Hirotaka Ishii

Summary

Affiliation: Nippon Medical School
Country: Japan

Publications

  1. doi request reprint Novel splicing events and post-transcriptional regulation of human estrogen receptor α E isoforms
    Hirotaka Ishii
    Department of Physiology, Nippon Medical School, 1 Sendagi, Tokyo 113 8602, Japan
    J Steroid Biochem Mol Biol 133:120-8. 2013
  2. doi request reprint Identification of C-terminally and N-terminally truncated estrogen receptor α variants in the mouse
    Hirotaka Ishii
    Department of Physiology, Nippon Medical School, Tokyo, Japan
    J Steroid Biochem Mol Biol 124:38-46. 2011
  3. doi request reprint Complex organization of the 5'-untranslated region of the mouse estrogen receptor α gene: identification of numerous mRNA transcripts with distinct 5'-ends
    Hirotaka Ishii
    Department of Physiology, Nippon Medical School, 1 Sendagi, Bunkyo, Tokyo 113 8602, Japan
    J Steroid Biochem Mol Biol 125:211-8. 2011
  4. doi request reprint Gene structures, biochemical characterization and distribution of rat melatonin receptors
    Hirotaka Ishii
    Department of Physiology, Nippon Medical School, Bunkyo ku, Tokyo, 113 8602, Japan
    J Physiol Sci 59:37-47. 2009
  5. doi request reprint Cetrorelix, a gonadotropin-releasing hormone antagonist, induces the expression of melatonin receptor 1a in the gonadotropin-releasing hormone neuronal cell line GT1-7
    Hirotaka Ishii
    Department of Physiology, Nippon Medical School, Tokyo, Japan
    Neuroendocrinology 90:251-9. 2009
  6. doi request reprint Alternative promoter usage and alternative splicing of the rat estrogen receptor alpha gene generate numerous mRNA variants with distinct 5'-ends
    Hirotaka Ishii
    Department of Physiology, Nippon Medical School, Tokyo, Japan
    J Steroid Biochem Mol Biol 118:59-69. 2010
  7. doi request reprint Rat GnRH neurons exhibit large conductance voltage- and Ca2+-Activated K+ (BK) currents and express BK channel mRNAs
    Yoshie Hiraizumi
    Department of Physiology, Nippon Medical School, Tokyo, Japan
    J Physiol Sci 58:21-9. 2008
  8. doi request reprint Identification of novel splicing events and post-transcriptional regulation of human estrogen receptor α F isoforms
    Momoko Kobayashi
    Department of Physiology, Nippon Medical School, Tokyo, Japan
    Mol Cell Endocrinol 333:55-61. 2011
  9. doi request reprint Voltage-gated Ca2+ channel mRNAs and T-type Ca2+ currents in rat gonadotropin-releasing hormone neurons
    Nobuyuki Tanaka
    Department of Physiology, Nippon Medical School, Sendagi 1, Bunkyo, Tokyo, Japan
    J Physiol Sci 60:195-204. 2010
  10. ncbi request reprint Local production of sex hormones and their modulation of hippocampal synaptic plasticity
    Hirotaka Ishii
    Department of Biophysics and Life Sciences, Graduate School ofArts and Sciences, University of Tokyo, Tokyo, Japan
    Neuroscientist 13:323-34. 2007

Collaborators

Detail Information

Publications19

  1. doi request reprint Novel splicing events and post-transcriptional regulation of human estrogen receptor α E isoforms
    Hirotaka Ishii
    Department of Physiology, Nippon Medical School, 1 Sendagi, Tokyo 113 8602, Japan
    J Steroid Biochem Mol Biol 133:120-8. 2013
    ..Furthermore, the 5'-UTRs of the E isoforms post-transcriptionally control human ERα expression mainly through translational repression...
  2. doi request reprint Identification of C-terminally and N-terminally truncated estrogen receptor α variants in the mouse
    Hirotaka Ishii
    Department of Physiology, Nippon Medical School, Tokyo, Japan
    J Steroid Biochem Mol Biol 124:38-46. 2011
    ....
  3. doi request reprint Complex organization of the 5'-untranslated region of the mouse estrogen receptor α gene: identification of numerous mRNA transcripts with distinct 5'-ends
    Hirotaka Ishii
    Department of Physiology, Nippon Medical School, 1 Sendagi, Bunkyo, Tokyo 113 8602, Japan
    J Steroid Biochem Mol Biol 125:211-8. 2011
    ..In addition, both alternative promoter usage and alternative splicing contribute to the remarkable mRNA diversity of the mouse ERα gene...
  4. doi request reprint Gene structures, biochemical characterization and distribution of rat melatonin receptors
    Hirotaka Ishii
    Department of Physiology, Nippon Medical School, Bunkyo ku, Tokyo, 113 8602, Japan
    J Physiol Sci 59:37-47. 2009
    ..This study delineates the gene structures, fundamental properties, and distribution of both rat melatonin receptor subtypes, and may offer opportunities to assess the physiological significance of melatonin in rats...
  5. doi request reprint Cetrorelix, a gonadotropin-releasing hormone antagonist, induces the expression of melatonin receptor 1a in the gonadotropin-releasing hormone neuronal cell line GT1-7
    Hirotaka Ishii
    Department of Physiology, Nippon Medical School, Tokyo, Japan
    Neuroendocrinology 90:251-9. 2009
    ..These findings may provide one possible mechanism for the sexually dimorphic responses to melatonin in adult rat GnRH neurons...
  6. doi request reprint Alternative promoter usage and alternative splicing of the rat estrogen receptor alpha gene generate numerous mRNA variants with distinct 5'-ends
    Hirotaka Ishii
    Department of Physiology, Nippon Medical School, Tokyo, Japan
    J Steroid Biochem Mol Biol 118:59-69. 2010
    ....
  7. doi request reprint Rat GnRH neurons exhibit large conductance voltage- and Ca2+-Activated K+ (BK) currents and express BK channel mRNAs
    Yoshie Hiraizumi
    Department of Physiology, Nippon Medical School, Tokyo, Japan
    J Physiol Sci 58:21-9. 2008
    ..These currents control the action potential repolarization and probably also the firing pattern, thereby regulating the cell excitability of GnRH neurons...
  8. doi request reprint Identification of novel splicing events and post-transcriptional regulation of human estrogen receptor α F isoforms
    Momoko Kobayashi
    Department of Physiology, Nippon Medical School, Tokyo, Japan
    Mol Cell Endocrinol 333:55-61. 2011
    ....
  9. doi request reprint Voltage-gated Ca2+ channel mRNAs and T-type Ca2+ currents in rat gonadotropin-releasing hormone neurons
    Nobuyuki Tanaka
    Department of Physiology, Nippon Medical School, Sendagi 1, Bunkyo, Tokyo, Japan
    J Physiol Sci 60:195-204. 2010
    ..6 s. These results indicate that rat GnRH neurons express subtypes of the alpha(1) subunit for all five types of voltage-gated Ca(2+) channel, and that alpha(1H) was the dominant subtype in T-type Ca(2+) channels...
  10. ncbi request reprint Local production of sex hormones and their modulation of hippocampal synaptic plasticity
    Hirotaka Ishii
    Department of Biophysics and Life Sciences, Graduate School ofArts and Sciences, University of Tokyo, Tokyo, Japan
    Neuroscientist 13:323-34. 2007
    ..Activin A, a peptide sex hormone, may also play a role as a local endogenous modulator of synaptic plasticity...
  11. doi request reprint Establishment of an in vitro cell line experimental system for the study of inhalational anesthetic mechanisms
    Seiji Nagamoto
    Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan Department of Anesthesiology and Pain Medicine, Graduate School of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Neurosci Lett 620:163-8. 2016
    ....
  12. doi request reprint Human C-terminally truncated ERα variants resulting from the use of alternative exons in the ligand-binding domain
    Yujiro Hattori
    Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan Department of Neurosurgery, Graduate School of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Mol Cell Endocrinol 425:111-22. 2016
    ..In conclusion, we elucidated the structural and functional features of novel C-terminally truncated ERα variants and revealed the mechanisms underlying constitutive transactivation by C-terminally truncated nuclear receptor variants. ..
  13. doi request reprint Somatostatin inhibition of GnRH neuronal activity and the morphological relationship between GnRH and somatostatin neurons in rats
    Makiko Koyama
    Department of Physiology, Nippon Medical School, 1 Sendagi, Bunkyo, Tokyo 113 8602, Japan
    Endocrinology 153:806-14. 2012
    ..These findings suggest that somatostatin directly inhibits the activity of rat GnRH neurons through volume transmission in the organum vasculosum of the lamina terminalis region...
  14. ncbi request reprint 17beta-estradiol at physiological concentrations augments Ca(2+) -activated K+ currents via estrogen receptor beta in the gonadotropin-releasing hormone neuronal cell line GT1-7
    Ichiro Nishimura
    Department of Physiology, Nippon Medical School, Bunkyo, Tokyo, Japan
    Endocrinology 149:774-82. 2008
    ..In conclusion, E2 at physiological concentrations augments K(Ca) currents through ERbeta in the GT1-7 GnRH neuronal cell line and increases the expression of the BK channel subunit mRNAs, alpha and beta4...
  15. pmc Endogenous synthesis of corticosteroids in the hippocampus
    Shimpei Higo
    Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Tokyo, Japan
    PLoS ONE 6:e21631. 2011
    ..The endogenous synthesis of corticosteroids in the hippocampus, however, has been doubted because of the inability to detect deoxycorticosterone (DOC) synthase, cytochrome P450(c21)...
  16. doi request reprint Characterization of sevoflurane effects on Per2 expression using ex vivo bioluminescence imaging of the suprachiasmatic nucleus in transgenic rats
    Izumi Matsuo
    Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan Department of Anesthesiology and Pain Medicine, Graduate School of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Neurosci Res 107:30-7. 2016
    ..Current study elucidated the anesthetic effects on the molecular mechanisms of circadian rhythm. ..
  17. doi request reprint Characterization of the fundamental properties of the N-terminal truncation (Δ exon 1) variant of estrogen receptor α in the rat
    Yujiro Hattori
    Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan Department of Neurosurgery, Graduate School of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Gene 571:117-25. 2015
    ..Therefore, the present study provides fundamental and useful information for further research into the regulation and functions of ERα gene variants. ..
  18. ncbi request reprint Subunit profiling and functional characteristics of acetylcholine receptors in GT1-7 cells
    Yuki Arai
    Department of Anatomy and Neurobiology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, 113 8602, Japan
    J Physiol Sci . 2016
    ..These findings demonstrate the molecular profiles of AChRs, which directly contribute to GnRH secretion in GT1-7 cells, and provide one possible regulatory action of acetylcholine in GnRH neurons...
  19. ncbi request reprint Rapid modulation of long-term depression and spinogenesis via synaptic estrogen receptors in hippocampal principal neurons
    Hideo Mukai
    Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro, Tokyo, Japan
    J Neurochem 100:950-67. 2007
    ..Localization of ERalpha in spines of principal glutamatergic neurons was demonstrated using immunogold electron microscopy and immunohistochemistry. ERalpha was also located in nuclei, cytoplasm and presynapses...