Noriyoshi Teramoto

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint Comparative studies on the relaxing action of several adenosine 5'-triphosphate-sensitive K+ channel openers in pig urethra
    N Teramoto
    Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    J Smooth Muscle Res 35:11-22. 1999
  2. pmc Mefenamic acid as a novel activator of L-type voltage-dependent Ca2+ channels in smooth muscle cells from pig proximal urethra
    Noriyoshi Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi Ward, Fukuoka 812 8582, Japan
    Br J Pharmacol 144:919-25. 2005
  3. ncbi request reprint Effects of U-37883A on intracellular Ca2+ -activated large-conductance K+ channels in pig proximal urethral myocytes
    Noriyoshi Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi Ward, Fukuoka 812 8582, Japan
    Eur J Pharmacol 506:1-7. 2004
  4. ncbi request reprint Blocking actions of glibenclamide on ATP-sensitive K+ channels in pig urethral myocytes
    Noriyoshi Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    J Pharm Pharmacol 56:395-9. 2004
  5. pmc Multiple effects of mefenamic acid on K(+) currents in smooth muscle cells from pig proximal urethra
    N Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi Ward, Fukuoka 812 8582, Japan
    Br J Pharmacol 140:1341-50. 2003
  6. ncbi request reprint Pharmacological Profile of U-37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K Channels
    Noriyoshi Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Japan
    Cardiovasc Drug Rev 24:25-32. 2006
  7. ncbi request reprint [Molecular and electrophysiological investigation of ATP-sensitive K+ channels in lower urinary tract function: the aims for clinical treatment of unstable detrusor]
    Noriyoshi Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Nihon Yakurigaku Zasshi 121:317-24. 2003
  8. ncbi request reprint Modification of ATP-sensitive K+ channels by proteolysis in smooth muscle cells from pig urethra
    Noriyoshi Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi Ward, 812 8582, Fukuoka, Japan
    Life Sci 72:475-85. 2002
  9. pmc The involvement of L-type Ca(2+) channels in the relaxant effects of the ATP-sensitive K(+) channel opener ZD6169 on pig urethral smooth muscle
    N Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Br J Pharmacol 134:1505-15. 2001
  10. pmc Dual action of ZD6169, a novel K(+) channel opener, on ATP-sensitive K(+) channels in pig urethral myocytes
    N Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Br J Pharmacol 133:154-64. 2001

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Comparative studies on the relaxing action of several adenosine 5'-triphosphate-sensitive K+ channel openers in pig urethra
    N Teramoto
    Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    J Smooth Muscle Res 35:11-22. 1999
    ..These results indicate that the ability of K(ATP) openers to relax pig urethral smooth muscle can be accounted for by activation of glibenclamide-sensitive K+ channels...
  2. pmc Mefenamic acid as a novel activator of L-type voltage-dependent Ca2+ channels in smooth muscle cells from pig proximal urethra
    Noriyoshi Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi Ward, Fukuoka 812 8582, Japan
    Br J Pharmacol 144:919-25. 2005
    ..These results indicate that mefenamic acid increased voltage-dependent nifedipine-sensitive inward Ba2+ currents through the activation of L-type Ca2+ channels with different kinetics from those of Bay K 8644 in pig urethral myocytes...
  3. ncbi request reprint Effects of U-37883A on intracellular Ca2+ -activated large-conductance K+ channels in pig proximal urethral myocytes
    Noriyoshi Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi Ward, Fukuoka 812 8582, Japan
    Eur J Pharmacol 506:1-7. 2004
    ..These results shows that U-37883A affects channels other than the vascular KATP channel, and demonstrates how it inhibits the activities of BKCa channels in urethral smooth muscles...
  4. ncbi request reprint Blocking actions of glibenclamide on ATP-sensitive K+ channels in pig urethral myocytes
    Noriyoshi Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    J Pharm Pharmacol 56:395-9. 2004
    ..5 microM). Glibenclamide is the first reported sulphonylurea to selectively block K(ATP) channel, not only by decreasing the channel activity but also by reducing the unitary amplitude in smooth muscle...
  5. pmc Multiple effects of mefenamic acid on K(+) currents in smooth muscle cells from pig proximal urethra
    N Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi Ward, Fukuoka 812 8582, Japan
    Br J Pharmacol 140:1341-50. 2003
    ..These results indicate that mefenamic acid increases the channel activities of two distinct types of K+ channels (i.e. BKCa channels and KATP channels) and decreased 4-AP-sensitive K+ channels in pig urethral myocytes...
  6. ncbi request reprint Pharmacological Profile of U-37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K Channels
    Noriyoshi Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Japan
    Cardiovasc Drug Rev 24:25-32. 2006
    ..However, due to its multiple pharmacological actions on several ion channels and poor tissue selectivity, U-37883A should not be viewed as a selective blocker of smooth muscle K(ATP) channels...
  7. ncbi request reprint [Molecular and electrophysiological investigation of ATP-sensitive K+ channels in lower urinary tract function: the aims for clinical treatment of unstable detrusor]
    Noriyoshi Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Nihon Yakurigaku Zasshi 121:317-24. 2003
    ..We would like to introduce our recent evidence of novel synthesized detrusor-selective KATP channel openers and properties of KATP channels in the lower urinary tract...
  8. ncbi request reprint Modification of ATP-sensitive K+ channels by proteolysis in smooth muscle cells from pig urethra
    Noriyoshi Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi Ward, 812 8582, Fukuoka, Japan
    Life Sci 72:475-85. 2002
    ....
  9. pmc The involvement of L-type Ca(2+) channels in the relaxant effects of the ATP-sensitive K(+) channel opener ZD6169 on pig urethral smooth muscle
    N Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Br J Pharmacol 134:1505-15. 2001
    ....
  10. pmc Dual action of ZD6169, a novel K(+) channel opener, on ATP-sensitive K(+) channels in pig urethral myocytes
    N Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Br J Pharmacol 133:154-64. 2001
    ..7. These results demonstrate that ZD6169 possesses a dual effect on the activity of the K(ATP) channel; activating at low concentration and inhibiting at higher concentration...
  11. ncbi request reprint Possible underestimation of the channel conductance underlying pinacidil-induced K+ currents using noise analysis in pig urethral myocytes
    N Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pharm Pharmacol 52:1395-403. 2000
    ..These results indicate that pinacidil induces a glibenclamide-sensitive K+ current through only one type of K+ channel (K(ATP) channel) in pig urethra...
  12. pmc The effects of caffeine on ATP-sensitive K(+) channels in smooth muscle cells from pig urethra
    N Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi Ward, Fukuoka, 812 8582, Japan
    Br J Pharmacol 131:505-13. 2000
    ..These results suggest that caffeine can inhibit the activity of K(ATP) channels through a direct blocking effect on the pore-forming Kir subunit...
  13. pmc Properties and pharmacological modification of ATP-sensitive K(+) channels in cat tracheal myocytes
    N Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Br J Pharmacol 130:625-35. 2000
    ..e. K(ATP)) and can be activated by levcromakalim and that intracellular UDP causes a significant shift of the glibenclamide-sensitivity of these channels...
  14. ncbi request reprint Multiple actions of U-37883A, an ATP-sensitive K+ channel blocker, on membrane currents in pig urethra
    Toshihisa Tomoda
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Pharmacol 524:1-10. 2005
    ..These results demonstrate that U-37883A reduces not only the activities of K(ATP) channels but also voltage-dependent Ca(2+) channels. Therefore, it is not appropriate to define U-37883A as solely a vascular K(ATP) channel blocker...
  15. doi request reprint Characterization of NaV1.6-mediated Na+ currents in smooth muscle cells isolated from mouse vas deferens
    Hai Lei Zhu
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Cell Physiol 223:234-43. 2010
    ..6 in Na(V)1.6(+/+) myocytes. The gating properties of these channels suggest they play a major role in regulating smooth muscle excitability, particularly in response to rapid depolarizing stimuli...
  16. ncbi request reprint Different glibenclamide-sensitivity of ATP-sensitive K+ currents using different patch-clamp recording methods
    Noriyoshi Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi Ward, Fukuoka, 812 8582, Japan
    Eur J Pharmacol 531:34-40. 2006
    ....
  17. pmc Actions of veratridine on tetrodotoxin-sensitive voltage-gated Na currents, Na1.6, in murine vas deferens myocytes
    Hai Lei Zhu
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 157:1483-93. 2009
    ..The effects of veratridine, an alkaloid found in Liliaceae plants, on tetrodotoxin (TTX)-sensitive voltage-gated Na(+) channels were investigated in mouse vas deferens...
  18. doi request reprint Antagonistic actions of S(-)-Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba(2+) currents in guinea pig gastric antrum
    Hai Lei Zhu
    Department of Pharmacology, Kyushu University, Fukuoka, 812 8582, Japan
    Naunyn Schmiedebergs Arch Pharmacol 378:609-15. 2008
    ..These results indicate that S(-)-Bay K 8644, but not R(+)-Bay K 8644, can prevent the inhibitory actions of two distinct cyclic nucleotide pathways on I (Ba) in gastric myocytes of the guinea pig antrum...
  19. ncbi request reprint Effects of flavoxate hydrochloride on voltage-dependent Ba2+ currents in human detrusor myocytes at different experimental temperatures
    Toshihisa Tomoda
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi Ward, Fukuoka 812 8582, Japan
    Naunyn Schmiedebergs Arch Pharmacol 376:195-203. 2007
    ....
  20. pmc The effects of flavoxate hydrochloride on voltage-dependent L-type Ca2+ currents in human urinary bladder
    Toshihisa Tomoda
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 146:25-32. 2005
    ..2), in the bundles of human detrusor smooth muscle. These results suggest that flavoxate caused muscle relaxation through the inhibition of L-type Ca(2+) channels in human detrusor...
  21. pmc Actions of kurtoxin on tetrodotoxin-sensitive voltage-gated Na+ currents, NaV1.6, in murine vas deferens myocytes
    Hai Lei Zhu
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi Ward, Fukuoka, 812 8582, Japan
    Naunyn Schmiedebergs Arch Pharmacol 379:453-60. 2009
    ..These results suggest that kurtoxin is a modulator of Na(V)1.6 in native freshly dispersed smooth muscle cells from mouse vas deferens as well as its action on Ca(V)3.1...
  22. doi request reprint ATP-sensitive K+ channels in pig urethral smooth muscle cells are heteromultimers of Kir6.1 and Kir6.2
    Noriyoshi Teramoto
    Dept of Pharmacology, Graduate School of Medical Sciences, Kyushu Univ, 3 1 1 Maidashi, Higashi Ward, Fukuoka, 812 8582, Japan
    Am J Physiol Renal Physiol 296:F107-17. 2009
    ..1 channels of vascular myocytes and is responsible for the differences in inward rectification, conductance, and PKC regulation exhibited by the channels in these smooth muscle cell types...
  23. ncbi request reprint Comparative studies of ZD0947, a novel ATP-sensitive K(+) channel opener, on guinea pig detrusor and aortic smooth muscles
    Takakazu Yunoki
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi Ward, Fukuoka 812 8582, Japan
    Naunyn Schmiedebergs Arch Pharmacol 376:309-19. 2008
    ..These results show that ZD0947 caused a significant relaxation through the activation of K(ATP) channels in detrusor muscle...
  24. pmc Molecular analysis of ATP-sensitive K⁺ channel subunits expressed in mouse vas deferens myocytes
    Kazuomi Iwasa
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 171:145-57. 2014
    ..x associated with sulphonylurea receptor (SUR) subunits, have been detected in native smooth muscle cells, but it is currently not known which of these is expressed in mouse vas deferens myocytes...
  25. pmc Actions of two main metabolites of propiverine (M-1 and M-2) on voltage-dependent L-type Ca2+ currents and Ca2+ transients in murine urinary bladder myocytes
    Hai Lei Zhu
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi Ward, Fukuoka, 812 8582, Japan
    J Pharmacol Exp Ther 324:118-27. 2008
    ..These results suggest that M-1 acts, at least in part, as a Ca(2+) channel antagonist (as it inhibited I(Ca)), whereas M-2 has more direct antimuscarinic actions...
  26. pmc Molecular and biophysical properties of voltage-gated Na+ channels in murine vas deferens
    Hai Lei Zhu
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Biophys J 94:3340-51. 2008
    ..6(+/+)) littermates. This study demonstrates that the molecular identity of the voltage-gated Na(+) channels responsible for the TTX-sensitive I(Na) in murine vas deferens myocytes is primarily Na(V)1.6...
  27. pmc Functional involvement of sulphonylurea receptor (SUR) type 1 and 2B in the activity of pig urethral ATP-sensitive K+ channels
    Takakazu Yunoki
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi Ward, Fukuoka 812 8582, Japan
    Br J Pharmacol 139:652-60. 2003
    ..8 These results indicate that both SUR1 and SUR2B subunits play a functional role in regulating the activity of pig urethral K(ATP) channels and that SUR1 contributes less than 25% to total K(ATP) currents...
  28. ncbi request reprint The effects of MCC-134 on the ATP-sensitive K+ channels in pig urethra
    Takakazu Yunoki
    Faculty of Medicine, Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi Ward, Fukuoka 812 8582, Japan
    Eur J Pharmacol 482:287-95. 2003
    ..These results suggest that MCC-134 induces glibenclamide-sensitive K(ATP) currents in pig urethra...
  29. doi request reprint Dual action of AJG049, a novel gut selective Ca2+ channel antagonist, on Ba2+ currents and contractions in guinea-pig antrum myocytes
    Hai Lei Zhu
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Higashi Ward, Fukuoka, Japan
    Eur J Pharmacol 605:138-44. 2009
    ..These results suggest that AJG049 possesses a dual action on voltage-dependent Ca(2+) channels in circular layer of guinea-pig antrum...
  30. doi request reprint Resurgent-like currents in mouse vas deferens myocytes are mediated by NaV1.6 voltage-gated sodium channels
    Noriyoshi Teramoto
    Department of Pharmacology, Faculty of Medicine, Saga University, Saga, 849 8501, Japan
    Pflugers Arch 464:493-502. 2012
    ..6(+/+) but not Na(V)1.6(-/-) murine vas deferens myocytes. These results strongly indicate that, primarily, resurgent-like currents are generated as a result of Na(V)1.6 channel activity...
  31. pmc Physiological roles of ATP-sensitive K+ channels in smooth muscle
    Noriyoshi Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Physiol 572:617-24. 2006
    ....
  32. pmc Modulation of voltage-dependent Ba2+ currents in the guinea-pig gastric antrum by cyclic nucleotide-dependent pathways
    Hai Lei Zhu
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Higashi Ward, Fukuoka, Japan
    Br J Pharmacol 146:129-38. 2005
    ..These results indicate that two distinct cyclic nucleotide-dependent pathways are present in the guinea-pig gastric antrum, and that both inhibited I(Ba) in an independent manner...
  33. doi request reprint Activation of activin type IB receptor signals in pancreatic β cells leads to defective insulin secretion through the attenuation of ATP-sensitive K+ channel activity
    Masatoshi Nomura
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi Ward, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 450:440-6. 2014
    ..These results indicate that an appropriate level of activin signaling may be required for GSIS in pancreatic β cells, and that activin signaling involves modulation of KATP channel activity. ..
  34. doi request reprint SMAD2 disruption in mouse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sensitive K+ channel activity
    Masatoshi Nomura
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Higashi Ward, Fukuoka, Japan
    Diabetologia 57:157-66. 2014
    ..The TGF-β superfamily of ligands provides important signals for the development of pancreas islets. However, it is not yet known whether the TGF-β family signalling pathway is required for essential islet functions in the adult pancreas...
  35. doi request reprint Molecular analysis of ATP-sensitive K(+) channel subunits expressed in mouse portal vein
    Tadashi Yamamoto
    Department of Pharmacology Faculty of Medicine, Saga University, Saga 849 8501, Japan Department of Cardiovascular Medicine, Faculty of Medicine, Saga University, Saga 849 8501, Japan
    Vascul Pharmacol 75:29-39. 2015
    ..x) subunits associated with sulphonylurea receptor (SUR.x) subunits have been detected among ATP-sensitive K(+) (KATP) channels. It remains to be established which of these is expressed in native vascular smooth muscle...
  36. pmc Selective blocking effects of 4,9-anhydrotetrodotoxin, purified from a crude mixture of tetrodotoxin analogues, on NaV1.6 channels and its chemical aspects
    Noriyoshi Teramoto
    Department of Pharmacology, Faculty of Medicine, Saga University, Saga 849 8501, Japan
    Mar Drugs 13:984-95. 2015
    ..6 channels. In addition, chemical aspects of 4,9-anhydroTTX are briefly covered. ..
  37. doi request reprint Effects of Hange-shashin-to (TJ-14) and Keishi-ka-shakuyaku-to (TJ-60) on contractile activity of circular smooth muscle of the rat distal colon
    Yoshihiko Kito
    Department of Pharmacology, Faculty of Medicine, Saga University, Nabeshima, Saga 849 8501, Japan
    Am J Physiol Gastrointest Liver Physiol 303:G1059-66. 2012
    ..Since TJ-14 has potent inhibitory effects on myogenic and neurogenic contractile activity, TJ-14 may be useful in suppressing gastrointestinal motility...