Shinji Miura

Summary

Affiliation: National Institute of Infectious Diseases
Country: Japan

Publications

  1. pmc Overexpression of peroxisome proliferator-activated receptor gamma co-activator-1alpha leads to muscle atrophy with depletion of ATP
    Shinji Miura
    Nutritional Science Program, National Institute of Health and Nutrition, 1 23 1, Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Am J Pathol 169:1129-39. 2006
  2. doi request reprint Alpha2-AMPK activity is not essential for an increase in fatty acid oxidation during low-intensity exercise
    Shinji Miura
    Nutritional Science Program, National Institute of Health and Nutrition, 1 23 1, Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Am J Physiol Endocrinol Metab 296:E47-55. 2009
  3. doi request reprint Isoform-specific increases in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to beta2-adrenergic receptor activation and exercise
    Shinji Miura
    National Institute of Health and Nutrition, Tokyo 162 8636, Japan
    Endocrinology 149:4527-33. 2008
  4. ncbi request reprint An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation
    Shinji Miura
    Nutritional Science Program, National Institute of Health and Nutrition, 1 23 1, Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Endocrinology 148:3441-8. 2007
  5. ncbi request reprint Sterol-mediated regulation of hormone-sensitive lipase in 3T3-L1 adipocytes
    Shinji Miura
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422, Japan
    Lipids 38:743-50. 2003
  6. ncbi request reprint Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control
    Yasutomi Kamei
    PRESTO, Japan Science and Technology Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    J Biol Chem 279:41114-23. 2004
  7. doi request reprint Increased expression of DNA methyltransferase 3a in obese adipose tissue: studies with transgenic mice
    Yasutomi Kamei
    Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Obesity (Silver Spring) 18:314-21. 2010
  8. ncbi request reprint Nuclear factor 1 regulates adipose tissue-specific expression in the mouse GLUT4 gene
    Shinji Miura
    Division of Clinical Nutrition, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Biochem Biophys Res Commun 325:812-8. 2004
  9. pmc Skeletal muscle-specific expression of PGC-1α-b, an exercise-responsive isoform, increases exercise capacity and peak oxygen uptake
    Miki Tadaishi
    Department of Nutritional Science, National Institute of Health and Nutrition, Tokyo, Japan
    PLoS ONE 6:e28290. 2011
  10. ncbi request reprint Increased very low density lipoprotein secretion and gonadal fat mass in mice overexpressing liver DGAT1
    Tomomi Yamazaki
    Division of Clinical Nutrition, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    J Biol Chem 280:21506-14. 2005

Collaborators

Detail Information

Publications37

  1. pmc Overexpression of peroxisome proliferator-activated receptor gamma co-activator-1alpha leads to muscle atrophy with depletion of ATP
    Shinji Miura
    Nutritional Science Program, National Institute of Health and Nutrition, 1 23 1, Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Am J Pathol 169:1129-39. 2006
    ..Our results indicate that overexpression of PGC-1alpha in skeletal muscle increases not only mitochondrial biogenesis but also uncoupling of respiration, resulting in muscle atrophy...
  2. doi request reprint Alpha2-AMPK activity is not essential for an increase in fatty acid oxidation during low-intensity exercise
    Shinji Miura
    Nutritional Science Program, National Institute of Health and Nutrition, 1 23 1, Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Am J Physiol Endocrinol Metab 296:E47-55. 2009
    ..These findings suggest that an increased alpha(2)-AMPK activity is not essential for increased skeletal muscle fatty acid oxidation during endurance exercise...
  3. doi request reprint Isoform-specific increases in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to beta2-adrenergic receptor activation and exercise
    Shinji Miura
    National Institute of Health and Nutrition, Tokyo 162 8636, Japan
    Endocrinology 149:4527-33. 2008
    ..These data indicate that AR activation is a major mechanism of an increase in PGC-1alpha expression in skeletal muscles, and the increase in PGC-1alpha mRNAs was isoform specific...
  4. ncbi request reprint An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation
    Shinji Miura
    Nutritional Science Program, National Institute of Health and Nutrition, 1 23 1, Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Endocrinology 148:3441-8. 2007
    ..These data indicate that up-regulation of PGC-1alpha expression in skeletal muscle by exercise is mediated, at least in part, by beta-ARs activation. Among ARs, beta2-AR may mediate an increase in PGC-1alpha by exercise...
  5. ncbi request reprint Sterol-mediated regulation of hormone-sensitive lipase in 3T3-L1 adipocytes
    Shinji Miura
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422, Japan
    Lipids 38:743-50. 2003
    ..Sterol-mediated proteolysis may be involved in the loss of HSL protein...
  6. ncbi request reprint Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control
    Yasutomi Kamei
    PRESTO, Japan Science and Technology Agency, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    J Biol Chem 279:41114-23. 2004
    ..Activation of FOXO1 may be involved in the pathogenesis of sarcopenia, the age-related decline in muscle mass in humans, which leads to obesity and diabetes...
  7. doi request reprint Increased expression of DNA methyltransferase 3a in obese adipose tissue: studies with transgenic mice
    Yasutomi Kamei
    Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Obesity (Silver Spring) 18:314-21. 2010
    ..The data highlight the potential role of Dnmt3a in the adult tissue as well as in the developing embryo and cancer...
  8. ncbi request reprint Nuclear factor 1 regulates adipose tissue-specific expression in the mouse GLUT4 gene
    Shinji Miura
    Division of Clinical Nutrition, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Biochem Biophys Res Commun 325:812-8. 2004
    ..We propose a model that explains the requirement for both the ASE and the NF1-binding site for expression of GLUT4 in WAT...
  9. pmc Skeletal muscle-specific expression of PGC-1α-b, an exercise-responsive isoform, increases exercise capacity and peak oxygen uptake
    Miki Tadaishi
    Department of Nutritional Science, National Institute of Health and Nutrition, Tokyo, Japan
    PLoS ONE 6:e28290. 2011
    ..We investigated whether alterations of skeletal muscle metabolism by overexpression of PGC-1α-b in skeletal muscle, but not heart, would increase VO(2max) and exercise capacity...
  10. ncbi request reprint Increased very low density lipoprotein secretion and gonadal fat mass in mice overexpressing liver DGAT1
    Tomomi Yamazaki
    Division of Clinical Nutrition, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    J Biol Chem 280:21506-14. 2005
    ..These results indicate that DGAT1 but not DGAT2 has a role in VLDL synthesis and that increased plasma VLDL concentrations may promote obesity, whereas increased DGAT2 activity has a role in steatosis...
  11. doi request reprint Marked phenotypic differences of endurance performance and exercise-induced oxygen consumption between AMPK and LKB1 deficiency in mouse skeletal muscle: changes occurring in the diaphragm
    Shinji Miura
    Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Am J Physiol Endocrinol Metab 305:E213-29. 2013
    ..LKB1 mediated the change of fiber-type distribution in the diaphragm independently of AMPK and might be responsible for the phenotypes we observed. ..
  12. doi request reprint Dietary β-conglycinin prevents fatty liver induced by a high-fat diet by a decrease in peroxisome proliferator-activated receptor γ2 protein
    Tomomi Yamazaki
    Nutritional Science Program, National Institute of Health and Nutrition, Tokyo 162 8636, Japan
    J Nutr Biochem 23:123-32. 2012
    ..In conclusion, β-conglycinin effectively prevents fatty liver induced by a high-fat diet through a decrease in liver PPARγ2 protein...
  13. ncbi request reprint Effects of fish oil feeding and fasting on LXRalpha/RXRalpha binding to LXRE in the SREBP-1c promoter in mouse liver
    Teruyo Nakatani
    Division of Clinical Nutrition, National Institute of Health and Nutrition, 1 23 1, Toyama, Tokyo 162 8636, Japan
    Biochim Biophys Acta 1736:77-86. 2005
    ....
  14. ncbi request reprint Overexpression of peroxisome proliferator-activated receptor gamma coactivator-1alpha down-regulates GLUT4 mRNA in skeletal muscles
    Shinji Miura
    Division of Clinical Nutrition, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    J Biol Chem 278:31385-90. 2003
    ..Thus, an increase of PGC-1alpha plays a role in increasing mitochondrial biogenesis and fatty acid oxidation but not in increasing GLUT4 mRNA in skeletal muscles...
  15. ncbi request reprint Up-regulation of SREBP-1c and lipogenic genes in skeletal muscles after exercise training
    Shinobu Ikeda
    Division of Clinical Nutrition, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo, Japan
    Biochem Biophys Res Commun 296:395-400. 2002
    ..These data indicate that SREBP-1c, a key transcription factor of liver triglyceride synthesis, might also be responsible for skeletal muscle triglyceride synthesis after chronic exercise training...
  16. ncbi request reprint A forkhead transcription factor FKHR up-regulates lipoprotein lipase expression in skeletal muscle
    Yasutomi Kamei
    PRESTO, Japan Science and Technology Corporation, National Institute of Health and Nutrition, 1 23 1, Toyama Shinjuku ku, Tokyo 162 863, Japan
    FEBS Lett 536:232-6. 2003
    ..Ectopic expression of FKHR enhanced LPL gene expression in C2C12 muscle cells in culture. These results implicate FKHR as an important modulator of lipid metabolism in skeletal muscle...
  17. pmc Role of DNA methylation in the regulation of lipogenic glycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver
    Tatsuya Ehara
    Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Diabetes 61:2442-50. 2012
    ....
  18. ncbi request reprint Regulatory sequence elements of mouse GLUT4 gene expression in adipose tissues
    Shinji Miura
    Division of Clinical Nutrition, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Biochem Biophys Res Commun 312:277-84. 2003
    ..High-fat diet feeding down-regulated GLUT4 minigene mRNA in -701 transgenic mice, but not in -551 transgenic mice, indicating that HFRE is located within 150 bp between bases -701 and -551 of the GLUT4 gene and is distinct from ASE...
  19. doi request reprint Overexpression of FOXO1 in skeletal muscle does not alter longevity in mice
    Tsuyoshi Chiba
    Nutritional Science Program, National Institute of Health and Nutrition, Shinjuku ku, Tokyo, Japan
    Mech Ageing Dev 130:420-8. 2009
    ..These data suggest that an increase in FOXO1 protein and its activation in skeletal muscle does not extend lifespan in mice...
  20. doi request reprint Fish oil fed prior to ethanol administration prevents acute ethanol-induced fatty liver in mice
    Satoshi Wada
    Nutritional Science Program, National Institute of Health and Nutrition, 1 23 1, Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    J Hepatol 49:441-50. 2008
    ..We examined whether dietary fish oil can prevent acute ethanol (alcohol)-induced fatty liver...
  21. doi request reprint Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1α mRNA: a role of β₂-adrenergic receptor activation
    Miki Tadaishi
    National Institute of Health and Nutrition, Tokyo, Japan
    Am J Physiol Endocrinol Metab 300:E341-9. 2011
    ..Exercise or AICAR injection increased PGC-1α-b and PGC-1α-c mRNAs via β₂-AR activation, whereas high-intensity exercise increased PGC-1α-a expression by a multiple mechanism in which α2-AMPK is one of the signaling pathways...
  22. pmc Increased systemic glucose tolerance with increased muscle glucose uptake in transgenic mice overexpressing RXRγ in skeletal muscle
    Satoshi Sugita
    Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 6:e20467. 2011
    ..Previously, we established transgenic mice overexpressing RXRγ in skeletal muscle (RXRγ mice), which showed lower blood glucose than the control mice. Here we investigated their glucose metabolism...
  23. ncbi request reprint Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner
    Yasutomi Kamei
    Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Tokyo, Japan
    FEBS Lett 581:91-6. 2007
    ..We also demonstrated that the abundantly expressed Peg1/Mest in obese adipose tissue retained monoallelic expression. This is the first report of monoallelic induction of Peg1/Mest in adult tissues...
  24. doi request reprint An increase in liver PPARγ2 is an initial event to induce fatty liver in response to a diet high in butter: PPARγ2 knockdown improves fatty liver induced by high-saturated fat
    Tomomi Yamazaki
    Nutritional Science Program, National Institute of Health and Nutrition, Tokyo 162 8636, Japan
    J Nutr Biochem 22:543-53. 2011
    ..Inactivation of PPARγ2 may improve fatty liver induced by HF saturated fat...
  25. doi request reprint Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2
    Iori Sakakibara
    Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan
    Cell Metab 9:191-202. 2009
    ..Our findings demonstrate that activation of acetate by AceCS2 plays a pivotal role in thermogenesis, especially under low-glucose or ketogenic conditions, and is crucially required for survival...
  26. pmc PGC-1α-mediated branched-chain amino acid metabolism in the skeletal muscle
    Yukino Hatazawa
    Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan Laboratory of Molecular Nutrition, Graduate School of Environmental and Life Science, Kyoto Prefectural University, Kyoto, Japan
    PLoS ONE 9:e91006. 2014
    ..In C2C12 cells, the overexpression of PGC-1α significantly increased the expression of BCAT2 and BCKDH but not BCKDK. Thus, PGC-1α in the skeletal muscle is considered to significantly contribute to BCAA metabolism. ..
  27. doi request reprint Control of microvascular PO₂ kinetics following onset of muscle contractions: role for AMPK
    Yutaka Kano
    Dept of Engineering Science, Bioscience and Technology Program, Univ of Electro Communications, Chofu, Tokyo, 1828585, Japan
    Am J Physiol Regul Integr Comp Physiol 301:R1350-7. 2011
    ..e., oxidative phosphorylation response) and impairs the hyperemic response at the onset of contractions thereby sowing the seeds for exercise intolerance...
  28. ncbi request reprint Mechanism for peroxisome proliferator-activated receptor-alpha activator-induced up-regulation of UCP2 mRNA in rodent hepatocytes
    Teruyo Nakatani
    Division of Clinical Nutrition, National Institute of Health and Nutrition, 1 23 1, Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    J Biol Chem 277:9562-9. 2002
    ....
  29. doi request reprint The effects of PGC-1α on control of microvascular P(O2) kinetics following onset of muscle contractions
    Yutaka Kano
    Department of Engineering Science, University of Electro Communications, Chofu, Tokyo, Japan
    J Appl Physiol (1985) 117:163-70. 2014
    ..Moreover, overexpression of PGC-1α may accelerate O2 utilization kinetics to a greater extent than O2 delivery kinetics...
  30. pmc PGC-1α-mediated changes in phospholipid profiles of exercise-trained skeletal muscle
    Nanami Senoo
    Laboratories of Nutritional Biochemistry Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Suruga ku, Shizuoka 422 8526, Japan
    J Lipid Res 56:2286-96. 2015
    ..Because phospholipid fatty acid composition influences cell permeability and receptor stability at the cell membrane, these phospholipids may contribute to exercise training-mediated functional changes in the skeletal muscle. ..
  31. doi request reprint Regulation of SREBP1c gene expression in skeletal muscle: role of retinoid X receptor/liver X receptor and forkhead-O1 transcription factor
    Yasutomi Kamei
    Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Endocrinology 149:2293-305. 2008
    ..These findings provide in vivo and in vitro evidence that RXR/LXR up-regulates SREBP1c gene expression and that FOXO1 antagonizes this effect of RXR/LXR in skeletal muscle...
  32. ncbi request reprint [Exercise induced utilization of glucose and lipids in skeletal muscle]
    Shinji Miura
    Division of Clinical Nutrition, Department of Human Nutrition, National Institute of Health and Nutrition
    Nihon Rinsho 60:267-72. 2002
  33. ncbi request reprint FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle
    Robert J Southgate
    Cellular and Molecular Metabolism Laboratory, The Baker Heart Research Institute, Commercial Road, Melbourne 3004, Victoria, Australia
    J Biol Chem 282:21176-86. 2007
    ..These data suggest that FOXO1 may be an important therapeutic target for human diseases where anabolism is impaired...
  34. ncbi request reprint Antitumor studies. Part 1: design, synthesis, antitumor activity, and AutoDock study of 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides as a new class of antitumor agents
    Hamed I Ali
    Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University 1 1 1, Tsushima Naka, Okayama 700 8530, Japan
    Bioorg Med Chem 15:242-56. 2007
    ..In particular, 2-deoxo-2-phenylflavin-5-oxides exhibited the highest potential binding affinity within the binding pocket of PTK...
  35. ncbi request reprint Inhibitory effects of 9-(4-thio-beta-D-ribo-pentofuranosyl)guanine on tumor growth and angiogenesis
    Shinji Miura
    Biochemicals Division, Yamasa Corporation, 2 10 1 Araoi cho, Choshi, Chiba 288 0056, Japan
    Biol Pharm Bull 27:520-3. 2004
    ..To find a nucleoside with anti-angiogenic activity, we tried to screen an active compound from our nucleoside library...
  36. ncbi request reprint Potent antitumor effect of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine on peritoneal dissemination models of gastrointestinal cancers
    Shinji Miura
    Biochemicals Division, Yamasa Corporation, Choshi, Chiba 288 0056, Japan
    Oncol Rep 9:1319-22. 2002
    ..In conclusion, 4'-thio-FAC is a promising therapeutic agent for use against peritoneal dissemination of gastrointestinal cancers...
  37. ncbi request reprint Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium
    Shinji Miura
    Membrane Regulation Section, Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20992 8028, USA
    J Biol Chem 277:32253-7. 2002
    ....