T Ochiai

Summary

Country: Japan

Publications

  1. pmc Recurrence of hepatocellular carcinoma with rapid growth after spontaneous regression
    Tomoki Nakajima
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    World J Gastroenterol 10:3385-7. 2004
  2. ncbi request reprint Gastric cancer presenting with extremely rapid growth: unprecedented morphologic change in a short time and endoscopic estimation of its doubling time
    T Nakajima
    Department of Gastroenterology, Kyoto Prefectural Yosano umi Hospital, Japan
    Endoscopy 32:994-7. 2000
  3. ncbi request reprint Tumor size-independence of telomere length indicates an aggressive feature of HCC
    Tomoki Nakajima
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 325:1131-5. 2004
  4. doi request reprint Greater age and hepatocellular aging are independent risk factors for hepatocellular carcinoma arising from non-B non-C non-alcoholic chronic liver disease
    Tomoki Nakajima
    Departments of Medicine Clinical Pathology, Saiseikai Kyoto Hospital, Nagaoka kyo Molecular Gastroenterology and Hepatology, Kyoto, Japan
    Pathol Int 61:572-6. 2011
  5. doi request reprint Nuclear size measurement is a simple method for the assessment of hepatocellular aging in non-alcoholic fatty liver disease: Comparison with telomere-specific quantitative FISH and p21 immunohistochemistry
    Tomoki Nakajima
    Department of Medicine, Saiseikai Kyoto Hospital, Nagaoka kyo City, Japan
    Pathol Int 60:175-83. 2010
  6. ncbi request reprint Centrosome aberration accompanied with p53 mutation can induce genetic instability in hepatocellular carcinoma
    Tomoki Nakajima
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan
    Mod Pathol 17:722-7. 2004
  7. pmc Multifocal intraportal invasion of breast carcinoma diagnosed by laparoscopy-assisted liver biopsy
    Tomoki Nakajima
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    World J Gastroenterol 11:2360-3. 2005
  8. ncbi request reprint Premature telomere shortening and impaired regenerative response in hepatocytes of individuals with NAFLD
    Tomoki Nakajima
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan
    Liver Int 26:23-31. 2006
  9. ncbi request reprint Intrahepatic splenosis with severe iron deposition presenting with atypical magnetic resonance images
    Tomoki Nakajima
    Department of Internal Medicine, Saiseikai Kyoto Hospital, Nagaoka kyo
    Intern Med 47:743-6. 2008
  10. ncbi request reprint Anatomy of the right anterosuperior area (segment 8) of the liver: evaluation with helical CT during arterial portography
    A Cho
    Second Department of Surgery, Chiba University School of Medicine, Japan
    Radiology 214:491-5. 2000

Collaborators

Detail Information

Publications60

  1. pmc Recurrence of hepatocellular carcinoma with rapid growth after spontaneous regression
    Tomoki Nakajima
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    World J Gastroenterol 10:3385-7. 2004
    ....
  2. ncbi request reprint Gastric cancer presenting with extremely rapid growth: unprecedented morphologic change in a short time and endoscopic estimation of its doubling time
    T Nakajima
    Department of Gastroenterology, Kyoto Prefectural Yosano umi Hospital, Japan
    Endoscopy 32:994-7. 2000
    ..Besides, this case reinforces that follow-up study is important in terms of clinical management of ulcerative lesions...
  3. ncbi request reprint Tumor size-independence of telomere length indicates an aggressive feature of HCC
    Tomoki Nakajima
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 325:1131-5. 2004
    ..Therefore, we considered that a lack of correlation between telomere length and tumor size, namely, size-independence of telomere length, is associated with unfavorable clinicopathological features of hepatocellular carcinomas...
  4. doi request reprint Greater age and hepatocellular aging are independent risk factors for hepatocellular carcinoma arising from non-B non-C non-alcoholic chronic liver disease
    Tomoki Nakajima
    Departments of Medicine Clinical Pathology, Saiseikai Kyoto Hospital, Nagaoka kyo Molecular Gastroenterology and Hepatology, Kyoto, Japan
    Pathol Int 61:572-6. 2011
    ..Only age and RNS retained significance in multivariate analysis. All of the HCC patients were older than 50 and showed RNS values higher than 2.00. Therefore, such patients are classified as a high risk group of HCC...
  5. doi request reprint Nuclear size measurement is a simple method for the assessment of hepatocellular aging in non-alcoholic fatty liver disease: Comparison with telomere-specific quantitative FISH and p21 immunohistochemistry
    Tomoki Nakajima
    Department of Medicine, Saiseikai Kyoto Hospital, Nagaoka kyo City, Japan
    Pathol Int 60:175-83. 2010
    ..This all indicates that nuclear enlargement progresses in parallel with reduced regenerative responses, telomere shortening, and p21 upregulation. Nuclear size measurement is an effective method for estimation of hepatocellular aging...
  6. ncbi request reprint Centrosome aberration accompanied with p53 mutation can induce genetic instability in hepatocellular carcinoma
    Tomoki Nakajima
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan
    Mod Pathol 17:722-7. 2004
    ..This potential effect occurs irrespective of the tumor size or stage...
  7. pmc Multifocal intraportal invasion of breast carcinoma diagnosed by laparoscopy-assisted liver biopsy
    Tomoki Nakajima
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    World J Gastroenterol 11:2360-3. 2005
    ..These morphologic findings are compatible with those of HLC. Laparoscopy-assisted liver biopsy was useful to make definite diagnosis, even though the hepatic deformity was radiologically undetectable...
  8. ncbi request reprint Premature telomere shortening and impaired regenerative response in hepatocytes of individuals with NAFLD
    Tomoki Nakajima
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan
    Liver Int 26:23-31. 2006
    ..The risk factors associated with poor prognosis of nonalcoholic fatty liver disease (NAFLD) are not fully understood. Our aim was to assess the role of progressive hepatocellular telomere shortening in the clinical course of NAFLD...
  9. ncbi request reprint Intrahepatic splenosis with severe iron deposition presenting with atypical magnetic resonance images
    Tomoki Nakajima
    Department of Internal Medicine, Saiseikai Kyoto Hospital, Nagaoka kyo
    Intern Med 47:743-6. 2008
    ..In addition, severe iron deposition was histologically demonstrated, which was considered as the cause of the hypointense T2-weighted images...
  10. ncbi request reprint Anatomy of the right anterosuperior area (segment 8) of the liver: evaluation with helical CT during arterial portography
    A Cho
    Second Department of Surgery, Chiba University School of Medicine, Japan
    Radiology 214:491-5. 2000
    ..To evaluate the segmental anatomy of the right anterosuperior area (segment 8) of the liver by using helical computed tomography during arterial portography (CTAP)...
  11. ncbi request reprint Natural course of asymptomatic hepatitis C virus-infected patients and hepatocellular carcinoma after interferon therapy
    Takeshi Okanoue
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Clin Gastroenterol Hepatol 3:S89-91. 2005
    ..Approximately 30% of HCV-infected patients with PNAL become candidates for antiviral therapy within 5 years. Interferon therapy lowers the rate of the development of HCC in both sustained responders and transient biochemical responders...
  12. doi request reprint Oxidative stress may enhance the malignant potential of human hepatocellular carcinoma by telomerase activation
    Taichiro Nishikawa
    Kyoto Prefectural University of Medicine Graduate School of Medical Science, Molecular Gastroenterology and Hepatology, Kyoto, Japan
    Liver Int 29:846-56. 2009
    ..We examined the correlations of OS with telomere length of cancer cells, telomerase activity and other clinicopathological factors in 68 HCCs...
  13. ncbi request reprint In vivo expression patterns of survivin and its splicing variants in chronic liver disease and hepatocellular carcinoma
    Hidetaka Takashima
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto 602 8566, Japan
    Liver Int 25:77-84. 2005
    ..Our aim was to clarify the significance of expression levels and post-transcriptional splicing patterns of survivin during multistep hepatocarcinogenesis and tumor progression...
  14. ncbi request reprint Simple tumor profile chart based on cell kinetic parameters and histologic grade is useful for estimating the natural growth rate of hepatocellular carcinoma
    Tomoki Nakajima
    Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Hum Pathol 33:92-9. 2002
    ..This grouping system is useful for approximating the growth rate of HCCs in a clinical setting, even when only histologic parameters are available...
  15. doi request reprint A novel amplification target, ARHGAP5, promotes cell spreading and migration by negatively regulating RhoA in Huh-7 hepatocellular carcinoma cells
    Yasuyuki Gen
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto 602 8566, Japan
    Cancer Lett 275:27-34. 2009
    ....
  16. doi request reprint PEG10 is a probable target for the amplification at 7q21 detected in hepatocellular carcinoma
    Kazuhiro Tsuji
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    Cancer Genet Cytogenet 198:118-25. 2010
    ..These results suggest that PEG10 is a probable target, acting as a driving force for amplification of the 7q21 region, and may therefore be involved in the development or progression of HCCs...
  17. ncbi request reprint Clonal expansion in evolution of chronic hepatitis to hepatocellular carcinoma as seen at an X-chromosome locus
    T Ochiai
    Department of Surgery, Kyoto Prefectural Yosanoumi Hospital, Otokoyama, Iwataki cho, Yosa gun, Kyoto, Japan
    Hepatology 31:615-21. 2000
    ..1 and 3.3 mm(2). Our results suggest that areas representing a single clone of hepatocytes are present in normal liver, and these progressively expand as changes advance from chronic hepatitis to hepatocellular carcinoma...
  18. ncbi request reprint Chemokine CCL20 enhances the growth of HuH7 cells via phosphorylation of p44/42 MAPK in vitro
    Hideki Fujii
    Graduate School of Medical Science, Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Biochem Biophys Res Commun 322:1052-8. 2004
    ..CCR6 expression in human HCC tissues was confirmed by RT-PCR. These results indicate that the growth of a proportion of human HCC cells may be mediated by CCL20-CCR6 axis, like HuH7 cells, in an autocrine or paracrine manner...
  19. ncbi request reprint Measurement of hepatitis B virus core-related antigen is valuable for identifying patients who are at low risk of lamivudine resistance
    Eiji Tanaka
    Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Liver Int 26:90-6. 2006
    ..The clinical usefulness of hepatitis B virus core-related antigen (HBVcrAg) assay was compared with that of HBV DNA assay in predicting the occurrence of lamivudine resistance in patients with chronic hepatitis B...
  20. pmc Detection of BCL2-IGH rearrangement on paraffin-embedded tissue sections obtained from a small submucosal tumor of the rectum in a patient with recurrent follicular lymphoma
    Naohisa Yoshida
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto 602 8566, Japan
    World J Gastroenterol 10:2602-4. 2004
    ..T-FISH method is useful for the detection of a monoclonality of atypical lymphocytes in an SMT of the gastrointestinal tract, and particularly for the detection of chromosomal translocations specific to lymphoma subtypes...
  21. ncbi request reprint The severity of ultrasonographic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat accumulation
    Masahide Hamaguchi
    Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Am J Gastroenterol 102:2708-15. 2007
    ..Nonalcoholic fatty liver disease (NAFLD) is closely associated with the metabolic syndrome...
  22. ncbi request reprint The copper chelator trientine has an antiangiogenic effect against hepatocellular carcinoma, possibly through inhibition of interleukin-8 production
    Michihisa Moriguchi
    Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Cancer 102:445-52. 2002
    ..In conclusion, the chelating effect of trientine prevented copper from functioning as a cofactor in angiogenesis, which resulted in reduced IL-8 production from HuH-7 cells...
  23. ncbi request reprint Infrequent amplification of JUN in hepatocellular carcinoma
    Mio Endo
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto 602 8566, Japan
    Anticancer Res 29:4989-94. 2009
    ..To determine whether JUN (the oncogene encoding c-Jun protein) is amplified and overexpressed in hepatocellular carcinoma (HCC)...
  24. ncbi request reprint CREB3L4, INTS3, and SNAPAP are targets for the 1q21 amplicon frequently detected in hepatocellular carcinoma
    Yoshikazu Inagaki
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho Kamigyo ku, Kyoto 602 8566, Japan
    Cancer Genet Cytogenet 180:30-6. 2008
    ..The findings suggest that CREB3L4, INTS3, and SNAPAP are probable targets for the amplification mechanism and may therefore be involved, together or separately, in the development or progression of HCCs...
  25. ncbi request reprint A follow-up study to determine the value of liver biopsy and need for antiviral therapy for hepatitis C virus carriers with persistently normal serum aminotransferase
    Takeshi Okanoue
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    J Hepatol 43:599-605. 2005
    ..Long-term follow-up study was performed to identify the candidates for antiviral therapy for hepatitis C virus (HCV) infection among carriers with persistently normal aminotransferase (ALT< or = 30 U/L) levels (PNAL)...
  26. ncbi request reprint Association of gankyrin protein expression with early clinical stages and insulin-like growth factor-binding protein 5 expression in human hepatocellular carcinoma
    Atsushi Umemura
    Department of Clinical Molecular Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Hepatology 47:493-502. 2008
    ..In HCC specimens, positive staining for IGFBP-5 was observed by immunohistochemistry in 41.9% (18/43), and the level of expression was significantly correlated with that of gankyrin (rho = 0.629, P < 0.001)...
  27. ncbi request reprint Loss of p53 transcriptional activity in hepatocellular carcinoma evaluated by yeast-based functional assay: comparison with p53 immunohistochemistry
    Yasuhide Mitsumoto
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Japan
    Hum Pathol 35:350-6. 2004
    ..These yeast-based assays suggested that p53 function was retained in some mutant cases. Immunohistochemistry was helpful in screening functionally inactive p53 protein in HCCs...
  28. doi request reprint Investigation of histological vascular invasion from preoperative evaluation in patients with hepatocellular carcinoma who underwent living donor liver transplantation
    K Sakai
    Department of Transplantation and Regenerative Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Transplant Proc 44:409-11. 2012
    ..Even if the tumor was within Milan criteria, namely, maximum size 3 cm and number of tumors 3, preoperative treatment may be a preoperative predictive factor for positive histological vascular invasion...
  29. ncbi request reprint Non-cavernomatous superior mesenteric thrombosis successfully recanalized with interventional radiological procedures carried out with a combination transmesenteric and transjugular approaches
    T Yamagami
    Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo, Kyoto, Japan
    Australas Radiol 50:495-9. 2006
    ..In the second session, devices were advanced over a guidewire inserted from the right jugular vein and pulled out of the ileocolic vein using the pull-through technique...
  30. doi request reprint ERK5 is a target for gene amplification at 17p11 and promotes cell growth in hepatocellular carcinoma by regulating mitotic entry
    Keika Zen
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Genes Chromosomes Cancer 48:109-20. 2009
    ..In conclusion, our results suggest that MAPK7 is likely the target of 17p11 amplification and that the ERK5 protein product of MAPK7 promotes the growth of HCC cells by regulating mitotic entry...
  31. ncbi request reprint Insulin resistance/beta-cell function and serum ferritin level in non-diabetic patients with hepatitis C virus infection
    Masanori Furutani
    Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Liver Int 23:294-9. 2003
    ..e., insulin secretion, and serum ferritin levels in patients with HCV infection, especially non-diabetic patients...
  32. ncbi request reprint Macroscopic and microscopic findings of livers in malignant hematologic disorders, biopsied under peritoneoscopy
    Masaki Iwai
    Third Department of of Internal Medicine, Kyoto Prefectural University School of Medicine, Kamigyo ku, Japan
    J Clin Gastroenterol 35:262-5. 2002
    ..Thus, peritoneoscopy with liver biopsy appears to be a useful tool not only to detect early liver involvement in malignant hematologic disorders but also to make their accurate diagnosis...
  33. ncbi request reprint Influence of transfection with connexin 26 gene on malignant potential of human hepatoma cells
    Akira Muramatsu
    Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
    Carcinogenesis 23:351-8. 2002
    ..Tumor growth of PLC/Cx26 was retarded. These findings suggest that transfection with Cx26 gene into human hepatoma cells reduces their malignant potential...
  34. ncbi request reprint Role of cell-cycle turnover and oxidative stress in telomere shortening and cellular senescence in patients with chronic hepatitis C
    Satoru Sekoguchi
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan
    J Gastroenterol Hepatol 22:182-90. 2007
    ..We investigated the effects of cell-cycle turnover and oxidative stress on cellular senescence in hepatitis C virus (HCV)-related chronic liver injury...
  35. ncbi request reprint Characteristics of patients with chronic hepatitis C who develop hepatocellular carcinoma after a sustained response to interferon therapy
    Akiko Makiyama
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kawaramachi Hirokouji, Kamigyou ku, Japan
    Cancer 101:1616-22. 2004
    ..The objective of the current study was to determine the characteristic features of sustained responders who develop hepatocellular carcinoma after treatment with interferon for chronic hepatitis C...
  36. ncbi request reprint [Treatment of nonalcoholic steatohepatitis (NASH)]
    Toshiaki Nakashima
    Department of Internal Medicine, Saiseikai Kyoto Hospital
    Nihon Shokakibyo Gakkai Zasshi 101:1204-8. 2004
  37. ncbi request reprint Interferon therapy for aged patients with chronic hepatitis C: improved survival in patients exhibiting a biochemical response
    Yasuharu Imai
    Department of Internal Medicine, Ikeda Municipal Hospital, 3 1 18 Johnan, 563 8510, Ikeda, Japan
    J Gastroenterol 39:1069-77. 2004
    ..In Japan, generally, patients with chronic hepatitis C are aged. The aim of this study was to investigate the effect of interferon (IFN) therapy on the mortality of chronic hepatitis C patients over age 60...
  38. ncbi request reprint Update of research and management of hepatitis B
    Takeshi Okanoue
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Hirokoji, Kawaramachi, Kamigyo ku, Kyoto 602 8566, Japan
    J Gastroenterol 41:107-18. 2006
  39. ncbi request reprint Soluble TRAIL gene and actinomycin D synergistically suppressed multiple metastasis of TRAIL-resistant colon cancer in the liver
    Michiaki Ishii
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Cancer Lett 245:134-43. 2007
    ..The gene therapy of sTRAIL with a suboptimal dose of an anticancer drug is a new strategy for treatment of multiple liver metastasis...
  40. ncbi request reprint Hepatitis B virus-related insertional mutagenesis in chronic hepatitis B patients as an early drastic genetic change leading to hepatocarcinogenesis
    Masahito Minami
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Hirokoji, Kawaramachi, Kamigyo ku, Kyoto 602 8566, Japan
    Oncogene 24:4340-8. 2005
    ....
  41. ncbi request reprint Correlation between cyclooxygenase-2, proliferative activity, and mucin phenotype in human advanced gastric cancer
    Mariko Yamagishi
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, 465 Kajii cho, Kamigyo ku, Kyoto, 602 8566, Japan
    J Gastroenterol 39:1143-9. 2004
    ....
  42. ncbi request reprint Different effects of constitutive nitric oxide synthase and heme oxygenase on pulmonary or liver metastasis of colon cancer in mice
    Takeshi Ishikawa
    Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Clin Exp Metastasis 20:445-50. 2003
    ..These results suggest that the activities of NOS and HO could influence experimental metastasis in an organ-specific manner...
  43. ncbi request reprint PPARalpha ligands activate antioxidant enzymes and suppress hepatic fibrosis in rats
    Tetsuya Toyama
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan
    Biochem Biophys Res Commun 324:697-704. 2004
    ..PPARalpha ligands have an antifibrotic action in the rat TAA model of liver cirrhosis, probably due to an antioxidant effect of enhanced catalase expression and activity in the liver...
  44. ncbi request reprint Esophageal intramural pseudodiverticulosis: a case of a young woman
    Natsuko Tatsumi
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 456 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, Kyoto 604 0911, Japan
    Dig Dis Sci 49:1556-9. 2004
  45. doi request reprint SOX2 identified as a target gene for the amplification at 3q26 that is frequently detected in esophageal squamous cell carcinoma
    Yasuyuki Gen
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Cancer Genet Cytogenet 202:82-93. 2010
    ..Our results suggest that SOX2 is likely to be a target of the 3q26 amplification and may therefore be involved in the development or progression of ESCC...
  46. ncbi request reprint Clinical characteristics and prevalence of GB virus C, SEN virus, and HFE gene mutation in Japanese patients with nonalcoholic steatohepatitis
    Norihito Yamauchi
    Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    J Gastroenterol 39:654-60. 2004
    ....
  47. doi request reprint Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice
    Kanji Yamaguchi
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Lab Invest 90:1169-78. 2010
    ..These findings suggest that hepatic IL-6 signaling has a protective role against the progression of hepatic steatosis but may enhance liver inflammation...
  48. doi request reprint Steatosis and hepatic expression of genes regulating lipid metabolism in Japanese patients infected with hepatitis C virus
    Kohichiroh Yasui
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto 602 8566, Japan
    J Gastroenterol 45:95-104. 2010
    ..The aims of this study were to elucidate risk factors associated with steatosis and to evaluate the association between steatosis and hepatic expression of genes regulating lipid metabolism...
  49. doi request reprint Risk factors and clinical course of portal and/or splenic vein thrombosis after partial splenic embolization
    Tomohiro Matsumoto
    Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, Japan
    Acta Radiol 50:617-23. 2009
    ..Although portal and/or splenic vein thrombosis after partial splenic embolization (PSE) is a well-known complication, few reports evaluating risk factors have been published...
  50. ncbi request reprint Correlations between p53 gene mutations and histologic characteristics of pancreatic ductal carcinoma
    Atsuko Taii
    Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Pancreas 38:e60-7. 2009
    ....
  51. doi request reprint Molecular characterization of a variant virus that caused de novo hepatitis B without elevation of hepatitis B surface antigen after chemotherapy with rituximab
    Masami Miyagawa
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Med Virol 80:2069-78. 2008
    ..These findings have important clinical implications for the prevention and management of HBV reactivation and may explain partially the mechanism of recent, unusual cases of HBV reactivation...
  52. pmc Lack of evidence for leukocyte maternal microchimerism in primary biliary cirrhosis
    Kenichi Nomura
    Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 0841, Japan
    World J Gastroenterol 10:2415-6. 2004
    ..Maternal microchimerism has not been investigated until now. The current study aimed to clear either maternal microchimerism was involved in the pathogenesis of PBC or not...
  53. ncbi request reprint Engineered long terminal repeats of retroviral vectors enhance transgene expression in hepatocytes in vitro and in vivo
    Kanji Yamaguchi
    Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, 606 8507, Kyoto, Japan
    Mol Ther 8:796-803. 2003
    ..5- to 5-fold in comparison with a Moloney murine leukemia virus-based vector or a vector containing the wild-type LTR of SFFVp, respectively, in murine hepatocytes in vivo...
  54. pmc Successful treatment with rifampin for fulminant antibiotics-associated colitis in a patient with non-Hodgkin's lymphoma
    Kenichi Nomura
    Molecular Hematology and Oncology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 0841, Japan
    World J Gastroenterol 10:765-6. 2004
    ..After administration of rifampin, fever alleviated and diarrhea was improved. Because AAC may result in significant mortality, patients with refractory or fulminant AAC should be treated with oral rifampin from outset...
  55. ncbi request reprint Lamivudine therapy for Japanese patients with cirrhosis B
    Takeshi Okanoue
    Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medicine, Kamigyo ku, Kyoto, 602 8566, Japan
    Intervirology 46:394-9. 2003
    ..The aim of this study was to investigate the emergence of YMDD mutants in patients with chronic hepatitis B during lamivudine therapy and to compare the emergence patterns of YMDD mutants in cirrhotic and noncirrhotic patients...
  56. ncbi request reprint Comparison of clinical features and patient background in functional dyspepsia and peptic ulcer
    Hiroko Nakao
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural, University of Medicine Graduate School of Medical Science, Kyoto, Japan
    Dig Dis Sci 52:2152-8. 2007
    ..These results indicate that FD markedly decreases quality of life in a variety of aspects...
  57. ncbi request reprint Cytogenetic and clinicopathological characterization by fluorescence in situ hybridization on paraffin-embedded tissue sections of twenty-six cases with malignant lymphoma of small intestine
    Naohisa Yoshida
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Scand J Gastroenterol 41:212-22. 2006
    ....
  58. ncbi request reprint Pathogenic role of endothelial nitric oxide synthase (eNOS/NOS-III) in cerulein-induced rat acute pancreatitis
    Yusuke Sugiyama
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kamigyo, Kyoto, 802 8566 Japan
    Dig Dis Sci 51:1396-403. 2006
    ..These results suggest that the uncoupled eNOS, probably caused by the decrease in endogenous BH4 availability, plays a deleterious role in the pathogenesis of cerulein-induced acute pancreatitis...
  59. ncbi request reprint In vivo selection of transduced hematopoietic stem cells and little evidence of their conversion into hepatocytes in vivo
    Kanji Yamaguchi
    Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, Kyoto, Japan
    J Hepatol 45:681-7. 2006
    ..Here, we examined whether these vectors could provide a sufficient drug-resistance gene expression in HSCs and whether transduced HSCs could differentiate into hepatocytes in vivo...
  60. ncbi request reprint Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, reduces hepatic steatosis and lipid peroxidation in fatty liver Shionogi mice with hereditary fatty liver
    Yuichi Harano
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Liver Int 26:613-20. 2006
    ..Peroxisome proliferator-activated receptor (PPAR) alpha controls fatty acid metabolism. In the present study, we investigated the effect of fenofibrate, a PPARalpha agonist, on hepatic steatosis in FLS mice...