Kikuyasu Nakamura

Summary

Affiliation: National Institute of Agrobiological Sciences
Country: Japan

Publications

  1. ncbi Pancreatic necrosis and ventricular erosion in adenovirus-associated hydropericardium syndrome of broilers
    K Nakamura
    National Institute of Animal Health, Tsukuba, Ibarakai, Japan
    Vet Pathol 39:403-6. 2002
  2. ncbi Pathogenesis of conjunctivitis caused by Newcastle disease viruses in specific-pathogen-free chickens
    Kikuyasu Nakamura
    National Institute of Animal Health 305 0856 Kannondai, Tsukuba, Ibaraki, Japan
    Avian Pathol 33:371-6. 2004
  3. ncbi Basophilic intracytoplasmic viral matrix inclusions distributed widely in layer hens affected with avian-leukosis-virus-associated tumours
    Kikuyasu Nakamura
    National Institute of Animal Health Kannondai, Tsukuba, Ibaraki 305 0856 Japan
    Avian Pathol 36:53-8. 2007
  4. ncbi Pathology of specific-pathogen-free chickens inoculated with H5N1 avian influenza viruses isolated in Japan in 2004
    Kikuyasu Nakamura
    National Institute of Animal Health, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Avian Dis 52:8-13. 2008
  5. doi Pathologic and immunohistochemical studies of Newcastle disease (ND) in broiler chickens vaccinated with ND: severe nonpurulent encephalitis and necrotizing pancreatitis
    K Nakamura
    National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    Vet Pathol 45:928-33. 2008
  6. ncbi Pathology and microbiology of dermal squamous cell carcinoma in young brown chickens reared on reused litter
    Kikuyasu Nakamura
    National Institute of Animal Health, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Avian Dis 54:1120-4. 2010
  7. ncbi Protective effects of sugar cane extract on endotoxic shock in mice
    Maki Motobu
    National Institute of Animal Health, National Agriculture and Bio Oriented Research Organization, Tsukuba, Ibaraki, Japan
    Phytother Res 20:359-63. 2006
  8. ncbi Protective effects of antimicrobial peptides derived from the beetle Allomyrina dichotoma defensin on endotoxic shock in mice
    Yukari Koyama
    Department of Epidemiology, National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    Int Immunopharmacol 6:234-40. 2006
  9. ncbi Reduced lipopolysaccharide (LPS)-induced nitric oxide production in peritoneal macrophages and inhibited LPS-induced lethal shock in mice by a sugar cane (Saccharum officinarum L.) extract
    Kenji Hikosaka
    National Institute of Animal Health, Tsukuba, Ibaraki
    Biosci Biotechnol Biochem 70:2853-8. 2006
  10. ncbi Cytotoxicity and antigenicity of antimicrobial synthesized peptides derived from the beetle Allomyrina dichotoma defensin in mice
    Yukari Koyama
    National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    Int Immunopharmacol 6:1748-53. 2006

Collaborators

Detail Information

Publications80

  1. ncbi Pancreatic necrosis and ventricular erosion in adenovirus-associated hydropericardium syndrome of broilers
    K Nakamura
    National Institute of Animal Health, Tsukuba, Ibarakai, Japan
    Vet Pathol 39:403-6. 2002
    ..The pathologic changes of the present cases differ from previous cases of HPS; therefore, the present strain of GIAAV may have different pathogenicity for chickens than the previous virus strain of HPS...
  2. ncbi Pathogenesis of conjunctivitis caused by Newcastle disease viruses in specific-pathogen-free chickens
    Kikuyasu Nakamura
    National Institute of Animal Health 305 0856 Kannondai, Tsukuba, Ibaraki, Japan
    Avian Pathol 33:371-6. 2004
    ..In marked lesions, the whole conjunctiva was affected with more severe and extensive lesions. The mesogenic and lentogenic NDV strains induced no gross conjunctival lesions, but induced mild conjunctivitis without vascular necrosis...
  3. ncbi Basophilic intracytoplasmic viral matrix inclusions distributed widely in layer hens affected with avian-leukosis-virus-associated tumours
    Kikuyasu Nakamura
    National Institute of Animal Health Kannondai, Tsukuba, Ibaraki 305 0856 Japan
    Avian Pathol 36:53-8. 2007
    ..This result suggests that MIs can be formed in organs rather than muscular systems in the chickens naturally affected with ALV-associated tumours...
  4. ncbi Pathology of specific-pathogen-free chickens inoculated with H5N1 avian influenza viruses isolated in Japan in 2004
    Kikuyasu Nakamura
    National Institute of Animal Health, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Avian Dis 52:8-13. 2008
    ..This study suggests H5N1 HPAI viruses isolated in Japan in 2004 cause pathologic conditions similar to natural cases...
  5. doi Pathologic and immunohistochemical studies of Newcastle disease (ND) in broiler chickens vaccinated with ND: severe nonpurulent encephalitis and necrotizing pancreatitis
    K Nakamura
    National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    Vet Pathol 45:928-33. 2008
    ..Severe nonpurulent encephalitis with extensive rarefaction and malacia, and necrotizing pancreatitis in the present case may suggest a close possibly causal relation with vaccination...
  6. ncbi Pathology and microbiology of dermal squamous cell carcinoma in young brown chickens reared on reused litter
    Kikuyasu Nakamura
    National Institute of Animal Health, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Avian Dis 54:1120-4. 2010
    ..No viruses could be isolated from the skin with DSCC. This study suggests that the chicken breed, reused litter, and season may be associated with the incidence of DSCC in brown chickens...
  7. ncbi Protective effects of sugar cane extract on endotoxic shock in mice
    Maki Motobu
    National Institute of Animal Health, National Agriculture and Bio Oriented Research Organization, Tsukuba, Ibaraki, Japan
    Phytother Res 20:359-63. 2006
    ..These results suggest that SCE has protective effects on LPS-induced mortality in this mouse model...
  8. ncbi Protective effects of antimicrobial peptides derived from the beetle Allomyrina dichotoma defensin on endotoxic shock in mice
    Yukari Koyama
    Department of Epidemiology, National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    Int Immunopharmacol 6:234-40. 2006
    ..These results suggest that peptide A has a protective effect on LPS-induced mortality in this mouse model...
  9. ncbi Reduced lipopolysaccharide (LPS)-induced nitric oxide production in peritoneal macrophages and inhibited LPS-induced lethal shock in mice by a sugar cane (Saccharum officinarum L.) extract
    Kenji Hikosaka
    National Institute of Animal Health, Tsukuba, Ibaraki
    Biosci Biotechnol Biochem 70:2853-8. 2006
    ..These results suggest that SCE had a protective effect on LPS-induced endotoxin shock via one of possible mechanisms involving the suppression of NO production in the mouse peritoneal cavity...
  10. ncbi Cytotoxicity and antigenicity of antimicrobial synthesized peptides derived from the beetle Allomyrina dichotoma defensin in mice
    Yukari Koyama
    National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    Int Immunopharmacol 6:1748-53. 2006
    ..The results indicated that peptides A and B were less cytotoxic than polymyxin B and also had poor antigenicity to produce specific antibody in mice...
  11. ncbi Genetic characterization of fowl adenoviruses isolated from chickens with hydropericardium syndrome in Japan
    Masaji Mase
    National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    J Vet Med Sci 71:1455-8. 2009
    ..This suggested that FAdV-4 from the HPS chickens in India and Pakistan was derived from a common ancestor, but the origin of the FAdV-4 from the HPS chickens in Japan was completely different...
  12. ncbi Pathogenesis in call ducks inoculated intranasally with H5N1 highly pathogenic avian influenza virus and transmission by oral inoculation of infective feathers from an infected call duck
    Yu Yamamoto
    National Institute of Animal Health, Kannondai, Tsukuba, Ibaraki, 305 0856 Japan
    Avian Dis 51:744-9. 2007
    ..It also suggests that feathers of call ducks infected with Ck/Yama/7/04 can be a potential source of infection for unaffected birds in nature...
  13. ncbi Reproduction of hydropericardium syndrome in three-week-old cyclophosphamide-treated specific-pathogen-free chickens by adenoviruses from inclusion body hepatitis
    Kikuyasu Nakamura
    National Institute of Animal Health, Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Avian Dis 47:169-74. 2003
    ..From the present findings, pathogenic characteristics of IBH strains and HPS strains in the chickens were essentially the same...
  14. ncbi Low pathogenicity H5N2 avian influenza outbreak in Japan during the 2005-2006
    Masatoshi Okamatsu
    Research Team for Zoonotic Diseases, National Institute of Animal Health, National Agriculture and Food Research Organization NARO, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Vet Microbiol 124:35-46. 2007
    ..These results suggested that the H5N2 LPAI viruses isolated in Japan were highly adapted to chickens...
  15. ncbi Detection of fowl adenovirus DNA from formalin-fixed and paraffin-embedded sections by PCR and classification of serotypes by sequencing of PCR products
    Takuya Ohizumi
    National Institute of Animal Health, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Avian Dis 56:741-3. 2012
    ..The PCR of FFPE sections, and serotyping by the sequencing of PCR products, are useful for diagnosis and epidemiologic analysis of FAV infections...
  16. ncbi Characterization of H5N1 influenza A viruses isolated during the 2003-2004 influenza outbreaks in Japan
    Masaji Mase
    Department of Infectious Diseases, National Institute of Animal Health, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Virology 332:167-76. 2005
    ..e., genotype Z) and that these highly pathogenic viruses can be transmitted to crows, which are highly susceptible to these viruses...
  17. ncbi Therapeutic effect of modified oligopeptides from the beetle Allomyrina dichotoma on methicillin-resistant Staphylococcus aureus (MRSA) infection in mice
    Manabu Yamada
    National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    J Vet Med Sci 67:1005-11. 2005
    ..The anti-bacterial activity of peptides A and B has a therapeutic effect on MRSA infection in mice even seven days after being challenged...
  18. ncbi Inclusion body hepatitis caused by fowl adenovirus in broiler chickens in Japan, 2009-2010
    Kikuyasu Nakamura
    National Institute of Animal Health, Tsukuba, Ibaraki 305 0856, Japan
    Avian Dis 55:719-23. 2011
    ..This study suggests that IBH produced by FAV is epidemic in broiler chicks in Japan and that the present cases occurred as the primary disease without the association of infectious bursal disease virus or chicken anemia virus...
  19. ncbi Presence of avian pneumovirus subtypes A and B in Japan
    Masaji Mase
    Department of Infectious Diseases, National Institute of Animal Health, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Avian Dis 47:481-4. 2003
    ..Several routes or sources are conceivable for APV to invade into Japan...
  20. pmc Persistence of avian influenza virus (H5N1) in feathers detached from bodies of infected domestic ducks
    Yu Yamamoto
    National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    Appl Environ Microbiol 76:5496-9. 2010
    ....
  21. ncbi Experimental assessment of the pathogenicity of H5N1 influenza A viruses isolated in Japan
    Masaji Mase
    Department of Infectious Diseases, National Institute of Animal Health, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Avian Dis 49:582-4. 2005
    ..However, both the mean time of onset of clinical signs and the mean death time of Ck/Yamaguchi/7/04 were shorter than those of Dk/Yokohama/aq10/03...
  22. ncbi Effects of antimicrobial peptides derived from the beetle Allomyrina dichotoma defensin on mouse peritoneal macrophages stimulated with lipopolysaccharide
    Maki Motobu
    Department of Production Diseases, National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    J Vet Med Sci 66:319-22. 2004
    ..Furthermore, NF-kappaB activation was also blocked by addition of peptide A. These results indicated that peptide A blocked macrophage activation induced by LPS...
  23. ncbi Severe nonpurulent encephalitis with mortality and feather lesions in call ducks (Anas platyrhyncha var. domestica) inoculated intravenously with H5N1 highly pathogenic avian influenza virus
    Yu Yamamoto
    National Institute of Animal Health, Kannondai, Tsukuba, Ibaraki, 305 0856 Japan
    Avian Dis 51:52-7. 2007
    ..Feather lesions with viral antigens and the virus isolation from the skin suggest that Ck/Yama/ 7/04 has a predilection for feathers in call ducks...
  24. ncbi Fowl adenoviruses isolated from chickens with inclusion body hepatitis in Japan, 2009-2010
    Masaji Mase
    National Institute of Animal Health, National Agriculture and Food Research Organization NARO, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    J Vet Med Sci 74:1087-9. 2012
    ..This suggests a common ancestor for the FAdVs obtained from chickens with IBH in Japan in 2010...
  25. ncbi Characterization of Fowl adenovirus serotype 4 isolated from chickens with hydropericardium syndrome based on analysis of the short fiber protein gene
    Masaji Mase
    Research Team for Zoonotic Diseases, National Institute of Animal Health, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    J Vet Diagn Invest 22:218-23. 2010
    ..The use of PCR-RFLP analysis of short fiber genes may be useful to distinguish among FAdV-4 strains...
  26. ncbi Pathology of cutaneous fowlpox with amyloidosis in layer hens inoculated with fowlpox vaccine
    Kikuyasu Nakamura
    National Institute of Animal Health, Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Avian Dis 50:152-6. 2006
    ..Amyloid deposition was observed in the Disse space of the liver, splenic sinus, and lamina propria of the bronchiolar, bronchial, and tracheal areas. Amyloidosis could be one factor inducing the fowlpox infection in vaccinated chickens...
  27. pmc Avian influenza virus (H5N1) replication in feathers of domestic waterfowl
    Yu Yamamoto
    National Institute of Animal Health, 3 1 5 Kannondai, Tsukuba, Ibaraki, Japan
    Emerg Infect Dis 14:149-51. 2008
    ..Together with virus isolation from the skin, the detection of viral antigens and ultrastructural observation of the virions in the feather epidermis raise the possibility of feathers as sources of infection...
  28. ncbi Immunohistochemical distribution of amyloid deposits in 25 cows diagnosed with systemic AA amyloidosis
    Manabu Yamada
    National Institute of Animal Health, Tsukuba, Japan
    J Vet Med Sci 68:725-9. 2006
    ..In contrast, five cases did not exhibit any chronic inflammation...
  29. ncbi Experimental gizzard erosions in specific-pathogen-free chicks by serotype 1 group I avian adenoviruses from broilers
    Kikuyasu Nakamura
    National Institute of Animal Health, Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Avian Dis 46:893-900. 2002
    ..These results suggest that gizzard erosions by serotype 1 GIAAV infection may occur in broiler chickens in Japan...
  30. doi Genetic characterization and susceptibility on poultry and mammal of H7N6 subtype avian influenza virus isolated in Japan in 2009
    Yuko Uchida
    Research Team for Zoonotic Diseases, National Institute of Animal Health, National Agriculture and Food Research Organization NARO, Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Vet Microbiol 147:1-10. 2011
    ..The pathogenicity of the quail strain for mammalian, pig and mouse was low, although it could replicate in those animals...
  31. pmc Association of increased pathogenicity of Asian H5N1 highly pathogenic avian influenza viruses in chickens with highly efficient viral replication accompanied by early destruction of innate immune responses
    Koutaro Suzuki
    Research Team for Zoonotic Diseases, National Institute of Animal Health NIAH, National Agriculture and Food Research Organization NARO, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    J Virol 83:7475-86. 2009
    ....
  32. pmc Pathogenesis of Newcastle disease in vaccinated chickens: pathogenicity of isolated virus and vaccine effect on challenge of its virus
    Kikuyasu Nakamura
    National Institute of Animal Health, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    J Vet Med Sci 76:31-6. 2014
    ..Vaccine diluted with fresh tap water had no effect on protection against the challenge of the ND virus. This study suggests that improper vaccination may be involved in outbreaks of ND in vaccinated chickens. ..
  33. pmc Highly pathogenic avian influenza virus (H5N1) isolated from whooper swans, Japan
    Yuko Uchida
    National Institute of Animal Health, Kannondai, Japan
    Emerg Infect Dis 14:1427-9. 2008
    ..Highly pathogenic avian influenza virus of the H5N1 subtype was isolated from specimens of the affected birds. The hemagglutinin (HA) gene of the isolate belongs to clade 2.3.2 in the HA phylogenetic tree...
  34. ncbi Immunohistochemical distribution of viral antigens in pigs naturally infected with porcine teschovirus
    Manabu Yamada
    National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    J Vet Med Sci 70:305-8. 2008
    ..In the other examined organ, PTV antigens were observed in bronchiolar epithelial cells in the lung, hepatocytes in the liver, epithelial cells in the tonsils and the myenteric nerve plexus in the small and large intestine...
  35. ncbi Outbreak of comb necrosis in layer breeder chickens
    K Nakamura
    Third Research Division, National Institute of Animal Health, Ibaraki, Japan
    Avian Dis 41:252-6. 1997
    ..Staphylococcus aureus and Pasturella spp. were isolated from comb lesions. There were no significant lesions causing leg weakness...
  36. ncbi Limited susceptibility of pigeons experimentally inoculated with H5N1 highly pathogenic avian influenza viruses
    Yu Yamamoto
    National Institute of Animal Health, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    J Vet Med Sci 74:205-8. 2012
    ..Our data suggest that the risk posed by pigeons with respect to the transmission of the H5N1 highly pathogenic avian influenza virus to poultry would be less than that for other susceptible avian species...
  37. ncbi Radioprotective effect of sugar cane extract in chickens
    Said Amer
    National Institute of Animal Health, National Agriculture and Bio orientated Research Organization, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Phytother Res 19:496-500. 2005
    ..Histopathological examination revealed the intestine of SCE administered chickens to have mild to moderate pathological changes, when compared with that of the irradiated control animals...
  38. ncbi Zoonotic risk for influenza A (H5N1) infection in wild swan feathers
    Yu Yamamoto
    National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    J Vet Med Sci 71:1549-51. 2009
    ..These results indicate that the feathers could have the risk for zoonotic infection from infected wild swans...
  39. ncbi Nephroblastoma with transcoelomic metastasis in a Japanese black bull
    Yu Yamamoto
    National Institute of Animal Health, Kannondai, Tsukuba, Ibaraki, Japan
    J Vet Med Sci 68:891-3. 2006
    ..Glomeruloid structures were scattered in these epithelial elements. Metastatic nodules were composed of blastemal and stromal elements, which were similar to those in the mass...
  40. ncbi Enterovirus encephalomyelitis in pigs in Japan caused by porcine teschovirus
    M Yamada
    National Institute of Animal Health, Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Vet Rec 155:304-6. 2004
  41. ncbi Immunohistochemical detection of porcine teschovirus antigen in the formalin-fixed paraffin-embedded specimens from pigs experimentally infected with porcine teschovirus
    M Yamada
    National Institute of Animal Health, Tsukuba, Ibaraki 305 0856, Japan
    J Vet Med A Physiol Pathol Clin Med 54:571-4. 2007
    ..This is the first study to demonstrate PTV antigen by immunohistochemistry in formalin-fixed paraffin-embedded tissue specimens from pigs infected with PTV...
  42. ncbi Pathological and immunological findings of athymic nude and congenic wild type BALB/c mice experimentally infected with Neospora caninum
    T Shibahara
    National Institute of Animal Health, Ministry of Agriculture, Forestry and Fisheries, Tsukuba shi, Ibaraki, Japan
    Vet Pathol 36:321-7. 1999
    ..Nude mice developed high level of serum interferon-gamma and interleukin-6 as infection proceeded. Inflammatory response to Neospora infection might be mediated by Th1-type dependent cellular immunity...
  43. ncbi Serum levels of interleukin-6, alpha1-acid glycoprotein, and corticosterone in two-week-old chickens inoculated with Escherichia coli lipopolysaccharide
    K Nakamura
    National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    Poult Sci 77:908-11. 1998
    ..The CORT level in the LPS group was higher than that of PBS group at 1 h. This study suggests that E. coli LPS may elevate serum IL-6 and CORT, and that IL-6 and CORT may increase the alpha1-AG level in the chicks...
  44. ncbi Hepatotoxin rubratoxin B induced the secretion of TNF-alpha, IL-8, and MCP-1 in HL60 cells
    H Nagashima
    National Food Research Institute, 2 1 12 Kannondai, Tsukuba, Ibaraki 305 8642, Japan
    Biochem Biophys Res Commun 287:829-32. 2001
    ....
  45. ncbi Nonsuppurative encephalitis in piglets after experimental inoculation of Japanese encephalitis flavivirus isolated from pigs
    M Yamada
    Laboratory of Chronic Disease Pathology, National Institute of Animal Health, Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    Vet Pathol 41:62-7. 2004
    ..Two JEV strains isolated from field pigs exhibited neurovirulence, inducing nonsup-purative encephalitis in piglets...
  46. ncbi Pathology of fatal highly pathogenic H5N1 avian influenza virus infection in large-billed crows (Corvus macrorhynchos) during the 2004 outbreak in Japan
    N Tanimura
    National Institute of Animal Health, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856 Japan
    Vet Pathol 43:500-9. 2006
    ..Thus we concluded that highly pathogenic avian influenza virus was associated with clinical disease, severe pathologic changes, and death in the 3 crows...
  47. ncbi Genetic characterization of Batai virus indicates a genomic reassortment between orthobunyaviruses in nature
    T Yanase
    Kyushu Research Station, National Institute of Animal Health, Kagoshima, Japan
    Arch Virol 151:2253-60. 2006
    ..Our results indicate that Ngari virus is a genetic reassortant with S and L RNA segments from Bunyamwera virus and an M RNA segment from Batai virus...
  48. ncbi Proliferation of lung macrophages in acute fatal viral infections in chickens
    K Nakamura
    National Institute of Animal Health, Kannondai, Tsukuba, Ibaraki, Japan
    Avian Dis 45:813-8. 2001
    ..This syndrome may be categorized as "virus-associated hemophagocytic syndrome."..
  49. ncbi Restriction fragment length polymorphism analysis of Akabane virus nucleoprotein gene
    H Akashi
    National Institute of Animal Health, Ibaraki, Japan
    J Vet Med Sci 59:837-40. 1997
    ..The data demonstrate the usefulness of analyzing the RFLP patterns to understand the genetic variability of AKA virus isolated in Japan and Australia...
  50. doi Brain lesions induced by experimental intranasal infection of Japanese encephalitis virus in piglets
    M Yamada
    National Institute of Animal Health, Tsukuba, Ibaraki 305 0856, Japan
    J Comp Pathol 141:156-62. 2009
    ..The distribution of the antigens corresponded closely with the distribution of brain lesions. These findings suggest that JEV may enter the brain by the olfactory pathway in addition to via haematogenous spread in piglets...
  51. doi Pathological changes in pigs experimentally infected with porcine teschovirus
    M Yamada
    National Institute of Animal Health, Tsukuba, Ibaraki 305 0856, Japan
    J Comp Pathol 141:223-8. 2009
    ..No lesions of the central nervous system were induced in pigs by oral or intranasal inoculation of this strain of PTV...
  52. ncbi Pathogenicity of Leucocytozoon caulleryi for specific pathogen-free laying hens
    K Nakamura
    National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    J Parasitol 87:1202-4. 2001
    ..The eggshell-secreting portion of the uterus exhibited the most severe damage in the oviduct. This experiment reconfirms that L. caulleryi may stop egg production in laying hens, presumably as a result of damage to ovaries and oviducts...
  53. ncbi The effect of mixed live vaccines of Newcastle disease and infectious bronchitis on the chicken respiratory tract
    K Nakamura
    Poultry Disease Laboratory, National Institute of Animal Health, Gifu, Japan
    J Comp Pathol 106:341-50. 1992
    ..coli in chickens inoculated with E. coli alone. The results suggest that these mixed live vaccines, especially vaccine 2, play a role in inducing or enhancing colibacillosis in the chicken...
  54. pmc Immunohistochemistry and molecular epidemiology of avian paramyxovirus 1 from formalin-fixed and paraffin-embedded sections of Japanese doves (Columba livia) affected with neurological signs
    Kikuyasu Nakamura
    National Institute of Animal Health, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    J Vet Med Sci 77:837-41. 2015
    ..The RT-PCR of FFPE sections and sequencing of RT-PCR products are useful for molecular epidemiology of the virus when viral isolation from fresh samples is unsuccessful. ..
  55. ncbi Congenital myopathy in Japanese Black calves
    Manabu Yamada
    National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    J Vet Med Sci 66:997-1001. 2004
    ..The present cases seem to be classified as congenital myopathy based on pathological alterations and age of onset...
  56. ncbi Partial protection against challenge with the highly pathogenic H5N1 influenza virus isolated in Japan in chickens infected with the H9N2 influenza virus
    K Imai
    National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    Arch Virol 152:1395-400. 2007
    ..p.c., respectively. This study shows that the H9N2 viruses may have the potential to induce cross-protection to the challenge with a recent lethal H5N1 virus (genotype V)...
  57. pmc Phylogenetic analysis of fowl adenoviruses isolated from chickens with gizzard erosion in Japan
    Masaji Mase
    National Institute of Animal Health, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    J Vet Med Sci 76:1535-8. 2014
    ..Thus, the same type of FAdV-1 has been associated with outbreaks of GE in Japanese chickens for the past 10 years, which may have spread from a common ancestor, although the epidemiological relationship is unknown. ..
  58. ncbi Effect of modified oligopeptides from the beetle Allomyrina dichotoma on Escherichia coli infection in mice
    Manabu Yamada
    National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    J Vet Med Sci 66:137-42. 2004
    ..coli. Also, modified peptides A and B produced no toxicity or side effects in mice. These results suggest that peptide B is useful for developing novel antibiotics against antibiotic-resistant pathogenic bacteria...
  59. ncbi The role of protein kinase C in the increased generation in isolated rat hepatocytes of the hydroxyl radical by puromycin aminonucleoside
    K Aoyagi
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Free Radic Res 32:487-96. 2000
    ..65-fold at 60 min incubation and 2.16-fold at 120 min with PAN, while it changed little without PAN. These results indicate that PAN activates PKC resulting in increased hydroxyl radical generation in isolated rat hepatocytes...
  60. ncbi Apoptosis in calf pneumonia induced by endobronchial inoculation with bovine adenovirus type 3 (BAV-3)
    M Yamada
    National Institute of Animal Health, Kannondai, Tsukuba, Ibaraki, 305 0856, Japan
    J Comp Pathol 128:140-5. 2003
    ..The results indicated that (1) the durability of BAV-3 infection in the lung was closely related to apoptosis, and (2) the host defence mechanism that induced apoptosis in infected cells was age-related...
  61. ncbi Gizzard nematodiasis in Japanese mountain hawk eagle (Spizaetus nipalensis)
    K Nakamura
    National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    Avian Dis 45:751-4. 2001
    ..The morphology suggests that the parasites may be nematodes, but the species of nematode could not be confirmed. The bird may have died from malabsorption and respiratory damage as a result of the gizzard and lung lesions...
  62. ncbi Antitumor activity of ER-51785, a new peptidomimetic inhibitor of farnesyl transferase: synergistic effect in combination with paclitaxel
    K Nakamura
    Tsukuba Research Laboratories, Eisai Co Ltd, Ibaraki, Japan
    Oncol Res 12:477-84. 2001
    ....
  63. ncbi Analysis of Escherichia coli 4.5S RNA binding affinity to Ffh and EF-G
    S Suzuma
    Institute of Biological Sciences, University of Tsukuba, Tsukuba shi, Ibaraki, Japan
    FEMS Microbiol Lett 180:271-7. 1999
    ..15 microM and 1.5 microM, respectively. Moreover, we also show that very little EF-G can form a stable complex with 4.5S RNA in vivo, whereas almost all Ffh binds to 4.5S RNA...
  64. ncbi Determination of a 21548 bp nucleotide sequence around the 24 degrees region of the Bacillus subtilis chromosome
    K Ogawa
    Institute of Biological Sciences, University of Tsukuba, Ibaraki, Japan
    Microbiology 141:269-75. 1995
    ..The remaining six ORFs showed no similarity to known proteins...
  65. ncbi Small cytoplasmic RNA (scRNA) gene from Clostridium perfringens can replace the gene for the Bacillus subtilis scRNA in both growth and sporulation
    K Nakamura
    Institute of Biological Sciences, University of Tsukuba, Ibaraki, Japan
    Microbiology 141:2965-75. 1995
    ..Since both E. coli 4.5S RNA and C. perfringens scRNA have the same binding specificity to B. subtilis Ffh protein, the difference in complementation activity reflects the function of domains I and II...
  66. doi Self-reported stroke and myocardial infarction had adequate sensitivity in a population-based prospective study JPHC (Japan Public Health Center)-based Prospective Study
    Kazumasa Yamagishi
    Department of Public Health Medicine, Graduate School of Comprehensive Human Sciences, and Institute of Community Medicine, University of Tsukuba, Tsukuba, Japan
    J Clin Epidemiol 62:667-73. 2009
    ....
  67. pmc Protective role of metallothionein in acute lung injury induced by bacterial endotoxin
    H Takano
    National Institute for Environmental Studies, Tsukuba, Japan
    Thorax 59:1057-62. 2004
    ..A study was undertaken to determine whether intrinsic MT protects against acute inflammatory lung injury induced by bacterial endotoxin in MT-I/II knock out (-/-) and wild type (WT) mice...
  68. ncbi Ground-glass hepatocytes in fibrinogen storage disease in Japanese Black calves
    M Yamada
    National Institute of Animal Health, Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    J Comp Pathol 126:95-9. 2002
    ..The results showed these inclusions to be entirely consistent with fibrinogen inclusions described in man. Hepatocellular fibrinogen storage disease, as identified in this study, has not previously been described in animals...
  69. pmc Cloning and characterization of a Bacillus subtilis gene encoding a homolog of the 54-kilodalton subunit of mammalian signal recognition particle and Escherichia coli Ffh
    K Honda
    Institute of Biological Sciences, University of Tsukuba, Ibaraki, Japan
    J Bacteriol 175:4885-94. 1993
    ..The depletion of ffh in B. subtilis led to growth arrest and drastic morphological changes. Furthermore, the translocation of beta-lactamase and alpha-amylase under the depleted condition was also defective...
  70. ncbi Determination of a 17,484 bp nucleotide sequence around the 39 degrees region of the Bacillus subtilis chromosome and similarity analysis of the products of putative ORFs
    E Akagawa
    Institute of Biological Sciences, University of Tsukuba, Ibaraki, Japan
    Microbiology 141:3241-5. 1995
    ..The amino acid sequence of Orf3 showed 34% identity with that of LeuC of B. subtilis, though they seem to be functionally different. The remaining seven ORFs did not show similarity to any known proteins...
  71. ncbi The Bacillus subtilis SRP54 homologue, Ffh, has an intrinsic GTPase activity and forms a ribonucleoprotein complex with small cytoplasmic RNA in vivo
    K Nakamura
    Institute of Biological Sciences, University of Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 199:1394-9. 1994
    ..These findings provide evidence of a ribonucleoprotein complex in B. subtilis, reminiscent of SRP...
  72. ncbi Synthesis of creatol, a hydroxyl radical adduct of creatinine and its increase by puromycin aminonucleoside in isolated rat hepatocytes
    K Aoyagi
    Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Free Radic Res 29:221-6. 1998
    ..These findings demonstrated that hepatocytes synthesize creatol prior to MG and are inhibited by a hydroxyl] radical scavenger. They also show that PAN increased hydroxyl radical generation in tissue cells...
  73. ncbi DNA sequence of proline permease gene from Pseudomonas fluorescens and predicted structure of proline permease
    H Hosoya
    National Institute of Bioscience and Human Technology, Agency of Industrial Science and Technology, Ibaraki, Japan
    Biosci Biotechnol Biochem 58:2099-101. 1994
    ..The DNA sequence is 71.0% and 70.7% identical and the amino acid sequence is 75.8% and 76.0% similar to those of Escherichia coli and Salmonella typhimurium, respectively...
  74. ncbi Preventive and therapeutic effects of sugar cane extract on cyclophosphamide-induced immunosuppression in chickens
    Moshira El-Abasy
    Department of Molecular Immunology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Int Immunopharmacol 4:983-90. 2004
    ..These results suggest that SCE has functionally and morphologically reconstituting effects on the bursa-dependent immune system in immunosuppressed chickens induced by injection of CPA...
  75. pmc Detecting avian influenza virus (H5N1) in domestic duck feathers
    Yu Yamamoto
    Emerg Infect Dis 14:1671-2. 2008
  76. ncbi Pathology of listerial encephalitis in chickens in Japan
    Mitsuteru Kurazono
    Kagoshima Central Livestock Hygiene Center, Higashiitiki, Hioki gun, Kagoshima 899 2201, Japan
    Avian Dis 47:1496-502. 2003
    ..Listeria monocytogenes (serotype 4b) was isolated from the medulla oblongata and spinal cord. The pathogenesis of listerial encephalitis in chickens was discussed...
  77. ncbi Encephalomalacia with Enterococcus durans infection in the brain stem and cerebral hemisphere in chicks in Japan
    Yuka Abe
    Akita Chuo Livestock Hygiene Service Center, Terauchihirune, Akita 011 0904, Japan
    Avian Dis 50:139-41. 2006
    ..Detection of gram-positive cocci within the blood vessels in the malacia lesions observed in these cases may more strongly suggest the pathogenic role of E. durans on the malacia lesions in the brain stem and cerebral hemisphere...
  78. ncbi Epidemiology, pathology, and immunohistochemistry of layer hens naturally affected with H5N1 highly pathogenic avian influenza in Japan
    Hidetsugu Nakatani
    Yamaguchi Chubu Livestock Hygiene Service Center, Kagawa, Yamaguchi 754 0897, Japan
    Avian Dis 49:436-41. 2005
    ..Virus antigen was mainly detected in the capillary endothelium and parenchymal cells. This suggests that virus excretion from the respiratory tract was not as prevalent as that from the digestive tract in the present cases...
  79. ncbi Protective effects of sugar cane extracts (SCE) on Eimeria tenella infection in chickens
    Moshira El-Abasy
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Vet Med Sci 65:865-71. 2003
    ..tenella oocysts showed lower numbers of schizonts, gametocytes and oocysts than those of infected control chickens. These results suggest that SCE have immunostimulating and protective effects against E. tenella infection in chickens...
  80. ncbi Glomerulopathy with renal tubular oxalosis in Japanese rock ptarmigan (Lagopus mutus)
    Keiichi Yoshikawa
    Matsumoto Livestock Hygiene Service Center, Matsumoto, Nagano, 390 0851, Japan
    Avian Pathol 34:399-401. 2005
    ..The primary renal lesion may have been glomerulonephropathy, which was subsequently associated with tubular oxalosis as the secondary renal lesion...