Rui Kano

Summary

Affiliation: Nihon University
Country: Japan

Publications

  1. ncbi request reprint PCR detection of the Cryptococcus neoformans CAPS9 gene from a biopsy specimen from a case of feline cryptococcosis
    R Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    J Vet Diagn Invest 13:439-42. 2001
  2. pmc Susceptibility testing of Malassezia species using the urea broth microdilution method
    Y Nakamura
    Department of Dermatology, Teikyo University School of Medicine, Tokyo, Nihon University School of Veterinary Medicine, Kanagawa
    Antimicrob Agents Chemother 44:2185-6. 2000
  3. ncbi request reprint The genetic diversity of clinical isolates of Malassezia pachydermatis from dogs and cats
    T Aizawa
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa Kanagawa, Japan
    Med Mycol 39:329-34. 2001
  4. ncbi request reprint In vitro effect of recombinant human granulocyte colony-stimulating factor on canine neutrophil apoptosis
    Keisuke Oguma
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Vet Immunol Immunopathol 108:307-14. 2005
  5. ncbi request reprint Acute monocytic leukaemia in a cat
    N Nagashima
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa Kanagawa 252 8510, Japan
    Vet Rec 157:347-9. 2005
  6. ncbi request reprint Two cases of feline orbital aspergillosis due to Aspergillus udagawae and A. viridinutans
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252 0880, Japan
    J Vet Med Sci 75:7-10. 2013
  7. doi request reprint Mating type gene (MAT1-1) in Japanese isolates of Trichophyton rubrum
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Fujisawa, Kanagawa, 252 0880, Japan
    Mycopathologia 175:171-3. 2013
  8. doi request reprint Feline demodicosis caused by an unnamed species
    Rui Kano
    Department of Pathobiology, Nihon University, School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252 0880, Japan
    Res Vet Sci 92:257-8. 2012
  9. ncbi request reprint Characterization of the cyclophilin of Trichophyton mentagrophytes
    R Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    Microbiol Immunol 44:51-6. 2000
  10. ncbi request reprint Differences among chitin synthase I gene sequences in Trichophyton rubrum and T. violaceum
    R Kano
    Department of Dermatology, Teikyo University School of Medicine, Japan
    Med Mycol 38:47-50. 2000

Detail Information

Publications124 found, 100 shown here

  1. ncbi request reprint PCR detection of the Cryptococcus neoformans CAPS9 gene from a biopsy specimen from a case of feline cryptococcosis
    R Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    J Vet Diagn Invest 13:439-42. 2001
    ..The assay detects the CAP59 gene of Cryptococcus neoformans and was used to substantiate cutaneous cryptococcosis in a 5-year-old cat submitted to the Veterinary Medicine Center at the University of Tokyo...
  2. pmc Susceptibility testing of Malassezia species using the urea broth microdilution method
    Y Nakamura
    Department of Dermatology, Teikyo University School of Medicine, Tokyo, Nihon University School of Veterinary Medicine, Kanagawa
    Antimicrob Agents Chemother 44:2185-6. 2000
    ..This method indicated the same sensitivities as the agar plate dilution method for isolates of Malassezia furfur, M. pachydermatis, M. slooffiae, and M. sympodialis...
  3. ncbi request reprint The genetic diversity of clinical isolates of Malassezia pachydermatis from dogs and cats
    T Aizawa
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa Kanagawa, Japan
    Med Mycol 39:329-34. 2001
    ..pachydermatis. The isolates of type A M. pachydermatis originated from lesions of all kinds of diseases. They were predominant on dog and cat skin. The other types, B, C, and D were isolated mainly from otitis externa...
  4. ncbi request reprint In vitro effect of recombinant human granulocyte colony-stimulating factor on canine neutrophil apoptosis
    Keisuke Oguma
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Vet Immunol Immunopathol 108:307-14. 2005
    ..In addition, the suppression of PMN apoptosis seems to be mediated by the induction of anti-apoptotic mcl-1 gene expression...
  5. ncbi request reprint Acute monocytic leukaemia in a cat
    N Nagashima
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa Kanagawa 252 8510, Japan
    Vet Rec 157:347-9. 2005
    ..The cat was in partial remission for 67 days and survived for 95 days after it was first examined...
  6. ncbi request reprint Two cases of feline orbital aspergillosis due to Aspergillus udagawae and A. viridinutans
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252 0880, Japan
    J Vet Med Sci 75:7-10. 2013
    ....
  7. doi request reprint Mating type gene (MAT1-1) in Japanese isolates of Trichophyton rubrum
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Fujisawa, Kanagawa, 252 0880, Japan
    Mycopathologia 175:171-3. 2013
    ..PCR detected the presence of MAT1-1 in all of the human and animal isolates. Therefore, all isolates examined were expected to react as (-) type on the mating test and not as (+) type...
  8. doi request reprint Feline demodicosis caused by an unnamed species
    Rui Kano
    Department of Pathobiology, Nihon University, School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252 0880, Japan
    Res Vet Sci 92:257-8. 2012
    ....
  9. ncbi request reprint Characterization of the cyclophilin of Trichophyton mentagrophytes
    R Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    Microbiol Immunol 44:51-6. 2000
    ..The protease digest of the fusion protein had a molecular weight of about 13 kDa and peptidyl-prolyl cis-trans isomerase (PPI) activity. This digest protein from T. mentagrophytes was confirmed to be cyclophilin by proving PPI activity...
  10. ncbi request reprint Differences among chitin synthase I gene sequences in Trichophyton rubrum and T. violaceum
    R Kano
    Department of Dermatology, Teikyo University School of Medicine, Japan
    Med Mycol 38:47-50. 2000
    ..rubrum but not in that of T. violaceum. A molecular analysis of CHS1 genes will provide useful information for the identification of these Trichophyton species and the understanding of their evolution...
  11. ncbi request reprint Phylogenetic relation of Epidermophyton floccosum to the species of Microsporum and Trichophyton in chitin synthase 1 (CHS1) gene sequences
    R Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Kanagawa, Japan
    Mycopathologia 146:111-3. 1999
    ..Phylogenetic analyses of the sequences from E. floccosum revealed that the genus Epidermophyton may be genetically distinct from Microsporum and Trichophyton...
  12. ncbi request reprint First isolation of Exophiala dermatitidis from a dog: identification by molecular analysis
    R Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Kameino, 252 8510, Fujisawa Kanagawa, Japan
    Vet Microbiol 76:201-5. 2000
    ..Nucleotide sequence analysis of the chitin synthase 2 (CHS2) gene fragments from the isolate and a reference strain of E. dermatitidis showed more than 99% similarity...
  13. ncbi request reprint Detection of Microsporum canis in the skin scrapings and hairs of dogs with dermatophytosis based on sequences of the chitin synthase 1 gene
    R Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    Microbiol Immunol 44:605-7. 2000
    ..The method presented in this study can rapidly detect the DNA of M. canis in skin scrapings, and we anticipate that it will be a useful microbiological tool for the diagnosis of M. canis infections in animals and humans...
  14. ncbi request reprint First isolation of Stephanoascus ciferrii from a cat
    R Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    Microbiol Immunol 44:711-3. 2000
    ..Therefore, the isolate was identified as Stephanoascus ciferrii, confirming the result of mycological examination by molecular analysis...
  15. ncbi request reprint Chitin synthase 1 (Chs1) gene sequences of Microsporum equinum and Trichophyton equinum
    R Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Kameino, Fujisawa, 252 8510, Kanagawa, Japan
    Vet Microbiol 78:85-90. 2001
    ..vanbreuseghemii. A molecular analysis of Chs1 genes will provide useful information for the genetic relatedness of M. equinum and T. equinum and confirm the value of DNA sequencing in identification of these two dermatophytes...
  16. pmc Expression of ubiquitin gene in Microsporum canis and Trichophyton mentagrophytes cultured with fluconazole
    R Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa Kanagawa 252 8510, Japan
    Antimicrob Agents Chemother 45:2559-62. 2001
    ..canis and T. mentagrophytes was enhanced when the fungi were cultured with fluconazole. The antifungal activity of fluconazole against these dermatophytes was increased in the presence of Ub proteasome inhibitor...
  17. ncbi request reprint Identification of Sporothrix schenckii based on sequences of the chitin synthase 1 gene
    R Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa Kanagawa, Japan
    Mycoses 44:261-5. 2001
    ..schenckii with ethidium bromide staining. This detection system will be useful as a microbiological tool for the diagnosis of human and animal sporotrichosis...
  18. ncbi request reprint Feline ubiquitin fusion protein genes
    R Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    Vet Res Commun 25:615-22. 2001
    ..These results suggested that there were more ubiquinated proteins in the heat-shocked CRFK cells than in the pre-heat-shocked cells...
  19. ncbi request reprint The first isolation of Nocardia veterana from a human mycetoma
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    Microbiol Immunol 46:409-12. 2002
    ..veterana showed 99.8% similarity. All data are consistent with the conclusion that the isolate in this human case of mycetoma is N. veterana...
  20. pmc First report on Schizophyllum commune from a dog
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Japan
    J Clin Microbiol 40:3535-7. 2002
    ..The clinical isolate was identified as S. commune by mycological examination and analysis of ribosomal DNA sequences...
  21. ncbi request reprint Isolation of Fusarium solani from a dog: identification by molecular analysis
    R Kano
    Department of Pathology, Nihon University School of Veterinary Medicine, Fujisawa Kanagawa, Japan
    Med Mycol 40:435-7. 2002
    ..Clinical isolates from this systemic infection were identified using microscopic examination and confirmed by molecular analysis...
  22. ncbi request reprint Molecular identification of Trichophyton rubrum isolate from a dog by chitin synthase 1 (CHS1) gene analysis
    R Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    Med Mycol 40:439-42. 2002
    ..The molecular typing suggested that isolates of T. rubrum from human and canine sources were genetically identical...
  23. ncbi request reprint Chitin synthase 1 gene of Arthroderma benhamiae isolates in Japan
    R Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Fujisawa, Kanagawa, 252 8510, Japan
    Mycoses 45:277-81. 2002
    ..benhamiae were included in the same cluster, and that the African race of A. benhamiae formed a cluster that was distinct from the Americano-European race of A. benhamiae, A. simii and A. vanbreuseghemii...
  24. ncbi request reprint First isolation of Cryptococcus magnus from a cat
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Fujisawa, Kanagawa, 252 8510, Japan
    Mycopathologia 157:263-4. 2004
    ..The isolate was identified as Cryptococcus magnus by mycological analysis and 28S ribosomal analysis...
  25. ncbi request reprint cDNA of canine heat shock protein 70 (HSP70)
    R Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Kameino, Fujisawa, Kanagawa, 252 8510, Japan
    Vet Res Commun 28:395-405. 2004
    ..Canine HSP70 mRNA was detectable in canine peripheral blood mononuclear cells and stomach but not in liver, kidney, spleen, small intestine, large intestine and skin of dogs...
  26. ncbi request reprint Canine CD20 gene
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameiho, Fujisawa, Kanagawa 252 8510, Japan
    Vet Immunol Immunopathol 108:265-8. 2005
    ..From these results, canine CD20 might be targeted for monoclonal antibody therapy against B-cell lymphoma of dogs...
  27. ncbi request reprint Metalloprotease gene of Arthroderma gypseum
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Kanagawa 252 8510, Japan
    Jpn J Infect Dis 58:214-7. 2005
    ..gypseum. Reverse transcriptase-PCR analysis suggested that keratin might stimulate the expression of MEP mRNA in A. gypseum...
  28. ncbi request reprint First case of feline systemic Cryptococcus albidus infection
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Kameino, Fujisawa Kanagawa 252 8510, Japan
    Med Mycol 46:75-7. 2008
    ..albidus by molecular analysis, as well as through morphologic and biochemical studies. Therefore, this case indicates that C. albidus should be considered as a potential feline pathogen...
  29. doi request reprint Expression of Bcl-2 in feline lymphoma cell lines
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    Vet Clin Pathol 37:57-60. 2008
    ..The Bcl-2 gene is a member of the rapidly expanding Bcl-2 family of genes that regulate apoptosis. Bcl-2 has been shown to repress cell death triggered by a diverse array of stimuli, including chemotherapy and gamma irradiation...
  30. doi request reprint A new genotype of Arthroderma benhamiae
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Kanagawa, Japan
    Med Mycol 46:739-44. 2008
    ..benhamiae. These results were confirmed by ITS analysis. Therefore, it was proposed that genotypes could be established for the isolates of A. benhamiae in association with the mating behavior...
  31. doi request reprint Effectiveness of small interfering RNA (siRNA) against the Mcl-1 gene in a canine mammary gland tumor cell line
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Res Vet Sci 87:64-6. 2009
    ..Our study suggests the importance of Mcl-1 in canine mammary tumors for inducing apoptosis and reinforces using Mcl-1 as a putative therapeutic target in canine mammary gland tumor...
  32. doi request reprint Isolation of Trichophyton rubrum var. raubitschekii from a dog
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Kanagawa, Japan
    Med Mycol 48:653-5. 2010
    ..8S-ITS2 sequences suggest that human and canine isolates of T. rubrum and T. rubrum var. raubitschekii are genetically identical. Therefore, T. rubrum, including T. rubrum var. raubitschekii, might be pathogenic to humans and dogs...
  33. doi request reprint Arthroderma benhamiae (the teleomorph of Trichophyton mentagrophytes) mating type-specific genes
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Kameino, Fujisawa, Kanagawa, 252 0880, Japan
    Mycopathologia 171:333-7. 2011
    ..benhamiae (+) mating type strains but not in (-) mating type strains. These findings suggest that the HMG and alpha-box genes could be specific to the (+) and (-) mating types, respectively...
  34. doi request reprint The first reported case of canine subcutaneous Cryptococcus flavescens infection
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    Mycopathologia 173:179-82. 2012
    ..Isolates from the biopsy specimens were identified as C. flavescens by molecular analysis as well as morphologic and biochemical examination, indicating that C. flavescens is a potential canine pathogen...
  35. doi request reprint Mating genes of the Trichophyton mentagrophytes complex
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    Mycopathologia 173:103-12. 2012
    ..simii, the third cluster consisting of A. benhamiae and the fourth cluster consisting of M. gypseum. These results indicate that anthropophilic T. mentagrophytes evolved from the A. vanbreuseghemii (+) mating strain...
  36. ncbi request reprint Rapid identification of Candida tropicalis from canine cystitis
    Hiroko Ozawa
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Kameino, Kanagawa Perfecture, Fujisawa, Japan
    Mycopathologia 160:159-62. 2005
    ..The patient dog, a 10-year-old male Shih Tzu dog (7.0 kg) referred for examination of cystitis was successfully treated with itraconazole...
  37. ncbi request reprint Direct detection of dermatophytes in skin samples based on sequences of the chitin synthase 1 (CHS1) gene
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Kanagawa, Japan
    J Vet Med Sci 65:267-70. 2003
    ..By PCR analysis with the primer pair, dermatophyte DNA could be diagnosed directly and rapidly in clinical skin samples...
  38. ncbi request reprint Molecular taxonomy of dermatophytes and related fungi by chitin synthase 1 (CHS1) gene sequences
    Asuka Hirai
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Antonie Van Leeuwenhoek 83:11-20. 2003
    ..The molecular taxonomy of the CHS1 gene sequences revealed that Microsporum was genetically distinct from Chrysosporium and Trichophyton, as classified by morphological characteristics...
  39. ncbi request reprint Molecular cloning of canine Mcl-1 gene and its expression in tumor cell lines
    Junichi Sano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Kanagawa, Japan
    J Vet Med Sci 66:709-12. 2004
    ....
  40. ncbi request reprint The effect of small interfering RNA (siRNA) against the Bcl-2 gene on apoptosis and chemosensitivity in a canine mammary gland tumor cell line
    Kota Nagamatsu
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa 252 8510, Japan
    Res Vet Sci 84:49-55. 2008
    ..This study indicated that downregulation of Bcl-2 expression by siRNA would be useful as a new protocol to increase the effect of doxorubicin on treatment of canine mammary gland tumors, requiring a detailed evaluation of siRNA in vivo...
  41. ncbi request reprint The effect of dermatophytes on cytokine production by human keratinocytes
    Kenji Tani
    Department of Dermatology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo, 173 8605, Japan
    Arch Dermatol Res 299:381-7. 2007
    ....
  42. ncbi request reprint 26S rDNA-based phylogenetic investigation of Japanese cattle-associated Prototheca zopfii isolates
    Yuji Kishimoto
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Japan
    J Vet Med Sci 72:123-6. 2010
    ..blaschkeae by 26S rDNA analysis. The isolate was the first isolation in Japan...
  43. ncbi request reprint Capsule-associated genes of serotypes of Cryptococcus neoformans, especially serotype AD
    Ken Okabayashi
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa Kanagawa, Japan
    Med Mycol 44:127-32. 2006
    ..The present results indicated that serotypes of C. neoformans could be identified by the phylogenetic analyses of CAP genes...
  44. ncbi request reprint Antifungal activity of itraconazole and voriconazole against clinical isolates obtained from animals with mycoses
    Ken Okabayashi
    Department of Veterinary Biochemistry, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, Japan
    Nihon Ishinkin Gakkai Zasshi 50:91-4. 2009
    ....
  45. ncbi request reprint Detection of CAP59 gene in 2 feline cases of systemic cryptococcosis
    Ken Okabayashi
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Kameino, Fujisawa Kanagawa, Japan
    J Vet Med Sci 65:953-5. 2003
    ..The results of molecular analysis were consistent with the mycological findings...
  46. ncbi request reprint Cloning of canine toll-like receptor 9 and its expression in dog tissues
    Masashi Hashimoto
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Vet Immunol Immunopathol 106:159-63. 2005
    ....
  47. ncbi request reprint Molecular cloning of canine mucosal addressin cell adhesion molecule-1 cDNA and its expression in normal tissues
    Teruhisa Miura
    Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, Nihon University, Kanagawa, Japan
    J Vet Med Sci 67:1257-60. 2005
    ..Canine MAdCAM-1 mRNA was confirmed to express extremely in the mesenteric lymph node by RT-PCR...
  48. doi request reprint Chronic ulcerative dermatitis caused by Fusarium sporotrichioides
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    Med Mycol 49:303-5. 2011
    ..Based on these findings, F. sporotrichioides was established as the etiologic agent of the canine infection, a situation that has not been previously reported in dogs, as well as humans...
  49. ncbi request reprint Genotyping of Malassezia pachydermatis isolates from canine healthy skin and lesional skin of atopic dermatitis in Japan, Korea and Taiwan
    Anna Koike
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252 0880, Japan
    J Vet Med Sci 75:955-8. 2013
    ..All subtype isolates grew well on acidic medium (pH 6). However, subtype 3C and 3D isolates grew better than the other subtype isolates on medium at pH 8. ..
  50. ncbi request reprint Molecular cloning of canine thrombomodulin cDNA and expression in normal tissues
    Haruhiko Maruyama
    Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, Nihon University, Japan
    J Vet Med Sci 66:1423-7. 2004
    ..The present results provide valuable data for research into canine coagulation disorders...
  51. ncbi request reprint Effect of antineoplastic drugs on the expression of Bcl-2 and Bcl-xL genes in the feline T-cell leukemia cell line
    Junichi Sano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Kameino, Fujisawa, Kanagawa, 252 8510, Japan
    Res Vet Sci 79:197-201. 2005
    ..2- and 5.8-folds to the controls and inducible level of Bcl-xL by vincristine was decreased about 0.35-folds...
  52. ncbi request reprint Molecular cloning and tissue expression of canine Toll-like receptor 2 (TLR2)
    Mario Ishii
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Vet Immunol Immunopathol 110:87-95. 2006
    ....
  53. ncbi request reprint In vitro effect of recombinant human tumor necrosis factor-alpha on canine neutrophil apoptosis
    Keisuke Oguma
    Department of Pathobiology, Nihon University, School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Res Vet Sci 80:162-6. 2006
    ..Therefore, it is indicated that TNF-alpha is able to activate anti- and pro-apoptotic pathways in PMNs and that the inhibition of PMN apoptosis by TNF-alpha requires protein synthesis in the PMNs...
  54. ncbi request reprint Serotypes and mating types of clinical isolates from feline cryptococcosis in Japan
    Ken Okabayashi
    Department of Veterinary Biochemistry, College of Bioresource Sciences, Nihon University, Kanagawa 252 8510, Japan
    J Vet Med Sci 68:91-4. 2006
    ..The results showed that all clinical isolates examined were identified as serotype A, MATalpha, indicating that feline cryptococcsis cases in Japan are caused by C. neoformans serotype A, MATalpha, as is the case in humans...
  55. doi request reprint Molecular typing and in-vitro activity of azoles against clinical isolates of Aspergillus fumigatus and A. niger in Japan
    Moe Asano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa, 252 0880, Japan
    J Infect Chemother 17:483-6. 2011
    ..fumigatus was resistant to ITZ. Sequencing of the 14α-demethylase gene (cyp51A) of this isolate revealed a novel mutation (F332K) in the gene...
  56. ncbi request reprint Reticulated platelet levels in whole blood and platelet-rich plasma of dogs with various platelet counts measured by flow cytometry
    Haruhiko Maruyama
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    J Vet Med Sci 71:195-7. 2009
    ..The result revealed that WBM, as well as PRPM, can be used clinically to determine RP levels in dogs with abnormal platelet counts...
  57. doi request reprint Genotyping of Malassezia pachydermatis isolates from canine healthy skin and atopic dermatitis by internal spacer 1 (IGS1) region analysis
    Tetsuya Kobayashi
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252 0880, Japan
    Vet Dermatol 22:401-5. 2011
    ..Increased phospholipase A2 production may be involved in the inflammatory process associated with Malassezia dermatitis...
  58. ncbi request reprint A unique isolate of Malassezia from a cat
    Asuka Hirai
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    J Vet Med Sci 64:957-9. 2002
    ..In molecular analysis, however, it differed from the 7 species of Malassezia previously reported. Therefore, this clinical isolate from a cat might be a new species of Malassezia...
  59. ncbi request reprint Canine Bcl-xL gene and its expression in tumor cell lines
    Junichi Sano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Japan
    J Vet Med Sci 65:149-51. 2003
    ..3% homology with that of human, mouse, rat, sheep and pig Bcl-xL, respectively. RT-PCR analysis revealed that canine Bcl-xL mRNA was constitutively expressed in CL-1 (canine lymphoma) and GL-1 (canine B cell leukemia) cell lines...
  60. ncbi request reprint Malassezia nana sp. nov., a novel lipid-dependent yeast species isolated from animals
    Asuka Hirai
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Int J Syst Evol Microbiol 54:623-7. 2004
    ..sympodialis, but can be distinguished from these species by its inability to use Cremophor EL (Sigma) as the sole lipid source and to hydrolyse aesculin. The type strain of M. nana is NUSV 1003(T) (=CBS 9557(T)=JCM 12085(T))...
  61. ncbi request reprint Characterization of canine caspase-3
    Junichi Sano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    J Vet Med Sci 66:563-7. 2004
    ..6% homology with that of human, pig, mouse, chicken and zebra fish caspase-3, respectively. The caspase-3 mRNA was confirmed to express in skin, lymph node, bone marrow, small intestine and lung from a healthy dog by RT-PCR analysis...
  62. ncbi request reprint High expression of Bcl-xL in delayed apoptosis of canine neutrophils induced by lipopolysaccharide
    Junichi Sano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Res Vet Sci 78:183-7. 2005
    ..4-, 1.9-, 1.4- and 5.3-folds, in comparison to those in non-stimulated neutrophils, respectively. These results indicated that Bcl-xL was proved have an important role in the inhibition of canine neutrophil apoptosis by LPS...
  63. ncbi request reprint Apoptosis of canine mammary tumor cells induced by small interfering RNA (siRNA) against Bcl-xL gene
    Fumito Tsuchiya
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Kanagawa, Japan
    J Vet Med Sci 68:1199-201. 2006
    ..9%, 30%, 28.7% and 11.6% at 48-hr incubation, respectively, when evaluated by TUNEL assay. From these results, it was suggested that canine Bcl-xL might be an anticancer target of canine tumors...
  64. ncbi request reprint In vitro algaecide effect of disinfectants on Prototheca zopfii genotypes 1 and 2
    Hideto Sobukawa
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa 252 0880, Japan
    J Vet Med Sci 73:1527-9. 2011
    ..This in vitro study indicated that alkyldiaminoethylglycine hydrochloride, chlorhexidine, povidone iodine and sodium hypochlorous acid, but not dioxide chlorine, are effective against both genotypes of P. zopfii...
  65. ncbi request reprint Expression of apoptosis-related gene mRNAs in feline T-cells infected with feline immunodeficiency virus (FIV)
    Junpei Yamazaki
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Vet Microbiol 101:1-8. 2004
    ..The expression of bcl-2 mRNA in lymphocytes of established cell line was increased by FIV. The amounts of mRNAs of bax, caspase 3 and bcl-xL in FIV-infected cells were not different from those in uninfected control cells...
  66. ncbi request reprint Systemic treatment of sterile panniculitis with tacrolimus and prednisolone in dogs
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Kanagawa 252 8510, Japan
    J Vet Med Sci 68:95-6. 2006
    ..The oral tacrolimus treatment was proved to be an affordable medical protocol for canine sterile panniculitis with good efficacy and without adverse effects...
  67. ncbi request reprint An isolate of Prototheca wickerhamii from systemic canine protothecosis
    Hiroko Tsuji
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa, Japan
    Vet Microbiol 118:305-11. 2006
    ..including a standard strain of P. wickerhamii, and another group consisting of isolates previously reported to be close to the Auxenochorella species...
  68. doi request reprint In vitro susceptibility of Prototheca zopfii genotypes 1 and 2
    Hideto Sobukawa
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Kanagawa, Japan
    Med Mycol 49:222-4. 2011
    ..Moreover, genotype 2 isolates and seven isolates of genotype 1, including the type strain, are not susceptible to ITZ (>10 μg/ml). Thus, drug susceptibility of P. zopfii differs between these two genotypes...
  69. doi request reprint An azole-resistant isolate of Malassezia pachydermatis
    Misako Nijima
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Vet Microbiol 149:288-90. 2011
    ..Thus, isolate ASC-11 may be resistant to these azoles, making this the first report of a resistant isolate of M. pachydermatis to KTZ and ITZ...
  70. ncbi request reprint Gene expression of adrenomedullin in canine normal tissues and diseased hearts
    Nobuyuki Kanno
    Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Japan
    J Vet Med Sci 71:789-92. 2009
    ..In addition, the AM mRNA expression in the left atrium of dogs with MR was significantly higher than that in normal subjects. In conclusion, AM is a potential neurohumoral factor in dogs with CHF due to MR...
  71. ncbi request reprint Detection and identification of the Candida species by 25S ribosomal DNA analysis in the urine of candidal cystitis
    Rui Kano
    Department of Pathobiology, Nihon University, School of Veterinary Medicine, Fujisawa, Kangawa, Japan
    J Vet Med Sci 64:115-7. 2002
    ..parapsilosis, respectively. Confirming the results on the isolates cultured from the same urine samples. This PCR analysis method could be available for the direct identification of Candida species in urine samples within 2 days...
  72. ncbi request reprint Full-length cDNA cloning of Toll-like receptor 4 in dogs and cats
    Yuka Asahina
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Vet Immunol Immunopathol 96:159-67. 2003
    ..On the other hand, mRNA of feline TLR4 was expressed highly in lung, bladder and PBL, moderately in kidney, liver, spleen and large intestine and at low levels in pancreas and small intestine...
  73. doi request reprint Prototheca zopfii genotypes isolated from cow barns and bovine mastitis in Japan
    Takafumi Osumi
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Vet Microbiol 131:419-23. 2008
    ..zopfii genotype 2. P. zopfii isolates should thus be further explored with regard to genotype to clarify the reservoir of etiological agents in bovine Prototheca mastitis...
  74. ncbi request reprint Differentiation of Malassezia furfur and Malassezia sympodialis by glycine utilization
    T Murai
    Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan
    Mycoses 45:180-3. 2002
    ..furfur might be able to utilize glycine as a single nitrogen source, which the other Malassezia species could not. Therefore, glycine medium was recommended for the differentiation of M. furfur from other species of Malassezia...
  75. ncbi request reprint Severe calcification of mucocutaneous and gastrointestinal tissues induced by high dose administration of vitamin D in a puppy
    Yuka Nakamura
    Department of Veterinary Internal Medicine, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    J Vet Med Sci 66:1133-5. 2004
    ..Therefore, vitamin D should be carefully administrated to a puppy...
  76. ncbi request reprint Expression of capsule-associated genes of Cryptococcus neoformans
    Ken Okabayashi
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Kameino, 252 8510, Fujisawa Kanagawa, Japan
    Mycopathologia 160:1-7. 2005
    ....
  77. ncbi request reprint Small interfering RNA (siRNA) against the survivin gene increases apoptosis in a canine melanoma cell line
    Miyuki Moriyama
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Kanagawa, Japan
    J Vet Med Sci 72:1643-6. 2010
    ..These findings suggest the importance of survivin in canine melanoma tumors for inducing apoptosis, and reinforce the possibility of using survivin as a putative therapeutic target in canine malignant melanoma tumor...
  78. ncbi request reprint Parathyroid hormone-related protein (PTHrP) produced by dog lymphoma cells
    Akiko Kubota
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    J Vet Med Sci 64:835-7. 2002
    ..PTHrP mRNA was clearly detected not only in the lymphoma cells from this dog with hypercalcemia but also in lymphoma cells from 4 lymphoma cases without hypercalcemia and 2 canine lymphoma cell lines...
  79. pmc Nocardia africana isolated from a feline mycetoma
    Yousuke Hattori
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa 252 8510, Japan
    J Clin Microbiol 41:908-10. 2003
    ..The isolate developed orange, wrinkled colonies. The bacteria were rod shaped to coccoid (1 by 5 microm) and gram positive. Analysis of the 16S ribosomal DNAs of the isolate and a reference strain of N. africana showed 100% homology...
  80. ncbi request reprint VP2 gene of a canine parvovirus isolate from stool of a puppy
    Kentarou Hirayama
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Kameino, Fujisawa, Kanagawa, Japan
    J Vet Med Sci 67:139-43. 2005
    ..The result indicated that this clinical isolate was phylogenetically close to the isolate of wild-type CPV (strain CPV-T37) prevailing in Taiwan rather than isolates from Japan...
  81. ncbi request reprint Small interfering RNA (siRNA) against the Bcl-2 gene increases apoptosis in a canine melanoma cell line
    Yuzuru Watanabe
    Department of Pathobiology, Nihon University School of Veterinary Medicine 1866, Kameino, Fujisawa, Kanagawa 252 8510, Japan
    J Vet Med Sci 72:383-6. 2010
    ..Our study suggests the importance of Bcl-2 in canine melanoma tumors for inducing apoptosis and reinforces using Bcl-2 as a putative therapeutic target in canine malignant melanoma tumor...
  82. ncbi request reprint Characterization of a monoclonal antibody against desmoplakin 1 for use in dogs
    Yuka Nakamura
    Department of Veterinary Internal Medicine, Nihon University, School of Veterinary Medicine, Kanagawa, Japan
    Vet Dermatol 13:165-7. 2002
    ..17 using immunohistochemical analysis. From these results, DP2.17, developed for the examination of human skin, might be suitable for the investigation of Dsp-related skin disorders in dogs...
  83. pmc Interleukin-8 and tumor necrosis factor alpha production in human epidermal keratinocytes induced by Trichophyton mentagrophytes
    Yuka Nakamura
    Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan
    Clin Diagn Lab Immunol 9:935-7. 2002
    ..IL-8 and TNF-alpha mRNAs were also detected in the keratinocytes cocultured with T. mentagrophytes...
  84. ncbi request reprint Thiazole orange positive platelets in a dog with Evans' syndrome
    Takeshi Michimoto
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Kanagawa, Japan
    J Vet Med Sci 66:1305-6. 2004
    ..The result demonstrated that measurement of the RP% can be useful in evaluating platelet production in the bone marrow and response to treatment...
  85. ncbi request reprint Canine parvovirus binds to multiple cellular membrane proteins from both permissive and nonpermissive cell lines
    K Uwatoko
    Laboratory of Veterinary Virology, College of Agriculture and Veterinary Medicine, Nihon University, Kanagawa, Japan
    Vet Microbiol 51:267-73. 1996
    ..We confirm that the mechanism of nonpermissiveness to CPV is not operative at the cellular attachment level...
  86. ncbi request reprint Molecular epidemiology of Arthroderma benhamiae, an emerging pathogen of dermatophytoses in Japan, by polymorphisms of the non-transcribed spacer region of the ribosomal DNA
    T Mochizuki
    Department of Dermatology, Kanazawa Medical University, 920 0293, Ishikawa, Japan
    J Dermatol Sci 27:14-20. 2001
    ..benhamiae isolated in Japan. None of the five DNA types were found among the registered tester strains of A. benhamiae. Therefore, several different strains of A. benhamiae may have been brought into Japan separately...
  87. ncbi request reprint Susceptibility testing of Malassezia pachydermatis using the urea broth microdilution method
    T Murai
    Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan
    Mycoses 45:84-7. 2002
    ..Although the activity of antifungal drugs in combination with lysozyme is enhanced for other fungi. These results suggested that M. pachydermatis might not be affected by the host's natural defences...
  88. ncbi request reprint Molecular diagnosis of feline sporotrichosis
    R Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Vet Rec 156:484-5. 2005
  89. ncbi request reprint Gene expressions of canine angiopoietin-1 and -2 in normal tissues and spontaneous tumours
    Y Kato
    Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Kameino 1866, Fujisawa, Kanagawa 252 8510, Japan
    Res Vet Sci 81:280-6. 2006
    ..Higher mRNA expression level of canine Ang-2 was demonstrated in mammary simple carcinomas, haemangiosarcoma and hepatocellular carcinoma in comparison with normal tissues...
  90. ncbi request reprint [Chitin Synthase 2 (CHS2) gene of Malassezia species]
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    Nihon Ishinkin Gakkai Zasshi 46:157-61. 2005
    ..The phylogenetic analysis of the nucleotide sequences of CHS2 gene fragments of standard strains of 11 Malassezia species showed 11 distinct clusters of this species...
  91. ncbi request reprint In vitro selective suppression of feline myeloid colony formation is attributable to molecularly cloned strain of feline leukemia virus with unique long terminal repeat
    N Nagashima
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Res Vet Sci 78:151-4. 2005
    ..This suggests that FeLV C-33 has myeloid lineage-specific pathogenicity for cats, and that FeLV C-33 infection is useful as an experimental model for investigating pathogenesis of MDS and AML...
  92. ncbi request reprint Isolation of Penicillium commune from a pulmonary infection in a dog
    R Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Vet Rec 159:779-80. 2006
  93. ncbi request reprint [Cytokine production and dermatophytosis]
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa 252 8510, Japan
    Nihon Ishinkin Gakkai Zasshi 45:131-6. 2004
    ..The ELISA analysis of cytokine production by human keratinocytes will provide useful information in understanding the pathogenesis of dermatomycosis...
  94. ncbi request reprint Cloning of canine Toll-like receptor 7 gene and its expression in dog tissues
    Yasuhumi Okui
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Vet Immunol Immunopathol 121:156-60. 2008
    ..In other tissues (kidney, liver, lymph node, spleen, adrenal gland, and PBMCs), the level of TLR7 mRNA expression was different in individuals...
  95. ncbi request reprint Detection of autoantibodies against survivin in sera from cancer dogs
    Yumiko Tango
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Japan
    J Vet Med Sci 72:917-20. 2010
    ..Sera from 16 of 59 (27.1%) cancer and 3 of 25 (12%) non-cancer disease dogs were positive on ELISA. The highest positivity rates (>50%) among the cancer cases were seen in dogs with mammary tumor, squamous cell carcinoma and melanoma...
  96. pmc Molecular analysis of CAP59 gene sequences from five serotypes of Cryptococcus neoformans
    Y Nakamura
    Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan
    J Clin Microbiol 38:992-5. 2000
    ..The molecular analysis of the CAP59 gene will provide useful information for the differentiation of serotypes of C. neoformans and for an understanding of their phylogenetic relationships...
  97. ncbi request reprint Arthroderma benhamiae infection in a rabbit
    K Saito
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan
    J Vet Med Sci 63:929-31. 2001
    ..The isolate from the rabbit with dermatophytosis which was transmitted to the owners was proved to be Arthroderma benhamiae (-) by mating experiments as well as by chitin synthase 1 (CHSI) gene analysis...
  98. ncbi request reprint Accelerated neutrophil apoptosis in 2 canine cases of hepatic disorder
    Keisuke Oguma
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Kanagawa, Japan
    J Vet Med Sci 65:415-7. 2003
    ..Accelerated neutrophil apoptosis was confirmed by TUNEL assay in two canine cases of hepatic disorder. One dog was diagnosed as having lymphocytic hepatitis and the other lymphocytic cholangitis by histopathology of liver biopsy specimen...
  99. ncbi request reprint Expression of RANTES mRNA in skin lesions of feline eosinophilic plaque
    Tomoe Kimura
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Kameino, Fujisawa, Kanagawa, 252 8510, Japan
    Vet Dermatol 14:269-73. 2003
    ..The result suggested that RANTES might play a role to induce eosinophil infiltration in feline eosinophilic plaque lesions...
  100. ncbi request reprint Decreased apoptotic polymorphonuclear leukocyte rate in dogs with pyometra
    Junichi Sano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa 252 8510, Japan
    J Vet Med Sci 66:103-5. 2004
    ..4 +/- 5% and that in healthy dogs was 54.3 +/- 7%. The results indicated that apoptotic PMN rates in dogs with pyometra were significantly lower than those in control dogs (p<0.05), suggesting the prolongation of PMN survival...
  101. ncbi request reprint [Chitin synthase (CHS) gene analysis of dermatophytes]
    Rui Kano
    Department of Pathobiology, Nihon University School of Veterinary Medicine, 1866, Fujisawa, Kanagawa 252 8510, Japan
    Nihon Ishinkin Gakkai Zasshi 45:47-53. 2004
    ..RT-PCR analysis suggested that chitin synthase inhibitors (nikkomycin Z and polyoxin D) might stimulate the expression of CHS1 mRNA in A. benhamiae, and not the expression of CHS2 mRNA...