Takashi Kimitsuki

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. doi request reprint Salicylate-induced morphological changes of isolated inner hair cells and outer hair cells from guinea-pig cochlea
    Takashi Kimitsuki
    Department of Otolaryngology, Kyushu University, Higashi ku, Fukuoka, Japan
    Auris Nasus Larynx 36:152-6. 2009
  2. doi request reprint Effect of salicylate on potassium currents in inner hair cells isolated from guinea-pig cochlea
    Takashi Kimitsuki
    Department of Otolaryngology, Graduate School of Medical Sciences, Faculty of Medicine, Kyushu University, 3 1 1 Maidashi, Higasi ku, Fukuoka 812 8582, Japan
    Neurosci Lett 504:28-31. 2011
  3. doi request reprint Property of I(K,)(n) in inner hair cells isolated from guinea-pig cochlea
    Takashi Kimitsuki
    Department of Otolaryngology, Graduate School of Medical Sciences, Faculty of Medicine, Kyushu University, 3 1 1 Maidashi, Higasi ku, Fukuoka 812 8582, Japan
    Hear Res 261:57-62. 2010
  4. doi request reprint Dihydrostreptomycin goes through the mechano-electric transduction channel in chick cochlear hair cells
    Takashi Kimitsuki
    Department of Otolaryngology, Graduate School of Medical Sciences, Faculty of Medicine, Kyushu University, Fukuoka 812 8582, Japan
    ORL J Otorhinolaryngol Relat Spec 71:157-62. 2009
  5. doi request reprint Inactivating potassium currents in apical and basal turn inner hair cells from guinea-pig cochlea
    Takashi Kimitsuki
    Department of Otolaryngology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Brain Res 1228:68-72. 2008
  6. doi request reprint Effect of hydrogen peroxide on potassium currents in inner hair cells isolated from guinea pig cochlea
    Takashi Kimitsuki
    Department of Otolaryngology, Graduate School of Medical Sciences, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Neuroreport 21:1045-9. 2010
  7. doi request reprint Histochemical localization of the extracellular matrix components in the annular ligament of rat stapediovestibular joint with special reference to fibrillin, 36-kDa microfibril-associated glycoprotein (MAGP-36), and hyaluronic acid
    Mitsuru Ohashi
    Department of Anatomy, Ultrastructural Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki 889 1692, Japan
    Med Mol Morphol 41:28-33. 2008
  8. ncbi request reprint Calcium action on the membrane currents possessing the properties of mechano-electric transducer currents in inner hair cells of the Guinea-pig cochlea
    Takashi Kimitsuki
    Department of Otorhinolaryngology, Kyushu Central Hospital, Mutual Aid Association of Public School Teachers, Fukuoka, Japan
    Int J Neurosci 116:1327-35. 2006
  9. pmc No evidence for an association between persistent measles virus infection and otosclerosis among patients with otosclerosis in Japan
    Noritaka Komune
    Departments of Virology and Otorhinolaryngology, Kyushu University, Higashi ku, Fukuoka, Japan
    J Clin Microbiol 50:626-32. 2012
  10. ncbi request reprint [Efficacy of levofloxacin 500 mg for middle ear diseases]
    Takashi Kimitsuki
    Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Fukuoka Igaku Zasshi 103:43-8. 2012

Collaborators

  • Mitsuru Ohashi
  • Shizuo Komune
  • Noritaka Komune
  • Soyuki Ide
  • Tatsuo Suganuma
  • Nozomu Matsumoto
  • Yusuke Yanagi
  • Akira Sawaguchi

Detail Information

Publications16

  1. doi request reprint Salicylate-induced morphological changes of isolated inner hair cells and outer hair cells from guinea-pig cochlea
    Takashi Kimitsuki
    Department of Otolaryngology, Kyushu University, Higashi ku, Fukuoka, Japan
    Auris Nasus Larynx 36:152-6. 2009
    ..The aim of this study is to investigate the salicylate-induced morphological changes of cochlear inner hair cells (IHCs) and outer hair cells (OHCs)...
  2. doi request reprint Effect of salicylate on potassium currents in inner hair cells isolated from guinea-pig cochlea
    Takashi Kimitsuki
    Department of Otolaryngology, Graduate School of Medical Sciences, Faculty of Medicine, Kyushu University, 3 1 1 Maidashi, Higasi ku, Fukuoka 812 8582, Japan
    Neurosci Lett 504:28-31. 2011
    ..Salicylate blocked the outward K currents in a concentration-dependent manner according to Hill equation with a half-blocking concentration of 1.66mM, and the Hill coefficient of 1.86...
  3. doi request reprint Property of I(K,)(n) in inner hair cells isolated from guinea-pig cochlea
    Takashi Kimitsuki
    Department of Otolaryngology, Graduate School of Medical Sciences, Faculty of Medicine, Kyushu University, 3 1 1 Maidashi, Higasi ku, Fukuoka 812 8582, Japan
    Hear Res 261:57-62. 2010
    ..There was no significant difference in the size of I(K,)(n) between the apical and basal turn IHCs...
  4. doi request reprint Dihydrostreptomycin goes through the mechano-electric transduction channel in chick cochlear hair cells
    Takashi Kimitsuki
    Department of Otolaryngology, Graduate School of Medical Sciences, Faculty of Medicine, Kyushu University, Fukuoka 812 8582, Japan
    ORL J Otorhinolaryngol Relat Spec 71:157-62. 2009
    ..This study evaluated the ability of dihydrostreptomycin (DHSM) to go through the mechano-electric transduction (MET) channels in hair cells under physiological conditions...
  5. doi request reprint Inactivating potassium currents in apical and basal turn inner hair cells from guinea-pig cochlea
    Takashi Kimitsuki
    Department of Otolaryngology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Brain Res 1228:68-72. 2008
    ..Inactivation time constant was faster in basal IHCs than in apical IHCs and the degree of inactivation was greater in basal IHCs than in apical IHCs, suggesting that inactivation was more predominant in basal IHCs than in apical IHCs...
  6. doi request reprint Effect of hydrogen peroxide on potassium currents in inner hair cells isolated from guinea pig cochlea
    Takashi Kimitsuki
    Department of Otolaryngology, Graduate School of Medical Sciences, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Neuroreport 21:1045-9. 2010
    ..These results showed the vulnerability of inner hair cells to reactive oxygen species-induced inner ear disorders...
  7. doi request reprint Histochemical localization of the extracellular matrix components in the annular ligament of rat stapediovestibular joint with special reference to fibrillin, 36-kDa microfibril-associated glycoprotein (MAGP-36), and hyaluronic acid
    Mitsuru Ohashi
    Department of Anatomy, Ultrastructural Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki 889 1692, Japan
    Med Mol Morphol 41:28-33. 2008
    ..The present results provide a histochemical profile of the annular ligament of the rat stapediovestibular joint that may provide clues to elucidation of pathological changes in the ligaments and conductive hearing loss in humans...
  8. ncbi request reprint Calcium action on the membrane currents possessing the properties of mechano-electric transducer currents in inner hair cells of the Guinea-pig cochlea
    Takashi Kimitsuki
    Department of Otorhinolaryngology, Kyushu Central Hospital, Mutual Aid Association of Public School Teachers, Fukuoka, Japan
    Int J Neurosci 116:1327-35. 2006
    ..Treatment with the cAMP agonist, 8-bromo-cAMP, induced an effect similar to that caused by elevating the extracellular Ca2+...
  9. pmc No evidence for an association between persistent measles virus infection and otosclerosis among patients with otosclerosis in Japan
    Noritaka Komune
    Departments of Virology and Otorhinolaryngology, Kyushu University, Higashi ku, Fukuoka, Japan
    J Clin Microbiol 50:626-32. 2012
    ..Thus, our results do not support the hypothesis that persistent MV infection is involved in the pathoetiology of otosclerosis...
  10. ncbi request reprint [Efficacy of levofloxacin 500 mg for middle ear diseases]
    Takashi Kimitsuki
    Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Fukuoka Igaku Zasshi 103:43-8. 2012
    ..Three of eighteen cases were ineffective by LVFX treatment. Bacteriological examination indicated LVFX-resistant MRSA or Pseudomonas aeruginosa were isolated in these three cases...
  11. ncbi request reprint Three-dimensional regular arrangement of the annular ligament of the rat stapediovestibular joint
    Mitsuru Ohashi
    Department of Anatomy, Ultrastructural Cell Biology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Hear Res 213:11-6. 2006
    ..These results indicate that the annular ligament of the SVJ is mainly composed of mature elastic fibers...
  12. ncbi request reprint Dissociation enzyme effects on the potassium currents of inner hair cells isolated from guinea-pig cochlea
    Takashi Kimitsuki
    Department of Otorhinolaryngology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Miyazaki Gun 889 1692, Japan
    Hear Res 199:135-9. 2005
    ..5 ms. Papain is another enzyme that is sometimes used for dissociating IHCs, so effects of papain were observed. Extracellular papain application (8 unit/ml) demonstrated a slight increase of the outward potassium currents...
  13. ncbi request reprint Potassium current properties in apical and basal inner hair cells from guinea-pig cochlea
    Takashi Kimitsuki
    Department of Otorhinolaryngology, Miyazaki Medical College, 5200 Kihara, Kiyotake cho, Miyazaki 889 1692, Japan
    Hear Res 180:85-90. 2003
    ..The rate of outward current activation was voltage dependent and faster in basal IHCs than in apical IHCs. TEA effect was stronger on basal IHCs than on apical IHCs, suggesting that I(k,f) is dominant in basal IHCs...
  14. ncbi request reprint Glutamate induced currents in isolated inner hair cells from guinea-pig cochlea
    Takashi Kimitsuki
    Department of Otorhinolaryngology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Brain Res 976:135-8. 2003
    ..I-V relationships demonstrated that the reversal potential of Glu-induced current was near 0 mV. Glu-induced currents were dose-dependent, where the half maximum concentration (K(d)) was 41 microM and Hill coefficient (n) was 1.75...
  15. ncbi request reprint Neurotrophin-3 modifies potassium currents in isolated inner hair cells from guinea-pig cochlea
    Takashi Kimitsuki
    Department of Otorhinolaryngology, Miyazaki Medical College, 5200 Kihara, Kiyotake cho, Japan
    Auris Nasus Larynx 30:141-5. 2003
    ..Neurotrophins elicited short-term glutamate release from the presynaptic locus. The aim of this study was to investigate short-term effects of neurotrophin-3 (NT-3) on the membrane current of inner hair cells (IHCs)...
  16. ncbi request reprint Effect of cyclopiazonic acid on membrane currents in isolated inner hair cells from guinea-pig cochlea
    Takashi Kimitsuki
    Department of Otorhinolaryngology, Miyazaki Medical College, 5200 Kihara, Kiyotake cho, Miyazaki 889 1692, Japan
    Neurosci Lett 323:211-4. 2002
    ..This result suggests that Ca(2+)-activated currents were dominant in the basal IHCs of the cochlea...