Kazuhiko Otoguro

Summary

Affiliation: Kitasato University
Country: Japan

Publications

  1. doi request reprint In vitro antitrypanosomal activity of some phenolic compounds from propolis and lactones from Fijian Kawa (Piper methysticum)
    Kazuhiko Otoguro
    Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    J Nat Med 66:558-61. 2012
  2. doi request reprint In vitro antitrypanosomal activity of bis(bibenzyls)s and bibenzyls from liverworts against Trypanosoma brucei
    Kazuhiko Otoguro
    Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    J Nat Med 66:377-82. 2012
  3. doi request reprint In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei
    Kazuhiko Otoguro
    Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Phytochemistry 72:2024-30. 2011
  4. doi request reprint Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites
    Kazuhiko Otoguro
    Research Center for Tropical Diseases, The Kitasato Institute, Tokyo, Japan
    J Antibiot (Tokyo) 61:372-8. 2008
  5. doi request reprint In vitro and in vivo antitrypanosomal activitiy of two microbial metabolites, KS-505a and alazopeptin
    Aki Ishiyama
    Research Center for Tropical Diseases, Center for Basic Research, Kitasato University, Tokyo, Japan
    J Antibiot (Tokyo) 61:627-32. 2008
  6. doi request reprint In vitro and in vivo antimalarial activity of puberulic acid and its new analogs, viticolins A-C, produced by Penicillium sp. FKI-4410
    Masato Iwatsuki
    Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
    J Antibiot (Tokyo) 64:183-8. 2011
  7. doi request reprint Mangromicins A and B: structure and antitrypanosomal activity of two new cyclopentadecane compounds from Lechevalieria aerocolonigenes K10-0216
    Takuji Nakashima
    Research Organization for Infection Control Sciences, Kitasato University, Tokyo, Japan
    J Antibiot (Tokyo) 67:253-60. 2014
  8. doi request reprint Panowamycins A and B, new antitrypanosomal isochromans produced by Streptomyces sp. K07-0010
    Junko Hashida
    Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
    J Antibiot (Tokyo) 65:197-202. 2012
  9. doi request reprint Sinefungin VA and dehydrosinefungin V, new antitrypanosomal antibiotics produced by Streptomyces sp. K05-0178
    Megumi Niitsuma
    Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
    J Antibiot (Tokyo) 63:673-9. 2010
  10. doi request reprint In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin
    Aki Ishiyama
    Research Center for Tropical Diseases, Center for Basic Research, Kitasato Institute for Life Sciences and Graduate School of Infectious Control Sciences, Kitasato University, Tokyo, Japan
    J Antibiot (Tokyo) 62:303-8. 2009

Collaborators

Detail Information

Publications30

  1. doi request reprint In vitro antitrypanosomal activity of some phenolic compounds from propolis and lactones from Fijian Kawa (Piper methysticum)
    Kazuhiko Otoguro
    Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    J Nat Med 66:558-61. 2012
    ..Our findings represent the first report of the promising trypanocidal activity of these compounds...
  2. doi request reprint In vitro antitrypanosomal activity of bis(bibenzyls)s and bibenzyls from liverworts against Trypanosoma brucei
    Kazuhiko Otoguro
    Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    J Nat Med 66:377-82. 2012
    ..Our finding represents the first report of the promising trypanocidal activity of these compounds. The research also provides valuable insight into structure-activity relationships and the possible mode of action of the compounds...
  3. doi request reprint In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei
    Kazuhiko Otoguro
    Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Phytochemistry 72:2024-30. 2011
    ..Present results also provide some valuable insight with regard to structure-activity relationships and the possible mode of action of the compounds...
  4. doi request reprint Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites
    Kazuhiko Otoguro
    Research Center for Tropical Diseases, The Kitasato Institute, Tokyo, Japan
    J Antibiot (Tokyo) 61:372-8. 2008
    ..b. rhodesiense are presented. Cytotoxicity was determined using a human MRC-5 cell line. This is the first report of antitrypanosomal activities of the 10 microbial metabolites listed above...
  5. doi request reprint In vitro and in vivo antitrypanosomal activitiy of two microbial metabolites, KS-505a and alazopeptin
    Aki Ishiyama
    Research Center for Tropical Diseases, Center for Basic Research, Kitasato University, Tokyo, Japan
    J Antibiot (Tokyo) 61:627-32. 2008
    ..This is the first report of in vitro and in vivo antitrypanosomal activities of either KS-505a or alazopeptin...
  6. doi request reprint In vitro and in vivo antimalarial activity of puberulic acid and its new analogs, viticolins A-C, produced by Penicillium sp. FKI-4410
    Masato Iwatsuki
    Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
    J Antibiot (Tokyo) 64:183-8. 2011
    ..The compound also demonstrated a therapeutic effect in vivo, which compared well against the currently used antimalarial drugs, and thus shows promise as a leading candidate for development into a new antimalarial compound...
  7. doi request reprint Mangromicins A and B: structure and antitrypanosomal activity of two new cyclopentadecane compounds from Lechevalieria aerocolonigenes K10-0216
    Takuji Nakashima
    Research Organization for Infection Control Sciences, Kitasato University, Tokyo, Japan
    J Antibiot (Tokyo) 67:253-60. 2014
    ..4 and 43.4 μg ml(-1), respectively. The IC50 values of both compounds were lower than those of cytotoxicity against MRC-5 human fetal lung fibroblast cells. ..
  8. doi request reprint Panowamycins A and B, new antitrypanosomal isochromans produced by Streptomyces sp. K07-0010
    Junko Hashida
    Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
    J Antibiot (Tokyo) 65:197-202. 2012
    ..Panowamycins A and B showed moderate antitrypanosomal activity, with IC(50) values of 0.40 and 3.30 μg ml(-1), respectively...
  9. doi request reprint Sinefungin VA and dehydrosinefungin V, new antitrypanosomal antibiotics produced by Streptomyces sp. K05-0178
    Megumi Niitsuma
    Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
    J Antibiot (Tokyo) 63:673-9. 2010
    ..0026 μg ml(-1) in vitro without cytotoxicity against MRC-5 cells. Dehydrosinefungin V showed moderate antitrypanosomal activity (IC(50)=0.15 μg ml(-1))...
  10. doi request reprint In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin
    Aki Ishiyama
    Research Center for Tropical Diseases, Center for Basic Research, Kitasato Institute for Life Sciences and Graduate School of Infectious Control Sciences, Kitasato University, Tokyo, Japan
    J Antibiot (Tokyo) 62:303-8. 2009
    ..We also discuss their possible mode of action. This is the first report of in vitro and in vivo trypanocidal activity of leucinostatin A and B, alamethicin I and tsushimycin...
  11. doi request reprint Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460(T)
    Yuki Inahashi
    Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan
    J Antibiot (Tokyo) 64:303-7. 2011
    ..Spoxazomicin A showed potent and selective antitrypanosomal activity with an IC₅₀ value of 0.11 μg ml⁻¹ in vitro without cytotoxicity against MRC-5 cells (IC₅₀=27.8 μg ml⁻¹)...
  12. ncbi request reprint Total synthesis of borrelidin
    Tohru Nagamitsu
    School of Pharmacy, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    J Org Chem 72:2744-56. 2007
    ..The two key segments were synthesized through regioselective methylation, directed hydrogenation, stereoselective Reformatsky-type reaction, and MgBr2.Et2O-mediated chelation-controlled allylation...
  13. doi request reprint Borrelidin analogues with antimalarial activity: design, synthesis and biological evaluation against Plasmodium falciparum parasites
    Akihiro Sugawara
    The Kitasato Institute and Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Bioorg Med Chem Lett 23:2302-5. 2013
    ....
  14. doi request reprint Structure determination and total synthesis of (+)-16-hydroxy-16,22-dihydroapparicine
    Tomoyasu Hirose
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Chemistry 19:10741-50. 2013
    ..In addition, we evaluated the antimalarial activity of synthetic (+)-(15S,16R)-16-hydroxy-16,22-dihydroapparicine and its intermediate against chloroquine-resistant Plasmodium falciparum (K1 strain) parasites. ..
  15. doi request reprint Solid-phase synthesis and biological activity of malformin C and its derivatives
    Yasuhiro Kojima
    Kitasato Institute, Kitasato Institute for Life Science and Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan
    J Antibiot (Tokyo) 62:681-6. 2009
    ..Results indicate that the disulfide bond is essential and branched amino acids are also crucial components if the compound is to exhibit potent antimalarial and antitrypanosomal properties...
  16. pmc Synthesis and stereochemical determination of an antiparasitic pseudo-aminal type monoterpene indole alkaloid
    Yoshihiko Noguchi
    Kitasato Institute for Life Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo, 108 8641, Japan
    J Nat Med 70:302-17. 2016
    ..Furthermore, we evaluated the activity of the synthetic compound, as well as that of some intermediates, all of which showed weak activity against chloroquine-resistant Plasmodium falciparum (K1 strain) malaria parasites. ..
  17. doi request reprint Actinoallolides A-E, new anti-trypanosomal macrolides, produced by an endophytic actinomycete, Actinoallomurus fulvus MK10-036
    Yuki Inahashi
    Graduate School of Infection Control Sciences, Research Center for Tropical Diseases, Kitasato Institute for Life Sciences, and Kitasato Institute for Life Sciences, Kitasato University, 5 9 1, Shirokane, Minato ku, Tokyo, Japan
    Org Lett 17:864-7. 2015
    ..A new class of promising lead compounds was identified for the development of drugs for both sleeping sickness and Chagas disease. ..
  18. ncbi request reprint Total synthesis of (-)-borrelidin
    Tohru Nagamitsu
    School of Pharmaceutical Science, Kitasato University, Kitasato Institute for Life Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Org Lett 6:1865-7. 2004
    ..Et(2)O-mediated chelation-controlled allylation. [reaction: see text]..
  19. ncbi request reprint Effect of 14-membered macrolide compounds on monocyte to macrophage differentiation
    Toshiaki Sunazuka
    Kitasato Institute for Life Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    J Antibiot (Tokyo) 56:721-4. 2003
  20. ncbi request reprint Antimalarial activity of biflavonoids from Ochna integerrima
    Chikara Ichino
    Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
    Planta Med 72:611-4. 2006
    ..The stereoisomer of 1 ( = compound 2) was also isolated from this plant; however, its activity was significantly lower than that of 1...
  21. doi request reprint Anti-trypanosomal compound, sagamilactam, a new polyene macrocyclic lactam from Actinomadura sp. K13-0306
    Toru Kimura
    Department of Drug Discovery Sciences, Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan
    J Antibiot (Tokyo) 69:818-824. 2016
    ..Sagamilactam showed antitrypanosomal activity with an IC50 value of 0.25±0.11 μM...
  22. ncbi request reprint In vitro antimalarial activity of biflavonoids from Wikstroemia indica
    Shinyu Nunome
    The Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan
    Planta Med 70:76-8. 2004
    ..This is the first report of the biological activity of 1 and 2. As the structure of l has remained unsettled, we confirmed the conformation by (1)H- and (13)C-NMR...
  23. ncbi request reprint Satoshi Omura: in pursuit of nature's bounty
    Andy Crump
    Research Centre for Tropical Diseases, The Kitasato Institute, 5 9 1 Shirokane, Minato ku, Tokyo 108 8642, Japan
    Trends Parasitol 21:126-32. 2005
    ..It has also improved the health of pets and livestock around the globe, and encouraged development of a community-based delivery mechanism that could herald a revolution in public health care in Africa...
  24. ncbi request reprint The first total synthesis of (+/-)-arisugacin A, a potent, orally bioavailable inhibitor of acetylcholinesterase
    Toshiaki Sunazuka
    The Kitasato Institute and School of Pharmaceutical Sciences, Kitasato University, Tokyo 108 8642, Japan
    Org Lett 4:367-9. 2002
    ....
  25. ncbi request reprint Remarkable influence of the aromatic substructure in 9-methoxystrobilurin derivatives on their antifungal activity
    Hiromi Uchiro
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 12 Ichigayafunagawara machi, Shinjuku ku, Tokyo, Japan
    Bioorg Med Chem Lett 12:2699-702. 2002
    ..In addition, our results suggested that the strong growth-inhibitory activity of 9-methoxystrobilurin K against human-derived cell lines should be related to its hindered ether-type substructure...
  26. ncbi request reprint In vitro antimalarial activities of the microbial metabolites
    Kazuhiko Otoguro
    J Antibiot (Tokyo) 56:322-4. 2003
  27. ncbi request reprint Total syntheses of the AChE inhibitors (-)-arisugacins F and G
    Masaki Handa
    J Antibiot (Tokyo) 56:730-3. 2003
  28. ncbi request reprint Macrolides with promotive activity of monocyte to macrophage differentiation
    Kiminari Yoshida
    J Antibiot (Tokyo) 58:79-81. 2005
  29. ncbi request reprint Selective and potent in vitro antimalarial activities found in four microbial metabolites
    Hideaki Ui
    J Antibiot (Tokyo) 60:220-2. 2007
    ..The antimalarial effects of triacsins C and D are also reported...
  30. doi request reprint Acylated pregnane glycosides from Caralluma tuberculata and their antiparasitic activity
    Essam Abdel-Sattar
    Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
    Phytochemistry 69:2180-6. 2008
    ..All the isolated compounds were tested for their antimalarial and antitrypanosomal activities as well as their cytotoxicity against human diploid embryonic cell line (MRC5)...