K Hibi

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint Methylation pattern of HLTF gene in digestive tract cancers
    Kenji Hibi
    Gastroenterological Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Int J Cancer 104:433-6. 2003
  2. pmc Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer
    T Sakakibara
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Japan
    Br J Cancer 93:799-803. 2005
  3. ncbi request reprint Aberrant methylation of HLTF, SOCS-1, and CDH13 genes is shown in colorectal cancers without lymph node metastasis
    Kenji Hibi
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Dis Colon Rectum 48:1282-6. 2005
  4. ncbi request reprint A cancer-prone case with a background of methylation of p16 tumor suppressor gene
    Kenji Hibi
    Second Department of Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Clin Cancer Res 9:1053-6. 2003
  5. ncbi request reprint Identification of S100A2 as a target of the DeltaNp63 oncogenic pathway
    Kenji Hibi
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Clin Cancer Res 9:4282-5. 2003
  6. ncbi request reprint Lymph node metastasis is infrequent in patients with highly-methylated colorectal cancer
    Kenji Hibi
    Department of Surgery, Seirei Hospital, 56 Kawanayama machi, Showa Ku, Nagoya 466 8633, Japan
    Anticancer Res 26:55-8. 2006
  7. ncbi request reprint Detection of mitochondrial DNA alterations in primary tumors and corresponding serum of colorectal cancer patients
    K Hibi
    Second Department of Surgery, Nagoya University School of Medicine, Nagoya, Japan
    Int J Cancer 94:429-31. 2001
  8. ncbi request reprint Disseminated intravascular coagulation associated with systemic cytomegalovirus infection during cyclosporine therapy for ulcerative colitis: report of a case
    Kenji Hibi
    Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Dis Colon Rectum 49:127-31. 2006
  9. ncbi request reprint Molecular detection of p16 promoter methylation in the serum of patients with esophageal squamous cell carcinoma
    K Hibi
    Second Department of Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Clin Cancer Res 7:3135-8. 2001
  10. ncbi request reprint Plasminogen activator inhibitor-1 is a downstream mediator of the PGP9.5-related oncogenic pathway in esophageal squamous cell carcinoma
    Kenji Hibi
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Anticancer Res 24:3731-4. 2004

Collaborators

Detail Information

Publications89

  1. ncbi request reprint Methylation pattern of HLTF gene in digestive tract cancers
    Kenji Hibi
    Gastroenterological Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Int J Cancer 104:433-6. 2003
    ..These results suggested that HLTF might play a variety of roles depending on the tissue type and could be inactivated at an early stage in the tumorigenic pathway...
  2. pmc Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer
    T Sakakibara
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Japan
    Br J Cancer 93:799-803. 2005
    ..0432). These results suggested that PAI-1 might serve as a new parameter for the prediction of prognoses in CRC...
  3. ncbi request reprint Aberrant methylation of HLTF, SOCS-1, and CDH13 genes is shown in colorectal cancers without lymph node metastasis
    Kenji Hibi
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Dis Colon Rectum 48:1282-6. 2005
    ....
  4. ncbi request reprint A cancer-prone case with a background of methylation of p16 tumor suppressor gene
    Kenji Hibi
    Second Department of Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Clin Cancer Res 9:1053-6. 2003
    ..In this study, we tested for the methylation status of p16 promoter in normal tissue specimens using the methylation-specific PCR technique to examine whether p16 methylation already existed in the background of tumors...
  5. ncbi request reprint Identification of S100A2 as a target of the DeltaNp63 oncogenic pathway
    Kenji Hibi
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Clin Cancer Res 9:4282-5. 2003
    ..To gain additional insight into this pathway, we examined global patterns of gene expression in cancer cells after DeltaNp63 gene introduction using the oligonucleotide microarray approach...
  6. ncbi request reprint Lymph node metastasis is infrequent in patients with highly-methylated colorectal cancer
    Kenji Hibi
    Department of Surgery, Seirei Hospital, 56 Kawanayama machi, Showa Ku, Nagoya 466 8633, Japan
    Anticancer Res 26:55-8. 2006
    ..There was also a significant gender difference (p = 0.0248) when the methylation status was compared. Colorectal cancer without lymph node metastasis frequently exhibited aberrant methylation of the p16, p14, HLTF, CDH13 and RUNX3 genes...
  7. ncbi request reprint Detection of mitochondrial DNA alterations in primary tumors and corresponding serum of colorectal cancer patients
    K Hibi
    Second Department of Surgery, Nagoya University School of Medicine, Nagoya, Japan
    Int J Cancer 94:429-31. 2001
    ..Of 7 alterations that were examined, 1 (14%) could be detected in the serum. This result suggested that the mtDNA alteration could also be used as a tumor marker to detect tumor DNA in the serum...
  8. ncbi request reprint Disseminated intravascular coagulation associated with systemic cytomegalovirus infection during cyclosporine therapy for ulcerative colitis: report of a case
    Kenji Hibi
    Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Dis Colon Rectum 49:127-31. 2006
  9. ncbi request reprint Molecular detection of p16 promoter methylation in the serum of patients with esophageal squamous cell carcinoma
    K Hibi
    Second Department of Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Clin Cancer Res 7:3135-8. 2001
    ..We have examined promoter hypermethylation of the p16 gene in esophageal squamous cell carcinoma (SCC) using methylation-specific PCR to detect tumor DNA in the serum...
  10. ncbi request reprint Plasminogen activator inhibitor-1 is a downstream mediator of the PGP9.5-related oncogenic pathway in esophageal squamous cell carcinoma
    Kenji Hibi
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Anticancer Res 24:3731-4. 2004
    ..To examine the PGP9.5-related oncogenic pathway, we tested for global patterns of gene expression in cancer cells following PGP9.5 gene introduction using an oligonucleotide microarray approach...
  11. pmc CDH13 promoter region is specifically methylated in poorly differentiated colorectal cancer
    K Hibi
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Br J Cancer 90:1030-3. 2004
    ....
  12. pmc Methylation pattern of CDH13 gene in digestive tract cancers
    K Hibi
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Br J Cancer 91:1139-42. 2004
    ..These results suggested that CDH13 might play a variety of roles depending on the tissue type...
  13. ncbi request reprint Colorectal cancers with both p16 and p14 methylation show invasive characteristics
    Kenji Hibi
    Second Department of Surgery, Nagoya University School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Jpn J Cancer Res 93:883-7. 2002
    ..Inactivation of both p16 and p14 genes may result in a malignant change in colorectal cancer cells, leading to advanced cancers with a smaller size than those with p16 or p14 activity...
  14. ncbi request reprint AIS overexpression in advanced esophageal cancer
    K Hibi
    Second Department of Surgery, Nagoya University School of Medicine, Japan
    Clin Cancer Res 7:469-72. 2001
    ..Moreover, high AIS gene expression was significantly associated with lymph node metastases in esophageal cancer (P = 0.0271). These results suggested that AIS may be useful as a marker for advanced esophageal cancer...
  15. ncbi request reprint Mitochondrial DNA alteration in esophageal cancer
    K Hibi
    Second Department of Surgery, Nagoya University School of Medicine, Nagoya, Japan
    Int J Cancer 92:319-21. 2001
    ..Although the mutation rate of mitochondrial tumor DNA within the D-loop was not high, this result suggested that mtDNA mutations play a role in the development of esophageal cancer...
  16. ncbi request reprint PAI-1 expression levels in esophageal and colorectal cancers are closely correlated to those in corresponding normal tissues
    T Sakakibara
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Anticancer Res 26:4343-7. 2006
    ..Taken together, PAI-1 overexpression in esophageal and colorectal cancers might originate from higher PAI-1 expression in corresponding normal tissues and result in a malignant phenotype of these cancers...
  17. ncbi request reprint Pharmacodynamics induced by direct electric current for the treatment of 5-fluorouracil resistant tumor: an animal experiment
    K Ito
    Department of Surgery, School of Medicine, Nagoya University, Japan
    Int J Colorectal Dis 16:326-30. 2001
    ..This elevated 5-FU concentration in the tumor tissue is considered one of the reasons for the effective inhibition of 5-FU resistance in clinical cases...
  18. ncbi request reprint Oral HCFU for prevention of hepatic metastasis in an experimental colorectal carcinoma
    K Ito
    Department of Surgery II, School of Medicine, Nagoya University, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550 Japan
    Anticancer Res 21:899-904. 2001
    ..An animal experimental study was performed to clarify the preventive effect of oral HCFU (1-hexylcarbamoyl-5-fluorouracil) on hepatic metastasis...
  19. ncbi request reprint Aberrant methylation is frequently observed in advanced esophageal squamous cell carcinoma
    Tomoki Fukuoka
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Anticancer Res 26:3333-5. 2006
    ..ESCC with methylation-positive genes showed a trend towards larger tumor size and deeper invasion (p = 0.139 and p = 0.0664, respectively). Thus, the methylation of the p16, HLTF and CDH13 genes is a high malignancy factor in ESCC...
  20. ncbi request reprint Newly developed drug delivery system in cancer chemotherapy using direct electric current
    K Ito
    Department of Surgery II, Nagoya University School of Medicine, Japan
    ASAIO J 47:338-41. 2001
    ..05). Electric therapy using a slight direct current could gather anionized MTX to the cathode, while reducing MTX concentration in the serum of experimental rats...
  21. ncbi request reprint Paired tumor marker of soluble E-selectin and its ligand sialyl Lewis A in colorectal cancer
    K Ito
    Second Department of Surgery, School of Medicine, Nagoya University, Japan
    J Gastroenterol 36:823-9. 2001
    ..The elevation of E-selectin alone or both E-selectin and sialyl Lewis A may be one of the useful indexes for more precise diagnosis of hematogenous metastases of human colorectal cancer...
  22. ncbi request reprint Small incisional esophagectomy with endoscopic assistance: evaluation of a new technique
    S Akiyama
    Department of Surgery II, Nagoya University School of Medicine, Aichi, Japan
    Surg Today 31:378-82. 2001
    ..The postoperative courses of 20 consecutive patients who underwent this procedure were generally uneventful, and significant improvements in terms of intensive care and analgesic requirements were observed...
  23. ncbi request reprint S100A2 overexpression is frequently observed in esophageal squamous cell carcinoma
    Masahiko Imazawa
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Anticancer Res 25:1247-50. 2005
    ..We identified S100A2, a Ca2+-binding protein, as a novel downstream mediator of deltaNp63...
  24. ncbi request reprint Molecular detection of circulating esophageal squamous cell cancer cells in the peripheral blood
    Masahiko Koike
    Second Department of Surgery, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    Clin Cancer Res 8:2879-82. 2002
    ....
  25. ncbi request reprint Prognostic significance of intraperitoneal cancer cells in gastric carcinoma: detection of cytokeratin 20 mRNA in peritoneal washes, in addition to detection of carcinoembryonic antigen
    Yasuhiro Kodera
    Second Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Gastric Cancer 8:142-8. 2005
    ..A search for other molecular markers is ongoing...
  26. ncbi request reprint Aberrant methylation of the CHFR gene in advanced hepatocellular carcinoma
    Mitsuru Sakai
    Department of Surgery II, Graduate School of Medicine, Nagoya University, Japan
    Hepatogastroenterology 52:1854-7. 2005
    ..We examined the methylation status of the CHFR gene in primary hepatocellular carcinomas (HCCs) and evaluated the correlation between the methylation status and the malignancy of HCC...
  27. ncbi request reprint Plasminogen activator inhibitor-1 as a potential marker for the malignancy of esophageal squamous cell carcinoma
    Takumi Sakakibara
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Clin Cancer Res 10:1375-8. 2004
    ....
  28. ncbi request reprint Plasminogen activator inhibitor-1 as a potential marker for the malignancy of gastric cancer
    Takumi Sakakibara
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Cancer Sci 97:395-9. 2006
    ..0450). These results suggested that PAI-1 might serve as a new and promising parameter for the prediction of prognosis in gastric cancer...
  29. ncbi request reprint Aberrant methylation of the CHFR gene in digestive tract cancer
    Yuki Morioka
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Anticancer Res 26:1791-5. 2006
    ..Recently, aberrant methylation of the CHFR gene associated with gene silencing has been reported in several cancers. The methylation status of the CHFR gene was examined in primary esophageal and gastric carcinomas...
  30. ncbi request reprint Detection of p16 promoter hypermethylation in serum of gastric cancer patients
    Yasuaki Kanyama
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8560, Japan
    Cancer Sci 94:418-20. 2003
    ..No methylation was found in serum DNA of these control groups. Our results suggest that p16 methylation would be a good marker for the detection of tumor DNA in the serum of primary gastric cancer patients...
  31. ncbi request reprint Aberrant methylation of SOCS-1 was observed in younger colorectal cancer patients
    Shinichi Fujitake
    Gastrointestinal Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gastroenterol 39:120-4. 2004
    ..To define the role of SOCS-1 in the tumorigenic pathway of the colorectum, we examined the methylation of SOCS-1 in tumors of colorectal cancer patients...
  32. ncbi request reprint Methylation-mediated silencing of SOCS-1 gene in hepatocellular carcinoma derived from cirrhosis
    Osamu Okochi
    Second Department of Surgery, Nagoya University School of Medicine, Nagoya, Japan
    Clin Cancer Res 9:5295-8. 2003
    ..Recently, it was demonstrated that SOCS-1 gene was silenced frequently by methylation of CpG island in human hepatocellular carcinoma (HCC). We examined the methylation-mediated silencing of SOCS-1 in tumors of HCC patients...
  33. ncbi request reprint Ectopic expression of c-kit in small-cell lung cancer
    T Hida
    Department of Internal Medicine, Aichi Cancer Center, Nagoya, Japan
    Int J Cancer Suppl 8:108-9. 1994
    ..We also found that significant chemotactic response as well as moderate in vitro cell growth occurred in SCLC cell lines upon addition of recombinant human stem-cell factor...
  34. ncbi request reprint Laparoscopy-assisted distal gastrectomy with systemic lymph node dissection: a phase II study following the learning curve
    Michitaka Fujiwara
    Department of Surgery II, Nagoya University School of Medicine, Nagoya Aichi, Japan
    J Surg Oncol 91:26-32. 2005
    ..A preliminary study on the use of laparoscopy-assisted approach to treat gastric carcinoma resulted in higher morbidity...
  35. ncbi request reprint PGP9.5 as a marker for invasive colorectal cancer
    Taiji Yamazaki
    Second Department of Surgery, Japan
    Clin Cancer Res 8:192-5. 2002
    ..In this study, we examined the expression of PGP9.5 in primary colorectal cancers using immunohistochemistry and correlated the result with the clinicopathological features...
  36. ncbi request reprint MACC1 as a marker for advanced colorectal carcinoma
    Atsushi Shirahata
    Department of Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 30:2689-92. 2010
    ..Recently, Stein et al. identified the metastasis-associated in colon cancer 1 (MACC1) gene by genome-wide search for differentially expressed genes in human colon cancer tissues and metastases...
  37. ncbi request reprint Expression level of thymidylate synthase is a good predictor of chemosensitivity to 5-fluorouracil in colorectal cancer
    Tamotsu Inoue
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8560, Japan
    J Gastroenterol 40:143-7. 2005
    ..To avoid unnecessary medication and uncomfortable side effects, it is important to estimate the chemosensitivity of cancers to 5-fluorouracil (5-FU) before chemotherapy...
  38. ncbi request reprint Frequent methylation of Vimentin in well-differentiated gastric carcinoma
    Yo Hei Kitamura
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:2227-9. 2009
    ..Recently, it was shown that the vimentin gene, usually activated in mesenchymal cells, was highly methylated in colorectal carcinoma...
  39. ncbi request reprint Methylation of the p16 gene is frequently detected in lymphatic-invasive gastric cancer
    Tetsuhiro Goto
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 30:2701-3. 2010
    ..A tumor suppressor gene, p16, was found to harbor promoter methylation associated with the loss of protein expression in cancer cells, suggesting that p16 inactivation due to promoter methylation may be important for gastric tumorigenesis...
  40. ncbi request reprint MACC 1 as a marker for peritoneal-disseminated gastric carcinoma
    Atsushi Shirahata
    Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 30:3441-4. 2010
    ..Previously, the MACC1 expression levels were examined in colorectal carcinomas and it was found that MACC1 expression showed significant correlation with peritoneal dissemination and higher stage of TNM classification...
  41. ncbi request reprint Demethylation of the CD133 gene is frequently detected in advanced colorectal cancer
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:2235-7. 2009
    ..Furthermore, it has been reported that CD133 expression is directly regulated by epigenetic modifications. Therefore, it is possible that CD133 expression by gene demethylation is related to colorectal carcinogenesis...
  42. ncbi request reprint Efficacy of intraperitoneal chemotherapy with paclitaxel targeting peritoneal micrometastasis as revealed by GFP-tagged human gastric cancer cell lines in nude mice
    Norifumi Ohashi
    Department of Surgery II, Nagoya University School of Medicine, Tsurumai cho, Showa Ku, Nagoya 466 8550, Japan
    Int J Oncol 27:637-44. 2005
    ..These results indicate that intraperitoneal paclitaxel is effective against peritoneal metastasis in early phase...
  43. ncbi request reprint RUNX3 promoter region is specifically methylated in poorly-differentiated colorectal cancer
    Yasuhiro Imamura
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Anticancer Res 25:2627-30. 2005
    ..In this study, we investigated the methylation status of the RUNX3 gene in 92 resected primary colorectal cancers using methylation-specific PCR (MSP) and correlated the results with the clinicopathological features of affected patients...
  44. ncbi request reprint Methylation of the MGMT gene is frequently detected in advanced gastric carcinoma
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:5053-5. 2009
    ..Recently, Herfarth et al. reported that a subset of colorectal tumors was characterized by a specific methylation pattern in the MGMT promoter associated with reduced MGMT expression...
  45. ncbi request reprint TAOS1, a novel marker for advanced esophageal squamous cell carcinoma
    Yoshinao Komatsu
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Anticancer Res 26:2029-32. 2006
    ..TAOS1 (tumor amplified and overexpressed sequence 1) was recently cloned and found to be possibly important in driving the amplification of 11q13 in oral squamous cell carcinoma (SCC)...
  46. ncbi request reprint Methylation of HACE1 in gastric carcinoma
    Makiko Sakata
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:2231-3. 2009
    ..0612), suggesting that HACE1 might present a malignant potential in colorectal cancer. These results prompted us to examine the methylation status of the HACE1 gene in gastric carcinomas...
  47. ncbi request reprint Demethylation of the CDH3 gene is frequently detected in advanced colorectal cancer
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:2215-7. 2009
    ..These results indicated that epigenetic demethylation of the CDH3 promoter in the human intestine permits its ectopic expression in colorectal cancer...
  48. ncbi request reprint Detection of disseminated cancer cells in linitis plastica-type gastric carcinoma
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Jpn J Clin Oncol 34:525-31. 2004
    ..Reverse transcriptase polymerase chain reaction (RT-PCR) is a sensitive technique for detecting these cells...
  49. ncbi request reprint Prolonged cytostatic tumor dormancy induced by serial exchange of chemotherapy in colorectal carcinoma
    Katsuki Ito
    Department of Gastroenterological Surgery, Nagoya University School of Medicine, Japan
    Nagoya J Med Sci 67:9-15. 2004
    ..To improve quality of life cytostatic effect of serially changed chemotherapy was investigated...
  50. ncbi request reprint Obesity and outcome of distal gastrectomy with D2 lymphadenectomy for carcinoma
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University School of Medicine Nagoya, Aichi 466 8550, Japan
    Hepatogastroenterology 51:1225-8. 2004
    ..Obesity has correlated with surgical outcome in patients undergoing elective surgery for various cancers. This relationship has not been examined for gastric cancer surgery performed at a specialized high-volume center...
  51. ncbi request reprint Follow-up surveillance for recurrence after curative gastric cancer surgery lacks survival benefit
    Yasuhiro Kodera
    Department of Surgery II, Nagoya University School of Medicine, Aichi, Japan
    Ann Surg Oncol 10:898-902. 2003
    ..Although routine follow-up to detect asymptomatic recurrence after surgery for gastric cancer is recommended, the effect of such reassessment on survival has not been evaluated...
  52. ncbi request reprint Usefulness of analytical CEA doubling time and half-life time for overlooked synchronous metastases in colorectal carcinoma
    Katsuki Ito
    Department of Surgery II, School of Medicine, Nagoya University, Nagoya, Japan
    Jpn J Clin Oncol 32:54-8. 2002
    ..The validity however, is still controversial. We investigated serial changes in CEA values to calculate whether the CEA doubling time and half-life time could predict metastatic progression or prognosis in colorectal carcinoma...
  53. ncbi request reprint Frequent promoter methylation and gene silencing of CDH13 in pancreatic cancer
    Mitsuru Sakai
    Department of Surgery II, Nagoya University School of Medicine, Showa Ku, Nagoya 466 8560, Japan
    Cancer Sci 95:588-91. 2004
    ..Our results suggest that the aberrant methylation of CDH13 occurs frequently in pancreatic cancer, even at a relatively early stage...
  54. ncbi request reprint Frequent CDH3 demethylation in advanced gastric carcinoma
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:3945-7. 2009
    ..We recently found that CDH3 was frequently demethylated in advanced colorectal carcinomas. This prompted us to examine the demethylation status of the CDH3 gene in gastric carcinomas...
  55. ncbi request reprint Aberrant methylation of the CHFR gene is frequently detected in non-invasive colorectal cancer
    Yuki Morioka
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8560, Japan
    Anticancer Res 26:4267-70. 2006
    ..In order to define the role of CHFR in the tumorigenic pathway of the colorectum, the methylation of CHFR was examined in tumors from colorectal cancer patients...
  56. ncbi request reprint Molecular detection of p16 promoter methylation in the serum of recurrent colorectal cancer patients
    Hiroshi Nakayama
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Int J Cancer 105:491-3. 2003
    ..These results suggested that MSP might be a sensitive and useful method to detect recurrent colorectal cancer in serum...
  57. ncbi request reprint PAI-1 expression levels in gastric cancers are closely correlated to those in corresponding normal tissues
    Takumi Sakakibara
    Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tusrumai cho, Showa Ku, Nagoya 466 8560, Japan
    Hepatogastroenterology 55:1480-3. 2008
    ..To investigate the mechanism of PAI-1 overexpression in gastric cancers, the PAI-1 expression levels in gastric cancers were compared to those in the corresponding normal tissues...
  58. ncbi request reprint Laparoscopy-assisted distal gastrectomy with systemic lymph node dissection for early gastric carcinoma: a review of 43 cases
    Michitaka Fujiwara
    Department of Surgery II, Nagoya University School of Medicine, Nagoya Aichi, Japan
    J Am Coll Surg 196:75-81. 2003
    ..But the use of this approach in gastric carcinoma has received little attention, possibly from the low incidence of early-stage disease in the West and the relative complexity of the surgical procedure...
  59. ncbi request reprint P16 methylation in serum as a potential marker for the malignancy of colorectal carcinoma
    Goro Nakayama
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Anticancer Res 27:3367-70. 2007
    ....
  60. ncbi request reprint PTCH gene expression as a potential marker for esophageal squamous cell carcinoma
    Akiharu Ishiyama
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Anticancer Res 26:195-8. 2006
    ..The PTCH expression level in esophageal squamous cell carcinoma (SCC) was examined...
  61. ncbi request reprint A highly sensitive method for the detection of p16 methylation in the serum of colorectal cancer patients
    Goro Nakayama
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8560, Japan
    Anticancer Res 27:1459-63. 2007
    ..An attempt to increase the sensitivity of this assay is reported for colorectal cancer...
  62. ncbi request reprint [Colorectal cancers with both p16 and p14 methylation showing invasive characteristics]
    Kenji Hibi
    Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine
    Nihon Rinsho 61:225-8. 2003
  63. ncbi request reprint WNT5A gene is aberrantly methylated from the early stages of colorectal cancers
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Hepatogastroenterology 56:1007-9. 2009
    ..Recently, it has been reported that WNT5A methylation was frequently detected in colorectal cancers. However, the relationship between the WNT5A methylation and the characteristics of these cancers remains unknown...
  64. ncbi request reprint Telomerase activity as prognostic factor in gastrointestinal stromal tumors of the stomach
    Jun Kawai
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya University Hospital, Nagoya, Japan
    Hepatogastroenterology 52:959-64. 2005
    ..Telomerase activity, often detected in malignant tumors, may have a role as a marker for high-grade malignancy...
  65. ncbi request reprint Laparoscopy-assisted distal gastrectomy with systemic lymph node dissection: a critical reappraisal from the viewpoint of lymph node retrieval
    Shinichi Miura
    Department of Surgery II, Nagoya University School of Medicine, Nagoya Aichi, Japan
    J Am Coll Surg 198:933-8. 2004
    ..Laparoscopy-assisted surgery has proved useful in the treatment of early gastric cancer, but its use in advanced cancer may be hindered by limitations in lymphadenectomy...
  66. ncbi request reprint Aberrant upregulation of a novel integrin alpha subunit gene at 3p21.3 in small cell lung cancer
    K Hibi
    Laboratory of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Oncogene 9:611-9. 1994
    ....
  67. ncbi request reprint Detection of mitochondrial DNA alterations in the serum of hepatocellular carcinoma patients
    Osamu Okochi
    Second Department of Surgery, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    Clin Cancer Res 8:2875-8. 2002
    ..These mutations could possibly be detected in serum because mtDNA has a higher copy number than nuclear DNA. Thus, we examined genetic alterations in the D-loop region of mtDNA in hepatocellular carcinoma (HCC) patients...
  68. ncbi request reprint PGP9.5 methylation as a marker for metastatic colorectal cancer
    Hiroki Mizukami
    Department of Surgery, Showa University Fujigaoka Hospital, Yokohama 227 8501, Japan
    Anticancer Res 28:2697-700. 2008
    ..5 expression is related to tumor progression and may be useful as a marker for invasive colorectal cancer. These results prompted us to examine the methylation status of the PGP9.5 gene in colorectal cancer...
  69. ncbi request reprint PGP9.5 was less frequently methylated in advanced gastric carcinoma
    Hirohi Mizukami
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama 227 8501, Japan
    Hepatogastroenterology 56:1576-9. 2009
    ..029), suggesting that PGP9.5 was less frequently methylated in metastatic colorectal cancer. This result prompted us to examine the methylation status of the PGP9.5 gene in gastric cancers...
  70. ncbi request reprint Aberrant methylation of the p16 gene is frequently detected in advanced colorectal cancer
    Tetsuhiro Goto
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:275-7. 2009
    ....
  71. ncbi request reprint CD133 gene overexpression is frequently observed in early colorectal carcinoma
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Hepatogastroenterology 56:995-7. 2009
    ..The present study examined the CD133 gene expression in colorectal carcinomas we surgically removed...
  72. ncbi request reprint Gene expression profile of 5-fluorouracil metabolic enzymes in primary colorectal cancer: potential as predictive parameters for response to fluorouracil-based chemotherapy
    Mizunobu Kinoshita
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65, Tsurumai cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Anticancer Res 27:851-6. 2007
    ..Therapy guided by chemotherapy sensitivity and resistance assays may lead to rational treatment decisions...
  73. ncbi request reprint Highly-methylated colorectal cancers show poorly-differentiated phenotype
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 26:4263-6. 2006
    ..0041) was observed when the number of methylated genes of poorly-differentiated colorectal cancers was compared to that of other differentiated ones. Poorly-differentiated colorectal cancers preferentially exhibited gene methylation...
  74. ncbi request reprint PGP9.5 overexpression in esophageal squamous cell carcinoma
    Tsunenobu Takase
    Second Department of Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Hepatogastroenterology 50:1278-80. 2003
    ..To better characterize its role in digestive tract cancers, we examined PGP9.5 expression retrospectively in esophageal cancers...
  75. ncbi request reprint TNF-alpha promotes progression of peritoneal metastasis as demonstrated using a green fluorescence protein (GFP)-tagged human gastric cancer cell line
    Yoshinari Mochizuki
    Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    Clin Exp Metastasis 21:39-47. 2004
    ....
  76. ncbi request reprint [Molecular detection of tumor DNA in the serum of colorectal cancer patients]
    Kenji Hibi
    Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine
    Nihon Rinsho 61:197-200. 2003
  77. ncbi request reprint Vimentin methylation as a marker for advanced colorectal carcinoma
    Atsushi Shirahata
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:279-81. 2009
    ..Moreover, Vimentin methylation can be applied for the screening or as a diagnostic tool of colorectal carcinomas in the fecal DNA test...
  78. ncbi request reprint Possible involvement of the interleukin-15 and interleukin-15 receptor system in a heightened state of lamina propria B cell activation and differentiation in patients with inflammatory bowel disease
    Tsuyoshi Nishiwaki
    Department of Therapeutic Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    J Gastroenterol 40:128-36. 2005
    ..We investigated the possible roles of the interleukin (IL)-15 and IL-15 receptor (IL-15R) system in a heightened state of B-cell activation and differentiation in intestinal mucosa with inflammatory bowel disease (IBD)...
  79. ncbi request reprint [Genetic changes in colorectal cancer]
    Kenji Hibi
    Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine
    Nihon Rinsho 61:77-80. 2003
  80. ncbi request reprint Molecular detection of p16 promoter methylation in the serum of colorectal cancer patients
    Hiroshi Nakayama
    Second Department of Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, 466 8550, Nagoya, Japan
    Cancer Lett 188:115-9. 2002
    ..Moreover, abnormal methylation was found in the serum of patients in all clinical stages, suggesting that early colorectal cancer could be detected using the MSP method...
  81. ncbi request reprint DeltaNp63 induces beta-catenin nuclear accumulation and signaling
    Meera Patturajan
    Department of Otolaryngology Head and Neck Surgery, John Hopkins School of Medicine, Baltimore, MD 21205, USA
    Cancer Cell 1:369-79. 2002
    ..Our results suggest that DeltaNp63 isotypes act as positive regulators of the beta-catenin signaling pathway, providing a basis for their oncogenic properties...
  82. ncbi request reprint Aberrant methylation of the HACE1 gene is frequently detected in advanced colorectal cancer
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 28:1581-4. 2008
    ..It has been recently reported that HACE1, the E3 ubiquitin ligase, is epigenetically inactivated in human Wilms' tumors and HACE1 expression was also down-regulated in colon carcinomas...
  83. ncbi request reprint Possible involvement of neutrophil elastase in impaired mucosal repair in patients with ulcerative colitis
    Yuji Kuno
    First Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Gastroenterol 37:22-32. 2002
    ..We investigated their possible roles in epithelial cell restitution and proliferation in patients with IBD...
  84. ncbi request reprint Detection of K-ras mutations in the plasma DNA of pancreatic cancer patients
    Takanori Uemura
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Gastroenterol 39:56-60. 2004
    ..To diagnose pancreatic cancer correctly at an early stage, we attempted to detect tumor DNA in the plasma of pancreatic cancer patients using a more sensitive and specific method...
  85. ncbi request reprint Immunomodulatory therapy for inflammatory bowel disease
    Kazuo Kusugami
    Department of Therapeutic Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    J Gastroenterol 39:1129-37. 2004
    ..This will help provide each patient with optimized and individualized therapy, thereby increasing therapeutic efficacy and reducing possible side effects...
  86. ncbi request reprint Laparoscopic distal gastrectomy for severe corrosive gastritis: report of a case
    Yasuaki Kanyama
    Second Department of Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Surg Today 33:937-9. 2003
    ..The patient had an uneventful postoperative course and was discharged on the 13th day after her operation. She was subsequently able to tolerate a normal diet, gained weight, and is now emotionally stable...
  87. ncbi request reprint A new method of thermo-chemotherapy using a stent for patients with esophageal cancer
    Seiji Akiyama
    Department of Surgery, Ichinomiya Municipal Hospital, 2 2 22 Bunkyo, Ichinomiya, Aichi 491 8558, Japan
    Surg Today 36:19-24. 2006
    ..To our knowledge, there are no other reports of thermotherapy using metallic stents. We report our clinical results of treating patients with this new technique...
  88. ncbi request reprint Laparoscopy-assisted total gastrectomy for a case of MALT lymphoma: a case report
    Michitaka Fujiwara
    Department of Surgery II, Nagoya University, Nagoya, Japan
    Hepatogastroenterology 53:648-50. 2006
    ..Laparoscopic operation could be a useful option in the second-line treatment for MALT lymphoma after failure to eradicate H. pylori...
  89. ncbi request reprint Detection of tumor DNA in serum of colorectal cancer patients
    Seiji Ito
    Second Department of Surgery, Nagoya University School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Jpn J Cancer Res 93:1266-9. 2002
    ..K-ras mutation was found even in serum DNA of patients with Dukes A cancer, suggesting that colorectal cancer might be detected even in patients without symptoms by using this ligation assay...