Takuji Nakashima

Summary

Country: Japan

Publications

  1. ncbi request reprint Producing mechanism of an algicidal compound against red tide phytoplankton in a marine bacterium gamma-proteobacterium
    Takuji Nakashima
    Division of Biochemistry, Faculty of Fisheries, Nagasaki University, Nagasaki 852 8521, Japan
    Appl Microbiol Biotechnol 73:684-90. 2006
  2. ncbi request reprint A novel method using micropig stratum corneum in vitro for the evaluation of anti-Trichophyton mentagrophytes activity
    Takuji Nakashima
    Pharmaceutical R and D Laboratories, POLA Chemical Industries, Inc, Yokohama, Kanagawa, Japan
    Microbiol Immunol 46:521-5. 2002
  3. ncbi request reprint Experimental tinea unguium model to assess topical antifungal agents using the infected human nail with dermatophyte in vitro
    Takuji Nakashima
    Pharmaceutical R and D Laboratories, POLA Chemical Industries, Inc, 560 Kashio cho, Totsuka ku, Yokohama 244 0812, Japan
    J Infect Chemother 8:331-5. 2002
  4. ncbi request reprint Inhibitory or scavenging action of ketoconazole and ciclopiroxolamine against reactive oxygen species released by primed inflammatory cells
    T Nakashima
    NITE Biological Research Center NBRC, National Institute of Technology and Evaluation, Chiba, Japan
    Br J Dermatol 156:720-7. 2007
  5. ncbi request reprint Characterization of bacterium isolated from the sediment at coastal area of Omura Bay in Japan and several biological activities of pigment produced by this isolate
    Takuji Nakashima
    Division of Biochemistry, Faculty of Fisheries, Nagasaki University, Japan
    Microbiol Immunol 49:407-15. 2005
  6. ncbi request reprint Evaluation of the anti-Trichophyton activity of a prodigiosin analogue produced by gamma-proteobacterium, using stratum corneum epidermis of the Yucatan micropig
    Takuji Nakashima
    Division of Biochemistry, Faculty of Fisheries, Nagasaki University, Nagasaki, Japan
    J Infect Chemother 11:123-8. 2005
  7. ncbi request reprint Apoptosis-mediated cytotoxicity of prodigiosin-like red pigment produced by gamma-Proteobacterium and its multiple bioactivities
    Takuji Nakashima
    Division of Biochemistry, Faculty of Fisheries, Nagasaki University, Japan
    Biol Pharm Bull 28:2289-95. 2005
  8. ncbi request reprint Production of bioactive compounds based on phylogeny in the genus Penicillium preserved at NBRC
    Takuji Nakashima
    NITE Biotechnology Development Center NBDC, National Institute of Technology and Evaluation NITE, Chiba, Japan
    Biosci Biotechnol Biochem 72:3051-4. 2008
  9. ncbi request reprint Comparison of the activities of various alginates to induce TNF-alpha secretion in RAW264.7 cells
    Maki Kurachi
    Division of Biochemistry, Faculty of Fisheries, Nagasaki University, Japan
    J Infect Chemother 11:199-203. 2005
  10. ncbi request reprint Production of reactive oxygen species (ROS) by devil stinger (Inimicus japonicus) during embryogenesis
    Kazushi Kadomura
    Nagasaki Prefectural Institute of Fisheries, Nagasaki, Japan
    Fish Shellfish Immunol 21:209-14. 2006

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Producing mechanism of an algicidal compound against red tide phytoplankton in a marine bacterium gamma-proteobacterium
    Takuji Nakashima
    Division of Biochemistry, Faculty of Fisheries, Nagasaki University, Nagasaki 852 8521, Japan
    Appl Microbiol Biotechnol 73:684-90. 2006
    ..This bacterium and other algicidal bacteria might be concerned in regulating the blooms of harmful flagellate algae through the quorum sensing system...
  2. ncbi request reprint A novel method using micropig stratum corneum in vitro for the evaluation of anti-Trichophyton mentagrophytes activity
    Takuji Nakashima
    Pharmaceutical R and D Laboratories, POLA Chemical Industries, Inc, Yokohama, Kanagawa, Japan
    Microbiol Immunol 46:521-5. 2002
    ..95 for BFZ, 1.42 for LCZ and 8.87 for TBF. This novel method of antidermatophytic susceptibility testing using SCE would be useful as an in vitro screening of proper antimycotics for topical treatment of dermatophytosis...
  3. ncbi request reprint Experimental tinea unguium model to assess topical antifungal agents using the infected human nail with dermatophyte in vitro
    Takuji Nakashima
    Pharmaceutical R and D Laboratories, POLA Chemical Industries, Inc, 560 Kashio cho, Totsuka ku, Yokohama 244 0812, Japan
    J Infect Chemother 8:331-5. 2002
    ..This model enables one to evaluate the activity of a topical antifungal agent that has penetrated human nail tissue, and it may facilitate research on a topical agent for onychomycosis...
  4. ncbi request reprint Inhibitory or scavenging action of ketoconazole and ciclopiroxolamine against reactive oxygen species released by primed inflammatory cells
    T Nakashima
    NITE Biological Research Center NBRC, National Institute of Technology and Evaluation, Chiba, Japan
    Br J Dermatol 156:720-7. 2007
    ..Reactive oxygen species (ROS) released from inflammatory cells constitute one of the critical causative factors in inflammatory skin diseases such as seborrhoeic dermatitis and atopic dermatitis...
  5. ncbi request reprint Characterization of bacterium isolated from the sediment at coastal area of Omura Bay in Japan and several biological activities of pigment produced by this isolate
    Takuji Nakashima
    Division of Biochemistry, Faculty of Fisheries, Nagasaki University, Japan
    Microbiol Immunol 49:407-15. 2005
    ..aureus, which colonized skin on atopic dermatitis as well as suppression of activated lymphocyte proliferation and superoxide generation from leucocytes...
  6. ncbi request reprint Evaluation of the anti-Trichophyton activity of a prodigiosin analogue produced by gamma-proteobacterium, using stratum corneum epidermis of the Yucatan micropig
    Takuji Nakashima
    Division of Biochemistry, Faculty of Fisheries, Nagasaki University, Nagasaki, Japan
    J Infect Chemother 11:123-8. 2005
    ..In spite of the lower efficiency of PG-L-1 transfer into SCE from medium than that of bifonazole, PG-L-1 transferred into SCE showed more potent antifungal activity than bifonazole, at lower concentrations...
  7. ncbi request reprint Apoptosis-mediated cytotoxicity of prodigiosin-like red pigment produced by gamma-Proteobacterium and its multiple bioactivities
    Takuji Nakashima
    Division of Biochemistry, Faculty of Fisheries, Nagasaki University, Japan
    Biol Pharm Bull 28:2289-95. 2005
    ....
  8. ncbi request reprint Production of bioactive compounds based on phylogeny in the genus Penicillium preserved at NBRC
    Takuji Nakashima
    NITE Biotechnology Development Center NBDC, National Institute of Technology and Evaluation NITE, Chiba, Japan
    Biosci Biotechnol Biochem 72:3051-4. 2008
    ..The strains in two clusters, of which P. chrysogenum and P. citrinum are representative, showed higher rates of positive strains with multi-biological activities...
  9. ncbi request reprint Comparison of the activities of various alginates to induce TNF-alpha secretion in RAW264.7 cells
    Maki Kurachi
    Division of Biochemistry, Faculty of Fisheries, Nagasaki University, Japan
    J Infect Chemother 11:199-203. 2005
    ..These results suggest that the underlying mechanism of the TNF-alpha-inducing activity of enzymatically depolymerized alginate oligomers is not necessarily the same as that of original alginate polymer...
  10. ncbi request reprint Production of reactive oxygen species (ROS) by devil stinger (Inimicus japonicus) during embryogenesis
    Kazushi Kadomura
    Nagasaki Prefectural Institute of Fisheries, Nagasaki, Japan
    Fish Shellfish Immunol 21:209-14. 2006
    ..Our results suggest that devil stinger has ROS generation system that is already activated at fairly early stage of development before the maturation of usual immune system...
  11. ncbi request reprint Development of a new medium useful for the recovery of dermatophytes from clinical specimens by minimizing the carryover effect of antifungal agents
    Takuji Nakashima
    Pharmaceutical R and D Laboratories, POLA Chemical Industries, Inc, Yokohama, Kanagawa, Japan
    Microbiol Immunol 46:83-8. 2002
    ....
  12. doi request reprint Taxonomic distribution of Streptomyces species capable of producing bioactive compounds among strains preserved at NITE/NBRC
    Kozue Anzai
    NITE Biological Research Center NBRC, National Institute of Technology and Evaluation NITE, 2 5 8, Kazusakamatari, Kisarazu shi, Chiba, 292 0818, Japan
    Appl Microbiol Biotechnol 80:287-95. 2008
    ..Further information on the relationship between the microbial taxonomy and the bioactive compounds produced would be useful for the utilization of industrial microorganisms...
  13. doi request reprint Actinomycete bacteria isolated from the sediments at coastal and offshore area of Nagasaki Prefecture, Japan: diversity and biological activity
    Kozue Anzai
    NITE Biotechnology Development Center, National Institute of Technology and Evaluation, Kisarazu shi, Chiba, Japan
    J Biosci Bioeng 106:215-7. 2008
    ..The isolates were compared with taxa and biological activities of their secondary metabolites. It is suggested that a variety of actinomycetes are isolated from different marine environments...
  14. ncbi request reprint Isolation and characterization of light-dependent hemolytic cytotoxin from harmful red tide phytoplankton Chattonella marina
    Aiko Kuroda
    Division of Biochemistry, Faculty of Fisheries, Nagasaki University, Bunkyo Machi, Nagasaki 852 8521, Japan
    Comp Biochem Physiol C Toxicol Pharmacol 141:297-305. 2005
    ....
  15. ncbi request reprint Purification and characterization of photosensitizing hemolytic toxin from harmful red tide phytoplankton, Heterocapsa circularisquama
    Yousuke Miyazaki
    Division of Biochemistry, Faculty of Fisheries, Nagasaki University, 1 14 Bunkyo machi, Nagasaki, Nagasaki 852 8521, Japan
    Aquat Toxicol 73:382-93. 2005
    ..Since H2-a showed potent photosensitizing cytotoxicity toward HeLa cells in a concentration-dependent manner as well as hemolytic activity, H2-a may be a novel porphyrin derivative with photosensitizing hemolytic cytotoxicity...
  16. ncbi request reprint Structure-activity relationship of alginate oligosaccharides in the induction of cytokine production from RAW264.7 cells
    Mami Iwamoto
    Division of Biochemistry, Faculty of Fisheries, Nagasaki University, Nagasaki 852 8521, Japan
    FEBS Lett 579:4423-9. 2005
    ....
  17. ncbi request reprint Comparison of groupings among members of the genus Aspergillus based on phylogeny and production of bioactive compounds
    Kozue Anzai
    NITE Biotechnology Development Center, Department of Biotechnology, National Institute of Technology and Evaluation, Chiba, Japan
    Biosci Biotechnol Biochem 72:2199-202. 2008
    ..8S rRNA and biological activities of their secondary metabolites. The results showed relatively well correlation between the phylogenetic distribution and the production of bioactive compounds, especially, antimicrobial activities...
  18. ncbi request reprint Cytotoxicity of a GalNAc-specific C-type lectin CEL-I toward various cell lines
    Takuya Kuramoto
    Division of Biochemistry, Faculty of Fisheries, and Department of Applied Chemistry, Faculty of Engineering, Nagasaki University, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Biochem 137:41-50. 2005
    ..Our results demonstrated that CEL-I showed a potent cytotoxic effect, especially on MDCK cells, by causing plasma membrane disorder without induction of apoptosis...
  19. doi request reprint Cytotoxic action mode of a novel porphyrin derivative isolated from harmful red tide dinoflagellate Heterocapsa circularisquama
    Daekyung Kim
    College of Ocean Science, School of Applied Marine Science Post BK 21, Cheju National University, 66 Jejudaehakno, Jeju Si, Jeju Special Self Governing Province 690 756, Korea
    J Biochem Mol Toxicol 22:158-65. 2008
    ..The relatively high affinity of H2-a to the plasma membrane might result in the potent and quick cytotoxicity without induction of apoptotic signal transduction...
  20. doi request reprint Ciclopirox olamine directly scavenges hydroxyl radical
    Emiko Sato
    New Industry Creation Hatchery Center, Tohoku University, 6 6 10 Aoba, Aramaki, Aoba ku, Sendai 980 8579, Japan
    Int J Dermatol 47:15-8. 2008
  21. ncbi request reprint A novel indole-diterpenoid, JBIR-03 with anti-MRSA activity from Dichotomomyces cejpii var. cejpii NBRC 103559
    Masahiro Ogata
    Department of Microbiology, Faculty of Pharmaceutical Sciences, Aomori University, Japan
    J Antibiot (Tokyo) 60:645-8. 2007
    ..1 exhibited anti-MRSA (methicillin-resistant Staphylococcus aureus) activity and antifungal activity against apple Valsa canker-causing fungus, Valsa ceratosperma, while it exhibited no toxicity towards human cancer cells...
  22. ncbi request reprint Some dinophycean red tide plankton species generate a superoxide scavenging substance
    Emiko Sato
    New Industry Creation Hatchery Center, Tohoku University, Sendai, Miyagi, Japan
    Biosci Biotechnol Biochem 71:704-10. 2007
    ..This is the first report on the production of a superoxide-scavenger by dinophycean red tide flagellates...
  23. ncbi request reprint A novel nuclear export inhibitor JBIR-02, a new piericidin discovered from Streptomyces sp. ML55
    Jun ya Ueda
    Japan Biological Information Research Center JBIRC, Japan Biological Informatics Consortium JBIC, Tokyo, Japan
    J Antibiot (Tokyo) 60:459-62. 2007
    ..The structure was determined on the basis of spectroscopic data. JBIR-02 inhibited nuclear export of beta-arrestin in HeLa cells at the concentration of 20 microM...
  24. ncbi request reprint A prodigiosin analogue inactivates NADPH oxidase in macrophage cells by inhibiting assembly of p47phox and Rac
    Takuji Nakashima
    NITE Biological Resource Center NBRC, National Institute of Technology and Evaluation NITE, Japan
    J Biochem 143:107-15. 2008
    ..7 cells. These results suggest that PG-L-1 inactivates NADPH oxidase through the inhibition of the binding of p47(phox) and Rac to the membrane components of NADPH oxidase...