National Institute for Environmental Studies

Summary

Organization: National Institute for Environmental Studies
Country: Japan

Top Publications

  1. doi Dioxin-like activity in Japanese indoor dusts evaluated by means of in vitro bioassay and instrumental analysis: brominated dibenzofurans are an important contributor
    Go Suzuki
    Research Center for Material Cycles and Waste Management, National Institute for Environmental Studies, Tsukuba 305 8506, Japan
    Environ Sci Technol 44:8330-6. 2010
  2. doi Effects of pH on the water solubility and 1-octanol-water partition coefficient of 2,4,6-tribromophenol
    Hidetoshi Kuramochi
    Research Center for Material Cycles and Waste Management, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki, 305 8506, Japan
    J Environ Monit 10:206-10. 2008
  3. ncbi Effects of nanoparticles on lung physiology in the presence or absence of antigen
    K Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Int J Immunopathol Pharmacol 20:737-44. 2007
  4. ncbi Evaluation of constructed wetlands by wastewater purification ability and greenhouse gas emissions
    P Gui
    National Institute for Environmental Studies, 305 8506, Onogawa 16 2, Tsukuba, Japan
    Water Sci Technol 56:49-55. 2007
  5. ncbi Function of multiple sperm-storage organs in female damselflies (Ischnura senegalensis): difference in amount of ejaculate stored, sperm loss, and priority in fertilization
    Miri Nakahara
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Tokyo, Japan
    J Insect Physiol 53:1046-54. 2007
  6. ncbi Bacillus selenatarsenatis sp. nov., a selenate- and arsenate-reducing bacterium isolated from the effluent drain of a glass-manufacturing plant
    Shigeki Yamamura
    Water and Soil Environment Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Int J Syst Evol Microbiol 57:1060-4. 2007
  7. ncbi Dietary exposure to organophosphorus pesticides for young children in Tokyo and neighboring area
    Junko Kawahara
    National Institute for Environmental Study, Research Center for Risk Analysis, Japan
    Sci Total Environ 378:263-8. 2007
  8. ncbi Formation and durability of dithiocarbamic metals in stabilized air pollution control residue from municipal solid waste incineration and melting processes
    Hirofumi Sakanakura
    National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Environ Sci Technol 41:1717-22. 2007
  9. ncbi A murine scavenger receptor MARCO recognizes polystyrene nanoparticles
    Sanae Kanno
    Environmental Nanotoxicology Section, Research Center for Environmental Risk, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki, Japan
    Toxicol Sci 97:398-406. 2007
  10. ncbi Congener profiles of PCB and a proposed new set of indicator congeners
    Yukari Ishikawa
    National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Chemosphere 67:1838-51. 2007

Detail Information

Publications62

  1. doi Dioxin-like activity in Japanese indoor dusts evaluated by means of in vitro bioassay and instrumental analysis: brominated dibenzofurans are an important contributor
    Go Suzuki
    Research Center for Material Cycles and Waste Management, National Institute for Environmental Studies, Tsukuba 305 8506, Japan
    Environ Sci Technol 44:8330-6. 2010
    ....
  2. doi Effects of pH on the water solubility and 1-octanol-water partition coefficient of 2,4,6-tribromophenol
    Hidetoshi Kuramochi
    Research Center for Material Cycles and Waste Management, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki, 305 8506, Japan
    J Environ Monit 10:206-10. 2008
    ..The model was found to be highly useful for predicting the pH dependence within the range of pH 3 to 9...
  3. ncbi Effects of nanoparticles on lung physiology in the presence or absence of antigen
    K Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Int J Immunopathol Pharmacol 20:737-44. 2007
    ..These data suggest that carbon nanoparticles can enhance lung hyperresponsiveness, especially in the presence of antigen. The effects may be mediated, at least partly, through the enhanced lung expression of Muc5ac...
  4. ncbi Evaluation of constructed wetlands by wastewater purification ability and greenhouse gas emissions
    P Gui
    National Institute for Environmental Studies, 305 8506, Onogawa 16 2, Tsukuba, Japan
    Water Sci Technol 56:49-55. 2007
    ....
  5. ncbi Function of multiple sperm-storage organs in female damselflies (Ischnura senegalensis): difference in amount of ejaculate stored, sperm loss, and priority in fertilization
    Miri Nakahara
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Tokyo, Japan
    J Insect Physiol 53:1046-54. 2007
    ....
  6. ncbi Bacillus selenatarsenatis sp. nov., a selenate- and arsenate-reducing bacterium isolated from the effluent drain of a glass-manufacturing plant
    Shigeki Yamamura
    Water and Soil Environment Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Int J Syst Evol Microbiol 57:1060-4. 2007
    ..nov. is proposed. The type strain is SF-1(T) (=JCM 14380(T)=DSM 18680(T))...
  7. ncbi Dietary exposure to organophosphorus pesticides for young children in Tokyo and neighboring area
    Junko Kawahara
    National Institute for Environmental Study, Research Center for Risk Analysis, Japan
    Sci Total Environ 378:263-8. 2007
    ..Frequent detection of fenitrothion in diet is a significant trend observed in Japan, and is considered due to the high and widespread usage of the pesticide inside of the country...
  8. ncbi Formation and durability of dithiocarbamic metals in stabilized air pollution control residue from municipal solid waste incineration and melting processes
    Hirofumi Sakanakura
    National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Environ Sci Technol 41:1717-22. 2007
    ..On the other hand, sealed conditions did not bring about a decrease over the course of the experiment. These results imply that DCM degradation proceeds when the treated residue comes into contact with air in actual landfills...
  9. ncbi A murine scavenger receptor MARCO recognizes polystyrene nanoparticles
    Sanae Kanno
    Environmental Nanotoxicology Section, Research Center for Environmental Risk, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki, Japan
    Toxicol Sci 97:398-406. 2007
    ..These results suggest that macrophages associate with nanoparticles (20 nm) at least in part through MARCO and that MARCO plays a role in clearing nanoparticles which can deposit in the alveolar region...
  10. ncbi Congener profiles of PCB and a proposed new set of indicator congeners
    Yukari Ishikawa
    National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Chemosphere 67:1838-51. 2007
    ..These data were valuable for the rough estimation of the TEQ of Co-PCB without separation from other PCB before individual measurements...
  11. ncbi Toluene induces rapid and reversible rise of hippocampal glutamate and taurine neurotransmitter levels in mice
    Tin Tin Win-Shwe
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Lett 168:75-82. 2007
    ..Therefore, we suggest that toluene may mediate its action through the glutamatergic and taurinergic neurotransmission in the hippocampus of freely moving mice...
  12. ncbi Increased Fos immunoreactivity in suprachiasmatic nucleus before luteinizing hormone surge in estrogen-treated ovariectomized female rats
    Shinji Tsukahara
    Graduate School of Science and Technology, Kobe University, Nada Ku, Kobe, Japan
    Neuroendocrinology 83:303-12. 2006
    ..It also included examination of temporal changes in plasma LH levels and temporal changes in Fos levels in the anteroventral periventricular nucleus (AVPV) and gonadotropin-releasing hormone (GnRH) neurons...
  13. ncbi Increased hippocampal mRNA expression of neuronal synaptic plasticity related genes in mice chronically exposed to toluene at a low-level human occupational-exposure
    Sohel Ahmed
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Ibaraki, Japan
    Neurotoxicology 28:168-74. 2007
    ....
  14. ncbi Effects of bismuth contamination on the growth and activity of soil microorganisms using thiols as model compounds
    Tomoyoshi Murata
    Water and Soil Environment Division, National Institute for Environmental Studies, Japan
    J Environ Sci Health A Tox Hazard Subst Environ Eng 41:161-72. 2006
    ..These results indicate that the effects of Bi on soil microbes may depend on mutual reactions with organic matter in the environment...
  15. doi Carbon black nanoparticles promote the maturation and function of mouse bone marrow-derived dendritic cells
    Eiko Koike
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Chemosphere 73:371-6. 2008
    ..In addition, BMDC-mediated MLR might be useful assay for in vitro screening for adjuvant activity of environmental toxicants...
  16. ncbi Photolysis studies of technical decabromodiphenyl ether (DecaBDE) and ethane (DeBDethane) in plastics under natural sunlight
    Natsuko Kajiwara
    Research Center for Material Cycles and Waste Management, National Institute for Environmental Studies NIES, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Environ Sci Technol 42:4404-9. 2008
    ....
  17. doi Effects of pulmonary exposure to diesel exhaust particles on extrathoracic CD4 polarization in asthmatic mice
    Ken ichiro Inoue
    National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Immunopharmacol Immunotoxicol 31:71-4. 2009
    ..Furthermore, the number was significantly greater in the DEP + OVA than in the DEP or the OVA group. Taken together, in vivo DEP exposure amplified extrathoracic CD4 polarization in asthmatic subjects...
  18. doi Uptake and cytotoxic effects of multi-walled carbon nanotubes in human bronchial epithelial cells
    Seishiro Hirano
    Environmental Nanotoxicology Section, RCER, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Toxicol Appl Pharmacol 249:8-15. 2010
    ..Collectively, MWCNT activated NF-κB, enhanced phosphorylation of MAP kinase pathway components, and increased production of proinflammatory cytokines in human bronchial epithelial cells...
  19. doi Bismuth solubility through binding by various organic compounds and naturally occurring soil organic matter
    Tomoyoshi Murata
    Water and Soil Environment Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    J Environ Sci Health A Tox Hazard Subst Environ Eng 45:746-53. 2010
    ..The solubility of Bi by naturally occurring DOM derived from the soil organic horizon (Oi) and its pH dependence were different from those associated with HA and varied among tree species...
  20. doi Spatial distribution and partitioning of polychlorinated biphenyls in Tokyo Bay, Japan
    Jun Kobayashi
    National Institute for Environmental Studies, Research Center for Environment Risk, Tsukuba, Ibaraki, Japan
    J Environ Monit 12:838-45. 2010
    ..5 in the dissolved phase in the water column...
  21. ncbi Profiles of Chemical Effects on Cells (pCEC): a toxicogenomics database with a toxicoinformatics system for risk evaluation and toxicity prediction of environmental chemicals
    Hideko Sone
    Research Center for Environmental Risk, National Institute for Environmental Studies, Ibaraki
    J Toxicol Sci 35:115-23. 2010
    ..This database is available online at http://project.nies.go.jp/eCA/cgi-bin/index.cgi. The current version of the database has information on the hepatotoxicity, reproductive toxicity and embryotoxicity of chemicals...
  22. doi The expression of nerve growth factor in mice lung following low-level toluene exposure
    Hidekazu Fujimaki
    National Institute for Environmental Studies, Tsukuba, Ibaraki, 305 8506, Japan
    Toxicol Lett 191:240-5. 2009
    ..These findings suggest that the exposure with volatile organic compounds enhanced NGF expression and airway inflammation stronger in allergic individuals than in healthy individuals...
  23. doi Peroxiredoxin I is a negative regulator of Th2-dominant allergic asthma
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Int Immunopharmacol 9:1281-8. 2009
    ..Our findings implicate an alternative therapeutic value of Prx I in the treatment of Th2-skewed allergic airway inflammatory diseases such as atopic asthma...
  24. ncbi Children's immunology, what can we learn from animal studies (2): Modulation of systemic Th1/Th2 immune response in infant mice after prenatal exposure to low-level toluene and toll-like receptor (TLR) 2 ligand
    Shoji Yamamoto
    National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    J Toxicol Sci 34:SP341-8. 2009
    ..Our findings indicate that modulation of Th1- and Th2-responses may occur in low-level toluene exposure and/or combination with PGN stimulation in infant mice...
  25. ncbi Pulmonary exposure to soluble cell wall beta-(1, 3)-glucan of aspergillus induces proinflammatory response in mice
    K Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Int J Immunopathol Pharmacol 22:287-97. 2009
    ..These results suggest that pulmonary exposure to ASBG confers lung inflammation, at least partly, via the enhanced local expression of proinflammatory cytokines, likely through NF-kB-dependent pathway...
  26. pmc Metallothionein as an anti-inflammatory mediator
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Mediators Inflamm 2009:101659. 2009
    ..Also, MT expression in various organs/tissues can be enhanced by inflammatory stimuli, implicating in inflammatory diseases. In this paper, we review the role of MT of various inflammatory conditions...
  27. ncbi Dioxin-induced up-regulation of the active form of vitamin D is the main cause for its inhibitory action on osteoblast activities, leading to developmental bone toxicity
    Noriko Nishimura
    Research Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba 305 8506, Japan
    Toxicol Appl Pharmacol 236:301-9. 2009
    ..Together, these data suggest that the impaired mineralization resulting from reduction of the osteoblastic activity, which is caused by TCDD-induced up-regulation of vitamin D, is responsible for its bone developmental toxicity...
  28. doi Predicting the phenotypic response of resource-competing communities to environmental change
    Yoshinari Tanaka
    Research Center for Environmental Risk, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 306 8506, Japan
    J Theor Biol 257:627-41. 2009
    ....
  29. ncbi Characterization of dilution conditions for diesel nanoparticle inhalation studies
    Yuji Fujitani
    National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Japan
    Inhal Toxicol 21:200-9. 2009
    ..We therefore set the secondary dilution ratios for the middle- and low-concentration chambers to 13.5 and 40.5 times, respectively...
  30. ncbi Antioxidative role of interleukin-6 in septic lung injury in mice
    K Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Int J Immunopathol Pharmacol 21:501-7. 2008
    ..These data suggest that the possible mechanisms in which endogenous IL-6 protects against septic lung injury induced by LPS involve, at least in part, its antioxidative properties...
  31. ncbi Feminization of Japanese medaka (Oryzias latipes) exposed to 17beta-estradiol: formation of testis-ova and sex-transformation during early-ontogeny
    Narisato Hirai
    National Institute for Environmental Studies, Onogawa 16 2, Tsukuba 305 8506, Japan
    Aquat Toxicol 77:78-86. 2006
    ..6 ng/L) than lower concentrations (33.5 ng/L) of estradiol. The results also demonstrated that testis-ova first appear in the central area of the transverse axis of testis...
  32. ncbi Induction of oxidative stress and inhibition of plasminogen activator inhibitor-1 production in endothelial cells following exposure to organic extracts of diesel exhaust particles and urban fine particles
    Akiko Furuyama
    Inhalation Toxicology Team, PM2 5 and DEP Research Project, National Institute for Environmental Studies, 16 2 Onogawa, 305 8506 Tsukuba, Japan
    Arch Toxicol 80:154-62. 2006
    ..These results suggest that exposure to the soluble organic fraction of PM and DEP induced oxidative stress and reduced the PAI-1 production of endothelial cells...
  33. ncbi Comparison of PCDD/F and coplanar PCB concentrations in Japanese human adipose tissue collected in 1970-1971, 1994-1996 and 2000
    Jae Won Choi
    National Institute for Environmental Studies, Ibaraki, Japan
    Chemosphere 47:591-7. 2002
    ..A comparison of data using the latest PCB-TEQ showed no significant changes. Therefore, research on source characterization and monitoring of short-term temporal trends on these compounds should be carried out continuously...
  34. ncbi Developmental stage-specific effects of perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on reproductive organs of male rat offspring
    Seiichiroh Ohsako
    Molecular and Cellular Toxicology Section, Environmental Health Sciences Division, Endocrine Disruptors and Dioxin Research Project, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Toxicol Sci 66:283-92. 2002
    ..These results suggest the presence of a critical window during development with regard to impairments of male reproductive organs by in utero and lactational exposure to a low dose of TCDD...
  35. ncbi Strong emission of methyl chloride from tropical plants
    Yoko Yokouchi
    National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Nature 416:163-5. 2002
    ..Conversely, the abundance of massive ferns in the Carboniferous period may have created an atmosphere rich in methyl chloride...
  36. ncbi Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on T cell-derived cytokine production in ovalbumin (OVA)-immunized C57Bl/6 mice
    Keiko Nohara
    Environmental Health Sciences Division, National Institute for Environmental Studies, Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicology 172:49-58. 2002
    ..These results suggested compromised T cell activation and suppressed type-2 cytokine production by T cells to be involved in the impaired humoral immunity associated with TCDD exposure...
  37. ncbi Dioxin-like PCBs released from waste incineration and their deposition flux
    S Akai
    National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Environ Sci Technol 35:3601-7. 2001
    ..ii) For congeners whose percentages were high in the waste incineration emission gas (e.g., 126 and 189), the amounts deposited were similar to the amounts released in the waste emission gas...
  38. ncbi Type II glucocorticoid receptors are involved in neuronal death and astrocyte activation induced by trimethyltin in the rat hippocampus
    H Imai
    Regional Environment Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, 305 0053, Japan
    Exp Neurol 171:22-8. 2001
    ..Dexamethasone, but not aldosterone, could be substituted for corticosterone, suggesting a novel neuroprotective action of type II glucocorticoid receptors in the hippocampus...
  39. ncbi The beta-actin gene of two species of southern top mouth minnow (Pseudorasbora parva) and the common fat minnow (Rhynchocypris oxycephalus) from the family Cyprinidae
    J S Lee
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    DNA Seq 11:301-7. 2000
    ..The amino acid sequence identity between the two species is 100.0% while there is a lower degree of homology with other species in the range of 98.7% to 100.0%. The expression of the beta-actin gene was confirmed in liver...
  40. ncbi Renal toxicity caused by cisplatinum in glutathione-depleted metallothionein-null mice
    M Satoh
    Environmental Health Sciences Division, National Institute for Environmental Studies, 305 0053, Tsukuba, Japan
    Biochem Pharmacol 60:1729-34. 2000
    ..Moreover, the renal MT preinduced by zinc could protect mice from cis-DDP nephrotoxicity enhanced by GSH depletion...
  41. ncbi Increased mutant frequency and altered mutation spectrum of the lacI transgene in Wilson disease rats with hepatitis
    H Sone
    Regional Environment Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Cancer Res 60:5080-6. 2000
    ..These findings suggest that the increase in mutant frequencies and/or the specific type of mutation according to copper accumulation play a crucial role in hepatocarcinogenesis in LEC rats...
  42. pmc Epidermal growth factor regulation of glutathione S-transferase gene expression in the rat is mediated by class Pi glutathione S-transferase enhancer I
    M Matsumoto
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 0053, Japan
    Biochem J 349:225-30. 2000
    ..Since the sequence of GPEI is similar to that of the antioxidant responsive element (ARE), some factors which bind to ARE might play a role in GPEI-mediated gene expression...
  43. pmc Identification of an enhancer element of class Pi glutathione S-transferase gene required for expression by a co-planar polychlorinated biphenyl
    M Matsumoto
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 0053, Japan
    Biochem J 338:599-605. 1999
    ..GPEI is already known to contain a dyad of PMA responsive element-like elements oriented palindromically. It is suggested that a novel signal transduction pathway activated by PenCB contributes to the stimulation of GSTP1 expression...
  44. ncbi Diesel exhaust inhalation enhances airway hyperresponsiveness in mice
    Y Miyabara
    Research Team for Health Effects of Air Pollutants, National Institute for Environmental Studies, Ibaraki, Japan
    Int Arch Allergy Immunol 116:124-31. 1998
    ..However, the effects of daily inhalation of diesel exhaust may differ from the effects of direct instillation...
  45. ncbi Diesel exhaust enhances allergic airway inflammation and hyperresponsiveness in mice
    Y Miyabara
    Research Team for Health Effects of Air Pollutants, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Am J Respir Crit Care Med 157:1138-44. 1998
    ....
  46. ncbi Pb and 206Pb/207Pb isotopic analysis of a tree bark pocket near Sheffield, UK recording historical change in airborne pollution during the 20th century
    David J Bellis
    Centre for Analytical Sciences, Department of Chemistry, University of Sheffield, UK
    Sci Total Environ 289:169-76. 2002
    ..The highest Pb concentrations were recorded from ca. 1951 to 1973, suggesting a high level of industrial pollution. A reduction in Pb concentration and reversal of the trend in 206Pb/207Pb was observed in the current bark...
  47. ncbi Evolution of water chemistry in natural acidic environments in Yangmingshan, Taiwan
    Yuka Ezoe
    Department of Chemistry and Physics of Condensed Matter, Graduate School of Sciences, Kyushu University, Ropponmatsu, Fukuoka 810 8560, Japan
    J Environ Monit 4:533-40. 2002
    ..While flowing down surface streams, iron(II) is oxidised to iron(III) and then hydrolysed to cause further acidification under oxic conditions. The concentrations of iron and aluminium are controlled by redox and dissolution equilibria...
  48. ncbi [Effects of global warming on productivity and soil moisture in Taihang mountain: a transplant study]
    Yonghui Yang
    Shijiazhuang Institute of Agricultural Modernization, Chinese Academy of Sciences, Shijiazhuang 050021
    Ying Yong Sheng Tai Xue Bao 13:667-71. 2002
    ..Soil moisture condition under treatments with higher precipitation was generally higher than that under treatments with lower precipitation. In the warmer site, soil moisture became higher since the beginning of the second year...
  49. pmc Effects of nano particles on antigen-related airway inflammation in mice
    Ken ichiro Inoue
    Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Respir Res 6:106. 2005
    ..We investigated the effects of nano particles with a diameter of 14 nm or 56 nm on antigen-related airway inflammation...
  50. ncbi Continuing observation of disturbed reproductive cycle and ovarian spermatogenesis in the giant abalone, Haliotis madaka from an organotin-contaminated site of Japan
    Toshihiro Horiguchi
    National Institute for Environmental Studies, Environmental Chemistry Division, 16 2, Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Mar Pollut Bull 51:817-22. 2005
    ..4+/-0.6 ng/g wet wt. and 0.5+/-0.9 ng/g wet wt., respectively, (p > 0.05 for TBT; p < 0.001 for TPhT). Thus, endocrine disruption as well as contamination by organotins in the giant abalone from Jogashima is still persisting...
  51. ncbi Deuterium exchange in arsenobetaine and dimethylarsinoylacetic acid
    John S Edmonds
    Endocrine Disrupter Research Laboratory, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    J Inorg Biochem 99:747-54. 2005
    ..The half-life of the reaction was maximum for arsenobetaine at pH values of 5-6, and for dimethylarsinoylacetic acid at 6.5-8.5. Mechanisms are suggested for the exchange reactions involved...
  52. ncbi Overexpression of Bcl-2 inhibits nuclear localization of annexin I during tumor necrosis factor-alpha-mediated apoptosis in porcine renal LLC-PK1 cells
    Masami Ishido
    Endocrine Disruptors Research Projects, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Regul Pept 124:45-51. 2005
    ..Thus, it is first time to show that annexin I is regulated by an anti-apoptotic Bcl-2 protein in TNF-alpha-induced renal apoptotic events...
  53. ncbi MNNG-induced mutations in the adult gill and hepatopancreas and in embryos of rpsL transgenic zebrafish
    Kimiko Amanuma
    Research Center for Environmental Risk, National Institute for Environmental Studies, Onogawa, Tsukuba 305 8506, Japan
    Mutat Res 556:151-61. 2004
    ..Thus, MNNG induces typical mutations in the gill and hepatopancreas of adult fish, and in embryos, suggesting that the rpsL zebrafish is a useful tool for monitoring genotoxicity caused by water-borne mutagens...
  54. ncbi Inhalation of low-level formaldehyde enhances nerve growth factor production in the hippocampus of mice
    Hidekazu Fujimaki
    National Institute for Environmental Studies, Tsukuba 305 8506, Japan
    Neuroimmunomodulation 11:373-5. 2004
    ..The effects of low-level formaldehyde (FA) inhalation on the amount of nerve growth factor (NGF) in the hippocampus of immunized mice were studied...
  55. ncbi Dicyclohexylphthalate causes hyperactivity in the rat concomitantly with impairment of tyrosine hydroxylase immunoreactivity
    Masami Ishido
    National Institute for Environmental Studies, Tsukuba, Japan
    J Neurochem 91:69-76. 2004
    ..We conclude that DCHP affected the developing rat brain, resulting in hyperactivity, probably as a result of degeneration of mesencephalic tyrosine hydroxylase rather than alteration of the level of gene expression...
  56. ncbi By-side impurities in chloronaphthalene mixtures of the Halowax series: all 209 chlorobiphenyls
    Y Noma
    National Institute for Environmental Studies, Tsukuba, Japan
    J Environ Sci Health A Tox Hazard Subst Environ Eng 39:2035-58. 2004
    ....
  57. ncbi The reaction of bisphenol A 3,4-quinone with DNA
    John S Edmonds
    Endocrine Disrupter Research Laboratory, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Biochem Biophys Res Commun 319:556-61. 2004
    ..The relevance of this adduct formation to the potential mutagenicity and carcinogenicity of BPA will depend upon confirmation of the necessary metabolic oxidative transformation of BPA in vivo...
  58. ncbi Juvenile hormone agonists affect the occurrence of male Daphnia
    Norihisa Tatarazako
    National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba City, Ibaraki 305 8506, Japan
    Chemosphere 53:827-33. 2003
    ..7 x 10(3), 3.3 x 10(5), and 1.3 x 10(5) ngl(-1), respectively). Our findings suggest that juvenile hormone agonists, including some insecticides, affect the chemical signaling responsible for inducing the production of male offspring...
  59. ncbi Difference in uptake and toxicity of trivalent and pentavalent inorganic arsenic in rat heart microvessel endothelial cells
    Seishiro Hirano
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, 305 8506, Tsukuba, Ibaraki, Japan
    Arch Toxicol 77:305-12. 2003
    ....
  60. ncbi Leaching characteristics of polycyclic aromatic hydrocarbons (PAHs) from spiked sandy soil
    Yong Jin Kim
    Research Center for Material Cycles and Waste Management, The National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba shi, Ibaraki 305 8506, Japan
    Chemosphere 51:387-95. 2003
    ..It is therefore reasonable to use an alternative reagent having an effect similar to that of DHM...
  61. ncbi Differential ozone sensitivity among Arabidopsis accessions and its relevance to ethylene synthesis
    Masanori Tamaoki
    Biodiversity Conservation Research Project, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki, 305 8506 Japan
    Planta 216:552-60. 2003
    ....
  62. ncbi Enhanced renal toxicity by inorganic mercury in metallothionein-null mice
    M Satoh
    Environmental Health Sciences Division, Tsukuba, Ibaraki 305, Japan
    J Pharmacol Exp Ther 283:1529-33. 1997
    ..Based on the present results, we conclude that MT is an important protective factor against the renal toxicity caused by inorganic mercury and that it may play a major role in the retention of mercury in the kidney...