S Ikeda

Summary

Affiliation: Nagasaki University
Country: Japan

Publications

  1. ncbi request reprint Possible involvement of interferon regulatory factor 4 (IRF4) in a clinical subtype of adult T-cell leukemia
    Y Imaizumi
    Division of Cytokine Signaling, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Medical Science, Nagasaki 852 8523, Japan
    Jpn J Cancer Res 92:1284-92. 2001
  2. ncbi request reprint Enhancement of in vivo antitumor activity of a novel antimitotic 1-phenylpropenone derivative, AM-132, by tumor necrosis factor-alpha or interleukin-6
    Y Tatsumi
    Pharmacology Division, National Cancer Center Research Institute, National Cancer Center Hospital, Chuo-ku, Tokyo 104-0045, Japan
    Jpn J Cancer Res 92:768-77. 2001
  3. ncbi request reprint SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein
    K Nakamura
    Department of Neurology, Division of Neuroscience, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hum Mol Genet 10:1441-8. 2001
  4. ncbi request reprint Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers
    K Tsukasaki
    Division of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, 90024, USA
    Cancer Res 61:3770-4. 2001
  5. ncbi request reprint Sensitivity of adult T-cell leukaemia lymphoma cells to tumour necrosis factor-related apoptosis-inducing ligand
    H Hasegawa
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan
    Br J Haematol 128:253-65. 2005
  6. ncbi request reprint Effects of mutation in hepatitis C virus nonstructural protein 5A on interferon resistance mediated by inhibition of PKR kinase activity in mammalian cells
    T Noguchi
    Central Pharmaceutical Research Institute, Japan Tobacco Inc, Takatsuki, Osaka
    Microbiol Immunol 45:829-40. 2001
  7. ncbi request reprint Chemotherapy targeting methylthioadenosine phosphorylase (MTAP) deficiency in adult T cell leukemia (ATL)
    H Harasawa
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Leukemia 16:1799-807. 2002
  8. ncbi request reprint Pathology of early- vs late-onset TTR Met30 familial amyloid polyneuropathy
    H Koike
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neurology 63:129-38. 2004
  9. ncbi request reprint Effects of ultraviolet B irradiation, proinflammatory cytokines and raised extracellular calcium concentration on the expression of ATP2A2 and ATP2C1
    N Mayuzumi
    Department of Dermatology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Br J Dermatol 152:697-701. 2005
  10. ncbi request reprint Effects of drugs and anticytokine antibodies on expression of ATP2A2 and ATP2C1 in cultured normal human keratinocytes
    N Mayuzumi
    Department of Dermatology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Br J Dermatol 152:920-4. 2005

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Possible involvement of interferon regulatory factor 4 (IRF4) in a clinical subtype of adult T-cell leukemia
    Y Imaizumi
    Division of Cytokine Signaling, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Medical Science, Nagasaki 852 8523, Japan
    Jpn J Cancer Res 92:1284-92. 2001
    ..Taken together, our results indicate that IRF4 is involved in the pathogenesis of ATL through its positive effect on the cell cycle, and that IRF4 can be used as a molecular marker of clinical subtype in ATL...
  2. ncbi request reprint Enhancement of in vivo antitumor activity of a novel antimitotic 1-phenylpropenone derivative, AM-132, by tumor necrosis factor-alpha or interleukin-6
    Y Tatsumi
    Pharmacology Division, National Cancer Center Research Institute, National Cancer Center Hospital, Chuo-ku, Tokyo 104-0045, Japan
    Jpn J Cancer Res 92:768-77. 2001
    ..These results suggest a combined effect of AM-132 and cytokines on the blood supply to tumors...
  3. ncbi request reprint SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein
    K Nakamura
    Department of Neurology, Division of Neuroscience, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hum Mol Genet 10:1441-8. 2001
    ..We therefore propose that this new disease be called SCA17 (TBP disease)...
  4. ncbi request reprint Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers
    K Tsukasaki
    Division of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, 90024, USA
    Cancer Res 61:3770-4. 2001
    ....
  5. ncbi request reprint Sensitivity of adult T-cell leukaemia lymphoma cells to tumour necrosis factor-related apoptosis-inducing ligand
    H Hasegawa
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan
    Br J Haematol 128:253-65. 2005
    ..Consequently, the resistant mechanism in ATLL cells against TRAIL was assigned to multiple factors and was not explained by a definitive single agent...
  6. ncbi request reprint Effects of mutation in hepatitis C virus nonstructural protein 5A on interferon resistance mediated by inhibition of PKR kinase activity in mammalian cells
    T Noguchi
    Central Pharmaceutical Research Institute, Japan Tobacco Inc, Takatsuki, Osaka
    Microbiol Immunol 45:829-40. 2001
    ..In addition, we showed that IFN sensitivity was determined not only by the ISDR but that the involvement of the C-terminal region of NS5A-1b is important for the suppression of PKR activity...
  7. ncbi request reprint Chemotherapy targeting methylthioadenosine phosphorylase (MTAP) deficiency in adult T cell leukemia (ATL)
    H Harasawa
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Leukemia 16:1799-807. 2002
    ..These results support the rationale for a chemotherapy regimen of L-alanosine combined with 5'-deoxyadenosine rescue in MTAP-deficient ATL...
  8. ncbi request reprint Pathology of early- vs late-onset TTR Met30 familial amyloid polyneuropathy
    H Koike
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neurology 63:129-38. 2004
    ..Late-onset type I familial amyloid polyneuropathy (FAP TTR Met30) cases unrelated to endemic foci in Japan show clinical features setting them apart from early-onset cases in endemic foci...
  9. ncbi request reprint Effects of ultraviolet B irradiation, proinflammatory cytokines and raised extracellular calcium concentration on the expression of ATP2A2 and ATP2C1
    N Mayuzumi
    Department of Dermatology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Br J Dermatol 152:697-701. 2005
    ..Mutations in ATP2A2 or ATP2C1 have been suggested as causing the conditions via the mechanism of haploinsufficiency. Ultraviolet (UV) B irradiation is thought to be an aggravating factor in both diseases...
  10. ncbi request reprint Effects of drugs and anticytokine antibodies on expression of ATP2A2 and ATP2C1 in cultured normal human keratinocytes
    N Mayuzumi
    Department of Dermatology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Br J Dermatol 152:920-4. 2005
    ..Exposure to ultraviolet (UV) B irradiation exacerbates the skin lesions, which can be treated with corticosteroids and retinoids...
  11. ncbi request reprint Twenty-year follow-up of a patient with subacute sclerosing panencephalitis
    T Hashimoto
    Third Department of Medicine Neurology, Shinshu University School of Medicine, Matsumoto, Japan
    Eur Neurol 54:60-2. 2005
  12. ncbi request reprint Retinoid receptor-specific agonists regulate bovine in vitro early embryonic development, differentiation and expression of genes related to cell cycle arrest and apoptosis
    A Rodriguez
    Genética y Reproducción SERIDA, Asturias, Spain
    Theriogenology 68:1118-27. 2007
    ..Z showed a strong, positive correlation (r=0.93; p<0.0001) in all experimental groups; both proteins are linked through the cell cycle. Agonists of RXR could be used to control blastocyst development and differentiation...
  13. ncbi request reprint Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human alpha-defensins from neutrophils
    Y Zheng
    Atopy Allergy Research Center, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Br J Dermatol 157:1124-31. 2007
    ..In contrast to atopic dermatitis, psoriasis exhibits low levels of skin infections due to the presence of antimicrobial agents, including cathelicidin LL-37. LL-37 kills a broad spectrum of microbes, and activates neutrophil chemotaxis...
  14. ncbi request reprint Keratin 14 gene mutations in patients with epidermolysis bullosa simplex
    H Chen
    Department of Dermatology, San Francisco General Hospital, University of California 94110, USA
    J Invest Dermatol 105:629-32. 1995
    ..Early onset of blistering in these ten families is correlated with more widespread distribution of lesions...
  15. ncbi request reprint [Elderly-onset anticentromere antibody-positive pulmonary-renal syndrome: report of an autopsy case]
    T Oide
    Department of Internal Medicine, Fujimi-Kougen Hospital, 11, 100 Ochiai, Fujimi-machi, Suwa-gun 399-0214, Nagano, Japan
    Nihon Kokyuki Gakkai Zasshi 39:498-503. 2001
    ..We speculated that anticentromere antibody-positive pulmonary-renal syndrome without any other symptoms or signs of connective tissue disease, such as our case, is a clinical entity distinct from typical SLE or CREST syndrome...
  16. ncbi request reprint Structure-function relationship of the eukaryotic DNA replication factor, proliferating cell nuclear antigen
    K Fukuda
    Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    J Biol Chem 270:22527-34. 1995
    ..Furthermore, the two side surfaces seem to be functionally distinguishable, and this may determine the orientation of tracking PCNA along the DNA...
  17. ncbi request reprint Fluorescence-based polymerase chain reaction-single-strand conformation polymorphism analysis of p53 gene by capillary electrophoresis
    K Katsuragi
    Diagnostics Division, Otsuka Pharmaceutical Co. Ltd, Tokushima, Japan
    J Chromatogr A 744:311-20. 1996
    ....
  18. ncbi request reprint Expression of murine novel zinc finger proteins highly homologous to Drosophila ovo gene product in testis
    Y Masu
    Department of Medical Chemistry, Kansai Medical University, Moriguchi, Osaka, Japan
    FEBS Lett 421:224-8. 1998
    ..The 1.3-kbp mRNAs are predominantly expressed in testis, and the expression increases from 3 weeks postnatal, implying that these proteins may play important roles in the development of the testes...
  19. ncbi request reprint Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes
    K Imai
    Department of Molecular Biology, Institute of Cellular and Molecular Biology, Okayama University Medical School, Okayama 700 8558, Japan
    Gene 222:287-95. 1998
    ..This paper demonstrates for the first time the spatial relationship of these three genes (TSC2, NTHL1 and SLC9A3R2) at the nucleotide level, and the presence of multiple transcription initiation sites of the NTHL1 and TSC2 genes...
  20. ncbi request reprint A novel frameshift mutation in the McLeod syndrome gene in a Japanese family
    N Hanaoka
    Department of Medicine Neurology, Shinshu University School of Medicine, Matsumoto, Japan
    J Neurol Sci 165:6-9. 1999
    ..We conclude this single-base deletion causes defective Kx protein, which is responsible for the McLeod phenotype in this patient...
  21. ncbi request reprint Alternative promoters direct tissue-specific expression of the mouse protein phosphatase 2Cbeta gene
    M Ohnishi
    Department of Biochemistry, Institute of Development, Tohoku University, Sendai, Japan
    Eur J Biochem 263:736-45. 1999
    ..These results suggest that the alternative usage of two promoters within the PP2Cbeta gene regulates tissue-specific expression of PP2Cbeta mRNA...
  22. ncbi request reprint GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin
    S Ikeda
    Department of Biochemistry, Hiroshima University School of Medicine, Japan
    Oncogene 19:537-45. 2000
    ..Taken together, these results suggest that GSK-3beta-dependent phosphorylation of APC can be modulated by beta-catenin and PP2A complexed with Axin...
  23. ncbi request reprint Activation of c-Jun amino-terminal kinase is required for retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells
    H Wang
    Department of Biochemistry, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    FEBS Lett 503:91-6. 2001
    ..Studies using protein phosphatase inhibitors and protein kinase inhibitors suggested that both okadaic acid-sensitive protein phosphatase(s) and protein kinase C participate in the RA-induced activation of JNK...
  24. doi request reprint Genetic polymorphisms of tumour necrosis factor receptor superfamily 1A and 1B affect responses to infliximab in Japanese patients with Crohn's disease
    H Matsukura
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Aliment Pharmacol Ther 27:765-70. 2008
    ..The genetic background of the individual may partially explain the differences of the responsiveness...