of Jiaotong University, Shanghai, PR China X Y, W S Departments of Cardiology X Y, J E, A A, T M, Y K, K I, T Y, K F, M S, Pulmonary Medicine A E H, T B, and Geriatric Medicine K S, Keio University School of Medicine, Tokyo, Japan Centre d Immunologie de Marseille Luminy, Universite de la Mediterranee, INSERM, Marseille, France E V Precursory Research for Embryonic Science and Technology PRESTO, Japan Science and Technology Agency, Tokyo, Japan M S
    Circ Res 114:637-49. 2014
    ..Natural killer (NK) cells are lymphocytes of the innate immune system that play specialized and niche-specific roles in distinct organs...
  74. ncbi request reprint Pulsatile cardiac tissue grafts using a novel three-dimensional cell sheet manipulation technique functionally integrates with the host heart, in vivo
    Akira Furuta
    Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine, Japan
    Circ Res 98:705-12. 2006
    ..Bidirectional smooth AP propagation between the host heart and the grafted CS was observed. This finding suggested functional integration of this CS graft with the host heart without serious arrhythmia...
  75. doi request reprint Ridge-related reentry: a variant of perimitral atrial tachycardia
    Seiji Takatsuki
    Department of Cardiology, Keio University Hospital, Tokyo, Japan
    J Cardiovasc Electrophysiol 24:781-7. 2013
    ..Following circumferential PV isolation and LMI linear ablation for the treatment of atrial fibrillation (AF), a critical pathway might develop over the ridge leading to a ridge-related reentry (RRR)...
  76. pmc Induction of human cardiomyocyte-like cells from fibroblasts by defined factors
    Rie Wada
    Department of Clinical and Molecular Cardiovascular Research, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Proc Natl Acad Sci U S A 110:12667-72. 2013
    ..These findings demonstrate that human fibroblasts can be directly converted to iCMs by defined factors, which may facilitate future applications in regenerative medicine. ..
  77. ncbi request reprint Significance of electrocardiographic right ventricular hypertrophy in patients with pulmonary hypertension with or without right ventricular systolic dysfunction
    Toshiyuki Nagai
    Division of Cardiology, Department of Medicine, Keio University School of Medicine, Japan
    Intern Med 51:2277-83. 2012
    ..We sought to determine the value of electrocardiographic right ventricular hypertrophy (ECG-RVH) in pulmonary hypertension (PH) patients with right ventricular systolic dysfunction defined by cardiac magnetic resonance (CMR-RVSD)...
  78. doi request reprint Percutaneous transluminal pulmonary angioplasty for the treatment of chronic thromboembolic pulmonary hypertension
    Masaharu Kataoka
    Division of Cardiology, Department of Medicine, Kyorin University School of Medicine, Keio University School of Medicine, Tokyo, Japan
    Circ Cardiovasc Interv 5:756-62. 2012
    ..The purpose of this study was to investigate the efficacy of percutaneous transluminal pulmonary angioplasty (PTPA) for the treatment of chronic thromboembolic pulmonary hypertension...
  79. ncbi request reprint Prognostic value of cardiac magnetic resonance imaging for idiopathic pulmonary arterial hypertension before initiating intravenous prostacyclin therapy
    Yoshitake Yamada
    Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo, Japan
    Circ J 76:1737-43. 2012
    ....
  80. ncbi request reprint Cardiac sympathetic rejuvenation: a link between nerve function and cardiac hypertrophy
    Kensuke Kimura
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Shinanomachi, Shinjuku ku, Tokyo, Japan
    Circ Res 100:1755-64. 2007
    ..This phenomenon was explained by the rejuvenation of cardiac sympathetic nerves as well as the hypertrophic cardiomyocytes, which also showed the fetal form gene expression...
  81. pmc Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis
    Satori Tokudome
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, School of Medicine, Keio University, Tokyo, Japan
    J Clin Invest 119:1477-88. 2009
    ..Taken together, these results suggest what we believe to be a novel interaction between glucocorticoid-GR signaling and the cardiomyocyte survival pathway mediated by the arachidonic acid cascade...
  82. doi request reprint Omentopexy enhances graft function in myocardial cell sheet transplantation
    Ryo Suzuki
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 387:353-9. 2009
    ..Taken together, we concluded that OP is a promising strategy for the enhancement of graft function in MCS transplantation...
  83. doi request reprint Sudden cardiac arrest and syncope triggered by coronary spasm
    Ikuko Togashi
    Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo, Japan
    Int J Cardiol 163:56-60. 2013
    ..We hypothesized that the nature of coronary spasm triggering lethal arrhythmias may be different from that which induces angina-only...
  84. doi request reprint Induction of cardiomyocyte-like cells in infarct hearts by gene transfer of Gata4, Mef2c, and Tbx5
    Kohei Inagawa
    Department of Clinical and Molecular Cardiovascular Research, Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
    Circ Res 111:1147-56. 2012
    ..We recently found that a combination of 3 cardiac transcription factors, Gata4, Mef2c, and Tbx5 (GMT), reprograms fibroblasts directly into functional cardiomyocytes in vitro...
  85. doi request reprint Successful percutaneous coil embolization of coronary-pulmonary, -carotid, and -internal mammary artery fistulas
    Yohei Numasawa
    Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Heart Vessels 27:331-6. 2012
    ..In the case reported herein, multislice computed tomography played a pivotal role in the preprocedure evaluation...
  86. ncbi request reprint Tumor necrosis factor-α converting enzyme inactivation ameliorates high-fat diet-induced insulin resistance and altered energy homeostasis
    Hidehiro Kaneko
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
    Circ J 75:2482-90. 2011
    ..The role of Tace in obesity-induced metabolic disorders was to be clarified in this study...
  87. doi request reprint Role of vascular endothelial growth factor-A in development of abdominal aortic aneurysm
    Hidehiro Kaneko
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
    Cardiovasc Res 91:358-67. 2011
    ..We sought to elucidate the role of vascular endothelial growth factor (VEGF)-A, a potent angiogenic and proinflammatory factor, in the development of AAA...
  88. doi request reprint Caloric restriction primes mitochondria for ischemic stress by deacetylating specific mitochondrial proteins of the electron transport chain
    Ken Shinmura
    Division of Geriatric Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Circ Res 109:396-406. 2011
    ..Thus, we hypothesized that deacetylation of specific mitochondrial proteins during CR preserves mitochondrial function and attenuates production of reactive oxygen species during ischemia/reperfusion...
  89. doi request reprint Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes
    Shugo Tohyama
    Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
    Cell Stem Cell 12:127-37. 2013
    ..We believe that our technological method broadens the range of potential applications for purified PSC-derived cardiomyocytes and could facilitate progress toward PSC-based cardiac regenerative therapy...
  90. doi request reprint High-mobility group box 1 protein blockade suppresses development of abdominal aortic aneurysm
    Takashi Kohno
    Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    J Cardiol 59:299-306. 2012
    ..We investigated the expression of HMGB1 in human AAA and mouse experimental AAA. Then, we evaluated the effect of HMGB1 blockade on AAA formation in the mouse model...
  91. doi request reprint miR-142-3p is essential for hematopoiesis and affects cardiac cell fate in zebrafish
    Takahiko Nishiyama
    Department of Cardiology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 425:755-61. 2012
    ..The findings of the present study indicate that miR-142-3p plays a critical role in hematopoiesis, cardiogenesis, and somitegenesis in the early stage of mesoderm formation via regulation of Rock2a...
  92. pmc PGD2-CRTH2 pathway promotes tubulointerstitial fibrosis
    Hideyuki Ito
    Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Am Soc Nephrol 23:1797-809. 2012
    ..Ablation of IL-4 and IL-13 also ameliorated renal fibrosis in the UUO kidney. Taken together, these data suggest that blocking the activation of CRTH2 by PGD(2) might be a strategy to slow the progression of renal fibrosis in CKD...
  93. ncbi request reprint A new method for manufacturing cardiac cell sheets using fibrin-coated dishes and its electrophysiological studies by optical mapping
    Yuji Itabashi
    Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine, Shinanomachi, Tokyo, Japan
    Artif Organs 29:95-103. 2005
    ..This simple method of cell sheet engineering may also be applicable for various other cell types...
  94. ncbi request reprint A novel cardiac hypertrophic factor, neurotrophin-3, is paradoxically downregulated in cardiac hypertrophy
    Haruko Kawaguchi-Manabe
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Life Sci 81:385-92. 2007
    ..These findings demonstrate that neurotrophin-3 is a unique hypertrophic factor, which is paradoxically downregulated in cardiac hypertrophy and might counteract hypertrophic change...
  95. ncbi request reprint Cardiac regenerative medicine
    Shinsuke Yuasa
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo, Japan
    Circ J 72:A49-55. 2008
    ..Despite these successes, the accumulating evidence from fields as diverse as developmental biology, stem cell biology and tissue engineering must be integrated to achieve the full potential of cardiac regenerative medicine...
  96. pmc Tissue- and context-dependent modulation of hormonal sensitivity of glucocorticoid-responsive genes by hexamethylene bisacetamide-inducible protein 1
    Noriaki Shimizu
    Division of Clinical Immunology, Advanced Clinical Research Center, Research Hospital, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Mol Endocrinol 22:2609-23. 2008
    ..Collectively, we may conclude that HEXIM1 may participate in tissue-selective determination of glucocorticoid sensitivity via direct interaction with GR at least in certain gene sets including atp1a1 and scnn1a...
  97. ncbi request reprint G-CSF and HGF: combination of vasculogenesis and angiogenesis synergistically improves recovery in murine hind limb ischemia
    Yasuyo Ieda
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Mol Cell Cardiol 42:540-8. 2007
    ....
  98. ncbi request reprint New aspects for the treatment of cardiac diseases based on the diversity of functional controls on cardiac muscles: the regulatory mechanisms of cardiac innervation and their critical roles in cardiac performance
    Masaki Ieda
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Japan
    J Pharmacol Sci 109:348-53. 2009
    ..The present review focuses on the regulatory mechanisms controlling cardiac innervation and the critical roles of these processes in cardiac performance...
  99. doi request reprint Creating frog heart as an organ: in vitro-induced heart functions as a circulatory organ in vivo
    Masayoshi Kinoshita
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Division of Cardiology, Keio University School of Medicine, Tokyo, Japan
    Int J Dev Biol 54:851-6. 2010
    ..This system should facilitate the study of heart organogenesis and may promote a shift from tissue to organ engineering for clinical applications...
  100. doi request reprint Impact of long-term caloric restriction on cardiac senescence: caloric restriction ameliorates cardiac diastolic dysfunction associated with aging
    Ken Shinmura
    Division of Geriatric Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Mol Cell Cardiol 50:117-27. 2011
    ..Enhanced autophagy via the suppression of mTOR during CR may retard cardiac senescence...
  101. ncbi request reprint Leukemia inhibitory factor activates cardiac L-Type Ca2+ channels via phosphorylation of serine 1829 in the rabbit Cav1.2 subunit
    Eiichi Takahashi
    Institute for Advanced Cardiac Therapeutics, Shinanomachi Research Park, Keio University School of Medicine, Tokyo, Japan
    Circ Res 94:1242-8. 2004
    ..2 subunit via the actions of extracellular signal-regulated kinase and that this phosphorylation increases I(CaL) in cardiomyocytes...