Atsuko Ishizuya-Oka

Summary

Affiliation: Nippon Medical School
Country: Japan

Publications

  1. ncbi request reprint Regulation of adult intestinal epithelial stem cell development by thyroid hormone during Xenopus laevis metamorphosis
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, Kawasaki, Kanagawa, Japan
    Dev Dyn 236:3358-68. 2007
  2. pmc Apoptosis in amphibian organs during metamorphosis
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, Kawasaki, Kanagawa, Japan
    Apoptosis 15:350-64. 2010
  3. doi request reprint Establishment of intestinal stem cell niche during amphibian metamorphosis
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, Kawasaki, Kanagawa, Japan
    Curr Top Dev Biol 103:305-27. 2013
  4. pmc The development of the adult intestinal stem cells: Insights from studies on thyroid hormone-dependent amphibian metamorphosis
    Yun Bo Shi
    Section on Molecular Morphogenesis, Laboratory of Gene Regulation and Development, Program in Cellular Regulation and Metabolism PCRM, Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, National Institutes of Health NIH, Bethesda, Maryland, 20892, USA
    Cell Biosci 1:30. 2011
  5. doi request reprint Amphibian organ remodeling during metamorphosis: insight into thyroid hormone-induced apoptosis
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, 2 297 2 Kosugi cho, Nakahara ku, Kawasaki, Kanagawa 211 0063, Japan
    Dev Growth Differ 53:202-12. 2011
  6. ncbi request reprint Epithelial-connective tissue cross-talk is essential for regeneration of intestinal epithelium
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, Kawasaki, Kanagawa 211 0063, Japan
    J Nippon Med Sch 72:13-8. 2005
  7. pmc Evolutionary insights into postembryonic development of adult intestinal stem cells
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, Kawasaki, Kanagawa 211 0063, Japan
    Cell Biosci 1:37. 2011
  8. ncbi request reprint Molecular mechanisms for thyroid hormone-induced remodeling in the amphibian digestive tract: a model for studying organ regeneration
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, 2 297 2 Kosugi cho, Nakahara ku, Kawasaki, Kanagawa 211 0063, Japan
    Dev Growth Differ 47:601-7. 2005
  9. ncbi request reprint Shh/BMP-4 signaling pathway is essential for intestinal epithelial development during Xenopus larval-to-adult remodeling
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, Kawasaki, Kanagawa, Japan
    Dev Dyn 235:3240-9. 2006
  10. ncbi request reprint Regeneration of the amphibian intestinal epithelium under the control of stem cell niche
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, 2 297 2 Kosugi cho, Nakahara ku, Kawasaki, Kanagawa 211 0063, Japan
    Dev Growth Differ 49:99-107. 2007

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Regulation of adult intestinal epithelial stem cell development by thyroid hormone during Xenopus laevis metamorphosis
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, Kawasaki, Kanagawa, Japan
    Dev Dyn 236:3358-68. 2007
    ....
  2. pmc Apoptosis in amphibian organs during metamorphosis
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, Kawasaki, Kanagawa, Japan
    Apoptosis 15:350-64. 2010
    ..Here, we propose that multiple intra- and extracellular apoptotic pathways are coordinately controlled by TH to ensure massive but well-organized apoptosis, which is essential for the proper progression of amphibian metamorphosis...
  3. doi request reprint Establishment of intestinal stem cell niche during amphibian metamorphosis
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, Kawasaki, Kanagawa, Japan
    Curr Top Dev Biol 103:305-27. 2013
    ..We here review recent progress in this field, focusing on key signaling pathways involved in establishment of the stem cell niche and discuss their evolutionarily conserved roles in the vertebrate intestine...
  4. pmc The development of the adult intestinal stem cells: Insights from studies on thyroid hormone-dependent amphibian metamorphosis
    Yun Bo Shi
    Section on Molecular Morphogenesis, Laboratory of Gene Regulation and Development, Program in Cellular Regulation and Metabolism PCRM, Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD, National Institutes of Health NIH, Bethesda, Maryland, 20892, USA
    Cell Biosci 1:30. 2011
    ..We will further review evidence suggesting similar T3-dependent formation of adult intestinal stem cells in other vertebrates...
  5. doi request reprint Amphibian organ remodeling during metamorphosis: insight into thyroid hormone-induced apoptosis
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, 2 297 2 Kosugi cho, Nakahara ku, Kawasaki, Kanagawa 211 0063, Japan
    Dev Growth Differ 53:202-12. 2011
    ..Here, I emphasize the importance of TH-induced multiple apoptotic pathways for massive and well-organized apoptosis in the amphibian organs and discuss their conservation in the mammalian organs...
  6. ncbi request reprint Epithelial-connective tissue cross-talk is essential for regeneration of intestinal epithelium
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, Kawasaki, Kanagawa 211 0063, Japan
    J Nippon Med Sch 72:13-8. 2005
    ..This Xenopus experimental system will certainly serve as a useful model for the study of the intestinal niche, whose clarification is urgently needed in regenerative medicine...
  7. pmc Evolutionary insights into postembryonic development of adult intestinal stem cells
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, Kawasaki, Kanagawa 211 0063, Japan
    Cell Biosci 1:37. 2011
    ....
  8. ncbi request reprint Molecular mechanisms for thyroid hormone-induced remodeling in the amphibian digestive tract: a model for studying organ regeneration
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, 2 297 2 Kosugi cho, Nakahara ku, Kawasaki, Kanagawa 211 0063, Japan
    Dev Growth Differ 47:601-7. 2005
    ..In this article, we review our recent findings in this field, focusing on the development of adult epithelium in the X. laevis intestine...
  9. ncbi request reprint Shh/BMP-4 signaling pathway is essential for intestinal epithelial development during Xenopus larval-to-adult remodeling
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, Kawasaki, Kanagawa, Japan
    Dev Dyn 235:3240-9. 2006
    ..These results strongly suggest that the Shh/BMP-4 signaling pathway plays key roles in the amphibian intestinal remodeling through epithelial-connective tissue interactions...
  10. ncbi request reprint Regeneration of the amphibian intestinal epithelium under the control of stem cell niche
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, 2 297 2 Kosugi cho, Nakahara ku, Kawasaki, Kanagawa 211 0063, Japan
    Dev Growth Differ 49:99-107. 2007
    ..laevis intestine and sheds light on molecular aspects of the stem cell niche that are common to the mammalian intestine...
  11. pmc Origin of the adult intestinal stem cells induced by thyroid hormone in Xenopus laevis
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, 2 297 2 Kosugi cho, Nakahara ku, Kawasaki, Kanagawa 211 0063, Japan
    FASEB J 23:2568-75. 2009
    ..Our results provide direct evidence that stem cells that generate the adult intestinal epithelium originate from the larval epithelium, through thyroid hormone-induced dedifferentiation...
  12. doi request reprint Sonic hedgehog and bone morphogenetic protein-4 signaling pathway involved in epithelial cell renewal along the radial axis of the intestine
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, Kawasaki, Kanagawa, Japan
    Digestion 77:42-7. 2008
    ....
  13. doi request reprint Thyroid hormone regulation of stem cell development during intestinal remodeling
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, Kawasaki, Kanagawa, Japan
    Mol Cell Endocrinol 288:71-8. 2008
    ..Here we will review recent findings from such studies with a special emphasis on the adult intestinal stem cells, and discuss the evolutionarily conserved roles of T3 in the epithelial cell-renewal in the vertebrate intestine...
  14. pmc Epithelial-connective tissue interactions induced by thyroid hormone receptor are essential for adult stem cell development in the Xenopus laevis intestine
    Takashi Hasebe
    Department of Biology, Nippon Medical School, Kawasaki, Kanagawa, Japan
    Stem Cells 29:154-61. 2011
    ....
  15. pmc Thyroid hormone-up-regulated hedgehog interacting protein is involved in larval-to-adult intestinal remodeling by regulating sonic hedgehog signaling pathway in Xenopus laevis
    Takashi Hasebe
    Department of Biology, Nippon Medical School, Nakahara ku, Kawasaki, Kanagawa, Japan
    Dev Dyn 237:3006-15. 2008
    ..Finally, we demonstrate that Hip binds to the N-terminal fragment of processed Shh in vivo, suggesting that Hip suppresses Shh signaling through sequestering Shh...
  16. doi request reprint Thyroid hormone-regulated expression of nuclear lamins correlates with dedifferentiation of intestinal epithelial cells during Xenopus laevis metamorphosis
    Takashi Hasebe
    Department of Biology, Nippon Medical School, 2 297 2 Kosugi cho, Nakahara ku, Kawasaki, Kanagawa 211 0063, Japan
    Dev Genes Evol 221:199-208. 2011
    ..laevis intestine, suggesting the involvement of the lamins in the process of dedifferentiation during amphibian metamorphosis...
  17. pmc Thyroid hormone-induced sonic hedgehog signal up-regulates its own pathway in a paracrine manner in the Xenopus laevis intestine during metamorphosis
    Takashi Hasebe
    Department of Biology, Nippon Medical School, Nakahara ku, Kawasaki, Kanagawa, Japan
    Dev Dyn 241:403-14. 2012
    ..Here, we analyzed the spatiotemporal expression of Patched (Ptc)-1, Smoothened (Smo), Gli1, Gli2, and Gli3 during natural and TH-induced intestinal remodeling...
  18. pmc Expression profiling of intestinal tissues implicates tissue-specific genes and pathways essential for thyroid hormone-induced adult stem cell development
    Guihong Sun
    National Institutes of Health, National Institute of Child Health and Human Development, Laboratory of Gene Regulation and Development, Building 18T, Room 106, 18 Library Drive, MSC 5431, Bethesda, Maryland 20892 Rachel A Heimeier, Section on Molecular Morphogenesis, Program in Cellular Regulation and Metabolism, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 or Atsuko Ishizuya Oka, Department of Biology, Nippon Medical School, Kawasaki, Kanagawa 211 0063, Japan or
    Endocrinology 154:4396-407. 2013
    ....
  19. ncbi request reprint Expression profiles of the duplicated matrix metalloproteinase-9 genes suggest their different roles in apoptosis of larval intestinal epithelial cells during Xenopus laevis metamorphosis
    Takashi Hasebe
    Department of Biology, Nippon Medical School, Nakahara ku, Kawasaki, Kanagawa, Japan
    Dev Dyn 236:2338-45. 2007
    ....
  20. doi request reprint Thyroid Hormone-Induced Activation of Notch Signaling is Required for Adult Intestinal Stem Cell Development During Xenopus Laevis Metamorphosis
    Takashi Hasebe
    Department of Biology, Nippon Medical School, Musashino, Tokyo, Japan
    Stem Cells . 2016
    ..Stem Cells 2016...
  21. doi request reprint RCAN1 regulates vascular branching during Xenopus laevis angiogenesis
    Masakazu Fujiwara
    Department of Molecular Pathology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Kawasaki, Japan
    J Vasc Res 48:104-18. 2011
    ..In this study, we evaluate the involvement of regulator of calcineurin 1 (RCAN1), a regulatory protein in the calcineurin/NFAT signal transduction pathway, in vascular morphology to gain further insight into these mechanisms...
  22. doi request reprint Thyroid hormone activates Wnt/β-catenin signaling involved in adult epithelial development during intestinal remodeling in Xenopus laevis
    Takashi Hasebe
    Department of Biology, Nippon Medical School, 1 7 1 Kyonan cho, Musashino, Tokyo, 180 0023, Japan
    Cell Tissue Res 365:309-18. 2016
    ..Thus, TH-up-regulated SFRP2 in the postembryonic intestine promotes adult stem cell development, possibly by acting as an agonist of both canonical and non-canonical Wnt signaling. ..
  23. pmc Thyroid hormone-induced cell-cell interactions are required for the development of adult intestinal stem cells
    Takashi Hasebe
    Department of Biology, Nippon Medical School, 2 297 2 Nakahara ku, Kosugi cho, Kawasaki, Kanagawa, 211 0063, Japan
    Cell Biosci 3:18. 2013
    ..Molecular analyses suggest that cell-cell interactions involving hedgehog and BMP pathways are critical for the establishment of the stem cell niche that is essential for the formation of the adult intestinal stem cells...
  24. ncbi request reprint Xenopus laevis as a model for the functional analysis of genes involved in embryogenesis and postembryonic organ regeneration
    Takashi Hasebe
    Department of Biology, Nippon Medical School, Kanagawa, Japan
    J Nippon Med Sch 74:266-7. 2007
  25. pmc Thyroid hormone-regulated Wnt5a/Ror2 signaling is essential for dedifferentiation of larval epithelial cells into adult stem cells in the Xenopus laevis intestine
    Atsuko Ishizuya-Oka
    Department of Biology, Nippon Medical School, Kyonan cho, Musashino, Tokyo, Japan
    PLoS ONE 9:e107611. 2014
    ..To clarify its molecular mechanisms, we here investigated roles of non-canonical Wnt signaling in the larval-to-adult intestinal remodeling during Xenopus laevis metamorphosis...
  26. pmc Involvement of androgen receptor in sex determination in an amphibian species
    Jun Fujii
    Department of Biology, Waseda University, Tokyo, Japan
    PLoS ONE 9:e93655. 2014
    ..Testosterone, supplied to the rearing water, completed the female-to-male sex-reversal in the AR-Tg ZW frogs. Here we report that Z-AR is involved in male sex-determination in an amphibian species. ..
  27. pmc Regulation of extracellular matrix remodeling and cell fate determination by matrix metalloproteinase stromelysin-3 during thyroid hormone-dependent post-embryonic development
    Yun Bo Shi
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Building 18T, Room 106, Bethesda, MD 20892, USA
    Pharmacol Ther 116:391-400. 2007
    ..We will further discuss the potential mechanisms of ST3 function during metamorphosis and its broader implications...
  28. ncbi request reprint Thyroid hormone-induced expression of a bZip-containing transcription factor activates epithelial cell proliferation during Xenopus larval-to-adult intestinal remodeling
    Masayuki Ikuzawa
    Life Science Institute, Sophia University, Tokyo, 102 8554, Japan
    Dev Genes Evol 216:109-18. 2006
    ..These results indicate that TH/bZip functions as a growth activator during amphibian intestinal remodeling, although TH/bZip expression in the epithelium alone is not sufficient for inducing the stem cells...
  29. ncbi request reprint A causative role of stromelysin-3 in extracellular matrix remodeling and epithelial apoptosis during intestinal metamorphosis in Xenopus laevis
    Liezhen Fu
    Laboratory of Gene Regulation and Development, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:27856-65. 2005
    ..These results thus suggest that ST3 regulates cell fate and tissue morphogenesis through direct or indirect ECM remodeling...
  30. ncbi request reprint Spatial and temporal expression pattern of a novel gene in the frog Xenopus laevis: correlations with adult intestinal epithelial differentiation during metamorphosis
    Daniel R Buchholz
    Section on Molecular Morphogenesis, Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bldg 18T, Rm 106, Bethesda, MD 20892, USA
    Gene Expr Patterns 4:321-8. 2004
    ....
  31. ncbi request reprint Thyroid hormone-upregulated expression of Musashi-1 is specific for progenitor cells of the adult epithelium during amphibian gastrointestinal remodeling
    Atsuko Ishizuya-Oka
    Department of Histology and Neurobiology, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    J Cell Sci 116:3157-64. 2003
    ....
  32. ncbi request reprint Isolation of connective-tissue-specific genes involved in Xenopus intestinal remodeling: thyroid hormone up-regulates Tolloid/BMP-1 expression
    Katsuhiko Shimizu
    Department of Histology and Neurobiology, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Dev Genes Evol 212:357-64. 2002
    ..These results suggest that TH directly up-regulates Xtld expression in the connective tissue along the anteroposterior axis, which in turn plays important roles in adult epithelial development during amphibian intestinal remodeling...