Yasuyuki Ikeda

Summary

Affiliation: National Cardiovascular Center
Country: Japan

Publications

  1. ncbi request reprint A compound heterozygote for a novel missense mutation (G105R) in exon 3 and a missense mutation (D204E) in exon 5 of the lipoprotein lipase gene in a Japanese infant with hyperchylomicronaemia
    Y Ikeda
    Department of Etiology and Pathophysiology, National Cardiovascular Center Research Institute, Fujishirodai, Suita, Osaka 565 8565, Japan
    Clin Sci (Lond) 99:569-78. 2000
  2. ncbi request reprint Novel compound heterozygous mutations for lipoprotein lipase deficiency. A G-to-T transversion at the first position of exon 5 causing G154V missense mutation and a 5' splice site mutation of intron 8
    Y Ikeda
    Departments of Etiology and Pathophysiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    J Lipid Res 42:1072-81. 2001
  3. ncbi request reprint A family-based study of hyperinsulinemia and hypertriglyceridemia in heterozygous lipoprotein lipase deficiency
    Yasuyuki Ikeda
    Department of Etiology and Pathophysiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Clin Chim Acta 316:179-85. 2002
  4. ncbi request reprint [Genetic disorder causing dyslipoproteinemia]
    Yasuyuki Ikeda
    Department of Etiology and Pathophysiology, National Cardiovascular Center Research Institute
    Nihon Rinsho 65:128-35. 2007
  5. ncbi request reprint Clinical features and genetic analysis of autosomal recessive hypercholesterolemia
    Mariko Harada-Shiba
    Department of Bioscience, National Cardiovascular Center Research Institute, Suita, Osaka 565 8565, Japan
    J Clin Endocrinol Metab 88:2541-7. 2003
  6. ncbi request reprint Change in immunoreactive human hepatic triglyceride lipase (HTGL) mass and the shelf-life of the HTGL ELISA kit in long-term storage
    Makoto Nishimura
    Division of Laboratory Products, Dainippon Pharmaceutical Co, Ltd, Osaka, Japan
    J Immunoassay Immunochem 27:89-102. 2006
  7. ncbi request reprint Genotyping of the human lipoprotein lipase gene by ferrocenylnaphthalene diimide-based electrochemical hybridization assay
    Takahiko Nojima
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 812 8581, Japan
    Anal Sci 21:1437-41. 2005
  8. ncbi request reprint Glucose-stimulated insulin response in non-diabetic patients with lipoprotein lipase deficiency and hypertriglyceridemia
    Naoki Tamasawa
    Third Department of Internal Medicine, Hirosaki University School of Medicine, Zaifu 5, Hirosaki, Aomori 036 8562, Japan
    Diabetes Res Clin Pract 72:6-11. 2006
  9. ncbi request reprint [Analysis of lipoprotein lipase activity, immunoreactive mass and gene]
    Atsuko Takagi
    Department of Pharmacology, National Cardiovascular Center Research Institute
    Nihon Rinsho 62:71-8. 2004
  10. pmc A novel method of identifying genetic mutations using an electrochemical DNA array
    Junko Wakai
    TUM Gene, Inc, 3 1 Kazusa Koito Kimitsu, Chiba 292 1149 Japan
    Nucleic Acids Res 32:e141. 2004

Collaborators

  • Shinji Yokoyama
  • Hiroki Kondo
  • Makoto Nishimura
  • Atsuko Takagi
  • Takahiko Nojima
  • Shigeori Takenaka
  • Kenichi Yamashita
  • Naoki Tamasawa
  • Junko Wakai
  • Mariko Harada-Shiba
  • Makoto Takagi
  • Hiroshi Murakami
  • Jutaro Tanabe
  • Jun Matsui
  • Kohta Matsuki
  • Toshihiro Suda
  • Yoshiji Ogawa
  • Tsuyoshi Iwanaga
  • Masato Nakayama
  • Tomohiro Urata
  • Masahiko Amano
  • Takahito Miya
  • Takatoshi Miyahara
  • Akira Yamamoto
  • Motoo Tsushima
  • Yoshihiro Miyamoto

Detail Information

Publications14

  1. ncbi request reprint A compound heterozygote for a novel missense mutation (G105R) in exon 3 and a missense mutation (D204E) in exon 5 of the lipoprotein lipase gene in a Japanese infant with hyperchylomicronaemia
    Y Ikeda
    Department of Etiology and Pathophysiology, National Cardiovascular Center Research Institute, Fujishirodai, Suita, Osaka 565 8565, Japan
    Clin Sci (Lond) 99:569-78. 2000
    ..The novel G105R missense mutation could not be detected by conventional analysis of single-strand conformation polymorphism, but it was identified by extensive sequencing of the entire exons and their flanking regions in the LPL gene...
  2. ncbi request reprint Novel compound heterozygous mutations for lipoprotein lipase deficiency. A G-to-T transversion at the first position of exon 5 causing G154V missense mutation and a 5' splice site mutation of intron 8
    Y Ikeda
    Departments of Etiology and Pathophysiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    J Lipid Res 42:1072-81. 2001
    ..These additional mutations in the consensus sequences of the 3' and 5' splice sites might be useful for better understanding the factors that are involved in splice site selection in vivo...
  3. ncbi request reprint A family-based study of hyperinsulinemia and hypertriglyceridemia in heterozygous lipoprotein lipase deficiency
    Yasuyuki Ikeda
    Department of Etiology and Pathophysiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Clin Chim Acta 316:179-85. 2002
    ....
  4. ncbi request reprint [Genetic disorder causing dyslipoproteinemia]
    Yasuyuki Ikeda
    Department of Etiology and Pathophysiology, National Cardiovascular Center Research Institute
    Nihon Rinsho 65:128-35. 2007
  5. ncbi request reprint Clinical features and genetic analysis of autosomal recessive hypercholesterolemia
    Mariko Harada-Shiba
    Department of Bioscience, National Cardiovascular Center Research Institute, Suita, Osaka 565 8565, Japan
    J Clin Endocrinol Metab 88:2541-7. 2003
    ..Interestingly, ARH is caused by a mutation of cytosine to adenine at this same position. Both siblings exhibited fatty liver, which may also be related to this mutation...
  6. ncbi request reprint Change in immunoreactive human hepatic triglyceride lipase (HTGL) mass and the shelf-life of the HTGL ELISA kit in long-term storage
    Makoto Nishimura
    Division of Laboratory Products, Dainippon Pharmaceutical Co, Ltd, Osaka, Japan
    J Immunoassay Immunochem 27:89-102. 2006
    ..HTGL in PHP was stabilized by lyophilization and can be used as the standard material for HTGL ELISA; the HTGL ELISA kit has a long shelf-life, i.e., more than two years...
  7. ncbi request reprint Genotyping of the human lipoprotein lipase gene by ferrocenylnaphthalene diimide-based electrochemical hybridization assay
    Takahiko Nojima
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 812 8581, Japan
    Anal Sci 21:1437-41. 2005
    ..Blind tests were run to judge the genotype (WT/WT, WT/MT, or MT/MT) of 10 samples each for the G188E and Arita mutations and then, 8 and 10 of them were judged correctly, respectively...
  8. ncbi request reprint Glucose-stimulated insulin response in non-diabetic patients with lipoprotein lipase deficiency and hypertriglyceridemia
    Naoki Tamasawa
    Third Department of Internal Medicine, Hirosaki University School of Medicine, Zaifu 5, Hirosaki, Aomori 036 8562, Japan
    Diabetes Res Clin Pract 72:6-11. 2006
    ....
  9. ncbi request reprint [Analysis of lipoprotein lipase activity, immunoreactive mass and gene]
    Atsuko Takagi
    Department of Pharmacology, National Cardiovascular Center Research Institute
    Nihon Rinsho 62:71-8. 2004
  10. pmc A novel method of identifying genetic mutations using an electrochemical DNA array
    Junko Wakai
    TUM Gene, Inc, 3 1 Kazusa Koito Kimitsu, Chiba 292 1149 Japan
    Nucleic Acids Res 32:e141. 2004
    ..It turned out that all the results obtained were concordant with the sequencing results, demonstrating that this system is a powerful tool for clinical applications...
  11. ncbi request reprint [Studies on the antigenic stability of hepatic triglyceride lipase in human postheparin plasma during long-term storage]
    Makoto Nishimura
    Division of Laboratory Products, Dainippon Pharmaceutical Co, Ltd, 33 94 Enoki cho, Suita City 564 0053, Japan
    Yakugaku Zasshi 123:587-91. 2003
    ..These results indicate that lyophilized PHP stored at a temperature of less than 4 degrees C can be utilized as the standard material for the quantification of HTGL in human plasma using the HTGL ELISA MARUPI kit...
  12. ncbi request reprint Direct detection of single nucleotide polymorphism (SNP) with genomic DNA by the ferrocenylnaphthalene diimide-based electrochemical hybridization assay (FND-EHA)
    Takahiko Nojima
    Department of Applied Chemistry, School of Engineering, Kyushu University, Fukuoka 812 8581, Japan
    Anal Sci 19:79-83. 2003
    ..The electrochemical signal ratios obtained for WT/WT, WT/MT and MT/MT were close to the theoretical 2:1:0 with the S447 WT-modified electrode, and was again close to 0:1:2 with the S447X MT-modified one...
  13. ncbi request reprint Ferrocenylnaphthalene diimide-based electrochemical hybridization assay for a heterozygous deficiency of the lipoprotein lipase gene
    Kenichi Yamashita
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 812 8581, Japan
    Bioconjug Chem 13:1193-9. 2002
    ..This system was validated on 10 unknown samples of each of the two types of LPL mutation, which were correctly identified in every case...
  14. ncbi request reprint [Measurements of lipoprotein lipase (LPL) activity and immunoreactive mass, and diagnosis of LPL gene]
    Atsuko Takagi
    Department of Pharmacology, National Cardiovascular Center Research Institute
    Nihon Rinsho 65:182-90. 2007