Yae Kanai

Summary

Affiliation: National Cancer Center
Country: Japan

Publications

  1. ncbi request reprint Loss of blood group A antigen expression in bladder cancer caused by allelic loss and/or methylation of the ABO gene
    Yoshitomo Chihara
    Oncogene Research Unit Cancer Prevention Unit, Tochigi Cancer Center Research Institute, Tochigi 320 0834, Japan
    Lab Invest 85:895-907. 2005
  2. pmc Prognostication of patients with clear cell renal cell carcinomas based on quantification of DNA methylation levels of CpG island methylator phenotype marker genes
    Ying Tian
    Division of Molecular Pathology, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    BMC Cancer 14:772. 2014
  3. pmc DNA methyltransferase 3B expression is associated with poor outcome of stage I testicular seminoma
    Eri Arai
    Division of Molecular Pathology, National Cancer Center Research Institute, National Cancer Center Hospital, Tokyo, Japan
    Histopathology 60:E12-8. 2012
  4. pmc Single-CpG-resolution methylome analysis identifies clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas
    Eri Arai
    Division of Molecular Pathology, National Cancer Center Research Institute Tokyo 104 0045, Japan
    Carcinogenesis 33:1487-93. 2012
  5. pmc Diagnostic markers of urothelial cancer based on DNA methylation analysis
    Yoshitomo Chihara
    Department of Molecular Pathology, Nara Medical University, 840, Shijyo cho, Kashihara, Japan
    BMC Cancer 13:275. 2013
  6. ncbi request reprint Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state
    Yae Kanai
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 28:2434-42. 2007
  7. doi request reprint Genome-wide DNA methylation profiles in precancerous conditions and cancers
    Yae Kanai
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 101:36-45. 2010
  8. ncbi request reprint Alterations in gene expression associated with the overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, during human hepatocarcinogenesis
    Yae Kanai
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, 104 0045, Tokyo, Japan
    J Cancer Res Clin Oncol 130:636-44. 2004
  9. doi request reprint Alterations of DNA methylation and clinicopathological diversity of human cancers
    Yae Kanai
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Pathol Int 58:544-58. 2008
  10. ncbi request reprint Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers
    Yae Kanai
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Lett 192:75-82. 2003

Collaborators

Detail Information

Publications94

  1. ncbi request reprint Loss of blood group A antigen expression in bladder cancer caused by allelic loss and/or methylation of the ABO gene
    Yoshitomo Chihara
    Oncogene Research Unit Cancer Prevention Unit, Tochigi Cancer Center Research Institute, Tochigi 320 0834, Japan
    Lab Invest 85:895-907. 2005
    ....
  2. pmc Prognostication of patients with clear cell renal cell carcinomas based on quantification of DNA methylation levels of CpG island methylator phenotype marker genes
    Ying Tian
    Division of Molecular Pathology, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    BMC Cancer 14:772. 2014
    ..The aim of this study was to establish criteria for prognostication of patients with ccRCCs using the ccRCC-specific CIMP marker genes...
  3. pmc DNA methyltransferase 3B expression is associated with poor outcome of stage I testicular seminoma
    Eri Arai
    Division of Molecular Pathology, National Cancer Center Research Institute, National Cancer Center Hospital, Tokyo, Japan
    Histopathology 60:E12-8. 2012
    ....
  4. pmc Single-CpG-resolution methylome analysis identifies clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas
    Eri Arai
    Division of Molecular Pathology, National Cancer Center Research Institute Tokyo 104 0045, Japan
    Carcinogenesis 33:1487-93. 2012
    ..Accumulation of DNA hypermethylation on CpG islands and genome-wide DNA hypomethylation may each underlie distinct pathways of renal carcinogenesis...
  5. pmc Diagnostic markers of urothelial cancer based on DNA methylation analysis
    Yoshitomo Chihara
    Department of Molecular Pathology, Nara Medical University, 840, Shijyo cho, Kashihara, Japan
    BMC Cancer 13:275. 2013
    ..We aimed to establish diagnostic markers for UC based on DNA methylation...
  6. ncbi request reprint Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state
    Yae Kanai
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 28:2434-42. 2007
    ..Correction of DNA methylation status may offer a new strategy for prevention and therapy of cancers...
  7. doi request reprint Genome-wide DNA methylation profiles in precancerous conditions and cancers
    Yae Kanai
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 101:36-45. 2010
    ..Therefore, genome-wide DNA methylation profiling may provide optimal indicators for carcinogenetic risk estimation and prognostication, and thus provide an avenue for cancer prevention and therapy on an individual basis...
  8. ncbi request reprint Alterations in gene expression associated with the overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, during human hepatocarcinogenesis
    Yae Kanai
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, 104 0045, Tokyo, Japan
    J Cancer Res Clin Oncol 130:636-44. 2004
    ..We aimed to elucidate further the significance of DNMT3b4 during human hepatocarcinogenesis...
  9. doi request reprint Alterations of DNA methylation and clinicopathological diversity of human cancers
    Yae Kanai
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Pathol Int 58:544-58. 2008
    ..Genome-wide analysis of DNA methylation status based on array-based technology may identify DNA methylation profiles that can be used as appropriate indicators for carcinogenetic risk estimation and prognostication...
  10. ncbi request reprint Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers
    Yae Kanai
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Lett 192:75-82. 2003
    ..These data suggest that mutational inactivation of the DNMT1 gene that potentially causes a genome-wide alteration of DNA methylation status may be a rare event during human carcinogenesis...
  11. doi request reprint CUB domain-containing protein 1, a prognostic factor for human pancreatic cancers, promotes cell migration and extracellular matrix degradation
    Yuri Miyazawa
    Growth Factor Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 70:5136-46. 2010
    ....
  12. doi request reprint Combined functional genome survey of therapeutic targets for hepatocellular carcinoma
    Reiko Satow
    Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan
    Clin Cancer Res 16:2518-28. 2010
    ..The outcome of patients with advanced hepatocellular carcinoma (HCC) has remained unsatisfactory. Patients with HCC suffer from chronic hepatitis or liver cirrhosis, and their reserve liver function is often limited...
  13. doi request reprint Genome-wide DNA methylation profiles in liver tissue at the precancerous stage and in hepatocellular carcinoma
    Eri Arai
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 125:2854-62. 2009
    ..Genome-wide alterations of DNA methylation may participate in hepatocarcinogenesis from the precancerous stage, and DNA methylation profiling may provide optimal indicators for carcinogenetic risk estimation and prognostication...
  14. doi request reprint Genetic clustering of clear cell renal cell carcinoma based on array-comparative genomic hybridization: its association with DNA methylation alteration and patient outcome
    Eri Arai
    Pathology Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Clin Cancer Res 14:5531-9. 2008
    ..The aim of this study was to clarify genetic and epigenetic alterations occurring during renal carcinogenesis...
  15. doi request reprint Podoplanin expression identified in stromal fibroblasts as a favorable prognostic marker in patients with colorectal carcinoma
    Takahiro Yamanashi
    Pathology Division, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Oncology 77:53-62. 2009
    ..We investigated the clinicopathological significance of podoplanin expression in stromal fibroblasts in patients with colorectal cancer (CRC)...
  16. ncbi request reprint Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome
    Panayiotis Loukopoulos
    Pathology Division, National Cancer Center Research Institute, 51 1, Tsukiji, Chuo Ku, Tokyo, USA
    Cancer Sci 98:392-400. 2007
    ..Our results contribute to a complete description of genomic structural aberrations and the identification of potential therapeutic targets and genetic indicators that predict patient outcome in pancreatic adenocarcinoma...
  17. pmc Diagnosis and prognostication of ductal adenocarcinomas of the pancreas based on genome-wide DNA methylation profiling by bacterial artificial chromosome array-based methylated CpG island amplification
    Masahiro Gotoh
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Biomed Biotechnol 2011:780836. 2011
    ..Genome-wide DNA methylation profiling may provide optimal diagnostic markers and prognostic indicators for patients with PCs...
  18. pmc Genome-wide DNA methylation profiles in both precancerous conditions and clear cell renal cell carcinomas are correlated with malignant potential and patient outcome
    Eri Arai
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Carcinogenesis 30:214-21. 2009
    ..DNA methylation alterations in the precancerous stage may generate more malignant clear cell RCCs and determine patient outcome...
  19. doi request reprint Significance of PGP9.5 expression in cancer-associated fibroblasts for prognosis of colorectal carcinoma
    Yuri Akishima-Fukasawa
    National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Am J Clin Pathol 134:71-9. 2010
    ..These results indicate that PGP9.5 expression in CAFs is a helpful finding to represent the overall biologic behavior of advanced colorectal cancer...
  20. doi request reprint Genome-wide DNA methylation profiles in renal tumors of various histological subtypes and non-tumorous renal tissues
    Eri Arai
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Pathobiology 78:1-9. 2011
    ..The aim of this study is to clarify genome-wide DNA methylation profiles in renal tumors of various histological subtypes...
  21. ncbi request reprint Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: its association with clinicopathologic features
    Tatsuhiro Shibata
    Pathology Division, National Cancer Center Research Institute, Tsukjii, Tokyo, Japan
    Clin Cancer Res 11:6177-85. 2005
    ....
  22. doi request reprint Frequent inactivation of a putative tumor suppressor, angiopoietin-like protein 2, in ovarian cancer
    Ryoko Kikuchi
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Res 68:5067-75. 2008
    ..These results suggest that, at least partly, epigenetic silencing by hypermethylation of the ANGPTL2 promoter leads to a loss of ANGPTL2 function, which may be a factor in the carcinogenesis of OC in a stage-dependent manner...
  23. doi request reprint Frequent GNAS and KRAS mutations in pyloric gland adenoma of the stomach and duodenum
    Akiko Matsubara
    Pathology and Clinical Laboratories, National Cancer Centre Hospital, Tokyo, Japan
    J Pathol 229:579-87. 2013
    ..In particular, the present study identified the frequent presence of activating GNAS mutations, which are often associated with KRAS mutations, as a characteristic genetic feature of PGAs of the stomach and duodenum...
  24. doi request reprint MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma
    Yusuke Yamamoto
    Section for Studies on Metastasis, National Cancer Center Research Institute, 1 1 Tsukiji, 5 Chome, Chuo Ku, Tokyo 104 0045, Japan
    Biomarkers 14:529-38. 2009
    ..Our findings reveal that diverse changes of miRNAs occur during liver development and, one of these, miR-500 is an oncofetal miRNA relevant to the diagnosis of human HCC...
  25. doi request reprint Quantitative proteomics using formalin-fixed paraffin-embedded tissues of oral squamous cell carcinoma
    Ayako Negishi
    Chemotherapy Division, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Cancer Sci 100:1605-11. 2009
    ....
  26. doi request reprint Lobular endocervical glandular hyperplasia is a neoplastic entity with frequent activating GNAS mutations
    Akiko Matsubara
    Pathology and Clinical Laboratories, National Cancer Center Hospital Molecular Pathology Division, National Cancer Center Research Institute Division of Gynecology, National Cancer Center Hospital, Tokyo, Japan
    Am J Surg Pathol 38:370-6. 2014
    ..Although LEGH has been regarded as a metaplastic lesion, the frequent presence of genetic alterations suggests a neoplastic nature. ..
  27. ncbi request reprint Molecular markers and changes of computed tomography appearance in lung adenocarcinoma with ground-glass opacity
    Yukihiro Yoshida
    Cancer Genomics Project, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 37:907-12. 2007
    ..There is no consensus on the strategy for follow-up. Identification of the molecular mechanisms that are associated with the natural history of lung adenocarcinoma should provide useful information...
  28. pmc Epigenetic instability and chromosomal instability in hepatocellular carcinoma
    Hiroto Katoh
    Pathology Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Am J Pathol 168:1375-84. 2006
    ..Our results have clinical relevance because epigenetic instability-dependent HCCs may respond well to methylation inhibitory therapies...
  29. doi request reprint Pancreatic intraglandular metastasis predicts poorer outcome in postoperative patients with pancreatic ductal carcinoma
    Seiji Oguro
    Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan
    Am J Surg Pathol 37:1030-8. 2013
    ..002; hazard ratio=2.239; 95% confidence interval: 1.328-3.773). Our findings suggest that the presence of P-IM in patients with PDC is an independent prognosticator and may represent aggressive tumor behavior...
  30. doi request reprint Bile acids increase levels of microRNAs 221 and 222, leading to degradation of CDX2 during esophageal carcinogenesis
    Juntaro Matsuzaki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan Department of Internal Medicine, Saiseikai Central Hospital, Tokyo, Japan
    Gastroenterology 145:1300-11. 2013
    ..Reduced p27Kip1 increases degradation of the transcription factor CDX2; levels of CDX2 have been reported to decrease during progression of BE to EAC...
  31. ncbi request reprint Genetic inactivation of the APC gene contributes to the malignant progression of sporadic hepatocellular carcinoma: a case report
    Hiroto Katoh
    Cancer Genomics Project, National Cancer Center Research Institute, Tsukiji, Tokyo, Japan
    Genes Chromosomes Cancer 45:1050-7. 2006
    ....
  32. ncbi request reprint Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: identification of genetic indicators to predict patient outcome
    Hiroto Katoh
    Pathology Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, and Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Hepatol 43:863-74. 2005
    ..We conducted an analysis of chromosomal numerical aberrations and their clinical significance in hepatocellular carcinoma...
  33. ncbi request reprint Array-based comparative genomic hybridization analysis of high-grade neuroendocrine tumors of the lung
    Wei Xia Peng
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 96:661-7. 2005
    ..These results will be valuable for evaluating clinical status, including patient prognosis, and for identifying novel molecular targets for effective therapies...
  34. doi request reprint Ability of preoperative 3.0-Tesla magnetic resonance imaging to predict the absence of side-specific extracapsular extension of prostate cancer
    Tomohiko Hara
    Urology Division, National Cancer Center Hospital, Tokyo, Japan
    Int J Urol 20:993-9. 2013
    ..0-Tesla magnetic resonance imaging. We retrospectively assessed the ability of this imaging technique to predict side-specific extracapsular extension of prostate cancer...
  35. ncbi request reprint DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas
    Dun Fa Peng
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 27:1160-8. 2006
    ....
  36. doi request reprint Carcinogenetic risk estimation based on quantification of DNA methylation levels in liver tissue at the precancerous stage
    Ryo Nagashio
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 129:1170-9. 2011
    ..These criteria may be applicable for carcinogenetic risk estimation using liver biopsy specimens obtained from patients who are followed up because of chronic liver diseases...
  37. pmc Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers
    Tsuyoshi Etoh
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Am J Pathol 164:689-99. 2004
    ..Furthermore, DNMT1 may play a significant role in the development of poorly differentiated gastric cancers by inducing frequent DNA hypermethylation of multiple CpG islands...
  38. pmc Copy number alterations in urothelial carcinomas: their clinicopathological significance and correlation with DNA methylation alterations
    Naotaka Nishiyama
    Pathology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Carcinogenesis 32:462-9. 2011
    ..Both genetic and epigenetic events appear to accumulate during urothelial carcinogenesis, reflecting the clinicopathological diversity of UCs...
  39. ncbi request reprint Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas
    Yoshimasa Saito
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 105:527-32. 2003
    ..Increased DNMT1 protein expression may play a critical role in the malignant progression of HCCs and be a biologic predictor of both HCC recurrence and a poor prognosis in HCC patients...
  40. pmc DNA methylation profiles at precancerous stages associated with recurrence of lung adenocarcinoma
    Takashi Sato
    Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan
    PLoS ONE 8:e59444. 2013
    ..These data suggest that DNA methylation alterations at precancerous stages determine tumor aggressiveness and outcome through silencing of specific genes...
  41. ncbi request reprint Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas
    Dun Fa Peng
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 96:403-8. 2005
    ....
  42. ncbi request reprint DNA hypomethylation on pericentromeric satellite regions significantly correlates with loss of heterozygosity on chromosome 9 in urothelial carcinomas
    Tohru Nakagawa
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Urol 173:243-6. 2005
    ..We elucidated the significance of aberrant DNA methylation on pericentromeric satellite regions during urothelial carcinogenesis...
  43. doi request reprint Dicer is required for proper liver zonation
    Shigeki Sekine
    Pathology Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo, Japan
    J Pathol 219:365-72. 2009
    ..Dicer is essential for the suppression of periportal proteins by Wnt/beta-catenin/TCF signalling, albeit it likely acts in an indirect manner...
  44. doi request reprint Intraductal carcinosarcoma with a heterologous mesenchymal component originating in intraductal papillary-mucinous carcinoma (IPMC) of the pancreas with both carcinoma and osteosarcoma cells arising from IPMC cells
    Jun Okamura
    Pathology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    J Clin Pathol 63:266-9. 2010
    ..This is the first report of a carcinosarcoma originating in IPMC. These findings imply that carcinosarcoma with a heterologous mesenchymal component is of ductal origin...
  45. pmc CUB-domain-containing protein 1 regulates peritoneal dissemination of gastric scirrhous carcinoma
    Takamasa Uekita
    National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Am J Pathol 172:1729-39. 2008
    ..Therefore, it is both a potential prognostic and therapeutic target in certain types of gastrointestinal cancers, and suppression of its phosphorylation might be a useful strategy for modulating cancer metastasis...
  46. doi request reprint Pancreatic ducts as an important route of tumor extension for acinar cell carcinoma of the pancreas
    Daisuke Ban
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Am J Surg Pathol 34:1025-36. 2010
    ..These findings suggest that a significant proportion of ACC shows IPG, which is potentially linked to less aggressive clinicopathologic characteristics...
  47. doi request reprint Minimally invasive intraductal papillary-mucinous carcinoma of the pancreas: clinicopathologic study of 104 intraductal papillary-mucinous neoplasms
    Satoshi Nara
    Pathology Division, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Am J Surg Pathol 32:243-55. 2008
    ..These findings suggest that a category of MI-IPMC provides more accurate and useful information of the stage and the aggressiveness of I-IPMC...
  48. ncbi request reprint FOXP3+ regulatory T cells affect the development and progression of hepatocarcinogenesis
    Noritoshi Kobayashi
    Pathology Division, National Cancer Center Research Institute, National Cancer Center Hospital, Tokyo, and Gastroenterology Division, Yokohama City University Hospital, Yokohama, Japan
    Clin Cancer Res 13:902-11. 2007
    ..CD4+CD25+FOXP3+ regulatory T cells (Tregs) suppress the immune reaction. The aim of the present study was to investigate the clinicopathologic significance and roles of Tregs and CD8+ T cells during hepatocarcinogenesis...
  49. doi request reprint CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis
    Nobuyoshi Hiraoka
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 140:310-21. 2011
    ..We investigated when and how the human anti-tumor immune reaction changes during pancreatic tumor development...
  50. ncbi request reprint Clinicopathologic significance of dysadherin expression in cutaneous malignant melanoma: immunohistochemical analysis of 115 patients
    Aya Nishizawa
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer 103:1693-700. 2005
    ..Recently, the authors reported a novel cell membrane glycoprotein, dysadherin, which has an anti-cell-cell adhesion function and down-regulates E-cadherin...
  51. ncbi request reprint Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma
    Nobuhiro Nitori
    Pathology, National Cancer Center Research Institute, Tokyo, Japan
    Clin Cancer Res 11:2531-9. 2005
    ....
  52. ncbi request reprint Prognostic significance of dysadherin expression in tongue cancer: immunohistochemical analysis of 91 cases
    Yukihiro Nakanishi
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Appl Immunohistochem Mol Morphol 12:323-8. 2004
    ..0006). Increased dysadherin expression is a significant indicator of poor prognosis in patients with squamous cell carcinoma of the tongue...
  53. doi request reprint Genome-wide DNA methylation profiles in urothelial carcinomas and urothelia at the precancerous stage
    Naotaka Nishiyama
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 101:231-40. 2010
    ....
  54. ncbi request reprint Dysadherin expression facilitates cell motility and metastatic potential of human pancreatic cancer cells
    Takeshi Shimamura
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 64:6989-95. 2004
    ..Our study suggests that dysadherin is able to modulate actin structures, stimulate cell motility, and contribute directly to the metastatic potential of human pancreatic cancer cells...
  55. doi request reprint Expression of a splicing variant of the CADM1 specific to small cell lung cancer
    Shinji Kikuchi
    Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Sci 103:1051-7. 2012
    ..These findings suggest that CADM1 enhances the malignant features of SCLC, as is observed in ATL, and could provide a molecular marker specific to SCLC...
  56. ncbi request reprint Prognostic value of tumor architecture, tumor-associated vascular characteristics, and expression of angiogenic molecules in pancreatic endocrine tumors
    Yu Takahashi
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Clin Cancer Res 13:187-96. 2007
    ..It is difficult to predict the biological behavior of pancreatic endocrine tumors (PETs). Our aim was to evaluate the prognostic significance of certain variables in PETs...
  57. doi request reprint Establishment of six new human biliary tract carcinoma cell lines and identification of MAGEH1 as a candidate biomarker for predicting the efficacy of gemcitabine treatment
    Hidenori Ojima
    Pathology Division, Clinical Trials and Practice Support Division, Center for Cancer Control and Information Services, National Cancer Center, Chuo Ku, Tokyo, Japan
    Cancer Sci 101:882-8. 2010
    ..Negative expression of MAGEH1 protein serves as a potential predictive marker for the effectiveness of gemcitabine therapy in BTC...
  58. doi request reprint Solitary hepatic lymphangioma: report of a case
    Takuya Matsumoto
    Pathology Division, National Cancer Center Hospital, Tokyo, Japan
    Surg Today 40:883-9. 2010
    ..This case is presented with details of the pathologic and radiologic findings, because solitary hepatic lymphangioma is an extremely rare tumor and no previous reports have provided details of the immunohistochemical characteristics...
  59. ncbi request reprint DNA hypermethylation on multiple CpG islands associated with increased DNA methyltransferase DNMT1 protein expression during multistage urothelial carcinogenesis
    Tohru Nakagawa
    Pathology Division, National Cancer Center Research Institute, Department of Urology, Faculty of Medicine, Tokyo University, Tokyo, Japan
    J Urol 173:1767-71. 2005
    ..We elucidated the significance of aberrant DNA methylation on multiple CpG islands and its correlation with DNA methyltransferase DNMT1 protein expression during urothelial carcinogenesis...
  60. pmc Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis
    Shigeki Sekine
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 136:2304-2315.e1-4. 2009
    ..We describe experiments to address the physiologic roles of these new regulators of gene expression in the liver that are as of yet largely undefined...
  61. pmc Cytoplasmic p120ctn regulates the invasive phenotypes of E-cadherin-deficient breast cancer
    Tatsuhiro Shibata
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Am J Pathol 164:2269-78. 2004
    ..Collectively, our results suggest that cytoplasmic p120ctn may contribute to the invasive phenotype of E-cadherin-deficient breast cancer cells...
  62. pmc Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis
    Yoshimasa Saito
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Proc Natl Acad Sci U S A 99:10060-5. 2002
    ....
  63. doi request reprint A new formula for predicting liver metastasis in patients with colorectal cancer: immunohistochemical analysis of a large series of 439 surgically resected cases
    Hiroki Ochiai
    Divisions of Pathology, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Oncology 75:32-41. 2008
    ..The purpose of this study was to establish a new formula predicting liver metastasis in patients with colorectal cancer (CRC)...
  64. pmc Alterations of the spindle checkpoint pathway in clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas
    Eri Arai
    Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 137:2589-606. 2015
    ..These data suggest that abnormalities of the spindle checkpoint pathway participate in CIMP-positive renal carcinogenesis, and that AURKA and AURKB may be potential therapeutic targets in more aggressive CIMP-positive RCCs...
  65. doi request reprint Bile duct carcinoma involving the common channel associated with pancreaticobiliary maljunction shows an extension pattern similar to ductal carcinoma of the pancreas
    Nao Yoshida
    Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan
    Pathol Int 63:415-8. 2013
    ..During the follow-up of patients with PBM, attention should be paid to involvement of the common channel by BD cancer and also to cancer developing silently in the pancreas after extrahepatic BD resection. ..
  66. ncbi request reprint Regional DNA hypermethylation and DNA methyltransferase (DNMT) 1 protein overexpression in both renal tumors and corresponding nontumorous renal tissues
    Eri Arai
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 119:288-96. 2006
    ..Regional DNA hypermethylation may be associated with renal tumorigenesis from a precancerous condition to malignant progression and become a predictor of patient prognosis...
  67. doi request reprint Intraductal dissemination of papillary adenocarcinoma of the ampulla of Vater in the pancreatic duct
    Akiko Matsubara
    Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan
    Pathol Int 64:39-44. 2014
    ..These results imply that this papillary adenocarcinoma of the ampulla of Vater had disseminated to the pancreatic duct in a retrograde manner and recurred in the remnant pancreas. ..
  68. doi request reprint Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in gastric cancer
    Kazuhiro Yamanoi
    Department of Pathology, Keio University, Tokyo, Japan
    Pathol Int 63:13-9. 2013
    ..These results suggest that LGR5 can be a biomarker for malignancy in gastric cancer...
  69. doi request reprint The tumor suppressor microRNA-29c is downregulated and restored by celecoxib in human gastric cancer cells
    Yoshimasa Saito
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Int J Cancer 132:1751-60. 2013
    ..Selective COX-2 inhibitors may have clinical promise for the treatment of gastric cancer via restoration of miR-29c...
  70. ncbi request reprint Increased expression of DNA methyltransferase 1 (DNMT1) protein in uterine cervix squamous cell carcinoma and its precursor lesion
    Morio Sawada
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Lett 251:211-9. 2007
    ..2304). These data suggest that progressively increasing expression of DNMT1 protein is not entirely a secondary result of increased cell proliferative activity, but is associated with an early step of multistage cervical carcinogenesis...
  71. ncbi request reprint Solid-pseudopapillary neoplasms of the pancreas in men and women: do they differ?
    Yu Takahashi
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    Virchows Arch 448:561-9. 2006
    ..Nuclear accumulation of beta-catenin appears to be a useful marker of SPN, which allows male SPNs to be correctly diagnosed despite their less typical features...
  72. ncbi request reprint Laminin 5 beta3 and gamma2 chains are frequently coexpressed in cancer cells
    Shingo Akimoto
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Pathol Int 54:688-92. 2004
    ..0001). These results suggest that in squamous cell carcinoma of the tongue and colorectal carcinoma, laminin 5 gamma2 chain and beta3 chain are both important in the invasiveness of cancer cells...
  73. doi request reprint Prognostic significance of CXCL12 expression in patients with colorectal carcinoma
    Yuri Akishima-Fukasawa
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Am J Clin Pathol 132:202-10; quiz 307. 2009
    ..Furthermore, together with lymph node metastasis, a combination of both expression patterns was a more powerful independent prognostic factor...
  74. doi request reprint Prostate stem cell antigen, a presumable organ-dependent tumor suppressor gene, is down-regulated in gallbladder carcinogenesis
    Hiroe Ono
    Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan
    Genes Chromosomes Cancer 51:30-41. 2012
    ..These lines of in vivo and in vitro evidence suggest that PSCA is acting as a tumor suppressor in GBC development...
  75. ncbi request reprint Promoter hypermethylation of the potential tumor suppressor DAL-1/4.1B gene in renal clear cell carcinoma
    Daisuke Yamada
    Tumor Suppression and Functional Genomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 118:916-23. 2006
    ..038, relative risk 10.5). These results indicate that the promoter methylation of the 4.1B is one of the most frequent epigenetic alterations in RCCC and could predict the metastatic recurrence of the surgically resected RCCC...
  76. ncbi request reprint Mutations of the epidermal growth factor receptor gene in atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung
    Yukihiro Yoshida
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Lung Cancer 50:1-8. 2005
    ..In all cases each lesion had a different mutation status. This finding suggests that the genetic alterations responsible for the development of lung adenocarcinoma occur randomly even under exposure to the same carcinogen...
  77. ncbi request reprint Expression status of RUNX1/AML1 in normal gastric epithelium and its mutational analysis in microdissected gastric cancer cells
    Takebumi Usui
    Genetics Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Int J Oncol 29:779-84. 2006
    ..These results suggest that the transcriptional target genes are different between these two family genes...
  78. ncbi request reprint Primary adenocarcinoma of the rete testis with preceding diagnosis of pulmonary metastases
    Tohru Nakagawa
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Int J Urol 13:1532-5. 2006
    ..The diagnosis is often delayed because of non-specific clinical presentation and symptoms. We cannot forget that rete testis is a possible primary site for a primary, unknown metastatic adenocarcinoma...
  79. doi request reprint Characteristics of prostate cancers found in specimens removed by radical cystoprostatectomy for bladder cancer and their relationship with serum prostate-specific antigen level
    Tohru Nakagawa
    Urology Division, National Cancer Center Hospital, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 100:1880-4. 2009
    ..PSA still appears to be a useful screening tool for detecting prostate cancers with significant volume...
  80. doi request reprint Metaplastic carcinoma of the breast
    Nao Okada
    Pathology Consultation Service, Clinical Trials and Practice Support Division, Center for Cancer Control and Information Services, National Cancer Center, Tokyo 104 0045, Japan
    Hum Pathol 41:960-70. 2010
    ....
  81. ncbi request reprint Cell adhesion system and human cancer morphogenesis
    Setsuo Hirohashi
    Pathology Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 94:575-81. 2003
    ..In conclusion, inactivation of the E-cadherin cell adhesion system by both genetic and epigenetic mechanisms plays a significant role during multistage human carcinogenesis...
  82. ncbi request reprint 5-aza-2'-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis
    Jeong Seok Nam
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Clin Exp Metastasis 21:49-56. 2004
    ..Therefore, inhibition of DNA methylation may be useful for preventing cancer metastasis...
  83. pmc Correlation of DNA hypomethylation at pericentromeric heterochromatin regions of chromosomes 16 and 1 with histological features and chromosomal abnormalities of human breast carcinomas
    Hitoshi Tsuda
    Pathology Division, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Am J Pathol 161:859-66. 2002
    ..On the contrary, chromosome instability induced by mechanisms other than DNA hypomethylation in heterochromatin regions might cause the formation of der(16)t(1;16)/der(1;16) and less aggressive breast carcinomas...
  84. ncbi request reprint Overexpression of KIT in chromophobe renal cell carcinoma
    Ken Yamazaki
    Cancer Genomics Division, National Cancer Center Research Institute, Tokyo, Japan
    Oncogene 22:847-52. 2003
    ..As overexpression of KIT might be involved in tumor growth, KIT could be a new therapeutic target in this special type of RCC...
  85. ncbi request reprint Downregulation and growth inhibitory effect of epithelial-type Kr├╝ppel-like transcription factor KLF4, but not KLF5, in bladder cancer
    Shunsuke Ohnishi
    Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Biochem Biophys Res Commun 308:251-6. 2003
    ..The transduction of KLF4, but not KLF5, suppressed cell growth and induced apoptosis. Our study suggests that inactivation of KLF4 is one of the frequent steps towards bladder carcinogenesis...
  86. pmc Beta-catenin mutations are frequent in calcifying odontogenic cysts, but rare in ameloblastomas
    Shigeki Sekine
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukuji, Chuo Ku, Tokyo 104 0045, Japan
    Am J Pathol 163:1707-12. 2003
    ..Although ameloblastoma closely resembles COC histologically, the two have genetically distinctive features...
  87. ncbi request reprint Invasive biliary cystic tumor without ovarian-like stroma
    Yuji Ishibashi
    Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Pathol Int 57:794-8. 2007
    ..On the basis of the World Health Organization histological classification and these pathological findings, the present case was diagnosed as invasive-type biliary cystadenocarcinoma...
  88. ncbi request reprint Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder
    Tohru Nakagawa
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    J Urol 170:2463-6. 2003
    ..We elucidated the significance of aberrant protein expression of DNA methyltransferase (DNMT) 1, a major enzyme involved in the determination of genomic methylation patterns, during human urothelial carcinogenesis...
  89. doi request reprint Long-term recurrence-free survival in a patient with primary hepatic carcinosarcoma: case report with a literature review
    Yusuke Yamamoto
    Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Central Hospital, Tokyo, Japan
    Jpn J Clin Oncol 40:166-73. 2010
    ..Since relatively early-stage hepatic carcinosarcoma rarely seems to present as a small tumor showing a concentric growth pattern, we report this case with a review of the literature...
  90. ncbi request reprint Hypermethylation of an E-cadherin (CDH1) promoter region in high grade transitional cell carcinoma of the bladder comprising carcinoma in situ
    Yohei Horikawa
    Oncogene Research Unit Cancer Prevention Unit, Tochigi Cancer Center Research Institute and Department of Urology, Tochigi Cancer Hospital, Japan
    J Urol 169:1541-5. 2003
    ..We elucidated the role of methylation in the promoter region of the 1 gene in bladder carcinogenesis, particularly in those comprising carcinoma in situ...
  91. ncbi request reprint Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer
    Ryoko Kikuchi
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Japan
    Cancer Res 67:7095-105. 2007
    ....
  92. doi request reprint Overexpression of HDACs: a prognostic marker for gastric cancer identified by tissue microarray
    Yae Kanai
    Lancet Oncol 9:91-3. 2008
  93. ncbi request reprint Sensitive detection of FGFR3 mutations in bladder cancer and urine sediments by peptide nucleic acid-mediated real-time PCR clamping
    Makito Miyake
    Oncogene Research Unit Cancer Prevention Unit, Tochigi Cancer Center Research Institute, 4 9 13 Yonan, Utsunomiya, Tochigi 320 0834, Japan
    Biochem Biophys Res Commun 362:865-71. 2007
    ..3%) tumor tissues and 11 of 13 (84.6%) urine samples from patients with superficial bladder cancer, while no mutations were detected in tissues and/or urine samples from patients with muscle-invasive bladder cancer or chronic cystitis...