Takao Watanabe

Summary

Affiliation: Nihon University
Country: Japan

Publications

  1. pmc Anatomical variation of superior petrosal vein and its management during surgery for cerebellopontine angle meningiomas
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi ku, Tokyo, 173 8610, Japan
    Acta Neurochir (Wien) 155:1871-8. 2013
  2. ncbi request reprint Long-term remission of primary central nervous system lymphoma by intensified methotrexate chemotherapy
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Neurooncol 63:87-95. 2003
  3. ncbi request reprint Preliminary individualized chemotherapy for malignant astrocytomas based on O6-methylguanine-deoxyribonucleic acid methyltransferase methylation analysis
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    Neurol Med Chir (Tokyo) 46:387-93; discussion 393-4. 2006
  4. ncbi request reprint Human interferon beta, nimustine hydrochloride, and radiation therapy in the treatment of newly diagnosed malignant astrocytomas
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Tokyo, Itabashi ku, Japan
    J Neurooncol 72:57-62. 2005
  5. ncbi request reprint Promoter hypermethylation of mismatch repair gene hMLH1 predicts the clinical response of malignant astrocytomas to nitrosourea
    Takao Fukushima
    Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi, Tokyo 173 8610, Japan
    Clin Cancer Res 11:1539-44. 2005
  6. ncbi request reprint O6-methylguanine-DNA methyltransferase methylation and TP53 mutation in malignant astrocytomas and their relationships with clinical course
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi kamumachi, Itabashi ku, Tokyo 173 8610, Japan
    Int J Cancer 113:581-7. 2005
  7. ncbi request reprint Deregulation of the TP53/p14ARF tumor suppressor pathway in low-grade diffuse astrocytomas and its influence on clinical course
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo 173 8610, Japan
    Clin Cancer Res 9:4884-90. 2003
  8. ncbi request reprint Aberrant hypermethylation of p14ARF and O6-methylguanine-DNA methyltransferase genes in astrocytoma progression
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    Brain Pathol 17:5-10. 2007
  9. ncbi request reprint Treatment of low-grade diffuse astrocytomas by surgery and human fibroblast interferon without radiation therapy
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Neurooncol 61:171-6. 2003
  10. doi request reprint Lateral supracerebellar transtentorial approach for petroclival meningiomas: operative technique and outcome
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Neurosurg 115:49-54. 2011

Collaborators

Detail Information

Publications47

  1. pmc Anatomical variation of superior petrosal vein and its management during surgery for cerebellopontine angle meningiomas
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi ku, Tokyo, 173 8610, Japan
    Acta Neurochir (Wien) 155:1871-8. 2013
    ..In cases where the superior petrosal vein was previously occluded, other bridging veins could correspond with implications for the crucial venous drainage system, and should thus be identified and protected whenever possible. ..
  2. ncbi request reprint Long-term remission of primary central nervous system lymphoma by intensified methotrexate chemotherapy
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Neurooncol 63:87-95. 2003
    ..In older patients, WBRT should be avoided to sustain a meaningful survival, and SRT may provide a valid strategy in terms of enhancing local disease control without undue risk...
  3. ncbi request reprint Preliminary individualized chemotherapy for malignant astrocytomas based on O6-methylguanine-deoxyribonucleic acid methyltransferase methylation analysis
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    Neurol Med Chir (Tokyo) 46:387-93; discussion 393-4. 2006
    ..The PAV regimen is effective against MGMT-methylated malignant astrocytomas, but the CE regimen is not useful at the given dose and schedule in MGMT-unmethylated tumors...
  4. ncbi request reprint Human interferon beta, nimustine hydrochloride, and radiation therapy in the treatment of newly diagnosed malignant astrocytomas
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Tokyo, Itabashi ku, Japan
    J Neurooncol 72:57-62. 2005
    ..In addition, they emphasize the importance of a preserved KPS after cytoreductive surgery, which could produce a potential benefit for adjuvant therapy and could ultimately lead to a prolonged survival...
  5. ncbi request reprint Promoter hypermethylation of mismatch repair gene hMLH1 predicts the clinical response of malignant astrocytomas to nitrosourea
    Takao Fukushima
    Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi, Tokyo 173 8610, Japan
    Clin Cancer Res 11:1539-44. 2005
    ..The aim of the present study was to investigate the role of promoter methylation of the hMLH1 gene in malignant astrocytomas...
  6. ncbi request reprint O6-methylguanine-DNA methyltransferase methylation and TP53 mutation in malignant astrocytomas and their relationships with clinical course
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi kamumachi, Itabashi ku, Tokyo 173 8610, Japan
    Int J Cancer 113:581-7. 2005
    ..These findings highlight the importance of MGMT methylation as a specific predictive factor for responsiveness to nitrosourea chemotherapy...
  7. ncbi request reprint Deregulation of the TP53/p14ARF tumor suppressor pathway in low-grade diffuse astrocytomas and its influence on clinical course
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo 173 8610, Japan
    Clin Cancer Res 9:4884-90. 2003
    ..The role of each tumor suppressor pathway in low-grade diffuse astrocytomas and their relationships with clinical behavior remain to be elucidated...
  8. ncbi request reprint Aberrant hypermethylation of p14ARF and O6-methylguanine-DNA methyltransferase genes in astrocytoma progression
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    Brain Pathol 17:5-10. 2007
    ..Our findings suggest that p14(ARF) hypermethylation and MGMT hypermethylation constitute distinct molecular pathways of astrocytoma progression, which could differ in biological behavior and clinical outcome...
  9. ncbi request reprint Treatment of low-grade diffuse astrocytomas by surgery and human fibroblast interferon without radiation therapy
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Neurooncol 61:171-6. 2003
    ..Although our data from small cohort of patients may have modest value, our results suggest that HFIF may be useful in treating low-grade diffuse astrocytomas...
  10. doi request reprint Lateral supracerebellar transtentorial approach for petroclival meningiomas: operative technique and outcome
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Neurosurg 115:49-54. 2011
    ....
  11. doi request reprint Non-promoter hypermethylation of zygote arrest 1 (ZAR1) in human brain tumors
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi ku, Tokyo 173 8610, Japan
    Brain Tumor Pathol 28:199-202. 2011
    ..Our results indicate that hypermethylation of the ZAR1 non-promoter is extremely frequent in diffuse gliomas and pituitary adenomas, although ZAR1 expression is unlikely to play a tumorigenic role...
  12. ncbi request reprint Aberrant hypermethylation of non-promoter zygote arrest 1 (ZAR1) in human brain tumors
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    Neurol Med Chir (Tokyo) 50:1062-9. 2010
    ..Our findings indicate that non-promoter hypermethylation of ZAR1 is extremely frequent in diffuse gliomas and pituitary adenomas, but methylation-related aberrant ZAR1 expression is far less likely to be related to glioma tumorigenesis...
  13. ncbi request reprint Gene expression profiling predicts response to temozolomide in malignant gliomas
    Atsuo Yoshino
    Department of Neurological Surgery, Nihon University School of Medicine, Itabashi ku, Tokyo 173 8610, Japan
    Int J Oncol 36:1367-77. 2010
    ..Furthermore, the present study could provide a foundation for alternative therapeutic strategies including novel combination treatments that incorporate additional reagents directed at overcoming resistance to TMZ...
  14. ncbi request reprint Effect of IFN-beta on human glioma cell lines with temozolomide resistance
    Atsuo Yoshino
    Department of Neurological Surgery, Nihon University School of Medicine, Itabashi ku, Tokyo 173 8610, Japan
    Int J Oncol 35:139-48. 2009
    ..The data provide an experimental basis for future strategies in TMZ chemotherapy, although further studies are needed to determine the detailed role of combined IFN-beta and TMZ chemotherapy in increasing tumor sensitivity...
  15. ncbi request reprint Promoter hypermethylation profile of cell cycle regulator genes in pituitary adenomas
    Atsuo Yoshino
    Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi ku, Tokyo, 173 8610, Japan
    J Neurooncol 83:153-62. 2007
    ..We further obtained evidence to indicate that RB1 and p16(INK4a) methylations tended to be mutually exclusive, but did occasionally coincide with other cell cycle regulation gene methylations...
  16. ncbi request reprint Telomerase activity in pituitary adenomas: significance of telomerase expression in predicting pituitary adenoma recurrence
    Atsuo Yoshino
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Neurooncol 63:155-62. 2003
    ..Detection of telomerase expression may represent an additional useful means of identifying aggressive behavior, complementing the histopathological evaluation of benign-appearing pituitary adenomas...
  17. doi request reprint Gene expression profiles predicting the response to IFN-β and a combination of temozolomide and IFN-β in malignant gliomas
    Atsuo Yoshino
    Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi ku, Tokyo 173 8610, Japan
    Int J Oncol 39:529-42. 2011
    ....
  18. ncbi request reprint Aberrant promoter hypermethylation profile of cell cycle regulatory genes in malignant astrocytomas
    Takashi Ohta
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo 173 8610, Japan
    Oncol Rep 16:957-63. 2006
    ..Thus, this epigenetic change is unlikely to play an important role in the evolution and development of malignant astrocytomas...
  19. ncbi request reprint Relevance of MSP assay for the detection of MGMT promoter hypermethylation in glioblastomas
    Kazunari Yachi
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo 173 8610, Japan
    Int J Oncol 33:469-75. 2008
    ..In all of the cell lines with loss of MGMT expression, signals of methylated DNA were detected by MSP. Our data support the feasibility and reliability of MSP analysis, which could be routinely implemented in the diagnostic setting...
  20. ncbi request reprint Therapeutic implications of interferon regulatory factor (IRF)-1 and IRF-2 in diffusely infiltrating astrocytomas (DIA): response to interferon (IFN)-beta in glioblastoma cells and prognostic value for DIA
    Atsuo Yoshino
    Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Tokyo 173 8610, Japan
    J Neurooncol 74:249-60. 2005
    ..Thus, IRF-1 and IRF-2 could represent one of the therapeutic target sites for the regulation of cell growth in DIA...
  21. ncbi request reprint The p15(INK4b)/p16(INK4a)/RB1 pathway is frequently deregulated in human pituitary adenomas
    Akiyoshi Ogino
    Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi ku, Tokyo 173 8610, Japan
    J Neuropathol Exp Neurol 64:398-403. 2005
    ....
  22. ncbi request reprint Promoter hypermethylation of the DNA repair gene O6-methylguanine-DNA methyltransferase is an independent predictor of shortened progression free survival in patients with low-grade diffuse astrocytomas
    Chiaki Komine
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    Brain Pathol 13:176-84. 2003
    ..Since the presence of MGMT methylation is expected to predict an increased sensitivity to alkylating chemotherapeutic agents, earlier chemotherapy could serve to improve an unfavorable natural history in tumors with MGMT methylation...
  23. ncbi request reprint [Genetic analysis and individualized therapy for diffuse glioma]
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo 173 8610, Japan
    No Shinkei Geka 33:537-53. 2005
  24. ncbi request reprint Prediction of clinical course of diffusely infiltrating astrocytomas from telomerase expression and quantitated activity level
    Takao Fukushima
    Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi ku, Tokyo 173 8610, Japan
    Cancer Lett 187:191-98. 2002
    ..Telomerase expression and its quantitated activity level are also a good predictor of clinical course as compared with other biological markers and clinical factors...
  25. ncbi request reprint [Therapeutic efficacy and prognostic factors in diffuse astrocytomas]
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, Japan
    No Shinkei Geka 31:767-73. 2003
    ....
  26. ncbi request reprint TrkA expression is associated with an elevated level of apoptosis in classic medulloblastomas
    Takashi Ohta
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    Neuropathology 26:170-7. 2006
    ....
  27. doi request reprint Pleomorphic granular cell astrocytoma in the pineal gland: case report
    Takashi Ohta
    Department of Neurological Surgery, Division of Neurosurgery and Pathology, Nihon University School of Medicine, Tokyo, Japan
    Neuropathology 30:615-20. 2010
    ..However, it can be differentiated from the latter by the absence of reticulin fibers, absence of basement membrane between adjacent cells, and presence of large numbers of mitochondria...
  28. ncbi request reprint Isolated intracranial Rosai-Dorfman disease without dural attachment--case report
    Takao Fukushima
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    Neurol Med Chir (Tokyo) 51:136-40. 2011
    ..Magnetic resonance imaging including diffusion-weighted imaging may be helpful in the diagnosis of isolated intracranial Rosai-Dorfman disease...
  29. pmc Gamma knife surgery for brain metastases from ovarian cancer
    Akiyoshi Ogino
    Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi ku, Tokyo, 173 8610, Japan
    Acta Neurochir (Wien) 154:1669-77. 2012
    ..The purpose of this study was to investigate the characteristics of brain metastases from ovarian cancer, and to assess the efficacy of treatment with gamma knife surgery (GKS)...
  30. ncbi request reprint Metastatic pituitary tumor from renal cell carcinoma treated by fractionated stereotactic radiotherapy--case report
    Takakazu Yokoyama
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    Neurol Med Chir (Tokyo) 44:47-52. 2004
    ..Fractionated SRT appears to be effective for preserving or improving the residual vision in patients with visual loss secondary to metastatic tumor of the pituitary gland, and may result in a longer and better quality of life...
  31. ncbi request reprint Aberrant TP53 protein accumulation in the neuronal component of ganglioglioma
    Takao Fukushima
    Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi ku, Tokyo, 173 8610, Japan
    J Neurooncol 72:103-6. 2005
    ..GeneChip TP53 assay revealed a point mutation resulting in an exchange of amino acid. This case suggests that ganglion cells can participate in the neoplastic process of gangliogliomas...
  32. ncbi request reprint Atypical epidermoid cyst with repetitive hemorrhages in the supracallosal region: case report
    Takashi Morishita
    Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    Neurol Med Chir (Tokyo) 49:492-4. 2009
    ..The present case suggests that epidermoid cyst should be considered in the differential diagnosis of suspected cavernous malformation in any location...
  33. doi request reprint Hemangiopericytoma arising in the body of the lateral ventricle
    Koichiro Sumi
    Department of Neurological Surgery, Nihon University School of Medicine, Itabashi ku, Tokyo 173 8610, Japan
    Acta Neurochir (Wien) 152:145-9; discussion 150. 2010
    ..Since preoperative identification of hemangiopericytomas confers therapeutic advantages,it is important to be aware that they can occur at unusual ventricular sites...
  34. doi request reprint Corticospinal descending direct wave elicited by subcortical stimulation
    Chikashi Fukaya
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Clin Neurophysiol 28:297-301. 2011
    ..Further studies are required to clarify the relationship between the distance from the stimulating point to the CT and the amplitude of the subcortically elicited D-wave...
  35. ncbi request reprint [Surgical strategy for opercular gliomas]
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi Kamimachi, Itabashi ku, Tokyo 173 8610, Japan
    No Shinkei Geka 36:493-503. 2008
  36. ncbi request reprint Quantitative spectroscopic analysis of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence intensity in diffusely infiltrating astrocytomas
    Ryutaro Ishihara
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    Neurol Med Chir (Tokyo) 47:53-7; discussion 57. 2007
    ..This preliminary study suggests that spectroscopic analysis may be useful for optimizing the removal of diffuse gliomas...
  37. doi request reprint Non-promoter DNA hypermethylation of Zygote Arrest 1 (ZAR1) in neuroblastomas
    Kiminobu Sugito
    Department of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Pediatr Surg 48:782-8. 2013
    ..To search the non-promoter ZAR1 hypermethylation in neuroblastomas, we analyzed the levels of the methylation and transcript expression of ZAR1...
  38. ncbi request reprint Growth control of C6 glioma in vivo by nerve growth factor
    Shigeyoshi Kimura
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Neurooncol 59:199-205. 2002
    ....
  39. ncbi request reprint [Syringosubarachnoid shunt for noncommunicating syringomyelia associated with spinal lipoma: a case report]
    Shun Yamamuro
    Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    No Shinkei Geka 40:527-32. 2012
    ..S-S shunt placement was therefore considered to be an effective treatment option for noncommunicating syringomyelia associated with a spinal lipoma...
  40. doi request reprint Investigation of the effect of the uneven distribution of CYP3A4 and P-glycoprotein in the intestine on the barrier function against xenobiotics: a simulation study
    Takao Watanabe
    Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    J Pharm Sci 102:3196-204. 2013
    ....
  41. doi request reprint Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments
    Takao Watanabe
    Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    Drug Metab Dispos 39:1031-8. 2011
    ..It is also recommended that in vitro-in vivo extrapolation be performed in animals to obtain more reliable prediction...
  42. ncbi request reprint Rapid induction of uterine endometrial proliferative lesions in transgenic mice carrying a human prototype c-Ha-ras gene (rasH2 mice) given a single intraperitoneal injection of N-ethyl-N-nitrosourea
    Takao Watanabe
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3 5 8 Saiwai cho, Fuchu, 183 8509, Tokyo, Japan
    Cancer Lett 188:39-46. 2002
    ..The result in the present study suggests that female rasH2 mice are very susceptible to uterine carcinogenesis, providing a useful model for ENU-induced uterine epithelial tumors...
  43. ncbi request reprint Methylation of the p73 gene in gliomas
    Takao Watanabe
    Unit of Molecular Pathology, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Acta Neuropathol 104:357-62. 2002
    ..Analysis of a polymorphic site in exon 2 further showed that p73 was mono-allelically expressed in 6 out of 7 primary gliomas with heterozygous GC/TA polymorphism...
  44. ncbi request reprint Susceptibility of liver proliferative lesions in heterozygous p53 deficient CBA mice to various carcinogens
    Takeki Uehara
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3 5 8 Saiwai cho, Fuchu, Tokyo 158 8501, Japan
    J Vet Med Sci 64:551-6. 2002
    ..The present results suggest that p53 gene knocked out heterozygously does not enhance the chemical hepatocarcinogenesis in CBA mice...
  45. ncbi request reprint Validation of a food-frequency questionnaire for cohort studies in rural Japan
    Keiko Ogawa
    Division of Epidemiology, Department of Public Health, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Public Health Nutr 6:147-57. 2003
    ..To examine the validity and reproducibility of a self-administered food-frequency questionnaire (FFQ) used for two cohort studies in Japan...
  46. ncbi request reprint Phenotype versus genotype correlation in oligodendrogliomas and low-grade diffuse astrocytomas
    Takao Watanabe
    Unit of Molecular Pathology, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Acta Neuropathol 103:267-75. 2002
    ..There was no correlation with LOH on chromosomes 1p/19q, suggesting that MGMT may not be a prognostic marker for oligodendrogliomas...
  47. ncbi request reprint Tumor promoting effect of phenolphthalein on development of lung tumors induced by N-ethyl-N-nitrosourea in transgenic mice carrying human prototype c-Ha-ras gene
    Masako Imaoka
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Fuchu, Japan
    J Vet Med Sci 64:489-93. 2002
    ..In addition, the ratio of area of adenomas in the ENU + PhP group was significantly higher than that in the ENU alone group. The result of our study suggests that PhP has a clear tumor promoting effect in the lung of rasH2 mice...