Makoto Bonkobara

Summary

Affiliation: Nippon Veterinary and Life Science University
Country: Japan

Publications

  1. ncbi request reprint Blastic natural killer cell leukaemia in a dog--a case report
    Makoto Bonkobara
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    Vet J 174:659-62. 2007
  2. doi request reprint Dysregulation of tyrosine kinases and use of imatinib in small animal practice
    Makoto Bonkobara
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan Electronic address
    Vet J 205:180-8. 2015
  3. pmc Establishment of a PCR analysis method for canine BRCA2
    Yasunaga Yoshikawa
    Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    BMC Res Notes 5:173. 2012
  4. doi request reprint Canine intestinal mast cell tumor with c-kit exon 8 mutation responsive to imatinib therapy
    Masato Kobayashi
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    Vet J 193:264-7. 2012
  5. doi request reprint Imatinib-associated tumour response in a dog with a non-resectable gastrointestinal stromal tumour harbouring a c-kit exon 11 deletion mutation
    Masato Kobayashi
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    Vet J 198:271-4. 2013
  6. doi request reprint Mutations in the fifth immunoglobulin-like domain of kit are common and potentially sensitive to imatinib mesylate in feline mast cell tumours
    Mayu Isotani
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, Musashino shi, Tokyo, Japan
    Br J Haematol 148:144-53. 2010
  7. ncbi request reprint Comparison of dendritic cell-mediated immune responses among canine malignant cells
    Kyoichi Tamura
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 701 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    J Vet Med Sci 69:925-30. 2007
  8. doi request reprint Reconstruction of stratum corneum in organotypically cultured canine keratinocyte-derived CPEK cells
    Hiroko Yagihara
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo, 180 8602, Japan
    Vet Res Commun 35:433-7. 2011
  9. doi request reprint Imatinib elicited a favorable response in a dog with a mast cell tumor carrying a c-kit c.1523A>T mutation via suppression of constitutive KIT activation
    Osamu Yamada
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    Vet Immunol Immunopathol 142:101-6. 2011
  10. doi request reprint Identification of dasatinib as an in vitro potent growth inhibitor of canine histiocytic sarcoma cells
    Keita Ito
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    Vet J 196:536-40. 2013

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Blastic natural killer cell leukaemia in a dog--a case report
    Makoto Bonkobara
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    Vet J 174:659-62. 2007
    ..The prognosis of human NK cell leukaemia is usually poor. In this case, the dog died 10 days after initial presentation, despite chemotherapy...
  2. doi request reprint Dysregulation of tyrosine kinases and use of imatinib in small animal practice
    Makoto Bonkobara
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan Electronic address
    Vet J 205:180-8. 2015
    ..In conclusion, analysis of KIT mutations appears to provide valuable data for individual treatment with imatinib in dogs and cats...
  3. pmc Establishment of a PCR analysis method for canine BRCA2
    Yasunaga Yoshikawa
    Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Kitasato University, Aomori 034 8628, Japan
    BMC Res Notes 5:173. 2012
    ..However, clearly deleterious BRCA2 mutations have not been identified in any canine mammary tumors, as appropriate methods to detect mutations or a consensus BRCA2 sequence have not been reported...
  4. doi request reprint Canine intestinal mast cell tumor with c-kit exon 8 mutation responsive to imatinib therapy
    Masato Kobayashi
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    Vet J 193:264-7. 2012
    ..1250_1261dup mutation. This mutation caused ligand-independent phosphorylation of KIT, which was suppressed by imatinib. Inhibition of constitutively activated mutant KIT with imatinib could underlie the tumor response in this dog...
  5. doi request reprint Imatinib-associated tumour response in a dog with a non-resectable gastrointestinal stromal tumour harbouring a c-kit exon 11 deletion mutation
    Masato Kobayashi
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    Vet J 198:271-4. 2013
    ..The c-kit mutation found in the tumour cells appears to be a mutation driving oncogenesis, as evidenced by the partial remission elicited by imatinib in this dog...
  6. doi request reprint Mutations in the fifth immunoglobulin-like domain of kit are common and potentially sensitive to imatinib mesylate in feline mast cell tumours
    Mayu Isotani
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, Musashino shi, Tokyo, Japan
    Br J Haematol 148:144-53. 2010
    ..Mutations in the fifth IgD of kit thus appear to be common and potentially sensitive to imatinib mesylate in feline MCTs. These data provide an in vivo model for paediatric mastocytosis where mutations in the fifth IgD of kit also occur...
  7. ncbi request reprint Comparison of dendritic cell-mediated immune responses among canine malignant cells
    Kyoichi Tamura
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 701 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    J Vet Med Sci 69:925-30. 2007
    ..Our results encouraged further investigation of therapeutic vaccination for dogs with advanced squamous cell carcinoma in clinical trials...
  8. doi request reprint Reconstruction of stratum corneum in organotypically cultured canine keratinocyte-derived CPEK cells
    Hiroko Yagihara
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo, 180 8602, Japan
    Vet Res Commun 35:433-7. 2011
    ..The organotypic culture of CPEK cells could be useful for studying the barrier function of canine stratum corneum...
  9. doi request reprint Imatinib elicited a favorable response in a dog with a mast cell tumor carrying a c-kit c.1523A>T mutation via suppression of constitutive KIT activation
    Osamu Yamada
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    Vet Immunol Immunopathol 142:101-6. 2011
    ..From these findings, imatinib was considered to elicit a clinical response in a canine case of MCT via inhibition of the constitutively activated KIT caused by a c-kit c.1523A>T mutation...
  10. doi request reprint Identification of dasatinib as an in vitro potent growth inhibitor of canine histiocytic sarcoma cells
    Keita Ito
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    Vet J 196:536-40. 2013
    ..In conclusion, a kinase enzyme targeted by dasatinib appears to be crucial for growth in some subsets of HS and the on-target activity of dasatinib could underlie the marked growth inhibition in HS cells...
  11. ncbi request reprint Induction of dendritic cell-mediated immune responses against canine malignant melanoma cells
    Kyoichi Tamura
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, Tokyo 180 8602, Japan
    Vet J 175:126-9. 2008
    ..These findings demonstrate the potential utility of DC-based tumour vaccination in the treatment of canine malignant melanoma...
  12. ncbi request reprint Immunophenotyping and gene rearrangement analysis in dogs with lymphoproliferative disorders characterized by small-cell lymphocytosis
    Hiroko Yagihara
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, Tokyo, Japan
    J Vet Diagn Invest 21:197-202. 2009
    ....
  13. ncbi request reprint Identification of a c-kit exon 8 internal tandem duplication in a feline mast cell tumor case and its favorable response to the tyrosine kinase inhibitor imatinib mesylate
    Mayu Isotani
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    Vet Immunol Immunopathol 114:168-72. 2006
    ..It is, therefore, considered that the internal tandem duplication within the domain contributes to the neoplastic transformation of mast cells in the cat by increasing KIT phosphorylation...
  14. ncbi request reprint Light-chain multiple myeloma in a cat
    Osamu Yamada
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    J Vet Diagn Invest 19:443-7. 2007
    ..These data suggested that the neoplastic plasma cells produce light chain only, leading to the diagnosis of light-chain multiple myeloma in the cat...
  15. ncbi request reprint Genomic organization of the T-cell receptor gamma gene and PCR detection of its clonal rearrangement in canine T-cell lymphoma/leukemia
    Hiroko Yagihara
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    Vet Immunol Immunopathol 115:375-82. 2007
    ..This finding was considered to be valuable in PCR-based analysis for detecting T-cell clonality in canine lymphoma/leukemia...
  16. doi request reprint Expression of canine Kdap in normal, hyperplastic and neoplastic epidermis
    Hiroko Yagihara
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    Vet J 180:348-55. 2009
    ..These findings suggest that Kdap is closely related to the delay of terminal differentiation and/or release of cells in hyperplastic epidermis...
  17. doi request reprint The proteasome inhibitor bortezomib inhibits the growth of canine malignant melanoma cells in vitro and in vivo
    Keita Ito
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    Vet J 198:577-82. 2013
    ..Targeted therapy using bortezomib could therefore be beneficial in the management of canine malignant melanomas...
  18. ncbi request reprint Efficient generation of canine bone marrow-derived dendritic cells
    Mayu Isotani
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, Musashino shi, Tokyo, Japan
    J Vet Med Sci 68:809-14. 2006
    ..Our findings suggest that the bone marrow-derived dendritic cells are functional for the capturing and processing of antigens and the initiation of T cell responses...
  19. pmc Molecular Characterization of the Cytidine Monophosphate-N-Acetylneuraminic Acid Hydroxylase (CMAH) Gene Associated with the Feline AB Blood Group System
    Toshinori Omi
    Department of Basic Science, School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, Japan
    PLoS ONE 11:e0165000. 2016
    ....
  20. doi request reprint Oncocytic carcinoma of the salivary gland in a dog
    Rei Nakahira
    Departments of Veterinary Pathology Nakahira, Michishita, Kato, Okuno, Takahashi, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan
    J Vet Diagn Invest 29:105-108. 2017
    ..Ultrastructurally, tumor cells contained numerous mitochondria. Therefore, the tumor was diagnosed as an oncocytic carcinoma of the mandibular gland...
  21. doi request reprint Molecular changes associated with the development of resistance to imatinib in an imatinib-sensitive canine neoplastic mast cell line carrying a KIT c.1523A>T mutation
    Masato Kobayashi
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, Kyonan cho, Musashino shi, Tokyo, Japan
    Eur J Haematol 95:524-31. 2015
    ..Furthermore, KIT/SFK-independent activation of ERK would be involved in imatinib resistance when the neoplastic cells are exposed to higher concentrations of imatinib. ..
  22. ncbi request reprint Establishment and biological characterization of canine histiocytic sarcoma cell lines
    Daigo Azakami
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University, Musashino shi, Tokyo, Japan
    J Vet Med Sci 68:1343-6. 2006
    ..Because the established cell lines also showed phagocytic and processing activities, the HS tumor cells appear to originate from the mononuclear phagocytic system cells, despite their differences in locations or organs...
  23. doi request reprint Molecular cloning of canine co-chaperone small glutamine-rich tetratricopeptide repeat-containing protein α (SGTA) and investigation of its ability to suppress androgen receptor signalling in androgen-independent prostate cancer
    Yuiko Kato
    Department of Veterinary Nursing and Technology, School of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo 180 8602, Japan
    Vet J 206:143-8. 2015
    ..Altogether, these results suggest that canine SGTA may play an important role in the acquisition of androgen independence by canine prostate cancer cells. ..
  24. pmc The genetic association study between polymorphisms in uncoupling protein 2 and uncoupling protein 3 and metabolic data in dogs
    Chihiro Udagawa
    Department of Basic Science, School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino, Tokyo 180 8602, Japan
    BMC Res Notes 7:904. 2014
    ..The aim of this study was to examine the genetic association between polymorphisms in UCP2 and UCP3 and metabolic data in dogs...
  25. ncbi request reprint Establishment and characterization of canine rhabdomyosarcoma cell line CMS-C
    Daigo Azakami
    Department of Veterinary Nursing, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino, Tokyo 180 8602, Japan
    J Vet Med Sci 73:1105-8. 2011
    ..Therefore, the established CMS-C cell line appears to be of rhabdomyoblast cell origin. The CMS-C cell line established from pleomorphic RMS will be a useful tool for further studies about canine RMS...
  26. ncbi request reprint Neuronal expression of keratinocyte-associated transmembrane protein-4, KCT-4, in mouse brain and its up-regulation by neurite outgrowth of Neuro-2a cells
    Osamu Yamada
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Animal Science University, Musashino shi, Tokyo 180 8602, Japan
    Neurosci Lett 392:226-30. 2006
    ..Moreover, expression of KCT-4 mRNA was induced by neurite outgrowth of Neuro-2a. These data suggest that KCT-4 participates in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain...
  27. doi request reprint Analysis of mitochondrial DNA HVR1 haplotype of pure-bred domestic dogs in Japan
    Sho Sugiyama
    Department of Basic Science, School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    Leg Med (Tokyo) 15:303-9. 2013
    ..052, 0.722±0.029, 0.922±0.010, 0.877±0.020, and 0.443±0.084, respectively. The results of this genotype analysis were used to construct a dataset consisting of dog mtDNA HVR1 sequences for use in forensic applications in Japan. ..
  28. ncbi request reprint Changes in activities of enzymes related to energy metabolism in canine lymphoma cells
    Tsukimi Washizu
    Department of Clinical Pathology, Nippon Veterinary and Animal Science University, Musashino, Tokyo, Japan
    J Vet Med Sci 67:615-6. 2005
    ....
  29. ncbi request reprint Generation of monoclonal antibody against canine neural-cell adhesion molecule
    Yosuke Uematsu
    Canine Lab Inc, Kanda Ogawa machi, Chiyoda ku, Tokyo, Japan
    J Vet Med Sci 70:845-7. 2008
    ..From these results, K9BYU was considered to be a useful tool for research of canine N-CAM...
  30. ncbi request reprint In vitro differentiation of canine celiac adipose tissue-derived stromal cells into neuronal cells
    Ken Sago
    Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Vet Med Sci 70:353-7. 2008
    ..ATSCs can differentiate into early to mature neuronal cells and are candidate cells for autologous nerve regeneration therapy, although additional research is needed to examine functional characteristics of differentiated ATSCs...