Hiromi Ikadai

Summary

Affiliation: Kitasato University
Country: Japan

Publications

  1. ncbi request reprint Molecular evidence of Babesia equi transmission in Haemaphysalis longicornis
    Hiromi Ikadai
    Department of Veterinary Parasitology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan
    Am J Trop Med Hyg 76:694-7. 2007
  2. ncbi request reprint Molecular cloning and partial characterization of Babesia equi EMA-3
    Hiromi Ikadai
    Department of Veterinary Parasitology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori 034 8628, Japan
    Mol Biochem Parasitol 150:371-3. 2006
  3. ncbi request reprint Short report: molecular cloning and characterization of a putative binding protein of Babesia caballi
    Hiromi Ikadai
    Department of Veterinary Parasitology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan
    Am J Trop Med Hyg 73:1135-8. 2005
  4. ncbi request reprint Inhibitory effect of lactoferrin on in vitro growth of Babesia caballi
    Hiromi Ikadai
    Department of Veterinary Parasitology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan
    Am J Trop Med Hyg 73:710-2. 2005
  5. pmc Molecular evidence of infections with Babesia gibsoni parasites in Japan and evaluation of the diagnostic potential of a loop-mediated isothermal amplification method
    Hiromi Ikadai
    Department of Veterinary Parasitology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori 034 8628, Japan
    J Clin Microbiol 42:2465-9. 2004
  6. pmc An improved method for the in vitro differentiation of Plasmodium falciparum gametocytes into ookinetes
    Anil K Ghosh
    Johns Hopkins University School of Public Health, Dept of Molecular Microbiology and Immunology, Malaria Research Institute, Baltimore, MD 21205, USA
    Malar J 9:194. 2010
  7. ncbi request reprint A PCR-based epidemiological survey of Hepatozoon canis in dogs in Nigeria
    Mizuki Sasaki
    Department of Veterinary Parasitology, School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan
    J Vet Med Sci 70:743-5. 2008
  8. ncbi request reprint Short report: cloning of the Babesia gibsoni cytochrome B gene and isolation of three single nucleotide polymorphisms from parasites present after atovaquone treatment
    Aya Matsuu
    Department of Small Animal Internal Medicine 1, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan
    Am J Trop Med Hyg 74:593-7. 2006
  9. ncbi request reprint Efficacy of thiabendazole, mebendazole, levamisole and ivermectin against gullet worm, Gongylonema pulchrum: in vitro and in vivo studies
    Noboru Kudo
    Department of Veterinary Parasitology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan
    Vet Parasitol 151:46-52. 2008
  10. ncbi request reprint Incidence of canine Babesia gibsoni infection and subclinical infection among Tosa dogs in Aomori Prefecture, Japan
    Aya Matsuu
    Department of Small Animal Medicine, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan
    J Vet Med Sci 66:893-7. 2004

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Molecular evidence of Babesia equi transmission in Haemaphysalis longicornis
    Hiromi Ikadai
    Department of Veterinary Parasitology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan
    Am J Trop Med Hyg 76:694-7. 2007
    ..equi antigen was present in their salivary glands, indicating that transstadial transmission occurred. These findings suggest that H. longicornis may play a role in the transmission of B. equi...
  2. ncbi request reprint Molecular cloning and partial characterization of Babesia equi EMA-3
    Hiromi Ikadai
    Department of Veterinary Parasitology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori 034 8628, Japan
    Mol Biochem Parasitol 150:371-3. 2006
  3. ncbi request reprint Short report: molecular cloning and characterization of a putative binding protein of Babesia caballi
    Hiromi Ikadai
    Department of Veterinary Parasitology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan
    Am J Trop Med Hyg 73:1135-8. 2005
    ..Detailed observation showed that the reaction of MAbs against pear-shaped forms was markedly irregular, with either no reaction, or reaction with one or two brightly fluorescent pear-shaped forms (two parasites) of B. caballi...
  4. ncbi request reprint Inhibitory effect of lactoferrin on in vitro growth of Babesia caballi
    Hiromi Ikadai
    Department of Veterinary Parasitology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan
    Am J Trop Med Hyg 73:710-2. 2005
    ..These data indicate that apo LF had the strongest inhibitory effect on B. caballi. This may have been caused by inactivation or inhibition of a growth factor in the culture medium...
  5. pmc Molecular evidence of infections with Babesia gibsoni parasites in Japan and evaluation of the diagnostic potential of a loop-mediated isothermal amplification method
    Hiromi Ikadai
    Department of Veterinary Parasitology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori 034 8628, Japan
    J Clin Microbiol 42:2465-9. 2004
    ..Moreover, nonspecific reactions were not observed by the LAMP method. These results suggest that the LAMP method provides a useful tool for the detection of B. gibsoni infections in dogs...
  6. pmc An improved method for the in vitro differentiation of Plasmodium falciparum gametocytes into ookinetes
    Anil K Ghosh
    Johns Hopkins University School of Public Health, Dept of Molecular Microbiology and Immunology, Malaria Research Institute, Baltimore, MD 21205, USA
    Malar J 9:194. 2010
    ..This article reports on investigations of five different ookinete media, in an effort to improve the in vitro transformation efficiency of P. falciparum gametocytes into mature ookinetes and their infectivity of the mosquito midgut...
  7. ncbi request reprint A PCR-based epidemiological survey of Hepatozoon canis in dogs in Nigeria
    Mizuki Sasaki
    Department of Veterinary Parasitology, School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan
    J Vet Med Sci 70:743-5. 2008
    ..3%) produced 757 bp bands, which differed from the 698 bp band that corresponded to B. canis infection. The sequence of the PCR products of 10 samples were determined, all of which corresponded with the H. canis sequence...
  8. ncbi request reprint Short report: cloning of the Babesia gibsoni cytochrome B gene and isolation of three single nucleotide polymorphisms from parasites present after atovaquone treatment
    Aya Matsuu
    Department of Small Animal Internal Medicine 1, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan
    Am J Trop Med Hyg 74:593-7. 2006
    ..These results indicate that single nucleotide polymorphisms in the sequence for mitochondrial cytb gene may be associated with decreased susceptibility of Babesia species to atovaquone...
  9. ncbi request reprint Efficacy of thiabendazole, mebendazole, levamisole and ivermectin against gullet worm, Gongylonema pulchrum: in vitro and in vivo studies
    Noboru Kudo
    Department of Veterinary Parasitology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan
    Vet Parasitol 151:46-52. 2008
    ..These findings suggest that levamisole exhibits in vivo efficacy against G. pulchrum infection and that the larval invasion tests using mice could be used to screen for anthelmintic susceptibility of nematodes...
  10. ncbi request reprint Incidence of canine Babesia gibsoni infection and subclinical infection among Tosa dogs in Aomori Prefecture, Japan
    Aya Matsuu
    Department of Small Animal Medicine, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan
    J Vet Med Sci 66:893-7. 2004
    ..gibsoni subclinically and this pathogen might be successfully transmitted during dog fighting. Dogs with subclinical infections were at risk of chronic thrombocytopenia, which may be due to autoimmune mechanisms...
  11. ncbi request reprint Molecular survey of Babesia canis in dogs in Nigeria
    Mizuki Sasaki
    Department of Veterinary Parasitology, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034 8628, Japan
    J Vet Med Sci 69:1191-3. 2007
    ..Sequence analysis of the PCR products identified eight samples (2.0%) as B. canis rossi and the ninth (0.3%) as B. canis vogeli. This is the first report of the prevalence of B. canis rossi and B. canis vogeli in dogs in Nigeria...
  12. ncbi request reprint Development of a SYBR green real-time polymerase chain reaction assay for quantitative detection of Babesia gibsoni (Asian genotype) DNA
    Aya Matsuu
    Department of Small Animal Medicine, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan
    J Vet Diagn Invest 17:569-73. 2005
    ..89% and from 1.18% to 1.92%, respectively. This assay system was found to be reproducible and accurate for the quantification of parasite DNA in experimentally infected dogs and far more sensitive than traditional microscopic examination...
  13. ncbi request reprint Further observations on the development of Gongylonema pulchrum in rabbits
    Noboru Kudo
    Department of Veterinary Parasitology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori 034 8628, Japan
    J Parasitol 91:750-5. 2005
    ..The latter finding confirms the utility of the ratio for identification of the nematode...
  14. ncbi request reprint Efficacy of atovaquone against Babesia gibsoni in vivo and in vitro
    Aya Matsuu
    Department of Small Animal Medicine, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori 034 8628, Japan
    Vet Parasitol 124:9-18. 2004
    ..52 +/- 8.34% and 31.31 +/- 8.14% at this concentration after 48 h of incubation. Thus, the recurring parasites were less sensitive to atovaquone than the untreated originally isolated parasites...
  15. ncbi request reprint Morphological survey of bovine Setaria in the abdominal cavities of cattle in Aomori and Kumamoto Prefectures, Japan
    Hiroki Nakano
    Department of Veterinary Parasitology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan
    J Vet Med Sci 69:413-5. 2007
    ..Of these worms, 35 were identified as Setaria digitata, 14 as S. marshalli, and one as S. labiatopapillosa in Aomori Prefecture, while 816 were identified as S. digitata and 31 as S. marshalli in Kumamoto Prefecture...
  16. pmc Identification of immunodiagnostic antigens for cerebrospinal filariasis in horses by western blot analysis
    Masataka Takesue
    Laboratory of Veterinary Parasitology, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    J Equine Sci 27:17-8. 2016
    ..The results revealed S. digitata protein bands measuring 65, 34, 22, and 18 kDa in molecular weight. In particular, the 18 kDa band is a possible candidate for clinical immunodiagnosis on the basis of western blot findings. ..
  17. doi request reprint Encephalitozoon infections in Rodentia and Soricomorpha in Japan
    Ryusuke Tsukada
    Department of Veterinary Parasitology, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034 8628, Japan
    Vet Parasitol 198:193-6. 2013
    ..This study is the first report of Encephalitozoon infection in Rodentia and Soricomorpha in Japan, and our findings suggest that these hosts may play a role in the spread of microsporidian spores in the environment. ..
  18. ncbi request reprint Downregulation of hepatic cytochrome P450 3A in mice infected with Babesia microti
    Yoshinori Shimamoto
    Department of Veterinary Teaching Hospital, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034 8628, Japan
    J Vet Med Sci 74:241-5. 2012
    ..Since TNF-α is one of the potent mediators that induce NOS2 and repress CYP3A transcription, the possible involvement of TNF-α in this downregulation of CYP3A was discussed...
  19. ncbi request reprint Effects of oral administration of furosemide and torsemide in healthy dogs
    Yasutomo Hori
    Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University, 23 35 1 Higashi, Towada, Aomori 034 8628, Japan
    Am J Vet Res 68:1058-63. 2007
    ..To investigate the diuretic effects, tolerability, and adverse effects of furosemide and torsemide after short- and long-term administration in healthy dogs...
  20. pmc Effect of sex steroids on Babesia microti infection in mice
    Mizuki Sasaki
    Department of Veterinary Parasitology, School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan
    Am J Trop Med Hyg 88:367-75. 2013
    ..The results suggested that testosterone directly affects T or B cells, leading to delayed acquired immunity, dramatically increased parasitemia, and severe anemia...
  21. doi request reprint Inhibitory effects of oral disulfiram on endotoxin-induced uveitis in rats
    Kazutaka Kanai
    Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato, Towada, Aomori, Japan
    Curr Eye Res 35:892-9. 2010
    ..The aim of the present study was to investigate the effect of oral DSF on endotoxin-induced uveitis (EIU) in rats...
  22. pmc Serological survey of Encephalitozoon cuniculi infection in cats in Japan
    Ryusuke Tsukada
    Laboratory of Veterinary Parasitology, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034 8628, Japan
    J Vet Med Sci 78:1615-1617. 2016
    ..3%, 7/163). This suggests the possibility that the cats of our country have become a reservoir of E. cuniculi. This study is the first to demonstrate the prevalence of E. cuniculi infection in cats in Japan...
  23. pmc Repression of hepatic cytochrome P450 2D expression in mice during Babesia microti infection
    Yoshinori Shimamoto
    Department of Veterinary Teaching Hospital, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034 8628, Japan
    J Vet Med Sci 76:1147-51. 2014
    ..These results suggest that Babesia infection represses CYP2D expression in the mouse liver. The decline in CYP2D-dependent drug metabolism might be involved in the incidence of adverse drug reactions in patients with babesiosis. ..
  24. pmc Reduced efficacy of ivermectin treatments in gastrointestinal nematode infections of grazing cattle in Japan
    Noboru Kudo
    Department of Veterinary Parasitology, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034 8628, Japan
    J Vet Med Sci 76:1487-91. 2014
    ..296 µg/ml). The results of the LMIT corroborated the FECRT data, indicating the presence of IVM-resistant C. oncophora on Farm 1, at least in August. This is the first report of IVM-resistant nematodes in Japanese cattle. ..
  25. pmc Efficacy of levamisole alone and in combination with mebendazole against Gongylonema pulchrum infection in rabbits
    Noboru Kudo
    Department of Veterinary Parasitology, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034 8628, Japan
    J Vet Med Sci 77:113-6. 2015
    ..2%. These results suggest that this combined chemotherapy treatment may be effective against G. pulchrum infection, including buccal and lingual gongylonemiasis in primates. ..
  26. ncbi request reprint Experimental infection of laboratory animals and sheep with Gongylonema pulchrum in Japan
    Noboru Kudo
    School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan
    J Vet Med Sci 65:921-5. 2003
    ..No distinct morphological differences were observed in the worms from rabbits and sheep. These results indicate that rabbits are very suitable experimental definitive hosts for G. pulchrum...