M Asanuma

Summary

Affiliation: Okayama University
Country: Japan

Publications

  1. pmc 3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of L-DOPA
    Masato Asanuma
    Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama, 700 8558, Japan
    BMC Neurosci 17:52. 2016
  2. pmc Transplantation of melanocytes obtained from the skin ameliorates apomorphine-induced abnormal behavior in rodent hemi-parkinsonian models
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    PLoS ONE 8:e65983. 2013
  3. doi request reprint Cyclooxygenase-independent neuroprotective effects of aspirin against dopamine quinone-induced neurotoxicity
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    Neurochem Res 37:1944-51. 2012
  4. ncbi request reprint Neuroprotective effects of non-steroidal anti-inflammatory drugs by direct scavenging of nitric oxide radicals
    M Asanuma
    Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, Okayama, Japan
    J Neurochem 76:1895-904. 2001
  5. ncbi request reprint Preventing effects of a novel anti-parkinsonian agent zonisamide on dopamine quinone formation
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Neurosci Res 60:106-13. 2008
  6. ncbi request reprint Methamphetamine-induced increase in striatal p53 DNA-binding activity is attenuated in Cu,Zn-superoxide dismutase transgenic mice
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Neurosci Lett 325:191-4. 2002
  7. ncbi request reprint Common anti-inflammatory drugs are potentially therapeutic for Parkinson's disease?
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Exp Neurol 206:172-8. 2007
  8. ncbi request reprint Suppression of p53-activated gene, PAG608, attenuates methamphetamine-induced neurotoxicity
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Neurosci Lett 414:263-7. 2007
  9. ncbi request reprint Nonsteroidal anti-inflammatory drugs in Parkinson's disease: possible involvement of quinone formation
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Expert Rev Neurother 6:1313-25. 2006
  10. ncbi request reprint Dopamine- or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Neurotox Res 5:165-76. 2003

Collaborators

Detail Information

Publications83

  1. pmc 3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of L-DOPA
    Masato Asanuma
    Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama, 700 8558, Japan
    BMC Neurosci 17:52. 2016
    ..We examined changes in the numbers of dopaminergic neurons after treatment with L-DOPA and 3-OMD or entacapone, a peripheral COMT inhibitor, using primary cultured mesencephalic neurons and striatal astrocytes...
  2. pmc Transplantation of melanocytes obtained from the skin ameliorates apomorphine-induced abnormal behavior in rodent hemi-parkinsonian models
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    PLoS ONE 8:e65983. 2013
    ....
  3. doi request reprint Cyclooxygenase-independent neuroprotective effects of aspirin against dopamine quinone-induced neurotoxicity
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    Neurochem Res 37:1944-51. 2012
    ....
  4. ncbi request reprint Neuroprotective effects of non-steroidal anti-inflammatory drugs by direct scavenging of nitric oxide radicals
    M Asanuma
    Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, Okayama, Japan
    J Neurochem 76:1895-904. 2001
    ..Our findings identified novel pharmacological mechanisms of these drugs to exert not only their anti-inflammatory, analgesic, antipyretic activities but also neuroprotective activities against neurodegeneration...
  5. ncbi request reprint Preventing effects of a novel anti-parkinsonian agent zonisamide on dopamine quinone formation
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Neurosci Res 60:106-13. 2008
    ..Our results suggest that the novel anti-parkinsonian agent ZNS possesses preventing effects against DA quinone formation induced by excess amount of cytosolic DA outside the synaptic vesicles...
  6. ncbi request reprint Methamphetamine-induced increase in striatal p53 DNA-binding activity is attenuated in Cu,Zn-superoxide dismutase transgenic mice
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Neurosci Lett 325:191-4. 2002
    ....
  7. ncbi request reprint Common anti-inflammatory drugs are potentially therapeutic for Parkinson's disease?
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Exp Neurol 206:172-8. 2007
  8. ncbi request reprint Suppression of p53-activated gene, PAG608, attenuates methamphetamine-induced neurotoxicity
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Neurosci Lett 414:263-7. 2007
    ....
  9. ncbi request reprint Nonsteroidal anti-inflammatory drugs in Parkinson's disease: possible involvement of quinone formation
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Expert Rev Neurother 6:1313-25. 2006
    ..NSAIDs inhibit prostaglandin H synthase, thus suppressing dopamine oxidation and subsequent dopamine quinone formation. Therefore, this article also reviews possible suppressive effects of some NSAIDs against dopamine quinone generation...
  10. ncbi request reprint Dopamine- or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Neurotox Res 5:165-76. 2003
    ....
  11. ncbi request reprint [Expression profiling of molecules related to abused drug dependence and toxicity]
    Masato Asanuma
    Nihon Yakurigaku Zasshi 126:30-4, 42. 2005
  12. ncbi request reprint Methamphetamine-induced neurotoxicity in mouse brain is attenuated by ketoprofen, a non-steroidal anti-inflammatory drug
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Neurosci Lett 352:13-6. 2003
    ..This provides a possible new strategy against METH-induced neurotoxicity using commonly used NSAIDs...
  13. ncbi request reprint Pramipexole has ameliorating effects on levodopa-induced abnormal dopamine turnover in parkinsonian striatum and quenching effects on dopamine-semiquinone generated in vitro
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Neurol Res 27:533-9. 2005
    ....
  14. ncbi request reprint Neuroprotective effects of nonsteroidal anti-inflammatory drugs on neurodegenerative diseases
    M Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Curr Pharm Des 10:695-700. 2004
    ....
  15. ncbi request reprint Quinone formation as dopaminergic neuron-specific oxidative stress in the pathogenesis of sporadic Parkinson's disease and neurotoxin-induced parkinsonism
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Acta Med Okayama 58:221-33. 2004
    ....
  16. ncbi request reprint Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metallothionein-I and -II knock-out mouse brain
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Neurosci Lett 327:61-5. 2002
    ....
  17. ncbi request reprint Specific gene expression and possible involvement of inflammation in methamphetamine-induced neurotoxicity
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Ann N Y Acad Sci 1025:69-75. 2004
    ....
  18. ncbi request reprint Direct interactions of methamphetamine with the nucleus
    M Asanuma
    Molecular Neuropsychiatry Section, NIH NIDA, Intramural Research Program, Baltimore, MD, USA
    Brain Res Mol Brain Res 80:237-43. 2000
    ..The present study is the first demonstration that METH can have direct effects on DNA-binding protein complex by redistributing not only in the cytosol but also into the nucleus...
  19. doi request reprint Neuroprotective effects of zonisamide target astrocyte
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Ann Neurol 67:239-49. 2010
    ....
  20. ncbi request reprint Nonsteroidal anti-inflammatory drugs in experimental parkinsonian models and Parkinson's disease
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Curr Pharm Des 14:1428-34. 2008
    ..It also discusses the discrepancy between results in the experimental parkinsonian models and epidemiological data in prevalence of Parkinson's disease on the effects of NSAIDs...
  21. ncbi request reprint Pergolide scavenges both hydroxyl and nitric oxide free radicals in vitro and inhibits lipid peroxidation in different regions of the rat brain
    M Gómez-Vargas
    Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, Okayama, Japan
    Brain Res 790:202-8. 1998
    ..5 mg/kg/24 h, i.p. for 7 days). Our findings suggest a neuroprotective role for pergolide on dopaminergic neurons due to its free radical scavenging and antioxidant properties...
  22. ncbi request reprint Antioxidants protect against dopamine-induced metallothionein-III (GIF) mRNA expression in mouse glial cell line (VR-2g)
    C A Sogawa
    Department of Pharmacology, Okayama University Dental School, 2 5 1 Shikata cho, Okayama, Japan
    Brain Res 853:310-6. 2000
    ..Our results suggest that oxidative stress may be one of the principle factors that modulate MT-III mRNA expression...
  23. ncbi request reprint Delta opioid peptide [D-Ala2, D-Leu5]enkephalin causes a near complete blockade of the neuronal damage caused by a single high dose of methamphetamine: examining the role of p53
    T Hayashi
    Molecular Neuropsychiatry Section, Intramural Research Program, National Institute on Drug Abuse/NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Synapse 39:305-12. 2001
    ..The results also indicate an apparent discordance between the protein level of p53 and the neurotoxicity caused by a high dose of METH. Synapse 39:305-312, 2001. Published 2001 Wiley-Liss, Inc...
  24. ncbi request reprint Late-onset lipid peroxidation and neuronal cell death following transient forebrain ischemia in rat brain
    Y Kondo
    Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, Japan
    Brain Res 772:37-44. 1997
    ....
  25. doi request reprint Specific induction of PAG608 in cranial and spinal motor neurons of L-DOPA-treated parkinsonian rats
    Masako Shimizu
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Neurosci Res 60:355-63. 2008
    ..Taken together with the constitutive expression of PAG608 in the motor nuclei of cranial nerves, PAG608 may be a useful marker of stressed or activated lower motor neurons...
  26. ncbi request reprint Early treatment with cyclosporin A ameliorates the reduction of muscarinic acetylcholine receptors in gerbil hippocampus after transient forebrain ischemia
    Y Kondo
    Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, Japan
    Neurochem Res 24:9-13. 1999
    ....
  27. ncbi request reprint Methamphetamine-induced dopaminergic neurotoxicity is regulated by quinone-formation-related molecules
    Ikuko Miyazaki
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    FASEB J 20:571-3. 2006
    ..Our results indicate that DA quinone formation plays an important role, as a dopaminergic neuron-specific neurotoxic factor, in METH-induced neurotoxicity, which is regulated by quinone formation-related molecules...
  28. ncbi request reprint Dopamine agonist pergolide prevents levodopa-induced quinoprotein formation in parkinsonian striatum and shows quenching effects on dopamine-semiquinone generated in vitro
    Ikuko Miyazaki
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    Clin Neuropharmacol 28:155-60. 2005
    ..These suppressive and quenching effects of pergolide against cytotoxic DA quinones may play a key role in its neuroprotective mechanism in the parkinsonian brain...
  29. ncbi request reprint Protective effects of nicergoline against hydrogen peroxide toxicity in rat neuronal cell line
    E Iwata
    Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, Japan
    Neurosci Lett 251:49-52. 1998
    ..Our results suggest that nicergoline may induce the up-regulation of intracellular antioxidant defences and protect the neuronal cells against oxidative stress...
  30. ncbi request reprint Bifemelane hydrochloride protects against cytotoxicity of hydrogen peroxide on cultured rat neuroblastoma cell line
    I Miyazaki
    Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, Japan
    Neurochem Res 24:857-60. 1999
    ..Our results suggest that bifemelane hydrochloride provides a protective effect against H2O2 cytotoxicity partly due to its anti-oxidative properties...
  31. ncbi request reprint Effects of dihydroergotoxine on central cholinergic neuronal systems and discrimination learning test in aged rats
    N Ogawa
    Department of Neuroscience, Okayama University Medical School, Japan
    Brain Res 586:229-34. 1992
    ..These findings suggest that learning is impaired in aged rats due to impairment in the central cholinergic neuronal system, and that DHET normalizes the decreased function in this system, restoring the learning ability...
  32. ncbi request reprint Rotenone induces aggregation of gamma-tubulin protein and subsequent disorganization of the centrosome: relevance to formation of inclusion bodies and neurodegeneration
    F J Diaz-Corrales
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Neuroscience 133:117-35. 2005
    ....
  33. ncbi request reprint Bromocriptine markedly suppresses levodopa-induced abnormal increase of dopamine turnover in the parkinsonian striatum
    N Ogawa
    Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, Japan
    Neurochem Res 25:755-8. 2000
    ..Our findings explain the pharmacological basis for the introduction of bromocriptine during long-term levodopa therapy...
  34. ncbi request reprint Protective effects of metallothionein against dopamine quinone-induced dopaminergic neurotoxicity
    Ikuko Miyazaki
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    FEBS Lett 581:5003-8. 2007
    ..Our results suggested that intrinsic MT protects against L-DOPA-induced DA quinone neurotoxicity in parkinsonian mice by its quinone-quenching property...
  35. doi request reprint Protective effects of interferon-gamma against methamphetamine-induced neurotoxicity
    Hiroaki Hozumi
    Department of Clinical Pharmacology and Pharmacy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Toxicol Lett 177:123-9. 2008
    ....
  36. doi request reprint Reduction of nuclear peroxisome proliferator-activated receptor gamma expression in methamphetamine-induced neurotoxicity and neuroprotective effects of ibuprofen
    Takeshi Tsuji
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama, 700 8558, Japan
    Neurochem Res 34:764-74. 2009
    ....
  37. ncbi request reprint Molecular mechanism in activation of glutathione system by ropinirole, a selective dopamine D2 agonist
    K Tanaka
    Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, Japan
    Neurochem Res 26:31-6. 2001
    ..Thus, our results indicate that the GSH-activating effect of ropinirole may render this dopamine agonist beneficial as a neuroprotective drug...
  38. ncbi request reprint Nitric oxide modulates muscarinic acetylcholine receptor binding in the cerebral cortex of gerbils
    M Gómez-Vargas
    Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, Japan
    Neurochem Res 24:629-35. 1999
    ....
  39. ncbi request reprint Long-term time course of regional changes in cholinergic indices following transient ischemia in the spontaneously hypertensive rat brain
    N Ogawa
    Department of Neuroscience, Okayama University Medical School, Japan
    Brain Res 712:60-8. 1996
    ..The chronic state of SHR after the transient ischemia may be a useful pathophysiological model for human cerebral infarctions with hypertension...
  40. doi request reprint Effects of pramipexole on the duration of immobility during the forced swim test in normal and ACTH-treated rats
    Kouhei Kitagawa
    Department of Pharmaceutical Care and Health Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    Naunyn Schmiedebergs Arch Pharmacol 380:59-66. 2009
    ..The immobility-decreasing effect of pramipexole may be mediated by dopamine D2 and D3 receptors...
  41. ncbi request reprint Oxidation of 5-methoxy-N,N-diisopropyltryptamine in rat liver microsomes and recombinant cytochrome P450 enzymes
    Shizuo Narimatsu
    Laboratory of Health Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama, Japan
    Biochem Pharmacol 75:752-60. 2008
    ..These results provide valuable information on the metabolic fate of 5-MeO-DIPT in rats that can be used in the toxicological study of this designer drug...
  42. ncbi request reprint Apoptosis-inducing neurotoxicity of dopamine and its metabolites via reactive quinone generation in neuroblastoma cells
    M Emdadul Haque
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Biochim Biophys Acta 1619:39-52. 2003
    ..Therefore, the present results suggest that DA and its metabolites containing two hydroxyl residues exert cytotoxicity mainly due to generation of highly reactive quinones...
  43. ncbi request reprint [New aspects of neuroprotective effects of nonsteroidal anti-inflammatory drugs]
    Masato Asanuma
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1, Shikatacho, Okayama, 700 8558 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 23:111-9. 2003
    ....
  44. ncbi request reprint The p53-activated gene, PAG608, requires a zinc finger domain for nuclear localization and oxidative stress-induced apoptosis
    Youichirou Higashi
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikatacho, Japan
    J Biol Chem 277:42224-32. 2002
    ..These results suggest that PAG608 may induce or regulate p53 expression and translocate to the nucleus and nucleolus using its first zinc finger domain during oxidative stress-induced apoptosis of catecholamine-containing cells...
  45. ncbi request reprint Expression of metallothionein-III and cell death in differentiated catecholaminergic neuronal cells
    Youichirou Higashi
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Neurol Res 26:671-6. 2004
    ..These results imply that MT-III expression during the developmental period may be associated with the regulation of normal neural differentiation...
  46. ncbi request reprint Distribution of the beta-2 adrenergic receptor messenger RNA in the rat brain by in situ hybridization histochemistry: effects of chronic reserpine treatment
    M Asanuma
    Department of Neurochemistry, Okayama University Medical School, Japan
    Neurochem Res 16:1253-6. 1991
    ....
  47. ncbi request reprint Dopamine deficiency in the weaver mutant mouse: an animal model of olivopontocerebellar atrophy
    H Chou
    Department of Neurochemistry, Okayama University Medical School, Japan
    Res Commun Chem Pathol Pharmacol 74:117-20. 1991
    ..Noradrenaline levels did not differ from controls. This study shows that weaver mice have specific deficiencies in the dopamine system...
  48. ncbi request reprint Localization, regulation, and function of metallothionein-III/growth inhibitory factor in the brain
    C A Sogawa
    Department of Dental Pharmacology, Okayama University Dental School, Japan
    Acta Med Okayama 55:1-9. 2001
    ..MT-III fulfills unique biological roles in homeostasis of the central nervous system and in the etiology of neuropathological disorders...
  49. doi request reprint Effects of bupropion on the forced swim test and release of dopamine in the nucleus accumbens in ACTH-treated rats
    Yoshihisa Kitamura
    Department of Pharmaceutical Care and Health Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Kita ku, Okayama 700 8530, Japan
    Naunyn Schmiedebergs Arch Pharmacol 382:151-8. 2010
    ..These findings suggest the antidepressant-like effect of bupropion to be related to levels of dopamine in the rat nucleus accumbens...
  50. ncbi request reprint DISC1 localizes to the centrosome by binding to kendrin
    Ko Miyoshi
    Department of Brain Science, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Biochem Biophys Res Commun 317:1195-9. 2004
    ..The present study suggests the possible involvement of DISC1 in the pathophysiology of mental disorders due to its putative effect on centrosomal function...
  51. doi request reprint The roles of amino acid residues at positions 216 and 219 in the structural stability and metabolic functions of rat cytochrome P450 2D1 and 2D2
    Shizuo Narimatsu
    Laboratory of Health Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Chem Biol Interact 172:11-21. 2008
    ..These results indicate that amino acid residues at positions 216 and 219 have important roles in the enzymatic functions of rat CYP2D1 and CYP2D2...
  52. ncbi request reprint Dopaminergic neuron-specific oxidative stress caused by dopamine itself
    Ikuko Miyazaki
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 62:141-50. 2008
    ..In this article, we primarily review recent studies on the pathogenicity of quinone formation, in addition to several neuroprotective approaches against dopaminequinone-induced dysfunction of dopaminergic neurons...
  53. doi request reprint Approaches to prevent dopamine quinone-induced neurotoxicity
    Ikuko Miyazaki
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikatacho, Okayama, 700 8558, Japan
    Neurochem Res 34:698-706. 2009
    ..In this article, we review recent studies on some neuroprotective approaches against DA quinone-induced dysfunction and/or degeneration of dopaminergic neurons...
  54. doi request reprint Dopamine induces supernumerary centrosomes and subsequent cell death through Cdk2 up-regulation in dopaminergic neuronal cells
    Francisco J Diaz-Corrales
    Department of Brain Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Neurotox Res 14:295-305. 2008
    ..Our results demonstrated that DA could lead to cyclin E accumulation and Cdk2 up-regulation triggering supernumerary centrosomes and apoptotic cell death...
  55. ncbi request reprint Effects of imipramine and lithium on the suppression of cell proliferation in the dentate gyrus of the hippocampus in adrenocorticotropic hormone-treated rats
    Maho Doi
    Department of Pharmaceutical Care and Health Sciences, Okayama University Graduate School of Medicine, Detistry and Pharmaceucial Sciences, and Department of Pharmacy, Okayama University Hospital, Okayama 760 8530, Japan
    Acta Med Okayama 64:219-23. 2010
    ..The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH...
  56. ncbi request reprint Characterization of pericentrin isoforms in vivo
    Ko Miyoshi
    Department of Brain Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700 8558, Japan
    Biochem Biophys Res Commun 351:745-9. 2006
    ..Three pericentrin proteins of 360, 255, and 250 kDa revealed by immunoprecipitation analysis were thought to correspond to pericentrin B, pericentrin S, and an unknown N-terminal product...
  57. doi request reprint Lithium treatment elongates primary cilia in the mouse brain and in cultured cells
    Ko Miyoshi
    Department of Brain Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Biochem Biophys Res Commun 388:757-62. 2009
    ..These findings thus contribute novel insights into the pathophysiology of bipolar mood disorder and other psychiatric diseases...
  58. doi request reprint Induction of parkinsonism-related proteins in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene
    Nobutoshi Morimoto
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, Okayama, Japan
    J Neurosci Res 88:1804-11. 2010
    ..These results provide further evidence of the profound correlations between spinal motor neurons of amyotrophic lateral sclerosis and parkinsonism-related proteins...
  59. doi request reprint Pericentrin, a centrosomal protein related to microcephalic primordial dwarfism, is required for olfactory cilia assembly in mice
    Ko Miyoshi
    Department of Brain Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    FASEB J 23:3289-97. 2009
    ..Our findings suggest that pericentrin is essential for the assembly of chemosensory cilia of olfactory receptor neurons, but it is not globally required for cilia formation in mammals...
  60. ncbi request reprint The dopamine agonist cabergoline provides neuroprotection by activation of the glutathione system and scavenging free radicals
    Michiyo Yoshioka
    Department of Brain Science, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikatacho, Japan
    Neurosci Res 43:259-67. 2002
    ....
  61. ncbi request reprint Parkin attenuates manganese-induced dopaminergic cell death
    Youichirou Higashi
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Neurochem 89:1490-7. 2004
    ....
  62. ncbi request reprint Rotenone induces disassembly of the Golgi apparatus in the rat dopaminergic neuroblastoma B65 cell line
    Francisco J Diaz-Corrales
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Neurosci Lett 354:59-63. 2004
    ..Nevertheless, these type of cells without nuclear fragmentation did not show any caspase-3 expression. These results indicate that rotenone induces disassembly of the GA in the early stages of the apoptotic process...
  63. ncbi request reprint Overexpression of Cu-Zn superoxide dismutase protects neuroblastoma cells against dopamine cytotoxicity accompanied by increase in their glutathione level
    M Emdadul Haque
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Neurosci Res 47:31-7. 2003
    ..Therefore, Cu-Zn SOD overexpression may temporarily inhibit or delay DA autoxidation and consequently increase the GSH level, which then prevents the activation of apoptotic pathway and subsequent cell death...
  64. ncbi request reprint Oxidative metabolism of 5-methoxy-N,N-diisopropyltryptamine (Foxy) by human liver microsomes and recombinant cytochrome P450 enzymes
    Shizuo Narimatsu
    Laboratory of Health Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    Biochem Pharmacol 71:1377-85. 2006
    ..These results indicate that CYP2D6 is the major 5-MeO-DIPT O-demethylase, and CYP1A2, CYP2C8 and CYP3A4 are the major 5-MeO-DIPT N-deisopropylase enzymes in the human liver...
  65. ncbi request reprint Embryonic expression of pericentrin suggests universal roles in ciliogenesis
    Ko Miyoshi
    Department of Brain Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Dev Genes Evol 216:537-42. 2006
    ..Moreover, Pcnt was shown to be localized to the base of primary cilia in multiple embryonic tissues, in agreement with a recent study demonstrating the involvement of Pcnt in primary cilia formation using cultured mammalian cells...
  66. ncbi request reprint L-DOPA treatment from the viewpoint of neuroprotection. Possible mechanism of specific and progressive dopaminergic neuronal death in Parkinson's disease
    Norio Ogawa
    Dept of Brain Science, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    J Neurol 252:IV23-IV31. 2005
    ..Thus, it is now clear that the presence of high levels of discompartmentalized free dopamine in dopaminergic neurons may explain the specific vulnerability of dopaminergic neurons through the generation of highly toxic quinones...
  67. ncbi request reprint Age-related changes in expression of metallothionein-III in rat brain
    Ikuko Miyazaki
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Neurosci Res 43:323-33. 2002
    ..Since it has been reported that MT-III has neuroprotective roles as an antioxidant, present results suggest that MT-III is closely related to the neurodegeneration in the aged animals...
  68. ncbi request reprint Chronic treatment with imipramine and lithium increases cell proliferation in the hippocampus in adrenocorticotropic hormone-treated rats
    Yoshihisa Kitamura
    Department of Pharmaceutical Care and Health Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700 8530, Japan
    Biol Pharm Bull 34:77-81. 2011
    ..The coadministration of imipramine and lithium may have treatment-resistant antidepressive properties, which may be attributed, in part, to a normalization of hippocampal cell proliferation...
  69. ncbi request reprint Manda, a fermented natural food, suppresses lipid peroxidation in the senescent rat brain
    M Kawai
    Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, Japan
    Neurochem Res 23:455-61. 1998
    ..Our results suggest that Manda protects against age-dependent oxidative neuronal damage caused by oxidative stress and that this protective effect may be due, in part, to its scavenging activity against free radicals...
  70. ncbi request reprint Progressive cortical atrophy after forebrain ischemia in diabetic rats
    F Kondo
    Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, 2-5-1 Shikatacho, Okayama 700-8558, Japan
    Neurosci Res 39:339-46. 2001
    ..Our results indicate that brain ischemia in the presence of diabetes causes more severe late-onset damage culminating in brain atrophy, compared with non-diabetics...
  71. ncbi request reprint [Mechanism of specific dopaminergic neuronal death in Parkinson's disease]
    Norio Ogawa
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry
    Nihon Rinsho 62:1629-34. 2004
    ..Thus, DA quinones play an important role in 'specific' DAergic neuro-degeneration of PD...
  72. ncbi request reprint 5-Methoxy-N,N-diisopropyltryptamine (Foxy), a selective and high affinity inhibitor of serotonin transporter
    C Sogawa
    Department of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata 2 5 1, Okayama 700 8525, Japan
    Toxicol Lett 170:75-82. 2007
    ..These results demonstrated that 5-MeO-DIPT acts as a competitive SERT inhibitor and has an inability to cause reverse transport, underlying its serotonergic actions...
  73. ncbi request reprint Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia
    Ikuko Miyazaki
    Department of Brain Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Brain Res 1029:120-3. 2004
    ....
  74. ncbi request reprint Direct evidence for increased hydroxyl radicals in angiotensin II-induced cardiac hypertrophy through angiotensin II type 1a receptor
    Mikio Kakishita
    Department of Cardiovascular Medicine, Institute of Molecular and Cellular Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Cardiovasc Pharmacol 42:S67-70. 2003
    ..These findings in this study may provide important insights into the development of hypertrophy and the transition of hypertrophy to heart failure...
  75. ncbi request reprint Prednisolone inhibits proliferation of cultured pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension
    Aiko Ogawa
    Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Circulation 112:1806-12. 2005
    ..In this study, we tested the hypothesis that PSL has antiproliferative effects on pulmonary artery SMCs of patients with IPAH...
  76. doi request reprint Effects of galantamine on L-NAME-induced behavioral impairment in Y-maze task in mice
    Ken ichi Tanaka
    Department of Clinical Pharmacy, Shujitsu University School of Pharmacy, Okayama, Japan
    Neurosci Lett 462:235-8. 2009
    ..In the present study, we have determined that galantamine's protection against L-NAME-induced impairment of spontaneous alternation behavior in the Y-maze task might be mediated mainly by NOergic activation via the nAChR-related pathway...
  77. ncbi request reprint Involvement of STAT3 in bladder smooth muscle hypertrophy following bladder outlet obstruction
    Osamu Fujita
    Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 60:299-309. 2006
    ..These results suggest that STAT3 has an important role in the induction of bladder smooth muscle hypertrophy...
  78. doi request reprint Increased susceptibility to oxidant-mediated tissue injury and peritoneal fibrosis in acatalasemic mice
    Naomi Fukuoka
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Okayama, Japan
    Am J Nephrol 28:661-8. 2008
    ..Peritoneal fibrosis is a major complication leading to the loss of peritoneal function in patients undergoing peritoneal dialysis. However, the effect of catalase depletion on peritoneal fibrosis has not yet been investigated...
  79. ncbi request reprint Effects of HMGB1 on ischemia-reperfusion injury in the rat heart
    Susumu Oozawa
    Department of Cardiovascular Surgery, University of Okayama Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Circ J 72:1178-84. 2008
    ..In the present study a neutralizing monoclonal antibody (mAb) for HMGB1 was used to clarify the role of HMGB1 in cardiac I/R injury...
  80. ncbi request reprint [New perspectives on the mechanism of methamphetamine-induced neurotoxicity]
    Taizo Kita
    Laboratory of Pharmacology, Kyushu Nutrition Welfare University Graduate School of Food and Nutrition, 5 1 1 Shimoitozu, Kokurakita ku, Kitakyushu, 803 8511, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 28:49-61. 2008
    ..The objective of the present review will be to consolidate the new perspectives in an attempt to formulate a more cohesive explanation of the underlying mechanism responsible for METH-induced DA damage and its early biological markers...
  81. ncbi request reprint Common anti-apoptotic roles of parkin and alpha-synuclein in human dopaminergic cells
    Yutaka Machida
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 332:233-40. 2005
    ..Our findings indicate that both parkin and alpha-SN share a common pathway in DA metabolism whose abnormality leads to accumulation of oxidative DA metabolites and subsequent cell death...
  82. ncbi request reprint Molecular basis of 6-hydroxydopamine-induced caspase activations due to increases in oxidative stress in the mouse striatum
    Ken ichi Tanaka
    Department of Clinical Pharmacy, Shujitsu University School of Pharmacy, Okayama 703 8516, Japan
    Neurosci Lett 410:85-9. 2006
    ..In conclusion, 6-OHDA-induced dopaminergic dysfunction is mainly due to caspase activations by increases in oxidative stress in the mouse striatum...
  83. ncbi request reprint Molecular basis of anti-apoptotic effect of immunophilin ligands on hydrogen peroxide-induced apoptosis in human glioma cells
    Ken ichi Tanaka
    Department of Clinical Pharmacy, Shujitsu University School of Pharmacy, 1 6 1 Nishigawara, Okayama 703 8516, Japan
    Neurochem Res 29:1529-36. 2004
    ....