Hiroyasu Satoh

Summary

Affiliation: Nara Medical University
Country: Japan

Publications

  1. pmc Vascular pharmacology of mokuboito (mu-fang-yi-tang) and its constituents on the smooth muscle and the endothelium in rat aorta
    Seiichiro Nishida
    Department of Pharmacology, Division of Crude and Herbal Medicine, Nara Medical University Kashihara, Nara 634 8521, Japan
    Evid Based Complement Alternat Med 4:335-41. 2007
  2. pmc Cardiovascular pharmacology of sinomenine: the mechanical and electropharmacological actions
    Seiichiro Nishida
    Department of Pharmacology, Division of Traditional Medicine, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Drug Target Insights 2:97-104. 2007
  3. ncbi Effects of ginkgo biloba extract and bilobalide, a main constituent, on the ionic currents in guinea pig ventricular cardiomyocytes
    Hiroyasu Satoh
    Department of Pharmacology, Division of Molecular and Cellular Biology, Nara Medical University, Kashihara, Nara, Japan
    Arzneimittelforschung 53:407-13. 2003
  4. ncbi Suppression of pacemaker activity by Ginkgo biloba extract and its main constituent, bilobalide in rat sino-atrial nodal cells
    Hiroyasu Satoh
    Department of Pharmacology, Division of Molecular and Cellular Biology, Nara Medical University, School of Medicine, Kashihara, Nara 634 8521, Japan
    Life Sci 78:67-73. 2005
  5. ncbi Sino-atrial nodal cells of mammalian hearts: ionic currents and gene expression of pacemaker ionic channels
    Hiroyasu Satoh
    Department of Pharmacology, Division of Molecular and Cellular Biology, Nara Medical University, Kashihara, Nara 634 8521, Japan
    J Smooth Muscle Res 39:175-93. 2003
  6. ncbi Electropharmacological actions of Ginkgo biloba extract on vascular smooth and heart muscles
    Hiroyasu Satoh
    Department of Pharmacology, Division of Crude and Herbal Medicine, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Clin Chim Acta 342:13-22. 2004
  7. doi Acute effects of acupuncture treatment with Baihui (GV20) on human arterial stiffness and wave reflection
    Hiroyasu Satoh
    Department of Pharmacology, Division of Traditional Herbal Medicine, Nara Medical University, Kashihara, Nara, Japan
    J Acupunct Meridian Stud 2:130-4. 2009
  8. ncbi Electropharmacological actions of the constituents of Sinomeni Caulis et Rhizome and Mokuboi-to in guinea pig heart
    Hiroyasu Satoh
    Department of Pharmacology, Division of Oriental Medicine, Nara Medical University, School of Medicine, Kashihara, Nara 634 8521, Japan
    Am J Chin Med 33:967-79. 2005
  9. ncbi Modulation by taurine of human arterial stiffness and wave reflection
    Hiroyasu Satoh
    Department of Pharmacology, Nara Medical University, Nara, and Hyogo NCC College, Hyogo, Japan
    Adv Exp Med Biol 643:47-55. 2009
  10. ncbi Elecropharmacology of taurine on the hyperpolarization-activated inward current and the sustained inward current in spontaneously beating rat sino-atrial nodal cells
    Hiroyasu Satoh
    Department of Pharmacology, Division of Molecular and Cellular Biology, Nara Medical University, Japan
    J Pharmacol Sci 91:229-38. 2003

Collaborators

Detail Information

Publications42

  1. pmc Vascular pharmacology of mokuboito (mu-fang-yi-tang) and its constituents on the smooth muscle and the endothelium in rat aorta
    Seiichiro Nishida
    Department of Pharmacology, Division of Crude and Herbal Medicine, Nara Medical University Kashihara, Nara 634 8521, Japan
    Evid Based Complement Alternat Med 4:335-41. 2007
    ..Simultaneously, Mokuboito and S. acutum cause the vasoconstrictions mediated through alpha-adrenoceptor stimulation, but not sinomenine. Also, Mokuboito and sinomenine possess beta-adrenoreceptor stimulating action, but not S. acutum...
  2. pmc Cardiovascular pharmacology of sinomenine: the mechanical and electropharmacological actions
    Seiichiro Nishida
    Department of Pharmacology, Division of Traditional Medicine, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Drug Target Insights 2:97-104. 2007
    ..Therefore, sinomenine may be expected as one of effective therapeutic drugs for heart failure and dysrhythmias, and may maintain the cardiovascular functions due to modulation of cardiac ionic channels and blood vessels...
  3. ncbi Effects of ginkgo biloba extract and bilobalide, a main constituent, on the ionic currents in guinea pig ventricular cardiomyocytes
    Hiroyasu Satoh
    Department of Pharmacology, Division of Molecular and Cellular Biology, Nara Medical University, Kashihara, Nara, Japan
    Arzneimittelforschung 53:407-13. 2003
    ..Although each chemical exhibited the responses in opposite directions, GBE acts totally as a mixture...
  4. ncbi Suppression of pacemaker activity by Ginkgo biloba extract and its main constituent, bilobalide in rat sino-atrial nodal cells
    Hiroyasu Satoh
    Department of Pharmacology, Division of Molecular and Cellular Biology, Nara Medical University, School of Medicine, Kashihara, Nara 634 8521, Japan
    Life Sci 78:67-73. 2005
    ..05) at 0.3 microM bilobalide. These results indicate that cardiac ionic channels contributing to the pacemaking are highly sensitive to GBE and bilobalide, which can sufficiently modify the spontaneous activity in rat SA nodal cells...
  5. ncbi Sino-atrial nodal cells of mammalian hearts: ionic currents and gene expression of pacemaker ionic channels
    Hiroyasu Satoh
    Department of Pharmacology, Division of Molecular and Cellular Biology, Nara Medical University, Kashihara, Nara 634 8521, Japan
    J Smooth Muscle Res 39:175-93. 2003
    ....
  6. ncbi Electropharmacological actions of Ginkgo biloba extract on vascular smooth and heart muscles
    Hiroyasu Satoh
    Department of Pharmacology, Division of Crude and Herbal Medicine, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Clin Chim Acta 342:13-22. 2004
    ....
  7. doi Acute effects of acupuncture treatment with Baihui (GV20) on human arterial stiffness and wave reflection
    Hiroyasu Satoh
    Department of Pharmacology, Division of Traditional Herbal Medicine, Nara Medical University, Kashihara, Nara, Japan
    J Acupunct Meridian Stud 2:130-4. 2009
    ..Treatment by manual acupuncture needling affects the vascular wall tone, and hemodynamic parameters for arterial stiffness may be characterized by treatment at the traditional acupuncture point (acupoint) of Baihui (GV20)...
  8. ncbi Electropharmacological actions of the constituents of Sinomeni Caulis et Rhizome and Mokuboi-to in guinea pig heart
    Hiroyasu Satoh
    Department of Pharmacology, Division of Oriental Medicine, Nara Medical University, School of Medicine, Kashihara, Nara 634 8521, Japan
    Am J Chin Med 33:967-79. 2005
    ..Dysrhythmias were abolished under Ca(2+) overload conditions by sinomenine. These results indicate that at even acute administrations, these drugs exert the active electropharmacological actions and cardioprotections...
  9. ncbi Modulation by taurine of human arterial stiffness and wave reflection
    Hiroyasu Satoh
    Department of Pharmacology, Nara Medical University, Nara, and Hyogo NCC College, Hyogo, Japan
    Adv Exp Med Biol 643:47-55. 2009
    ..Based our previous experiments, therefore, taurine plays a role in the regulation of the cardiac and vascular function...
  10. ncbi Elecropharmacology of taurine on the hyperpolarization-activated inward current and the sustained inward current in spontaneously beating rat sino-atrial nodal cells
    Hiroyasu Satoh
    Department of Pharmacology, Division of Molecular and Cellular Biology, Nara Medical University, Japan
    J Pharmacol Sci 91:229-38. 2003
    ....
  11. ncbi Pharmacological actions of monovalent ionophores on spontaneously beating rabbit sino-atrial nodal cells
    H Satoh
    Department of Pharmacology, Nara Medical University, Kashihara, Japan
    Gen Pharmacol 33:151-9. 1999
    ..These results indicate that the monovalent ionophores depress the action potentials and produce a negative chronotropic effect due to direct and indirect modulations of the ionic currents and the [Ca2+]i level in rabbit SA nodal cells...
  12. ncbi Possible involvement of [Ca2+]i level in the modulation of the current-voltage relationship for the fast Na+ current in late embryonic chick cardiomyocytes
    H Satoh
    Department of Pharmacology, Nara Medical University, Kashihara, Japan
    Gen Pharmacol 32:335-9. 1999
    ....
  13. ncbi Comparative actions of cibenzoline and disopyramide on I(Kr) and I(Ks) currents in rat sino-atrial nodal cells
    H Satoh
    Department of Pharmacology, Division of Molecular and Cellular Biology, Nara Medical University, Nara 634 8521, Kashihara, Japan
    Eur J Pharmacol 407:123-9. 2000
    ..These results indicate that the ionic currents are more sensitive to cibenzoline than disopyramide in rat sino-atrial nodal cells, and that I(Ca) and I(Kr) make major contributions to pacemaking activity...
  14. ncbi [Ca2+]i-dependent actions of taurine in spontaneously beating rabbit sino-atrial nodal cells
    H Satoh
    Department of Pharmacology, Division of Molecular and Cellular Biology, Nara Medical University, Nara 634 8521, Kashihara, Japan
    Eur J Pharmacol 424:19-25. 2001
    ..However, taurine would possibly elicit a cellular Ca2+ overload, when taurine application was discontinued...
  15. pmc Taurine modulates I(Kr) but I(Ks) in guinea-pig ventricular cardiomyocytes
    H Satoh
    Department of Pharmacology, Nara Medical University, Kashihara, Japan
    Br J Pharmacol 126:87-92. 1999
    ..5. These results indicate that taurine modulates I(Kr) but not I(Ks), depending on [Ca2+]i, resulting in regulation of the APD...
  16. ncbi Inhibition by taurine of the inwardly rectifying K+ current in guinea pig ventricular cardiomyocytes
    H Satoh
    Department of Pharmacology, Nara Medical University, Kashihara, Japan
    Eur J Pharmacol 346:309-13. 1998
    ..001) at 20 mM. These responses were almost reversible. These results suggest that taurine directly modulates the open probability of the inwardly rectifying K+ current, resulting in regulation of the functions of heart cells...
  17. ncbi Modulation by nicotine of the ionic currents in guinea pig ventricular cardiomyocytes. Relatively higher sensitivity to IKr and IKl
    Hiroyasu Satoh
    Department of Pharmacology, Division of Molecular and Cellular Biology, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Vascul Pharmacol 39:55-61. 2002
    ..These results suggest that nicotine inhibits the ionic currents with relatively higher sensitivity to IKl and IKr, resulting in modulation of the cardiac functions...
  18. ncbi Modulations by taurine of the spontaneous action potentials in right atrial muscles of rats
    H Satoh
    Department of Pharmacology, Nara Medical University, Kashihara, Japan
    Gen Pharmacol 30:209-12. 1998
    ..4 mM [Ca]o, taurine (20 mM) reversed the positive to a negative chronotropic effect, presumably resulting in the development of cellular calcium overload...
  19. ncbi Cardiac electrophysiological modulation by NS-7, a novel neuroprotective drug, of guinea pig ventricular muscles
    Hiroyasu Satoh
    Department of Pharmacology, Division of Molecular and Cellular Biology, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Life Sci 72:1039-48. 2003
    ....
  20. ncbi Accumulation of elements in the arteries and cardiac valves of Thai with aging
    Yoshiaki Ohnishi
    Laboratory of Cell Biology, Department of Anatomy, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Biol Trace Elem Res 96:71-92. 2003
    ..in addition, no significant correlation was found in the calcium content between the aortic valve and coronary artery in the same individuals...
  21. ncbi Decreases of calcium and phosphorus in monkey cardiac walls with development and aging
    Setsuko Tohno
    Laboratory of Cell Biology, Department of Anatomy, Nara Medical University School of Medicine, Kashihara, Nara 634 8521, Japan
    Biol Trace Elem Res 110:233-49. 2006
    ..As Ca decreased in the cardic walls, P, Mg, and Zn decreased simultaneously in the cardiac walls. The mass ratio of Ca/P decreased gradually with Ca decrease in both the atrial and ventricular walls, but it was not constant...
  22. ncbi Age-related changes in the vasodilating actions of Ginkgo biloba extract and its main constituent, bilobalide, in rat aorta
    Seiichiro Nishida
    Department of Pharmacology, Division of Crude and Herbal Medicine, Nara Medical University, School of Medicine, Kashihara, Nara 634 8521, Japan
    Clin Chim Acta 354:141-6. 2005
    ..Age-related modulation in vasodilating actions induced by Ginkgo biloba extract (GBE) and bilobalide, a main constituent of GBE, were examined using rat aorta ring strips...
  23. ncbi Mechanisms for the vasodilations induced by Ginkgo biloba extract and its main constituent, bilobalide, in rat aorta
    Seiichiro Nishida
    Department of Pharmacology, Division of Crude and Herbal Medicine, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Life Sci 72:2659-67. 2003
    ..Bilobalide possesses the similar mechanisms for the vasodilation...
  24. doi Age-related changes of elements in the coronary arteries of monkeys in comparison with those of humans
    Yoshiyuki Tohno
    Laboratory of Cell Biology, Department of Anatomy, Nara Medical University School of Medicine, Kashihara, Nara, 634 8521, Japan
    Biol Trace Elem Res 125:141-53. 2008
    ..In contrast with monkeys, atherosclerosis occurred frequently in the coronary arteries of Japanese and Thai at old age...
  25. ncbi In vitro pharmacological actions of sinomenine on the smooth muscle and the endothelial cell activity in rat aorta
    Seiichiro Nishida
    Department of Pharmacology, Division of Crude and Herbal Medicine, Nara Medical University, School of Medicine, Kashihara, Nara 634 8521, Japan
    Life Sci 79:1203-6. 2006
    ....
  26. ncbi Prevention of the wortmannin-induced inhibition of phosphoinositide 3-kinase by sulfhydryl reducing agents
    Minoru Isosaki
    Department of Pharmacology, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Pharmacol Rep 63:733-9. 2011
    ....
  27. ncbi Different accumulation of elements in the rami of the coronary arteries of Thai
    Cho Azuma
    Laboratory of Cell Biology, Department of Anatomy, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Biol Trace Elem Res 95:211-8. 2003
    ..These results suggested that as calcium and phosphorus increased in the coronary arteries and their rami, magnesium increased simultaneously in all of the coronary arteries and their rami...
  28. ncbi Age-dependent effects induced by ouabain in rat heart muscles and cellular Ca2+ concentration
    Hiroyasu Satoh
    Department of Pharmacology, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Biol Trace Elem Res 92:151-60. 2003
    ....
  29. ncbi A special comment on trace metals in the viscera of turbo marmoratus, a toxic snail, on Ryukyu Island
    Masa oki Yamada
    Laboratory of Cell Biology, Department of Anatomy, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Biol Trace Elem Res 95:241-6. 2003
    ..This intestine maintained a considerable amount of Si (higher than Ca) which fluctuated in parallel with the taurine amount. These data suggest that the viscera of the alimentary tract accumulate some metals, especially Zn and Fe...
  30. ncbi Vascular modulation of rat aorta by taurine
    Seiichiro Nishida
    Department of Pharmacology, Nara Medical University, Nara, Japan
    Adv Exp Med Biol 643:37-46. 2009
    ..Thus, taurine modulates vascular wall tone to maintain blood flow. These results indicate that taurine plays an important homeostatic function on vascular smooth muscles as well as cardiac muscle...
  31. ncbi Comparative vasodilating actions among terpenoids and flavonoids contained in Ginkgo biloba extract
    Seiichiro Nishida
    Department of Pharmacology, Division of Crude and Herbal Medicine, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Clin Chim Acta 339:129-33. 2004
    ..Comparative vasodilating actions of the constituents of Ginkgo biloba extract (GBE), terpenoids (bilobalide, ginkgolides A, B and C) and flavonoids (quercetin and rutin), were examined using rat aorta ring strips...
  32. pmc Gender-related differences in a process of the age-dependent alterations of the elements in monkey sino-atrial node
    Hiroyasu Satoh
    Department of Pharmacology, Division of Molecular and Cellular Biology, Kashihara, Nara University 634 8521, Japan
    Korean J Physiol Pharmacol 14:249-56. 2010
    ..The different attenuations may be involved with the age- and gender-related SA nodal functions...
  33. doi Neuroprotective effects of pramipexole against tunicamycin-induced cell death in PC12 cells
    Hitoshi Nakayama
    Department of Pharmacology, Nara Medical University School of Medicine, Kashihara, Nara, Japan
    Clin Exp Pharmacol Physiol 36:1183-5. 2009
    ..5. In conclusion, we speculate that a combination of several mechanisms may be involved in PPX-induced neuroprotection...
  34. ncbi Cardiac functions and taurine's actions at different extracellular calcium concentrations in forced swimming stress-loaded rats
    Hiroyasu Satoh
    Department of Pharmacology, Nara Medical University, Kashihara, Japan
    Biol Trace Elem Res 87:171-82. 2002
    ..These results indicate that swimming stress causes a release of taurine into the serum and reduces the sensitivity to [Ca2+]o. Taurine administration might, in part, exhibit the protective actions on acute stress-induced responses...
  35. ncbi Taurine on sino-atrial nodal cells: Ca2+-dependent modulation
    Hiroyasu Satoh
    Department of Pharmacology, Nara Medical University, Kashihara, Japan
    Adv Exp Med Biol 526:17-23. 2003
  36. ncbi Subtypes of neuronal nicotinic acetylcholine receptors involved in nicotine-induced phosphorylation of extracellular signal-regulated protein kinase in PC12h cells
    Hitoshi Nakayama
    Department of Pharmacology, Nara Medical University School of Medicine, 840 Shijo Chou, Kashihara, Japan
    Neurosci Lett 392:101-4. 2006
    ..These results suggest the involvement of alpha3beta4 nAChRs in ERK phosphorylation in PC12h cells...
  37. ncbi Compositional changes of human mitral valves with aging
    Yoshiyuki Tohno
    Department of Anatomy, Nara Medical University, Kashihara, Japan
    Biol Trace Elem Res 88:203-13. 2002
    ..The present study revealed that with regard to the relationships among element contents, the compositional change of the mitral valve was intermediate between those of the thoracic aorta and the interventricular septum...
  38. pmc Possible Involvement of Ca Activated K Channels, SK Channel, in the Quercetin-Induced Vasodilatation
    Seiichiro Nishida
    Department of Pharmacology, Division of Traditional Herbal Medicine, Nara Medical University, Nara 634 8521, Japan
    Korean J Physiol Pharmacol 13:361-5. 2009
    ..Quercetin caused a concentration-dependent vasodilatation, due to the endothelium-dependent and -independent actions. Also quercetin contributes to the vasodilatation selectively with SK channel on smooth muscle...
  39. ncbi Local regulator adrenomedullin contributes to the circulatory disturbance in cirrhotic rats
    Shinya Sakurai
    Third Department of Internal Medicine, Nara Medical University, Nara 634 8522, Japan
    World J Gastroenterol 12:2095-102. 2006
    ..To investigate whether adrenomedullin, a potent vasodilator peptide, plays a role in the circulatory disturbance in cirrhosis...
  40. ncbi Age-dependent decreases of calcium, phosphorus, sulfur, and zinc in the cardiac valves of monkeys
    Federico Menetti
    Clinical Department of Radiologic and Histocytopathologic Sciences, Bologna University, Bologna 40139, Italy
    Biol Trace Elem Res 106:231-45. 2005
    ..Therefore, as Ca decreased in the four cardiac valves, P, S, and Zn decreased simultaneously in the same cardiac valves...
  41. ncbi Age-related attenuation in the elements in monkey sino-atrial node
    Hiroyasu Satoh
    Cooperation Research Program, Primate Research Institute, Kyoto University, Kyoto, Japan
    Biol Trace Elem Res 107:43-52. 2005
    ....