Kimihiko Sugaya

Summary

Affiliation: National Institute of Radiological Sciences
Country: Japan

Publications

  1. ncbi request reprint A mutation in the largest (catalytic) subunit of RNA polymerase II and its relation to the arrest of the cell cycle in G(1) phase
    K Sugaya
    Genome Research Group, National Institute of Radiological Sciences, 4 9 1, Anagawa, Chiba, 263 8555, Japan
    Gene 274:77-81. 2001
  2. ncbi request reprint Analysis of alpha- and beta-tubulin genes of Bombyx mori using an EST database
    Hideki Kawasaki
    Faculty of Agriculture, Utsunomiya University, 350 Mine, Utsunomiya, 321 8505, Tochigi, Japan
    Insect Biochem Mol Biol 33:131-7. 2003
  3. ncbi request reprint Amino acid substitution of the largest subunit of yeast RNA polymerase II: effect of a temperature-sensitive mutation related to G1 cell cycle arrest
    Kimihiko Sugaya
    Radiation Hazards Research Group, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Curr Microbiol 47:159-62. 2003
  4. ncbi request reprint A temperature-sensitive mutation in the WD repeat-containing protein Smu1 is related to maintenance of chromosome integrity
    Kimihiko Sugaya
    Radiation Hazards Research Group, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Exp Cell Res 306:242-51. 2005
  5. ncbi request reprint The conserved role of Smu1 in splicing is characterized in its mammalian temperature-sensitive mutant
    Kimihiko Sugaya
    Radiation Effect Mechanisms Research Group, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    J Cell Sci 119:4944-51. 2006
  6. ncbi request reprint Enlargement of speckles of SF2/ASF due to loss of function of Smu1 is characterized in the mammalian temperature-sensitive mutant
    Kimihiko Sugaya
    Radiation Effect Mechanisms Research Group, National Institute of Radiological Sciences, Chiba, Japan
    RNA Biol 8:488-95. 2011
  7. doi request reprint Characterization of cells expressing RNA polymerase II tagged with green fluorescent protein: effect of ionizing irradiation on RNA synthesis
    Etsuko Hongo
    Radiation Effect Mechanisms Research Group, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Int J Radiat Biol 84:778-87. 2008
  8. doi request reprint Effects of low-dose γ-rays on the embryonic development of mouse melanoblasts and melanocytes in the epidermis and hair bulbs
    Tomohisa Hirobe
    Radiation Effect Mechanisms Research Group, National Institute of Radiological Sciences, Anagawa, lnage Ku, Chiba 263 8555, Japan
    Zoolog Sci 28:389-96. 2011
  9. ncbi request reprint Effects of low-dose heavy ions on the postnatal development of mice and the yield of white spots in the mid-ventrum and tail-tips
    Tomohisa Hirobe
    Radiation Effect Mechanisms Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba
    J Radiat Res 52:278-86. 2011
  10. ncbi request reprint Regeneration of Murine Hair Follicles is Inhibited by Low-Dose-Rate Gamma Irradiation
    Kimihiko Sugaya
    1 Fukushima Project Headquarters, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Zoolog Sci 33:461-466. 2016

Collaborators

Detail Information

Publications14

  1. ncbi request reprint A mutation in the largest (catalytic) subunit of RNA polymerase II and its relation to the arrest of the cell cycle in G(1) phase
    K Sugaya
    Genome Research Group, National Institute of Radiological Sciences, 4 9 1, Anagawa, Chiba, 263 8555, Japan
    Gene 274:77-81. 2001
    ..Aligning the amino acid sequences from various species reveals that ala(315) is highly conserved in eukaryotes...
  2. ncbi request reprint Analysis of alpha- and beta-tubulin genes of Bombyx mori using an EST database
    Hideki Kawasaki
    Faculty of Agriculture, Utsunomiya University, 350 Mine, Utsunomiya, 321 8505, Tochigi, Japan
    Insect Biochem Mol Biol 33:131-7. 2003
    ....
  3. ncbi request reprint Amino acid substitution of the largest subunit of yeast RNA polymerase II: effect of a temperature-sensitive mutation related to G1 cell cycle arrest
    Kimihiko Sugaya
    Radiation Hazards Research Group, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Curr Microbiol 47:159-62. 2003
    ..The effect of another temperature-sensitive Rpb1 mutation was also small. These results suggest that mutation of the rpb1 gene, which is critical in mammalian cells, may not be deleterious in yeast cells...
  4. ncbi request reprint A temperature-sensitive mutation in the WD repeat-containing protein Smu1 is related to maintenance of chromosome integrity
    Kimihiko Sugaya
    Radiation Hazards Research Group, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Exp Cell Res 306:242-51. 2005
    ..Thus, Smu1 appears to be involved directly or indirectly in DNA replication, activation of cdc2 kinase, spindle assembly, and maintenance of chromosome integrity, reflecting the important roles of Smu1 in cellular function...
  5. ncbi request reprint The conserved role of Smu1 in splicing is characterized in its mammalian temperature-sensitive mutant
    Kimihiko Sugaya
    Radiation Effect Mechanisms Research Group, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    J Cell Sci 119:4944-51. 2006
    ..Comparison of the results of perlecan RT-PCR analysis with those of analysis of four other genes suggested that the splicing defect in the perlecan gene is unique and that it is conserved through evolution...
  6. ncbi request reprint Enlargement of speckles of SF2/ASF due to loss of function of Smu1 is characterized in the mammalian temperature-sensitive mutant
    Kimihiko Sugaya
    Radiation Effect Mechanisms Research Group, National Institute of Radiological Sciences, Chiba, Japan
    RNA Biol 8:488-95. 2011
    ..The significant decrease of Smu1 may lead the enlargement of speckles of SF2/ASF. These data show the importance of Smu1 as a regulator of splicing and genome maintenance...
  7. doi request reprint Characterization of cells expressing RNA polymerase II tagged with green fluorescent protein: effect of ionizing irradiation on RNA synthesis
    Etsuko Hongo
    Radiation Effect Mechanisms Research Group, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Int J Radiat Biol 84:778-87. 2008
    ..To isolate and to characterize cells expressing RNA polymerase II tagged with green fluorescent protein for analyses of the effects of ionizing radiation on transcription in living cells...
  8. doi request reprint Effects of low-dose γ-rays on the embryonic development of mouse melanoblasts and melanocytes in the epidermis and hair bulbs
    Tomohisa Hirobe
    Radiation Effect Mechanisms Research Group, National Institute of Radiological Sciences, Anagawa, lnage Ku, Chiba 263 8555, Japan
    Zoolog Sci 28:389-96. 2011
    ..These results suggest that low-dose γ-rays provoke the death of melanoblasts and melanocytes, or inhibit the proliferation and differentiation of melanoblasts and melanocytes, even at the low dose...
  9. ncbi request reprint Effects of low-dose heavy ions on the postnatal development of mice and the yield of white spots in the mid-ventrum and tail-tips
    Tomohisa Hirobe
    Radiation Effect Mechanisms Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba
    J Radiat Res 52:278-86. 2011
    ..3 (Si), 3.1 (Ar) and 4.5 (Fe). These results suggest that prenatal exposure to heavy ions possesses a greater effect on the postnatal development of mice as well as melanocyte development than does exposure to γ-rays...
  10. ncbi request reprint Regeneration of Murine Hair Follicles is Inhibited by Low-Dose-Rate Gamma Irradiation
    Kimihiko Sugaya
    1 Fukushima Project Headquarters, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Zoolog Sci 33:461-466. 2016
    ....
  11. doi request reprint Nuclear localization of ubiquitin-activating enzyme Uba1 is characterized in its mammalian temperature-sensitive mutant
    Kimihiko Sugaya
    Research Center for Radiation Protection and Fukushima Project Headquarters, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Genes Cells 20:659-66. 2015
    ..Uba1 plays an important role in the nucleus, and a ts mutation found in tsTM3 cells appears to result in the loss of localization of Uba1 in the nucleus. ..
  12. doi request reprint The effects of gamma rays on the regeneration of hair follicles are carried over to later hair cycles
    Kimihiko Sugaya
    a Fukushima Project Headquarters, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Biol 91:957-63. 2015
    ..The purpose of this study was to determine whether the effects of gamma rays on the regeneration of hair follicles are carried over to later hair cycles...
  13. pmc Characterization of ubiquitin-activating enzyme Uba1 in the nucleus by its mammalian temperature-sensitive mutant
    Kimihiko Sugaya
    Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan Fukushima Project Headquarters, National Institute of Radiological Sciences, Chiba, Japan
    PLoS ONE 9:e96666. 2014
    ..Incubation at 39°C caused an increase in endogenous geminin in tsTM3 cells. A ts mutation of Uba1 found in tsTM3 cells appears to be a novel mutation reflecting the important roles of Uba1 in nucleus. ..
  14. pmc The transcription cycle of RNA polymerase II in living cells
    Hiroshi Kimura
    Sir William Dunn School of Pathology, Oxford OX1 3RE, UK
    J Cell Biol 159:777-82. 2002
    ..Then, most expressed transcription units would spend significant times unassociated with engaged polymerases...