Genomes and Genes
Affiliation: Kurume University School of Medicine
- Identification and characterization of a cell division-regulating kinase AKB1 (associated kinase of Trypanosoma brucei 14-3-3) through proteomics study of the Tb14-3-3 binding proteinsMasahiro Inoue
Division of Eukaryotic Microbiology, Department of Infectious Medicine, Kurume University School of Medicine, 67 Asahi machi Kurume, Fukuoka 830 0011, Japan Department of Virology, Institute of Tropical Medicine, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan Department of Protozoology, Institute of Tropical Medicine, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan Fukuoka Tokushukai Medical Center, 4 5 Sugu kita, Kasuga, Fukuoka 816 0864, Japan Laboratory of Hygienic Chemistry, Daiichi University of Pharmacy, 22 1, Tamagawa cho, Minami Ku, Fukuoka 815 8511, Japan Department of Oncological Sciences, Experimental Therapeutics Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, Room 1520, New York, NY 10029, USA and Department of Radiation Oncology, Houston Methodist Research Institute, Weill Cornell Medical College, 6550 Fannin St
J Biochem 158:49-60. 2015..Taken together, these findings suggest that AKB1 might regulate cytokinesis and cell division by phosphorylating cytoskeleton-associated proteins. ..
- Phosphorylation-dependent protein interaction with Trypanosoma brucei 14-3-3 proteins that display atypical target recognitionMasahiro Inoue
Division of Eukaryotic Microbiology, Department of Infectious Medicine, Kurume University School of Medicine, Kurume, Japan
PLoS ONE 5:e15566. 2010..In Trypanosoma brucei, 14-3-3I and II play pivotal roles in motility, cytokinesis and the cell cycle. However, none of the T. brucei 14-3-3 binding proteins have previously been documented...
- The 14-3-3 proteins of Trypanosoma brucei function in motility, cytokinesis, and cell cycleMasahiro Inoue
Department of Parasitology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
J Biol Chem 280:14085-96. 2005..These findings indicate that the 14-3-3 proteins play important roles in cell motility, cytokinesis, and the cell cycle...
- Trypanosoma brucei 14-3-3I and II proteins predominantly form a heterodimer structure that acts as a potent cell cycle regulator in vivoMasahiro Inoue
Department of Infectious Medicine, Division of Eukaryotic Microbiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
J Biochem 153:431-9. 2013..These results suggest that heterodimers play more significant roles than homodimers not only in the maintenance of steady-state levels of the 14-3-3 proteins but also in the regulation of cytokinesis...
- Suppression of the invasive capacity of rat ascites hepatoma cells by knockdown of Slingshot or LIM kinaseYuji Horita
Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi, Japan
J Biol Chem 283:6013-21. 2008....
- Inhibition of transcellular tumor cell migration and metastasis by novel carba-derivatives of cyclic phosphatidic acidAyako Uchiyama
Department of Biology, Faculty of Science, Ochanomizu University, 2 1 1 Ohtsuka, Tokyo 112 8610, Japan
Biochim Biophys Acta 1771:103-12. 2007..The antimetastatic effect of carba-cPA was accompanied by the inhibition of RhoA activation and was not due to inhibition of the activation of LPA receptors...
- Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of RhoToshiyuki Kusama
Department of Tumor Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537 8511, Japan kusama to mc pref osaka jp
Int J Oncol 29:217-23. 2006..These results suggest that geranylgeranylation step of RhoA and RhoC could be a good therapeutic target for the prevention of invasion and metastasis of breast cancer cells...
- CD4+ T cell-mediated antigen-specific immunotherapy in a mouse model of cervical cancerDylan Daniel
Department of Biochemistry, Diabetes Center and Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143 0534, USA
Cancer Res 65:2018-25. 2005..Thus, an HPV16 E7 immunogen holds promise for noninvasive treatment and prevention of human cervical cancer...
- An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesisEnrico Giraudo
Department of Biochemistry and Biophysics, Diabetes Center, and Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA
J Clin Invest 114:623-33. 2004....
- Targeting hypoxic cancer cells with a protein prodrug is effective in experimental malignant ascitesMasahiro Inoue
Department of Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka 537 8511, Japan
Int J Oncol 25:713-20. 2004..Thus, TOP3 had a dramatic effect on malignant ascites and, hence, we propose that rodent malignant ascites is an appropriate platform for testing hypoxia-targeted drugs...
- LRP1B attenuates the migration of smooth muscle cells by reducing membrane localization of urokinase and PDGF receptorsKousei Tanaga
Department of Clinical Cell Biology, Chiba University Graduate School of Medicine, Chiba, Japan
Arterioscler Thromb Vasc Biol 24:1422-8. 2004....
- Tumor hypoxia: a target for selective cancer therapyShinae Kizaka-Kondoh
Department of Molecular Oncology, Kyoto University Graduate School of Medicine, 54 Shongoin Kawahararcho, Sakyo ku, Kyoto 606 8507
Cancer Sci 94:1021-8. 2003..These approaches include our work with a unique hypoxia-targeting protein drug, TOP3, with which we have sought to address the above three difficulties...
- Cloning, expression analysis, and tissue distribution of esp-1/testisin, a membrane-type serine protease from the ratYasuo Nakamura
Department of Dermatology, The University of Tokushima School of Medicine, Tokushima, Japan
J Med Invest 50:78-86. 2003..This different distribution profile suggests that Esp-1/Testisin plays a role in species-specific proteolytic events during spermatogenesis and fertilization...
- Sustained tyrosine-phosphorylation of FAK through Rho-dependent adhesion to fibronectin is essential for cancer cell migrationMutsuko Mukai
Department of Tumor Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
Anticancer Res 22:3175-84. 2002..Co-stimulation with lysophosphatidic acid (LPA) and fibronectin (FN) is essential for migration of rat ascites hepatoma MMI cells. We examined the roles of LPA and FN in Rho-FAK pathway to migration...