Shizuka Hirai

Summary

Affiliation: Kyoto University
Country: Japan

Publications

  1. ncbi request reprint Activin A inhibits differentiation of 3T3-L1 preadipocyte
    Shizuka Hirai
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake, Sakyo ku, Kyoto shi 606 8502, Japan
    Mol Cell Endocrinol 232:21-6. 2005
  2. ncbi request reprint Myostatin inhibits differentiation of bovine preadipocyte
    Shizuka Hirai
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake, Sakyo ku, Kyoto shi 606 8502, Japan
    Domest Anim Endocrinol 32:1-14. 2007
  3. ncbi request reprint Follistatin rescues the inhibitory effect of activin A on the differentiation of bovine preadipocyte
    Shizuka Hirai
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake, Sakyo ku, Kyoto shi 606 8502, Japan
    Domest Anim Endocrinol 33:269-80. 2007
  4. doi request reprint Auraptene suppresses inflammatory responses in activated RAW264 macrophages by inhibiting p38 mitogen-activated protein kinase activation
    Shan Lin
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan
    Mol Nutr Food Res 57:1135-44. 2013
  5. doi request reprint Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues
    Taku Uemura
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan
    Mol Nutr Food Res 54:1596-608. 2010
  6. doi request reprint Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice
    Tsuyoshi Goto
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji 611 0011, Japan
    J Nutr Biochem 23:768-76. 2012
  7. doi request reprint Diosgenin attenuates inflammatory changes in the interaction between adipocytes and macrophages
    Shizuka Hirai
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan
    Mol Nutr Food Res 54:797-804. 2010
  8. pmc Potent PPARα activator derived from tomato juice, 13-oxo-9,11-octadecadienoic acid, decreases plasma and hepatic triglyceride in obese diabetic mice
    Young Il Kim
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    PLoS ONE 7:e31317. 2012
  9. doi request reprint Bixin activates PPARα and improves obesity-induced abnormalities of carbohydrate and lipid metabolism in mice
    Tsuyoshi Goto
    Research Unit for Physiological Chemistry, The Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto 606 8501, Japan
    J Agric Food Chem 60:11952-8. 2012
  10. ncbi request reprint Comparative and stability analyses of 9- and 13-Oxo-octadecadienoic acids in various species of tomato
    Haruya Takahashi
    Laboratory of Molecular Functions of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan
    Biosci Biotechnol Biochem 75:1621-4. 2011

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Activin A inhibits differentiation of 3T3-L1 preadipocyte
    Shizuka Hirai
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake, Sakyo ku, Kyoto shi 606 8502, Japan
    Mol Cell Endocrinol 232:21-6. 2005
    ..On the other hand, activin A treatment had no effect on the mitotic clonal expansion. These results indicate that activin A inhibits adipogenesis via affecting the transcriptional factor cascade upstream of PPARgamma expression...
  2. ncbi request reprint Myostatin inhibits differentiation of bovine preadipocyte
    Shizuka Hirai
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake, Sakyo ku, Kyoto shi 606 8502, Japan
    Domest Anim Endocrinol 32:1-14. 2007
    ..These results suggest that myostatin inhibits bovine preadiopocyte differentiation through suppressing PPARgamma and C/EBPalpha mRNA expressions and that follistatin counteracts the suppressive effect of myostatin...
  3. ncbi request reprint Follistatin rescues the inhibitory effect of activin A on the differentiation of bovine preadipocyte
    Shizuka Hirai
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake, Sakyo ku, Kyoto shi 606 8502, Japan
    Domest Anim Endocrinol 33:269-80. 2007
    ..Endogenous activin A and/or myostatin possibly inhibit the differentiation of bovine preadipocytes...
  4. doi request reprint Auraptene suppresses inflammatory responses in activated RAW264 macrophages by inhibiting p38 mitogen-activated protein kinase activation
    Shan Lin
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan
    Mol Nutr Food Res 57:1135-44. 2013
    ..In this study, we examined whether auraptene, a citrus-fruit-derived compound, could suppress the production of inflammatory factors that mediate the interaction between adipocytes and macrophages...
  5. doi request reprint Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues
    Taku Uemura
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan
    Mol Nutr Food Res 54:1596-608. 2010
    ..Fenugreek containing diosgenin may be useful for ameliorating the glucose metabolic disorder associated with obesity...
  6. doi request reprint Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice
    Tsuyoshi Goto
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji 611 0011, Japan
    J Nutr Biochem 23:768-76. 2012
    ....
  7. doi request reprint Diosgenin attenuates inflammatory changes in the interaction between adipocytes and macrophages
    Shizuka Hirai
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan
    Mol Nutr Food Res 54:797-804. 2010
    ..Diosgenin may be useful for ameliorating the inflammatory changes in obese adipose tissues...
  8. pmc Potent PPARα activator derived from tomato juice, 13-oxo-9,11-octadecadienoic acid, decreases plasma and hepatic triglyceride in obese diabetic mice
    Young Il Kim
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    PLoS ONE 7:e31317. 2012
    ..In conclusion, our findings indicate that 13-oxo-ODA act as a potent PPARα agonist, suggesting a possibility to improve obesity-induced dyslipidemia and hepatic steatosis...
  9. doi request reprint Bixin activates PPARα and improves obesity-induced abnormalities of carbohydrate and lipid metabolism in mice
    Tsuyoshi Goto
    Research Unit for Physiological Chemistry, The Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto 606 8501, Japan
    J Agric Food Chem 60:11952-8. 2012
    ..These results indicate that bixin acts as a food-derived agonist of PPARα, and bixin treatment is useful for the management of obesity-induced metabolic dysfunctions in mice...
  10. ncbi request reprint Comparative and stability analyses of 9- and 13-Oxo-octadecadienoic acids in various species of tomato
    Haruya Takahashi
    Laboratory of Molecular Functions of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan
    Biosci Biotechnol Biochem 75:1621-4. 2011
    ..In this study, we found that various tomato samples contained 9-Oxo-(10E,12Z)-ODA and its 13-Oxo-ODA isomers. Furthermore, several isomers showed structural stability under hot and acidic conditions...
  11. pmc Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies
    Shizuka Hirai
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611 0011, Japan
    Mediators Inflamm 2010:367838. 2010
    ..In this review, we introduce the beneficial effects of anti-inflammatory phytochemicals that can help prevent obesity-induced inflammatory responses and pathologies...
  12. doi request reprint Dehydroabietic acid, a diterpene, improves diabetes and hyperlipidemia in obese diabetic KK-Ay mice
    Min Sook Kang
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan
    Biofactors 35:442-8. 2009
    ....
  13. ncbi request reprint Auraptene, a citrus fruit compound, regulates gene expression as a PPARalpha agonist in HepG2 hepatocytes
    Nobuyuki Takahashi
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan
    Biofactors 33:25-32. 2008
    ..These results indicate that auraptene acts as a PPARalpha agonist in hepatocytes and that auraptene may improve lipid abnormality through PPARalpha activation in the liver...
  14. doi request reprint Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation
    Min Sook Kang
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611 0011, Japan
    Biochem Biophys Res Commun 369:333-8. 2008
    ..These results suggest that DAA is a valuable medicinal and food component for improving inflammatory changes associated with obesity-related diabetes...
  15. doi request reprint Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways
    Tsuyoshi Goto
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Japan
    Am J Physiol Endocrinol Metab 301:E1022-32. 2011
    ..To our knowledge, this is the first study on the effect of the dual activators of PPARα and FXR on obesity-induced metabolic disorders...
  16. doi request reprint Luteolin, a food-derived flavonoid, suppresses adipocyte-dependent activation of macrophages by inhibiting JNK activation
    Chieko Ando
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611 0011, Japan
    FEBS Lett 583:3649-54. 2009
    ....
  17. doi request reprint Dehydroabietic acid activates peroxisome proliferator-activated receptor-γ and stimulates insulin-dependent glucose uptake into 3T3-L1 adipocytes
    Nobuyuki Takahashi
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan
    Biofactors 37:309-14. 2011
    ..These findings indicate that DAA stimulates adipocyte differentiation and insulin sensitivity in 3T3-L1 cells, suggesting that DAA is a valuable food-derived compound for the management of metabolic syndrome...
  18. pmc Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes
    Tsuyoshi Goto
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan
    J Lipid Res 52:873-84. 2011
    ..These findings indicate that the activation of PPARα affects energy metabolism in adipocytes, and PPARα activation in WAT may contribute to the clinical effects of fibrate drugs...
  19. doi request reprint Bixin regulates mRNA expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPARgamma activation
    Nobuyuki Takahashi
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji 611 0011, Japan
    Biochem Biophys Res Commun 390:1372-6. 2009
    ....
  20. ncbi request reprint Dietary regulation of nuclear receptors in obesity-related metabolic syndrome
    Teruo Kawada
    Kyoto University, Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Uji, Kyoto 611 0011, Japan
    Asia Pac J Clin Nutr 17:126-30. 2008
    ..These findings indicate that dietary factor acts as an agonist of PPARs and is a valuable medical and food component for the gradual improvement of metabolic syndrome...
  21. doi request reprint Involvement of mast cells in adipose tissue fibrosis
    Shizuka Hirai
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan
    Am J Physiol Endocrinol Metab 306:E247-55. 2014
    ..Induction of collagen V by MCP-6 might accelerate insulin resistance via the suppression of preadipocyte differentiation. ..
  22. doi request reprint 9-oxo-10(E),12(E)-Octadecadienoic acid derived from tomato is a potent PPAR α agonist to decrease triglyceride accumulation in mouse primary hepatocytes
    Young Il Kim
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan
    Mol Nutr Food Res 55:585-93. 2011
    ..Therefore, we focused on the activation of PPARα and attempted to detect active compounds activating PPARα in tomato...
  23. doi request reprint Tomato extract suppresses the production of proinflammatory mediators induced by interaction between adipocytes and macrophages
    Young Il Kim
    a Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan
    Biosci Biotechnol Biochem 79:82-7. 2015
    ..These results suggest that RF52 from tomatoes may have the potential to suppress inflammation by inhibiting the production of NO or proinflammatory cytokines during the interaction between adipocytes and macrophages. ..
  24. ncbi request reprint Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes
    Kayo Kuroyanagi
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611 0011, Japan
    Biochem Biophys Res Commun 366:219-25. 2008
    ....
  25. doi request reprint Taurine improves obesity-induced inflammatory responses and modulates the unbalanced phenotype of adipose tissue macrophages
    Shan Lin
    Division of Food Science and Biotechnology, Laboratory of Molecular Function of Food, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan
    Mol Nutr Food Res 57:2155-65. 2013
    ..We have therefore investigated the effects of taurine, a sulfated amino acid that is abundant in seafood, on obesity-related inflammation...
  26. doi request reprint Genome science of lipid metabolism and obesity
    Nobuyuki Takahashi
    Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    Forum Nutr 61:25-38. 2009
    ..Here, we provide several examples of food factors acting as agonists or antagonists, which are useful for the management of obesity accompanied by lipid metabolism abnormalities...
  27. doi request reprint Diosgenin, the main aglycon of fenugreek, inhibits LXRα activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice
    Taku Uemura
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611 0011, Japan
    J Nutr 141:17-23. 2011
    ..Fenugreek, which contains diosgenin, may be useful for the management of diabetes-related hepatic dyslipidemias...
  28. ncbi request reprint Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages
    Shizuka Hirai
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611 0011, Japan
    Life Sci 81:1272-9. 2007
    ..Naringenin chalcone may be useful for ameliorating the inflammatory changes in obese adipose tissue...
  29. ncbi request reprint Red yeast rice extracts suppress adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 cells
    Taeil Jeon
    Department of Applied Biology and Chemistry, Konkuk University, 1 Hwayang dong, Kwangjin gu, Seoul, 143 701, South Korea
    Life Sci 75:3195-203. 2004
    ..These results suggest that the inhibitory effect of RE on adipocyte differentiation might be mediated through the down-regulated expression of adipogenic transcription factors and other specific genes...