M Nakao

Summary

Affiliation: Kumamoto University
Country: Japan

Publications

  1. ncbi request reprint Visualization of transcription-dependent association of imprinted genes with the nuclear matrix
    Kazuhiro Kagotani
    Faculty of Bioresources, Mie University, 1515 Kamihama, Tsu, 514 8507, Japan
    Exp Cell Res 274:189-96. 2002
  2. pmc The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescence
    Nobuhiro Sasai
    Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    PLoS ONE 8:e68478. 2013
  3. pmc Higher-order chromatin regulation and differential gene expression in the human tumor necrosis factor/lymphotoxin locus in hepatocellular carcinoma cells
    Takehisa Watanabe
    Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, and the Global Center of Excellence Cell Fate Regulation Research and EducationUnit, Kumamoto University, Kumamoto, Japan
    Mol Cell Biol 32:1529-41. 2012
  4. ncbi request reprint Regulation of transcription and chromatin by methyl-CpG binding protein MBD1
    M Nakao
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2 2 1 Honjo, 860 0811, Kumamoto, Japan
    Brain Dev 23:S174-6. 2001
  5. ncbi request reprint Genomic imprinting: significance in development and diseases and the molecular mechanisms
    M Nakao
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine
    J Biochem 120:467-73. 1996
  6. ncbi request reprint Epigenetic system: a pathway to malignancies and a therapeutic target
    Mitsuyoshi Nakao
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Int J Hematol 80:103-7. 2004
  7. ncbi request reprint Epigenetics: interaction of DNA methylation and chromatin
    M Nakao
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Gene 278:25-31. 2001
  8. pmc Mechanism of transcriptional regulation by methyl-CpG binding protein MBD1
    N Fujita
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    Mol Cell Biol 20:5107-18. 2000
  9. ncbi request reprint Identification of the cis-acting region in the NF2 gene promoter as a potential target for mutation and methylation-dependent silencing in schwannoma
    T Kino
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto 860 8556, Japan
    Genes Cells 6:441-54. 2001
  10. ncbi request reprint DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain
    T Takizawa
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan
    Dev Cell 1:749-58. 2001

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Visualization of transcription-dependent association of imprinted genes with the nuclear matrix
    Kazuhiro Kagotani
    Faculty of Bioresources, Mie University, 1515 Kamihama, Tsu, 514 8507, Japan
    Exp Cell Res 274:189-96. 2002
    ..Our results suggest that the nuclear matrix plays an important role in gene expression, including imprinted genes, and that the FISH technique used here allows us to visualize the behaviors of genes at an individual cell level...
  2. pmc The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescence
    Nobuhiro Sasai
    Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    PLoS ONE 8:e68478. 2013
    ..Collectively, these results reveal that MCAF1 is an essential regulator of cellular senescence. ..
  3. pmc Higher-order chromatin regulation and differential gene expression in the human tumor necrosis factor/lymphotoxin locus in hepatocellular carcinoma cells
    Takehisa Watanabe
    Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, and the Global Center of Excellence Cell Fate Regulation Research and EducationUnit, Kumamoto University, Kumamoto, Japan
    Mol Cell Biol 32:1529-41. 2012
    ..These results suggest that insulators mediate the spatiotemporal control of enhancer-promoter associations in the TNF/LT gene cluster...
  4. ncbi request reprint Regulation of transcription and chromatin by methyl-CpG binding protein MBD1
    M Nakao
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2 2 1 Honjo, 860 0811, Kumamoto, Japan
    Brain Dev 23:S174-6. 2001
    ..MBD1 is also found to be a chromosomal protein that forms many foci within the nucleus. These findings suggest that MBD1 is a unique transcriptional regulator depending on the density of methyl-CpG pairs...
  5. ncbi request reprint Genomic imprinting: significance in development and diseases and the molecular mechanisms
    M Nakao
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine
    J Biochem 120:467-73. 1996
    ..The correlations between the differential gene activity and the changes in DNA methylation, higher order chromatin structure and replication timing, will shed light on gene regulation at the level of the chromosomal domain...
  6. ncbi request reprint Epigenetic system: a pathway to malignancies and a therapeutic target
    Mitsuyoshi Nakao
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Int J Hematol 80:103-7. 2004
    ..We discuss the molecular basis of the epigenetic mechanism in association with the development of cancer...
  7. ncbi request reprint Epigenetics: interaction of DNA methylation and chromatin
    M Nakao
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Gene 278:25-31. 2001
    ..Therefore, epigenetics will become the focus and a major target for emerging biological and medical discoveries...
  8. pmc Mechanism of transcriptional regulation by methyl-CpG binding protein MBD1
    N Fujita
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    Mol Cell Biol 20:5107-18. 2000
    ..Based on these findings we have concluded that MBD1 acts as a transcriptional regulator depending on the density of methyl-CpG pairs through the cooperation of MBD, CXXC, and TRD sequences...
  9. ncbi request reprint Identification of the cis-acting region in the NF2 gene promoter as a potential target for mutation and methylation-dependent silencing in schwannoma
    T Kino
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto 860 8556, Japan
    Genes Cells 6:441-54. 2001
    ....
  10. ncbi request reprint DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain
    T Takizawa
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan
    Dev Cell 1:749-58. 2001
    ..This CpG methylation leads to inaccessibility of STAT3 to the binding element. We suggest that methylation of a cell type-specific gene promoter is a pivotal event in regulating lineage specification in the developing brain...
  11. pmc Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells
    T Sudo
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2-2-1 Honjo, Kumamoto 860-0811, Japan
    EMBO J 20:6499-508. 2001
    ..Thus, activation of Cdh1-APC plays a crucial role in both cdk inhibitor-dependent G1 arrest and DNA damage-induced G2 arrest...
  12. pmc Methylation-mediated transcriptional silencing in euchromatin by methyl-CpG binding protein MBD1 isoforms
    N Fujita
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    Mol Cell Biol 19:6415-26. 1999
    ..These findings suggested that the MBD1 isoforms have different roles in methylation-mediated transcriptional silencing in euchromatin...
  13. ncbi request reprint PU.1 is involved in the regulation of B lineage-associated and developmental stage-dependent expression of the germinal center-associated DNA primase GANP
    M A EL-Gazzar
    Department of Immunology, Kumamoto University School of Medicine, 2 2 1, Honjo, Kumamoto, 860 0811 Japan
    J Biol Chem 276:48000-8. 2001
    ..1-mutated reporter construct. These results demonstrate that the germinal center-associated DNA primase expression is partly regulated by the transcription factor PU.1 expressed in B lineage cells...
  14. ncbi request reprint Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts
    K Ito
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, Japan
    Oncogene 18:7080-90. 1999
    ....
  15. ncbi request reprint In situ SUMOylation analysis reveals a modulatory role of RanBP2 in the nuclear rim and PML bodies
    Noriko Saitoh
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumanmoto 860 0811, Japan
    Exp Cell Res 312:1418-30. 2006
    ..Our data imply that SUMO E3 proteins like RanBP2 facilitate spatio-temporal SUMOylation for certain nuclear structure and function...
  16. ncbi request reprint Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins
    Takaya Ichimura
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    J Biol Chem 280:13928-35. 2005
    ..These data suggest that MBD1.MCAF1.SETDB1 complex facilitates the formation of heterochromatic domains, emphasizing the role of MCAF/AM family proteins in epigenetic control...
  17. ncbi request reprint Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression
    Naoyuki Fujita
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    J Biol Chem 278:24132-8. 2003
    ..These data indicate that MBD1 may tether the Suv39h1-HP1 complex to methylated DNA regions, suggesting the presence of a pathway from DNA methylation to the modifications of histones for epigenetic gene regulation...
  18. ncbi request reprint Overlapping roles of the methylated DNA-binding protein MBD1 and polycomb group proteins in transcriptional repression of HOXA genes and heterochromatin foci formation
    Yasuo Sakamoto
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Graduate School of Medical Sciences, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    J Biol Chem 282:16391-400. 2007
    ..Our present findings suggest that MBD1 and PcG proteins have overlapping roles in epigenetic gene silencing and heterochromatin foci formation through their interactions...
  19. ncbi request reprint Serum response factor is modulated by the SUMO-1 conjugation system
    Kazuhito Matsuzaki
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, 860 0811, Kumamoto, Japan
    Biochem Biophys Res Commun 306:32-8. 2003
    ..These data support the transcriptional role of SUMO-1 conjugating system in cellular serum response...
  20. ncbi request reprint Nuclear and chromatin reorganization in the MHC-Oct3/4 locus at developmental phases of embryonic stem cell differentiation
    Takahiro Aoto
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, The 21st Century COE, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Dev Biol 298:354-67. 2006
    ..These findings provide insights into the molecular basis of global nuclear reorganization and euchromatic gene silencing in differentiation through the spatiotemporal order of epigenetic controls...
  21. ncbi request reprint PML-nuclear bodies are involved in cellular serum response
    Kazuhito Matsuzaki
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    Genes Cells 8:275-86. 2003
    ..Serum stimulation leads to the activation of various signal transduction pathways in cells, and the resultant signals are integrated into the serum response factor (SRF)-dependent transcription of immediate-early genes such as c-fos...
  22. ncbi request reprint [Nuclear and chromatin dynamics]
    Noriko Saitoh
    Tanpakushitsu Kakusan Koso 51:302-9. 2006
  23. ncbi request reprint CTCF-dependent chromatin insulator is linked to epigenetic remodeling
    Ko Ishihara
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Mol Cell 23:733-42. 2006
    ..These findings provide insight into the role of CTCF-CHD8 complex in insulation and epigenetic regulation at active insulator sites...
  24. doi request reprint Polycomb group protein-associated chromatin is reproduced in post-mitotic G1 phase and is required for S phase progression
    Takahiro Aoto
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    J Biol Chem 283:18905-15. 2008
    ..The fact that PcG-associated chromatin is reproduced during post-mitotic G(1) phase suggests the possibility that PcG proteins enable their target chromatin to be remodeled in response to stimuli in the G(1) phase...
  25. ncbi request reprint [Nuclear organelles in the interchromosomal region]
    Noriko Saitoh
    Tanpakushitsu Kakusan Koso 51:1957-63. 2006
  26. doi request reprint MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity
    Lifeng Liu
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    J Biol Chem 284:5165-74. 2009
    ..Our data suggest that transcriptional function of MCAF1 facilitates telomerase expression by Sp1, which may be a common mechanism in proliferative cancer cells...
  27. ncbi request reprint The regulation of human beta-defensin 2 by the ETS transcription factor MEF (myeloid Elf-1-like factor) is enhanced by promyelocytic leukemia protein
    Mary Ann Suico
    Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Pharmacol Sci 95:466-70. 2004
    ..Here, we show that PML stimulated MEF transcriptional activity, resulting in the up-regulation of endogenous HBD 2 expression...
  28. ncbi request reprint The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 association
    Y Nagata
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Oncogene 18:6037-49. 1999
    ..These findings are evidence that mt p53 stabilization depends on the impaired ubiquitination due to both the loss of wt p53 function and the hsp90 association...
  29. ncbi request reprint Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes
    T Anan
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, Japan
    Genes Cells 3:751-63. 1998
    ..Nedd4 has been reported to be involved in the selective ubiquitination of some regulatory proteins in transcription and membrane transport...
  30. pmc MCAF mediates MBD1-dependent transcriptional repression
    Naoyuki Fujita
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Kumamoto University, Kumamoto 860 0811, Japan
    Mol Cell Biol 23:2834-43. 2003
    ..These data provide a mechanistic basis for direct inhibition of gene expression via methylation-dependent and histone deacetylation-resistant processes...
  31. ncbi request reprint Inhibition of DNA binding of Sox2 by the SUMO conjugation
    Shu Tsuruzoe
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Biochem Biophys Res Commun 351:920-6. 2006
    ..Further, SUMO-1-conjugated Sox2 at the lysine 247 or at the carboxyl terminus reduced the binding to the Fgf4 enhancer. These indicate that Sox2 sumoylation negatively regulates its transcriptional role through impairing the DNA binding...
  32. ncbi request reprint Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein
    K Makino
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, Honjo Kumamoto, Japan
    Oncogene 14:2425-33. 1997
    ..These data suggest that NE-dlg negatively regulates cell proliferation through its interaction with the APC protein...
  33. ncbi request reprint Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene
    N Mugita
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, Japan
    Biochem Biophys Res Commun 239:845-50. 1997
    ..These observations, together with the genetic information in C.elegans, suggest a unique function for htra-3 protein...
  34. ncbi request reprint Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region
    H Nakamura
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, Japan
    Oncogene 16:1009-19. 1998
    ....
  35. ncbi request reprint The aryl hydrocarbon receptor nuclear transporter is modulated by the SUMO-1 conjugation system
    Masahide Tojo
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    J Biol Chem 277:46576-85. 2002
    ..This exemplifies a crucial role of protein sumoylation in modulating protein-protein interactions...
  36. pmc Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin
    Sugiko Watanabe
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Proc Natl Acad Sci U S A 100:12859-64. 2003
    ..These data suggest that MBD1 cooperates with MPG for transcriptional repression and DNA repair. We hypothesize that MBD1 functions as a reservoir for MPG and senses the base damage in chromatin..
  37. pmc Architectural roles of multiple chromatin insulators at the human apolipoprotein gene cluster
    Tsuyoshi Mishiro
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    EMBO J 28:1234-45. 2009
    ....
  38. ncbi request reprint Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein
    Mary Ann Suico
    Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    J Biol Chem 279:19091-8. 2004
    ..Thus, the recruitment of MEF to PML nuclear bodies may partly regulate lysozyme transcription in epithelial cells...
  39. ncbi request reprint Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation
    Yasuhiro Uchimura
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    J Biol Chem 281:23180-90. 2006
    ..These findings provide insights into the roles of SUMOylation in the regulation of heterochromatin formation and gene silencing...
  40. ncbi request reprint Nucleotide sequence of the third cytokine LD78 gene and mapping of all three LD78 gene loci to human chromosome 17
    M Hirashima
    Molecular Genetic Laboratory, Chemo Sero Therapeutic Research Institute, Kumamoto, Japan
    DNA Seq 3:203-12. 1992
    ..The mechanism of generation of the three LD78 genes is discussed...
  41. doi request reprint Simian virus 40 large T antigen targets the microtubule-stabilizing protein TACC2
    Shuchin Tei
    Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo, Kumamoto, Japan
    J Cell Sci 122:3190-8. 2009
    ..Thus, TACC2 might be a key target of T antigen to disrupt microtubule regulation and chromosomal inheritance in the initiation of cell transformation...
  42. ncbi request reprint SUMO down-regulates the activity of Elf4/myeloid Elf-1-like factor
    Mary Ann Suico
    Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    Biochem Biophys Res Commun 348:880-8. 2006
    ..These findings contribute to our understanding of the regulation of the ETS factor MEF...
  43. doi request reprint The p150 subunit of CAF-1 causes association of SUMO2/3 with the DNA replication foci
    Junsuke Uwada
    Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, 2 39 1 Kurokami, Kumamoto 860 8555, Japan
    Biochem Biophys Res Commun 391:407-13. 2010
    ....
  44. pmc HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells
    Sugiko Watanabe
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Am J Pathol 174:854-68. 2009
    ..These data shed light on the importance of HMGA2 in reversibly maintaining EMT, suggesting that HMGA2 is a potential therapeutic target for the treatment of pancreatic cancer...
  45. ncbi request reprint Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response
    Yoshiomi Honda
    Department of Tumor Genetics and Biology and Department of Internal Medicine I, Kumamoto University School of Medicine, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    J Biol Chem 277:3599-605. 2002
    ..These results demonstrated that hHYD coordinated TopBP1 in the DNA damage response...
  46. ncbi request reprint Overproduction of eukaryotic SUMO-1- and SUMO-2-conjugated proteins in Escherichia coli
    Yasuhiro Uchimura
    Department of Regeneration Medicine, Institute of Molecular Embryology Genetics, Kumamoto University, Kumamoto, 860 0811, Japan
    Anal Biochem 331:204-6. 2004
  47. ncbi request reprint Generation of SUMO-1 modified proteins in E. coli: towards understanding the biochemistry/structural biology of the SUMO-1 pathway
    Yasuhiro Uchimura
    Department of Regeneration Medicine, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    FEBS Lett 564:85-90. 2004
    ....
  48. pmc Loss of expression of type IV collagen alpha5 and alpha6 chains in colorectal cancer associated with the hypermethylation of their promoter region
    Koei Ikeda
    Department of Surgical Pathology, Kumamoto University School of Medicine, Japan
    Am J Pathol 168:856-65. 2006
    ....
  49. ncbi request reprint Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria
    Yoshimi Arima
    Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Kumamoto University, Honjo, Kumamoto 860 8556, Japan
    J Biol Chem 280:19166-76. 2005
    ..Our data thus suggested that blockade of pol II-mediated transcription induced p53 accumulation in mitochondria and was the critical factor for eliciting p53-dependent but transcription-independent apoptosis...
  50. ncbi request reprint Epigenetic silencing of the imprinted gene ZAC by DNA methylation is an early event in the progression of human ovarian cancer
    Tetsuya Kamikihara
    Department of Molecular Genetics, Division of Molecular and Cell Therapeutics, Medical Institute of Bioregulation, Kyusyu University, Oita, Japan
    Int J Cancer 115:690-700. 2005
    ..Supplementary material for this article can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat/index.html.)..
  51. ncbi request reprint [Aging and DNA methylation]
    Yasuo Sakamoto
    Nihon Ronen Igakkai Zasshi 42:137-43. 2005
  52. doi request reprint Cohesin mediates transcriptional insulation by CCCTC-binding factor
    Kerstin S Wendt
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Nature 451:796-801. 2008
    ..We propose that cohesin functions as a transcriptional insulator, and speculate that subtle deficiencies in this function contribute to 'cohesinopathies' such as Cornelia de Lange syndrome...
  53. ncbi request reprint [Epigenetics and nuclear reprogramming: overview]
    Takahiro Aoto
    Tanpakushitsu Kakusan Koso 51:2024-6. 2006
  54. ncbi request reprint Dynamic changes in the epigenomic state and nuclear organization of differentiating mouse embryonic stem cells
    Satoru Kobayakawa
    Graduate School of Life and Environmental Sciences, University of Tsukuba, 1 1 1 Ten noudai, Tsukuba, Ibaraki 305 8572, Japan
    Genes Cells 12:447-60. 2007
    ..Thus, this experimental system should facilitate studies focusing on relationships between nuclear organization, epigenetic status and cell differentiation...
  55. pmc Activation of Sp1-mediated transcription by Rta of Epstein-Barr virus via an interaction with MCAF1
    Li Kwan Chang
    Faculty of Biological Medicine and Environmental Biology and Graduate Institute of Biochemistry, Kaohsiung Medical University, Kaohsiung, Taiwan
    Nucleic Acids Res 33:6528-39. 2005
    ..Our study documents the critical role of Rta in regulating the transcription of the genes that are mediated by Sp1...
  56. pmc Nedd4 regulates egress of Ebola virus-like particles from host cells
    Jiro Yasuda
    Division of Molecular Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita ku, Sapporo 060 0815, Japan
    J Virol 77:9987-92. 2003
    ..As expected, Tsg101 enhanced VP40-induced VLP release, and TsgDeltaC, which lacks its C-terminal half, inhibited VLP release. These results indicate that Nedd4, together with Tsg101, plays an important role in Ebola virus budding...
  57. ncbi request reprint Halogenated thymidine analogues restore the expression of silenced genes without demethylation
    Jun Fan
    Laboratory of Virus Immunology, Institute for Virus Research, Kyoto University, Kyoto, Japan
    Cancer Res 65:6927-33. 2005
    ..This study shows that halogenated thymidines have an antisilencing effect without changing DNA methylation status by interfering with step(s) between DNA methylation and histone acetylation...