T K Nemoto

Summary

Affiliation: Nagasaki University
Country: Japan

Publications

  1. pmc Degradation of Incretins and Modulation of Blood Glucose Levels by Periodontopathic Bacterial Dipeptidyl Peptidase 4.
    Yuko Ohara Nemoto
    Department of Oral Molecular Biology, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Infect Immun 85:. 2017
  2. ncbi request reprint Occurrence of staphylococci in the oral cavities of healthy adults and nasal oral trafficking of the bacteria
    Y Ohara-Nemoto
    Department of Oral Molecular Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8588, Japan
    J Med Microbiol 57:95-9. 2008
  3. doi request reprint Homologous and heterologous expression and maturation processing of extracellular glutamyl endopeptidase of Staphylococcus epidermidis
    Yuko Ohara-Nemoto
    Department of Oral Molecular Biology, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Biol Chem 389:1209-17. 2008
  4. ncbi request reprint Liberation of the intramolecular interaction as the mechanism of heat-induced activation of HSP90 molecular chaperone
    E Tanaka
    Department of Oral Biochemistry, Nagasaki University School of Dentistry, Nagasaki, Japan
    Eur J Biochem 268:5270-7. 2001
  5. ncbi request reprint Propeptide processing and proteolytic activity of proenzymes of the staphylococcal and enterococcal GluV8-family protease
    S M A Rouf
    Department of Oral Molecular Biology, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8588, Japan
    Indian J Biochem Biophys 49:421-7. 2012
  6. pmc Substrate-binding characteristics of proteins in the 90 kDa heat shock protein family
    T K Nemoto
    Department of Oral Biochemistry, Nagasaki University School of Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Biochem J 354:663-70. 2001
  7. ncbi request reprint Collagen-binding heat shock protein HSP47 expression during healing of fetal skin wounds
    Z L Wang
    Second Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry, Japan
    Int J Oral Maxillofac Surg 31:179-84. 2002
  8. ncbi request reprint Antisense oligonucleotide against 47-kDa heat shock protein (Hsp47) inhibits wound-induced enhancement of collagen production
    S Ohba
    Division of Oral and Maxillofacial Surgical Reconstruction and Functional Restoration, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto, Japan
    Arch Oral Biol 48:627-33. 2003
  9. doi request reprint RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma
    S Yamada
    Department of Oral and Maxillofacial Surgery, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Int J Oral Maxillofac Surg 39:61-7. 2010
  10. doi request reprint Involvement of geranylgeranylation of Rho and Rac GTPases in adipogenic and RANKL expression, which was inhibited by simvastatin
    T T Baba
    Department of Oral Molecular Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Cell Biochem Funct 31:652-9. 2013

Collaborators

Detail Information

Publications11

  1. pmc Degradation of Incretins and Modulation of Blood Glucose Levels by Periodontopathic Bacterial Dipeptidyl Peptidase 4.
    Yuko Ohara Nemoto
    Department of Oral Molecular Biology, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Infect Immun 85:. 2017
    ....
  2. ncbi request reprint Occurrence of staphylococci in the oral cavities of healthy adults and nasal oral trafficking of the bacteria
    Y Ohara-Nemoto
    Department of Oral Molecular Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8588, Japan
    J Med Microbiol 57:95-9. 2008
    ..Since the provision of micro-organisms from the nasal cavity was shown and occurrence rates in the oral cavity were adequate, these results suggest a possible peroral route of staphylococcal IE, as in cases of viridans streptococcal IE...
  3. doi request reprint Homologous and heterologous expression and maturation processing of extracellular glutamyl endopeptidase of Staphylococcus epidermidis
    Yuko Ohara-Nemoto
    Department of Oral Molecular Biology, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Biol Chem 389:1209-17. 2008
    ..These findings could offer clues to the molecular mechanism involved in the regulation of proteolytic activity of pathogenic proteases secreted from S. epidermidis...
  4. ncbi request reprint Liberation of the intramolecular interaction as the mechanism of heat-induced activation of HSP90 molecular chaperone
    E Tanaka
    Department of Oral Biochemistry, Nagasaki University School of Dentistry, Nagasaki, Japan
    Eur J Biochem 268:5270-7. 2001
    ..Taken together, we propose the liberation of the N-terminal client-binding domain from the middle suppressor domain is involved in the temperature-dependent activation mechanism of HSP90 molecular chaperone...
  5. ncbi request reprint Propeptide processing and proteolytic activity of proenzymes of the staphylococcal and enterococcal GluV8-family protease
    S M A Rouf
    Department of Oral Molecular Biology, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8588, Japan
    Indian J Biochem Biophys 49:421-7. 2012
    ..These results suggest that GluV8-family proenzymes with shortened propeptides intrinsically possess proteolytic activity and are involved in the propeptide shortening that facilitates the final hetero-catalytic maturation...
  6. pmc Substrate-binding characteristics of proteins in the 90 kDa heat shock protein family
    T K Nemoto
    Department of Oral Biochemistry, Nagasaki University School of Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Biochem J 354:663-70. 2001
    ..We therefore propose that the primary peptide-binding site is located in the N-terminal domain of HSP90-family proteins...
  7. ncbi request reprint Collagen-binding heat shock protein HSP47 expression during healing of fetal skin wounds
    Z L Wang
    Second Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry, Japan
    Int J Oral Maxillofac Surg 31:179-84. 2002
    ..We conclude that the scarless healing of fetal skin wounds is related to lack of change in HSP47 expression. HSP47 may thus be an important determinant of scar formation during wound healing...
  8. ncbi request reprint Antisense oligonucleotide against 47-kDa heat shock protein (Hsp47) inhibits wound-induced enhancement of collagen production
    S Ohba
    Division of Oral and Maxillofacial Surgical Reconstruction and Functional Restoration, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto, Japan
    Arch Oral Biol 48:627-33. 2003
    ..Therefore, we conclude that antisense oligonucleotide against Hsp47 inhibits the production of procollagen type I and III proteins in fibroblasts derived from wounded tongues, overcoming the increase in their mRNAs...
  9. doi request reprint RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma
    S Yamada
    Department of Oral and Maxillofacial Surgery, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Int J Oral Maxillofac Surg 39:61-7. 2010
    ..The study indicated that alpha-actinin-4 could be a potential molecular target for gene therapy by RNAi targeting for OSCC...
  10. doi request reprint Involvement of geranylgeranylation of Rho and Rac GTPases in adipogenic and RANKL expression, which was inhibited by simvastatin
    T T Baba
    Department of Oral Molecular Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Cell Biochem Funct 31:652-9. 2013
    ....
  11. ncbi request reprint Domain-domain interactions of HtpG, an Escherichia coli homologue of eukaryotic HSP90 molecular chaperone
    T K Nemoto
    Department of Oral Biochemistry, Nagasaki University School of Dentistry, Nagasaki, Japan
    Eur J Biochem 268:5258-69. 2001
    ..The C-terminal two-thirds of domain A, i.e. Asp116-Arg336, were sufficient for the binding to domain B. We finally propose the domain organization of an HtpG dimer...