Toshiaki Ishizuka

Summary

Affiliation: National Defense Medical College
Country: Japan

Publications

  1. doi request reprint Involvement of β-adrenoceptors in the differentiation of human induced pluripotent stem cells into mesodermal progenitor cells
    Toshiaki Ishizuka
    Department of Pharmacology, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama 359 8513, Japan Electronic address
    Eur J Pharmacol 740:28-34. 2014
  2. doi request reprint Stimulation of α₁-adrenoceptor or angiotensin type 1 receptor enhances DNA synthesis in human-induced pluripotent stem cells via Gq-coupled receptor-dependent signaling pathways
    Toshiaki Ishizuka
    Department of Pharmacology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Eur J Pharmacol 714:202-9. 2013
  3. ncbi request reprint Effect of nicotine on the proliferation and differentiation of mouse induced pluripotent stem cells
    T Ishizuka
    Department of Pharmacology, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama 359 8513, Japan
    Curr Med Chem 19:5164-9. 2012
  4. doi request reprint β1-adrenoceptor stimulation enhances the differentiation of mouse induced pluripotent stem cells into neural progenitor cells
    Toshiaki Ishizuka
    Department of Pharmacology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Neurosci Lett 525:60-5. 2012
  5. doi request reprint Involvement of nicotinic acetylcholine receptor in the proliferation of mouse induced pluripotent stem cells
    Toshiaki Ishizuka
    Department of Pharmacology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Life Sci 90:637-48. 2012
  6. doi request reprint Effect of angiotensin II on proliferation and differentiation of mouse induced pluripotent stem cells into mesodermal progenitor cells
    Toshiaki Ishizuka
    Department of Pharmacology, National Defense Medical College, Tokorozawa, Saitama 359 8513, Japan
    Biochem Biophys Res Commun 420:148-55. 2012
  7. doi request reprint α₁-Adrenoceptor stimulation enhances leukemia inhibitory factor-induced proliferation of mouse-induced pluripotent stem cells
    Toshiaki Ishizuka
    Department of Pharmacology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Eur J Pharmacol 668:42-56. 2011
  8. doi request reprint Acetylsalicylic acid provides cerebrovascular protection from oxidant damage in salt-loaded stroke-prone rats
    Toshiaki Ishizuka
    Department of Pharmacology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Life Sci 82:806-15. 2008
  9. doi request reprint Superoxide induced by a high-glucose concentration attenuates production of angiogenic growth factors in hypoxic mouse mesenchymal stem cells
    Toshiaki Ishizuka
    Department of Pharmacology, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Endocrinol 208:147-59. 2011
  10. ncbi request reprint Involvement of thromboxane A2 receptor in the cerebrovascular damage of salt-loaded, stroke-prone rats
    Toshiaki Ishizuka
    Department of Pharmacology, Kinki University School of Medicine, Ohno Higashi, Osaka, Japan
    J Hypertens 25:861-70. 2007

Collaborators

Detail Information

Publications27

  1. doi request reprint Involvement of β-adrenoceptors in the differentiation of human induced pluripotent stem cells into mesodermal progenitor cells
    Toshiaki Ishizuka
    Department of Pharmacology, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama 359 8513, Japan Electronic address
    Eur J Pharmacol 740:28-34. 2014
    ..These results suggest that β-adrenoceptor stimulation in human iPS cells may enhance their differentiation into mesodermal progenitor cells via the activation of either protein kinase A or p38 MAPK. ..
  2. doi request reprint Stimulation of α₁-adrenoceptor or angiotensin type 1 receptor enhances DNA synthesis in human-induced pluripotent stem cells via Gq-coupled receptor-dependent signaling pathways
    Toshiaki Ishizuka
    Department of Pharmacology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Eur J Pharmacol 714:202-9. 2013
    ..These results suggest that stimulation of α₁-adrenoceptor or AT₁ receptor may enhance DNA synthesis in human iPS cells via Gq-coupled receptor-dependent signaling pathways...
  3. ncbi request reprint Effect of nicotine on the proliferation and differentiation of mouse induced pluripotent stem cells
    T Ishizuka
    Department of Pharmacology, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama 359 8513, Japan
    Curr Med Chem 19:5164-9. 2012
    ....
  4. doi request reprint β1-adrenoceptor stimulation enhances the differentiation of mouse induced pluripotent stem cells into neural progenitor cells
    Toshiaki Ishizuka
    Department of Pharmacology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Neurosci Lett 525:60-5. 2012
    ..These findings suggest that β(1)-adrenoceptor stimulation enhances ATRA-induced neural differentiation of mouse iPS cells...
  5. doi request reprint Involvement of nicotinic acetylcholine receptor in the proliferation of mouse induced pluripotent stem cells
    Toshiaki Ishizuka
    Department of Pharmacology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Life Sci 90:637-48. 2012
    ..In the present study, we examined the involvement of nAchR in the proliferation of mouse iPS cells...
  6. doi request reprint Effect of angiotensin II on proliferation and differentiation of mouse induced pluripotent stem cells into mesodermal progenitor cells
    Toshiaki Ishizuka
    Department of Pharmacology, National Defense Medical College, Tokorozawa, Saitama 359 8513, Japan
    Biochem Biophys Res Commun 420:148-55. 2012
    ....
  7. doi request reprint α₁-Adrenoceptor stimulation enhances leukemia inhibitory factor-induced proliferation of mouse-induced pluripotent stem cells
    Toshiaki Ishizuka
    Department of Pharmacology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Eur J Pharmacol 668:42-56. 2011
    ..These results suggest that stimulation with α(1)-adrenoceptor may enhance DNA synthesis and proliferation of mouse iPS cells cultured with LIF via augmentation of both the MEK/MAPK and the PI3K/Akt pathways...
  8. doi request reprint Acetylsalicylic acid provides cerebrovascular protection from oxidant damage in salt-loaded stroke-prone rats
    Toshiaki Ishizuka
    Department of Pharmacology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Life Sci 82:806-15. 2008
    ..These results suggest that low-dose aspirin may exert protective effects against cerebrovascular inflammation and damage by salt loading through down-regulation of superoxide production and induction of nitric oxide synthesis...
  9. doi request reprint Superoxide induced by a high-glucose concentration attenuates production of angiogenic growth factors in hypoxic mouse mesenchymal stem cells
    Toshiaki Ishizuka
    Department of Pharmacology, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Endocrinol 208:147-59. 2011
    ....
  10. ncbi request reprint Involvement of thromboxane A2 receptor in the cerebrovascular damage of salt-loaded, stroke-prone rats
    Toshiaki Ishizuka
    Department of Pharmacology, Kinki University School of Medicine, Ohno Higashi, Osaka, Japan
    J Hypertens 25:861-70. 2007
    ..Thromboxane A2 (TP) receptor stimulation by 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha) is involved in the process of vascular inflammation...
  11. ncbi request reprint Vascularization in vivo caused by the controlled release of fibroblast growth factor-2 from an injectable chitosan/non-anticoagulant heparin hydrogel
    Masanori Fujita
    Department of Surgery II, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Biomaterials 25:699-706. 2004
    ..These results indicate that the controlled release of biologically active FGF-2 molecules is caused by biodegradation of the hydrogel, and that subsequent induction of the vascularization occurs...
  12. ncbi request reprint Inhibition of vascular prosthetic graft infection using a photocrosslinkable chitosan hydrogel
    Masanori Fujita
    Department of Medical Engineering, National Defense Medical College, Tokorozawa, Saitama 359 8513, Japan
    J Surg Res 121:135-40. 2004
    ..coli). The antibacterial activity by adhering a photocrosslinkable chitosan hydrogel to Dacron grafts was investigated in vitro and in vivo using a rabbit model...
  13. ncbi request reprint Significance of angioscopic morphology for the estimation of macrophage infiltration and vascular physiology
    Akira Kurita
    Department of Biomedical Engineering and Internal Medicine, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitma 359 8513, Japan
    Int J Cardiovasc Imaging 20:165-71. 2004
    ..The aim of the present study was to determine whether direct visual morphology can predict vascular physiology, macrophage infiltration and plaque architecture of atherosclerotic lesions...
  14. ncbi request reprint Osteogenic potential of human adipose tissue-derived stromal cells as an alternative stem cell source
    Hidemi Hattori
    Division of Biomedical Engineering, Research Institute, National Defense Medical College, Saitama, Japan
    Cells Tissues Organs 178:2-12. 2004
    ..Furthermore, osteoblastic lining in vivo was examined using ATSC-seeded or BMSC-seeded scaffolds in nude mice. The present results show that ATSCs have a similar ability to differentiate into osteoblasts to that of BMSCs...
  15. ncbi request reprint Ramatroban, a TP receptor antagonist, improves vascular responses to acetylcholine in hypercholesterolemic rabbits in vivo
    Toshiaki Ishizuka
    Department of Medical Engineering, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Eur J Pharmacol 468:27-35. 2003
    ..These findings suggest that ramatroban improves the vascular response in vivo to acetylcholine in hypercholesterolemic rabbits by blocking the action of 8-iso-prostaglandin F(2alpha)...
  16. ncbi request reprint A novel method to prevent secondary exposure of medical and rescue personnel to toxic materials under biochemical hazard conditions using microwave radar and infrared thermography
    Takemi Matsui
    Division of Biomedical Engineering, Research Institute, National Defense Medical College, 3 2 Namiki, Tokorozawa, Japan
    IEEE Trans Biomed Eng 51:2184-8. 2004
    ..A toxic condition was induced by intravenous administration of lipopolysaccharide (LPS) in rabbits. The exposure to LPS was determined by linear discriminant analysis using non-contact derived variables...
  17. ncbi request reprint Ramatroban (BAY u 3405): a novel dual antagonist of TXA2 receptor and CRTh2, a newly identified prostaglandin D2 receptor
    Toshiaki Ishizuka
    Department of Medical Engineering, National Defense Medical College, Namiki 3 2, Tokorozawa, Saitama 359, Japan
    Cardiovasc Drug Rev 22:71-90. 2004
    ..Therefore, ramatroban may be beneficial in the treatment of atherosclerosis...
  18. ncbi request reprint Effects of severe hyperbaric pressure on autonomic nerve functions
    Akira Kurita
    National Defense Medical College, Division of Biomedical Engineering, Tokorozawa, Saitama, Japan
    Mil Med 167:934-8. 2002
    ..Thus, the present results indicate that the autonomic nerve functions of people who work under deep-sea conditions can be evaluated adequately by measuring HRV...
  19. ncbi request reprint Controlled release of fibroblast growth factors and heparin from photocrosslinked chitosan hydrogels and subsequent effect on in vivo vascularization
    Masayuki Ishihara
    National Defense Medical College, Research Institute, Division of Biomedical Engineering, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Biomed Mater Res A 64:551-9. 2003
    ..These results indicate that the controlled release of biologically active FGF-1 and FGF-2 with heparin is caused by biodegradation of the chitosan hydrogel, and subsequent induction of vascularization...
  20. ncbi request reprint Noninvasive electrocardiographic findings and plasma norepinephrine levels in patients with post-myocardial infarction receiving anti-anginal agents
    Akira Kurita
    Department of Biomedical Engineering and Cardiology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Anadolu Kardiyol Derg 3:43-7. 2003
    ....
  21. ncbi request reprint A novel ferromagnetic thermo-stent for plaque stabilization that self-regulates the temperature
    Takemi Matsui
    Division of Biomedical Engineering, Research Institute, National Defense Medical College, Tokorozawa, Japan
    IEEE Trans Biomed Eng 49:621-3. 2002
    ..Stent implants of this type in human blood vessels could potentially enable thermotherapy and temperature determination without catheterization...
  22. doi request reprint Stimulation of 5-HT4 receptor enhances differentiation of mouse induced pluripotent stem cells into neural progenitor cells
    Toshiaki Ishizuka
    Department of Pharmacology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Clin Exp Pharmacol Physiol 41:345-50. 2014
    ..These findings suggest that stimulation of 5-HT4 receptors may enhance ATRA-induced neural differentiation of mouse iPS cells through activation of PKA and CREB. ..
  23. ncbi request reprint Biomedical engineering's contribution to defending the homeland
    Makoto Kikuchi
    National Defense Medical College Research Institute NDMCRI, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    IEEE Eng Med Biol Mag 23:175-86. 2004
  24. ncbi request reprint TP receptor as a therapeutic target in atherosclerosis and related cardiovascular diseases
    Toshiaki Ishizuka
    Department of Pharmacology, Kinki University School of Medicine, Osaka Sayama, Osaka 589 8511, Japan
    Recent Pat Cardiovasc Drug Discov 1:241-7. 2006
    ..These new compounds may be able to restrict further infiltration of inflammatory cells in atherosclerotic vessels, thus stabilizing vulnerable plaques in the related cardiovascular diseases...
  25. ncbi request reprint Ramatroban, a thromboxane A2 receptor antagonist, prevents macrophage accumulation and neointimal formation after balloon arterial injury in cholesterol-fed rabbits
    Toshiaki Ishizuka
    Department of Medical Engineering, National Defense Medical College, Tokorozawa, Saitama, Japan
    J Cardiovasc Pharmacol 41:571-8. 2003
    ..Thromboxane A(2) receptor blockade by ramatroban for 4 weeks after balloon angioplasty in the atherosclerotic rabbits prevented macrophage infiltration through MCP-1 downregulation and neointimal formation...
  26. ncbi request reprint Photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 stimulates wound healing in healing-impaired db/db mice
    Kiyohaya Obara
    Department of Surgery II, National Defence Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Biomaterials 24:3437-44. 2003
    ..Histological examination also has demonstrated an advanced granulation tissue formation, capillary formation and epithelialization in wounds treated with FGF-2-incorporated chitosan hydrogels in db/db mice...
  27. ncbi request reprint Significance of plasma nitric oxide/endothelial-1 ratio for prediction of coronary artery disease
    Akira Kurita
    Department of Biomedical Engineering and Internal Medicine, National Defensse Medical College, Saitma, Japan
    Angiology 56:259-64. 2005
    ..The present results suggest that plasma NO/ET-1 ratio is a useful biological marker for predicting CAD...