Toshiyoshi Fujiwara

Summary

Affiliation: Okayama University
Country: Japan

Publications

  1. ncbi request reprint Synergistic interaction of telomerase-specific oncolytic virotherapy and chemotherapeutic agents for human cancer
    Toshiyoshi Fujiwara
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Curr Pharm Biotechnol 13:1809-16. 2012
  2. pmc Establishment of a pancreatic stem cell line from fibroblast-derived induced pluripotent stem cells
    Takashi Kuise
    Department of Surgery, Chiba East National Hospital, National Hospital Organization, Chiba 260 8712, Japan
    Biomed Eng Online 13:64. 2014
  3. doi request reprint In vivo imaging of human cancer with telomerase-specific replication-selective adenovirus
    Toshiyoshi Fujiwara
    Center for Gene and Cell Therapy, Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Methods Mol Biol 872:129-39. 2012
  4. ncbi request reprint Multicenter phase I study of repeated intratumoral delivery of adenoviral p53 in patients with advanced non-small-cell lung cancer
    Toshiyoshi Fujiwara
    Center for Gene and Cell Therapy, Okayama University Hospital, Okayama 700 8558, Japan
    J Clin Oncol 24:1689-99. 2006
  5. ncbi request reprint Telomerase-specific oncolytic virotherapy for human cancer with the hTERT promoter
    Toshiyoshi Fujiwara
    Center for Gene and Cell Therapy, Okayama University Hospital, Okayama 700 8558, Japan
    Curr Cancer Drug Targets 7:191-201. 2007
  6. ncbi request reprint Telomerase-specific oncolytic virotherapy for human cancer with the hTERT promoter
    Toshiyoshi Fujiwara
    Center for Gene and Cell Therapy, Okayama University Hospital, Department of Surgery, Okayama Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Uirusu 58:11-8. 2008
  7. ncbi request reprint Telomerase-specific virotherapy for human squamous cell carcinoma
    Toshiyoshi Fujiwara
    Okayama University Hospital, Center for Gene and Cell Therapy, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Expert Opin Biol Ther 9:321-9. 2009
  8. doi request reprint Telomerase-specific oncolytic virotherapy for human gastrointestinal cancer
    Toshiyoshi Fujiwara
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Expert Rev Anticancer Ther 11:525-32. 2011
  9. ncbi request reprint A novel molecular therapy using bioengineered adenovirus for human gastrointestinal cancer
    Toshiyoshi Fujiwara
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Acta Med Okayama 65:151-62. 2011
  10. ncbi request reprint Enhanced antitumor efficacy of telomerase-selective oncolytic adenoviral agent OBP-401 with docetaxel: preclinical evaluation of chemovirotherapy
    Toshiya Fujiwara
    Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Int J Cancer 119:432-40. 2006

Detail Information

Publications103 found, 100 shown here

  1. ncbi request reprint Synergistic interaction of telomerase-specific oncolytic virotherapy and chemotherapeutic agents for human cancer
    Toshiyoshi Fujiwara
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Curr Pharm Biotechnol 13:1809-16. 2012
    ..This article reviews synergistic interaction of virotherapy and chemotherapy, and illustrates the potential application for the treatment of human cancer...
  2. pmc Establishment of a pancreatic stem cell line from fibroblast-derived induced pluripotent stem cells
    Takashi Kuise
    Department of Surgery, Chiba East National Hospital, National Hospital Organization, Chiba 260 8712, Japan
    Biomed Eng Online 13:64. 2014
    ..The purpose of this study was to establish a pancreatic stem cell line from iPS cells derived from mouse fibroblasts...
  3. doi request reprint In vivo imaging of human cancer with telomerase-specific replication-selective adenovirus
    Toshiyoshi Fujiwara
    Center for Gene and Cell Therapy, Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Methods Mol Biol 872:129-39. 2012
    ..This technology is adaptable to detect tumor metastasis and/or dissemination in vivo as a preclinical model of surgical navigation...
  4. ncbi request reprint Multicenter phase I study of repeated intratumoral delivery of adenoviral p53 in patients with advanced non-small-cell lung cancer
    Toshiyoshi Fujiwara
    Center for Gene and Cell Therapy, Okayama University Hospital, Okayama 700 8558, Japan
    J Clin Oncol 24:1689-99. 2006
    ....
  5. ncbi request reprint Telomerase-specific oncolytic virotherapy for human cancer with the hTERT promoter
    Toshiyoshi Fujiwara
    Center for Gene and Cell Therapy, Okayama University Hospital, Okayama 700 8558, Japan
    Curr Cancer Drug Targets 7:191-201. 2007
    ..This article reviews recent findings in this rapidly evolving field: cancer therapeutic and cancer diagnostic approaches using the hTERT promoter...
  6. ncbi request reprint Telomerase-specific oncolytic virotherapy for human cancer with the hTERT promoter
    Toshiyoshi Fujiwara
    Center for Gene and Cell Therapy, Okayama University Hospital, Department of Surgery, Okayama Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Uirusu 58:11-8. 2008
    ..This article reviews recent highlights in this rapidly evolving field: cancer therapeutic and cancer diagnostic approaches using the telomerase-specific oncolytic adenoviruses...
  7. ncbi request reprint Telomerase-specific virotherapy for human squamous cell carcinoma
    Toshiyoshi Fujiwara
    Okayama University Hospital, Center for Gene and Cell Therapy, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Expert Opin Biol Ther 9:321-9. 2009
    ..They are designed to induce lysis after propagation within the tumor. Human telomerase is active in over 85% of primary cancers and its activity correlates closely with human telomerase reverse transcriptase (hTERT) expression...
  8. doi request reprint Telomerase-specific oncolytic virotherapy for human gastrointestinal cancer
    Toshiyoshi Fujiwara
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Expert Rev Anticancer Ther 11:525-32. 2011
    ..In this article we show that intratumoral injection of OBP-301 mediates effective in vivo purging of metastatic tumor cells from regional lymph nodes, which may help optimize treatment of human gastrointestinal malignancies...
  9. ncbi request reprint A novel molecular therapy using bioengineered adenovirus for human gastrointestinal cancer
    Toshiyoshi Fujiwara
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Acta Med Okayama 65:151-62. 2011
    ..These results illustrate the potential of oncolytic virotherapy as a promising strategy in the management of human gastrointestinal cancer...
  10. ncbi request reprint Enhanced antitumor efficacy of telomerase-selective oncolytic adenoviral agent OBP-401 with docetaxel: preclinical evaluation of chemovirotherapy
    Toshiya Fujiwara
    Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Int J Cancer 119:432-40. 2006
    ..Thus, OBP-401 in combination with docetaxel efficiently enhances the antitumor efficacy both in vitro and in vivo, and the outcome has important implications for tumor-specific oncolytic chemovirotherapies for human cancers...
  11. ncbi request reprint Histone deacetylase inhibitor FR901228 enhances the antitumor effect of telomerase-specific replication-selective adenoviral agent OBP-301 in human lung cancer cells
    Takanori Watanabe
    Division of Surgical Oncology, Department of Surgery, Okayama University, Graduate School of Medicine and Dentistry, Okayama, Japan
    Exp Cell Res 312:256-65. 2006
    ....
  12. ncbi request reprint Quantitative analysis of p53-targeted gene expression and visualization of p53 transcriptional activity following intratumoral administration of adenoviral p53 in vivo
    Shoichiro Ohtani
    Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Mol Cancer Ther 3:93-100. 2004
    ....
  13. doi request reprint Combination of oncolytic adenovirotherapy and Bax gene therapy in human cancer xenografted models. Potential merits and hurdles for combination therapy
    Masayoshi Hioki
    Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Int J Cancer 122:2628-33. 2008
    ....
  14. ncbi request reprint A novel antiangiogenic effect for telomerase-specific virotherapy through host immune system
    Yoshihiro Ikeda
    Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Immunol 182:1763-9. 2009
    ..Our data suggest that OBP-301 seems to have antiangiogenic properties through the stimulation of host immune cells to produce endogenous antiangiogenic factors such as IFN-gamma...
  15. pmc Trastuzumab-Based Photoimmunotherapy Integrated with Viral HER2 Transduction Inhibits Peritoneally Disseminated HER2-Negative Cancer
    Michihiro Ishida
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Mol Cancer Ther 15:402-11. 2016
    ..In conclusion, the novel therapy of molecular-targeted PIT integrated with gene transfer technology is a promising approach for the treatment of peritoneal dissemination in gastric cancer...
  16. doi request reprint A genetically engineered oncolytic adenovirus decoys and lethally traps quiescent cancer stem-like cells in S/G2/M phases
    Shuya Yano
    Authors Affiliations Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Center for innovative clinical medicine, Okayama University Hospital, Okayama Oncolys BioPharma, Inc, Tokyo, Japan Department of Surgery, University of California San Diego and AntiCancer, Inc, San Diego, California
    Clin Cancer Res 19:6495-505. 2013
    ..Thus, we explored the use of a genetically-engineered telomerase-specific oncolytic adenovirus, OBP-301, to mobilize the cell cycle and kill quiescent cancer stem-like cells...
  17. ncbi request reprint Lentiviral transfer of the LacZ gene into human endothelial cells and human bone marrow mesenchymal stem cells
    Toshinori Totsugawa
    Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Japan
    Cell Transplant 11:481-8. 2002
    ..These findings provide evidence that lentiviral vectors are efficient tools for gene transfer and expression in human endothelial cells and stem cells that could be useful for tissue engineering...
  18. doi request reprint Targeted Photodynamic Virotherapy Armed with a Genetically Encoded Photosensitizer
    Kiyoto Takehara
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Mol Cancer Ther 15:199-208. 2016
    ..TelomeKiller-based PDT is a promising antitumor strategy to efficiently eradicate tumor cells...
  19. doi request reprint Telomerase-dependent oncolytic adenovirus sensitizes human cancer cells to ionizing radiation via inhibition of DNA repair machinery
    Shinji Kuroda
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Center for Gene and Cell Therapy, Okayama University Hospital, Okayama, Japan
    Cancer Res 70:9339-48. 2010
    ..These results illustrate the potential of combining oncolytic virotherapy and ionizing radiation as a promising strategy in the management of human cancer...
  20. ncbi request reprint [A case of advanced sigmoid colon cancer successfully treated with multimodality therapy]
    Naoki Nishie
    Dept of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    Gan To Kagaku Ryoho 40:1959-61. 2013
    ..Multimodality therapy could facilitate curative resection, thereby resulting in a good prognosis. ..
  21. doi request reprint A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression
    Yasumoto Yamasaki
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Eur J Cancer 48:2282-91. 2012
    ..This novel apoptotic mechanism suggests that the p53-expressing OBP-702 is a promising antitumour reagent for human cancer and could improve the clinical outcome...
  22. ncbi request reprint Visualization of intrathoracically disseminated solid tumors in mice with optical imaging by telomerase-specific amplification of a transferred green fluorescent protein gene
    Tatsuo Umeoka
    Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Cancer Res 64:6259-65. 2004
    ..Our results indicate that intratumoral or intrathoracic injection of Ad-GFP in combination with OBP-301 might be a useful diagnostic method that provides a foundation for future clinical application...
  23. ncbi request reprint Enhanced oncolysis by a tropism-modified telomerase-specific replication-selective adenoviral agent OBP-405 ('Telomelysin-RGD')
    Masaki Taki
    Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Oncogene 24:3130-40. 2005
    ..Our results suggest that fiber-modified replication-competent adenovirus OBP-405 exhibits a broad target range by increasing infection efficiency, an outcome that has important implications for the treatment of human cancers...
  24. doi request reprint Preclinical evaluation of differentially targeting dual virotherapy for human solid cancer
    Ryo Sakai
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Kita ku, Okayama, Japan
    Mol Cancer Ther 9:1884-93. 2010
    ....
  25. ncbi request reprint Transduction of immortalized human hepatocytes with p21 to enhance differentiated phenotypes
    Takemi Kunieda
    Department of Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan
    Cell Transplant 11:421-8. 2002
    ..We here show that exogenous expression of p21 augments cellular differentiation in immortalized human NKNT-3 cells...
  26. ncbi request reprint Telomerase-specific replication-selective virotherapy for human cancer
    Takeshi Kawashima
    Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Clin Cancer Res 10:285-92. 2004
    ..We investigated the antitumor effect of the hTERT-specific replication-competent adenovirus on human cancer cells...
  27. doi request reprint Preclinical evaluation of synergistic effect of telomerase-specific oncolytic virotherapy and gemcitabine for human lung cancer
    Dong Liu
    Center for Gene and Cell Therapy, Okayama University Hospital, and Department of Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Mol Cancer Ther 8:980-7. 2009
    ..We also found that the synergistic mechanism may be due to OBP-301-mediated cell cycle accumulation in S phase. These results have important implications for the treatment of human lung cancer...
  28. ncbi request reprint Late resistance to adenoviral p53-mediated apoptosis caused by decreased expression of Coxsackie-adenovirus receptors in human lung cancer cells
    Yasuhisa Tango
    Department of Surgery, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Cancer Sci 95:459-63. 2004
    ..Our results demonstrated that decreased CAR expression could be one of the mechanisms of late resistance to Ad-p53, which may have a significant impact on the outcome of adenovirus-based cancer gene therapy...
  29. doi request reprint In vivo biological purging for lymph node metastasis of human colorectal cancer by telomerase-specific oncolytic virotherapy
    Toru Kojima
    Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Ann Surg 251:1079-86. 2010
    ..Lymphatic invasion is a major route for cancer cell dissemination, and adequate treatment of locoregional lymph nodes is required for curative treatment in patients with malignancies...
  30. doi request reprint Risk factors for organ/space surgical site infection after hepatectomy for hepatocellular carcinoma in 359 recent cases
    Hiroshi Sadamori
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata, Okayama 700 8558, Japan
    J Hepatobiliary Pancreat Sci 20:186-96. 2013
    ..Surgical site infections (SSIs), particularly organ/space SSIs, remain a common cause of major morbidity after hepatectomy for hepatocellular carcinoma (HCC)...
  31. doi request reprint Poor prognosis of KRAS or BRAF mutant colorectal liver metastasis without microsatellite instability
    Yuzo Umeda
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, Okayama 700 8558, Japan
    J Hepatobiliary Pancreat Sci 20:223-33. 2013
    ..The discovery of practical biomarkers is important to realize personalized medicine for patients with malignant neoplasias, including colorectal cancer (CRC)...
  32. doi request reprint Surgical rationalization of living donor liver transplantation by abolition of hepatic artery reconstruction under a fixed microscope
    Takahito Yagi
    Department of Gastroenterological, Transplant Surgery and Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, Okayama City, Okayama, Japan
    Clin Transplant 26:877-83. 2012
    ..05). Significant reductions were observed in operation time (p<0.0001), blood loss (p<0.05), and hospital stay (p<0.01) in the non-micro group. Non-microscopic anastomosis is useful for the rationalization of LDLT...
  33. doi request reprint Mechanism of resistance to trastuzumab and molecular sensitization via ADCC activation by exogenous expression of HER2-extracellular domain in human cancer cells
    Ryosuke Yoshida
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama, 700 8558, Japan
    Cancer Immunol Immunother 61:1905-16. 2012
    ..Our data indicate that restoration of HER2-ECD expression sensitizes HER2-negative or HER2-downregulated human cancer cells to trastuzumab-mediated ADCC, an outcome that has important implications for the treatment of human cancers...
  34. pmc A simple biological imaging system for detecting viable human circulating tumor cells
    Toru Kojima
    Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Clin Invest 119:3172-81. 2009
    ..This GFP-expressing virus-based method is remarkably simple and allows precise enumeration of CTCs...
  35. ncbi request reprint Antitumor effect of intratumoral administration of bone marrow-derived dendritic cells transduced with wild-type p53 gene
    Takayoshi Murakami
    Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama University Hospital, Okayama, Japan
    Clin Cancer Res 10:3871-80. 2004
    ..We investigated the antitumor effect of intratumoral administration of bone marrow-derived dendritic cells transduced with wild-type p53 gene...
  36. ncbi request reprint In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus
    Hiroyuki Kishimoto
    Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Nat Med 12:1213-9. 2006
    ..This technology is adaptable to detect lymph node metastasis in vivo as a preclinical model of surgical navigation...
  37. doi request reprint Advances in adenovirus-mediated p53 cancer gene therapy
    Hiroshi Tazawa
    Okayama University Hospital, Center for Innovative Clinical Medicine, Okayama 700 8558, Japan
    Expert Opin Biol Ther 13:1569-83. 2013
    ..To restore wild-type p53 function in p53-inactivated tumors, adenovirus-mediated p53 gene therapy has been developed as a promising antitumor strategy in preclinical experiments and clinical studies...
  38. ncbi request reprint Living donor liver transplantation to a survivor of liver resection for hepatocellular carcinoma with major portal vein invasion
    Hiroshi Sadamori
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 67:117-21. 2013
    ..Based on these findings, living donor liver transplantation was performed using a right lobe graft from the patient's son. The patient is alive at 87 months after the transplantation, with no evidence of HCC recurrence...
  39. pmc Antiproliferative effect of a novel mTOR inhibitor temsirolimus contributes to the prolonged survival of orthotopic esophageal cancer-bearing mice
    Toshio Nishikawa
    Department of Gastroenterological Surgery and Surgical Oncology, Graduate School of Medicine Dentistry, Okayama University, Okayama, Japan
    Cancer Biol Ther 14:230-6. 2013
    ..0024). These data suggests that targeting mTOR by temsirolimus may become a therapeutic alternative for esophageal cancer, with a contribution to a better outcome...
  40. doi request reprint Intractable bile leakage after hepatectomy for hepatocellular carcinoma in 359 recent cases
    Hiroshi Sadamori
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Dig Surg 29:149-56. 2012
    ..Bile leakage is still a common cause of major morbidity after hepatectomy for hepatocellular carcinoma (HCC). The purpose of this study was to identify characteristics and risk factors for intractable bile leakage after hepatectomy for HCC...
  41. pmc Which patients respond best to hepatitis B vaccination after a hepatitis B virus-related liver transplantation?
    Akinobu Takaki
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama, 700 8558, Japan
    J Gastroenterol 48:1373-83. 2013
    ..However, frequent immunoglobulin treatment is expensive and inconvenient. This study investigated the efficacy of hepatitis B virus (HBV) vaccination in preventing the recurrence of hepatitis B after living donor OLT...
  42. ncbi request reprint In Vivo Isolation of a Highly-aggressive Variant of Triple-negative Human Breast Cancer MDA-MB-231 Using Serial Orthotopic Transplantation
    Shuya Yano
    AntiCancer, Inc, San Diego, CA, U S A Department of Surgery, University of California, San Diego, CA, U S A Department of Gastroenterological Surgery, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Anticancer Res 36:3817-20. 2016
    ..We describe the development of a highly-invasive, triple-negative breast cancer (TNBC) variant using serial orthotopic implantation of MDA-MB-231 human breast cancer in nude mice...
  43. pmc The hTERT promoter enhances the antitumor activity of an oncolytic adenovirus under a hypoxic microenvironment
    Yuuri Hashimoto
    Department of Gastroenterological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    PLoS ONE 7:e39292. 2012
    ..Regulation of oncolytic adenoviruses by the hTERT promoter is a promising antitumor strategy, not only for induction of tumor-specific oncolysis, but also for efficient elimination of hypoxic tumor cells...
  44. doi request reprint A novel synergistic effect of iron depletion on antiangiogenic cancer therapy
    Toshiaki Ohara
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Int J Cancer 132:2705-13. 2013
    ..Bevacizumab synergistically enhanced the iron-depleted antitumor effect. Treatment to deplete iron levels combined with anti-angiogenic therapy could induce a novel therapeutic effect in the treatment of cancer...
  45. doi request reprint Branched-chain amino acid-enriched nutrients improve nutritional and metabolic abnormalities in the early post-transplant period after living donor liver transplantation
    Ryuichi Yoshida
    Department of Gastroenterological Surgery Transplant, and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Hepatobiliary Pancreat Sci 19:438-48. 2012
    ..The aim of this study was to establish whether perioperative usage of branched-chain amino-acid (BCAA)-enriched nutrients improve metabolic abnormalities of patients undergoing LDLT...
  46. doi request reprint Oral administration of FAK inhibitor TAE226 inhibits the progression of peritoneal dissemination of colorectal cancer
    Hui Fang Hao
    Department of Gastroenterological Surgery, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikatacho, Kita ku, Okayama 700 8558, Japan
    Biochem Biophys Res Commun 423:744-9. 2012
    ..Taken together, a possible strategy for inhibiting peritoneal dissemination by targeting FAK with TAE226 appears to be applicable through anti-proliferative and anti-invasion/anti-migration mechanisms...
  47. doi request reprint Relative Prognostic and Predictive Value of Gene Signature and Histologic Grade in Estrogen Receptor-Positive, HER2-Negative Breast Cancer
    Takayuki Iwamoto
    Okayama University Hospital, Okayama, Japan Electronic address
    Clin Breast Cancer 16:95-100.e1. 2016
    ..We compared both the prognostic and predictive value of histologic grades and genomic markers...
  48. doi request reprint Antiproliferative effect of the HSP90 inhibitor NVP-AUY922 is determined by the expression of PTEN in esophageal cancer
    Xiao Hong Bao
    Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Oncol Rep 29:45-50. 2013
    ..The effect may be improved further by impeding PTEN expression...
  49. doi request reprint New surgical approach to large splenorenal shunt in living donor liver transplantation: diversion of SMV and SPV blood flow
    Hiroshi Sadamori
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata, Okayama, 700 8558, Japan
    J Gastrointest Surg 17:403-7. 2013
    ..The management of a large splenorenal shunt is important because it affects recipient outcome, particularly in living donor liver transplantation...
  50. doi request reprint Genetically engineered oncolytic adenovirus induces autophagic cell death through an E2F1-microRNA-7-epidermal growth factor receptor axis
    Hiroshi Tazawa
    Center for Gene and Cell Therapy, Okayama University Hospital, Okayama, Japan
    Int J Cancer 131:2939-50. 2012
    ..Our results suggest that oncolytic adenovirus induces autophagic cell death through an E2F1-miR-7-EGFR pathway in human cancer cells, providing a novel insight into the molecular mechanism of an anticancer virotherapy...
  51. ncbi request reprint Resection of metachronous lymph node metastases from hepatocellular carcinoma after hepatectomy: report of four cases
    Masashi Utsumi
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    Acta Med Okayama 66:177-82. 2012
    ..With the expectation of long-term survival, a single metachronous LN metastasis from HCC after hepatectomy should be resected in patients without uncontrollable intrahepatic or extrahepatic tumors...
  52. ncbi request reprint [Stent placement using a double-balloon endoscope for malignant duodenal obstruction with Roux-en-Y Anastomosis-a case report]
    Masahiko Oiwa
    Dept of Gastrointestinal Surgery, Okayama University Hospital, Japan
    Gan To Kagaku Ryoho 39:2372-4. 2012
    ..In the present case, this minimally invasive procedure avoided the need for surgery and greatly contributed to palliation. Thus, EMS placement using a DBE is a possible palliative treatment for malignant small bowel obstruction...
  53. doi request reprint Jejunal interposition reconstruction with a stomach preserving esophagectomy improves postoperative weight loss and reflux symptoms for esophageal cancer patients
    Eiji Yamada
    Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    J Surg Res 178:700-7. 2012
    ....
  54. ncbi request reprint [Successfully resected stage IIIA non-small cell lung cancer with mediastinal lymphnode metastasis after chemotherapy of cisplatin and docetaxel combined with concurrent radiation]
    Fuminori Teraishi
    Department of Surgical Oncology, Division of Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    Gan To Kagaku Ryoho 34:1493-5. 2007
    ..Finally, the case was diagnosed as a T1N1M0, stage IIA NSCLC pathologically. Our chemotherapy regimen consisting of CDDP and DOC combined with concurrent radiation might be as potent as neo-adjuvant therapy for clinical stage III NSCLC...
  55. ncbi request reprint Ectopic p21sdi1 gene transfer induces retinoic acid receptor beta expression and sensitizes human cancer cells to retinoid treatment
    Fuminori Teraishi
    Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Int J Cancer 103:833-9. 2003
    ..Our results indicate that recombinant adenovirus-mediated p21(sdi1) gene transfer could be potentially useful for the local induction of RA sensitivity in human premalignant and malignant lesions lacking appropriate RARbeta expression...
  56. ncbi request reprint ZD1839 (Gefitinib, 'Iressa'), an epidermal growth factor receptor-tyrosine kinase inhibitor, enhances the anti-cancer effects of TRAIL in human esophageal squamous cell carcinoma
    Fuminori Teraishi
    Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    FEBS Lett 579:4069-75. 2005
    ..ZD1839 also augmented the anti-cancer activity of TRAIL, even in TRAIL-resistant tumors. These results suggest that treatment with ZD1839 and TRAIL may have potential in the treatment of ESCC patients...
  57. doi request reprint Risk factors for acute renal injury in living donor liver transplantation: evaluation of the RIFLE criteria
    Masashi Utsumi
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Transpl Int 26:842-52. 2013
    ..Perioperative treatment strategies should be designed and balanced based on the risk factors for the further improvement of transplant prognosis...
  58. doi request reprint Dual programmed cell death pathways induced by p53 transactivation overcome resistance to oncolytic adenovirus in human osteosarcoma cells
    Joe Hasei
    Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Mol Cancer Ther 12:314-25. 2013
    ..These results suggest that OBP-702-mediated p53 transactivation is a promising antitumor strategy to induce dual apoptotic and autophagic cell death pathways via regulation of miRNA and DRAM in human osteosarcoma cells...
  59. ncbi request reprint The Maximum standardized uptake value is more reliable than size measurement in early follow-up to evaluate potential pulmonary malignancies following radiofrequency ablation
    Aierken Alafate
    Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 67:105-12. 2013
    ..SUVmax was more reliable than the size measurements by CT in the first 6 months after RFA, and PET/CT at 6 months post-RFA may be more appropriate for the assessment of FDG accumulation than that at 3 months post-RFA...
  60. doi request reprint Preventive effect of omental flap in pancreaticoduodenectomy against postoperative pseudoaneurysm formation
    Hiroaki Matsuda
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Okayama, Japan
    Hepatogastroenterology 59:578-83. 2012
    ..However, the efficiency of such a procedure remains to be verified. The purpose of this study was to determine the effect of omental flap placement in pancreaticoduodenectomy on the incidence of postoperative pseudoaneurysms...
  61. doi request reprint Bloodless donor hepatectomy in living donor liver transplantation: counterclockwise liver rotation and early hanging maneuver
    Hiroshi Sadamori
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata, Okayama 700 8558, Japan
    J Gastrointest Surg 17:203-6. 2013
    ..Living donor hepatectomy is important because it determines donor safety and recipient outcome...
  62. doi request reprint Multicenter phase II study of S-1 and docetaxel combination chemotherapy for advanced or recurrent gastric cancer patients with peritoneal dissemination
    Kunitoshi Shigeyasu
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    Cancer Chemother Pharmacol 71:937-43. 2013
    ..A multicenter phase II study was designed to evaluate the efficacy and tolerability of S-1 and docetaxel combination chemotherapy regimen for the treatment of advanced or recurrent gastric cancer patients with peritoneal dissemination...
  63. ncbi request reprint Recurrence after Endoscopic Curative Resection of Mucosal Gastric Cancer Associated with an Adjacent Neoplastic Precursor Lesion
    Satoru Kikuchi
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558
    Acta Med Okayama 70:213-216. 2016
    ..We speculated that a precancerous lesion close to the resected cancer developed into a local recurrence...
  64. pmc Enhancement of Programmed Death Ligand 2 on Hepatitis C Virus Infected Hepatocytes by Calcineurin Inhibitors
    Kazuko Koike
    1 Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Japan 2 Department of Gastroenterological Surgery Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Japan 3 Health Service Center, Okayama University, Okayama, Japan
    Transplantation 99:1447-54. 2015
    ..We hypothesized that this atypical molecule could affect the recurrence of post-OLT hepatitis. To test this hypothesis, we conducted immunohistochemical staining analysis and in vitro analysis of PD-L2...
  65. ncbi request reprint Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cells
    Koh Katsuda
    Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Oncogene 21:2108-13. 2002
    ..Our results support the clinical relevance of Adv/p16 as a treatment for p16-null human NSCLC that express wild-type p53...
  66. ncbi request reprint [A successful multimodality therapy for a case of recurrent rectal cancer with KRAS mutation]
    Ayako Watanabe
    Dept of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    Gan To Kagaku Ryoho 42:237-9. 2015
    ..The combination of appropriate local therapy with systemic chemotherapy is an essential strategy to treat advanced colorectal cancer, especially in patients with KRAS mutation when anti-EGFR antibodies are not effective...
  67. doi request reprint Preclinical evaluation of telomerase-specific oncolytic virotherapy for human bone and soft tissue sarcomas
    Tsuyoshi Sasaki
    Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita ku, Okayama, Japan
    Clin Cancer Res 17:1828-38. 2011
    ..However, it remains unclear whether OBP-301 is cytopathic for nonepithelial malignant cells. Here, we evaluated the antitumor effect of OBP-301 on human bone and soft tissue sarcoma cells...
  68. ncbi request reprint [A case of transverse myelopathy due to spinal bone metastasis of gastric cancer]
    Aiko Kono
    Dept of Gastrointestinal Surgery, Okayama University Hospital, Japan
    Gan To Kagaku Ryoho 39:2357-9. 2012
    ..Because of a rapidly deteriorating clinical course, early diagnosis and multidisciplinary approaches are important for gastric cancer patients with spinal metastasis...
  69. pmc CD14 upregulation as a distinct feature of non-alcoholic fatty liver disease after pancreatoduodenectomy
    Daisuke Satoh
    Daisuke Satoh, Takahito Yagi, Takeshi Nagasaka, Susumu Shinoura, Yuzo Umeda, Ryuichi Yoshida, Masashi Utsumi, Hiroshi Sadamori, Toshiyoshi Fujiwara, Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    World J Hepatol 5:189-95. 2013
    ..To investigate the pathogenesis of non-alcoholic fatty liver disease (NAFLD) after pancreatoduodenectomy (PD)...
  70. pmc Long-term outcome of induction chemoradiotherapy with docetaxel and cisplatin followed by surgery for non-small-cell lung cancer with mediastinal lymph node metastasis
    Shinichi Toyooka
    Department of Thoracic Surgery, Okayama University Hospital, Okayama, Japan
    Interact Cardiovasc Thorac Surg 14:565-9. 2012
    ..7 years, the 3-year and 7-year overall survival (OS) rates for the entire population were 72.7 and 63.6%, respectively. Our results suggest that tri-modality therapy is promising for NSCLC patients with mediastinal nodal metastasis...
  71. ncbi request reprint Human monocyte-derived dendritic cells pulsed with wild-type p53 protein efficiently induce CTLs against p53 overexpressing human cancer cells
    Naoyuki Tokunaga
    Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Clin Cancer Res 11:1312-8. 2005
    ..We examined whether monocyte-derived human dendritic cells pulsed with the purified full-length wt-p53 protein were also capable of inducing the specific antitumor responses against p53-overexpressing tumors in vitro...
  72. doi request reprint Inhibition of mTOR by temsirolimus contributes to prolonged survival of mice with pleural dissemination of non-small-cell lung cancer cells
    Toshiaki Ohara
    Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Cancer Sci 102:1344-9. 2011
    ..5 vs 72.5 days; P < 0.05). These results suggest that temsirolimus could be useful for NSCLC treatment, due to its antiproliferative effect, and could be a potential treatment for advanced NSCLC, giving prolonged survival...
  73. ncbi request reprint A case report--The marked response to gemcitabine combined with irinotecan and low-dose cisplatin chemotherapy for advanced gastric cancer with multiple liver metastases
    Fuminori Teraishi
    Dept of Gastroenterological Surgery, Okayama University Graduate School of Medicine and Dentistry, Japan
    Gan To Kagaku Ryoho 33:1885-7. 2006
    ..It may be possible that the current chemotherapy will be neoadjuvant chemotherapy, and curative surgical resection can be performed...
  74. ncbi request reprint Improvement in the differentiated hepatic phenotype of immortalized human hepatocytes by adenovirus mediated p21 gene transfer
    Oya Kobayashi
    Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Japan
    ASAIO J 48:355-9. 2002
    ..In the present work, we demonstrate that the exogenous expression of p21 enhances the differential phenotype of immortalized hepatocytic NKNT-3 cells...
  75. ncbi request reprint [Clinical study of adenoviral mediated p53 gene therapy for non-small cell lung cancer in Japan]
    Shunsuke Kagawa
    Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama, 700 8558, Japan
    Gan To Kagaku Ryoho 30:193-7. 2003
    ..As of September 2002, 13 patients were enrolled to this study, and safety and antitumor effects have been noted...
  76. ncbi request reprint [A case of advanced non-small lung cancer responding to tumor suppressor p53 gene therapy]
    Shunsuke Kagawa
    Center for Gene and Cell Therapy, Okayama University Hospital
    Gan To Kagaku Ryoho 31:1788-90. 2004
    ..In conclusion, gene therapy with ADVEXIN may be an effective treatment for locally advanced non-small lung cancer...
  77. ncbi request reprint Diagnostic and therapeutic application of telomerase-specific oncolytic adenoviral agents
    Toshiyoshi Fujiwara
    Center for Gene and Cell Therapy, Okayama University Hospital, Okayama 700 8558, Japan
    Front Biosci 13:1881-6. 2008
    ..This article reviews recent highlights in this rapidly evolving field: cancer therapeutic and cancer diagnostic approaches using the telomerase-specific oncolytic adenoviruses...
  78. doi request reprint F-18 FDG PET/CT contributes to more accurate detection of lymph nodal metastasis from actively proliferating esophageal squamous cell carcinoma
    Shunsuke Tanabe
    Department of Gastroenterological Surgery, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Clin Nucl Med 36:854-9. 2011
    ..In this study, we examined the diagnostic accuracy of fluorodeoxyglucose PET accompanied by computed tomography imaging (PET/CT) to detect regional lymph nodal metastasis from esophageal squamous cell carcinoma (ESCC)...
  79. ncbi request reprint [p53 gene therapy for lung cancer]
    Shunsuke Kagawa
    Division of Surgical Oncology, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry
    Nihon Rinsho 60:630-4. 2002
  80. ncbi request reprint [Adenoviral p53 gene therapy for human lung cancer]
    Toshiyoshi Fujiwara
    Division of Surgical Oncology, Dept of Surgery, Okayama University Graduate School of Medicine and Dentistry
    Gan To Kagaku Ryoho 30:460-7. 2003
    ..This approach has entered initial clinical testing and provided intriguing information about the intratumoral administration of an adenovirus vector expressing the wild-type p53 gene in non-small cell lung cancer patients...
  81. doi request reprint Portal/splenic vein thrombosis following splenectomy in gastric cancer surgery
    Shunsuke Kagawa
    Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
    Asian J Surg 33:208-11. 2010
    ..However, it has been underappreciated in cases of splenectomy for gastric cancer. The present case demonstrates the importance of considering PSVT as a possible complication of splenectomy in gastric cancer surgery...
  82. ncbi request reprint [Gene therapy for lung cancer]
    Toshiyoshi Fujiwara
    Center for Gene and Cell Therapy, Okayama University Hospital
    Nihon Rinsho 63:507-11. 2005
  83. ncbi request reprint Three cases of adenocarcinoma arising in extremely long-segment Barrett's esophagus
    Toshiya Fujiwara
    Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama, Japan
    Dig Dis Sci 51:533-8. 2006
  84. ncbi request reprint Effects of a novel palatinose based enteral formula (MHN-01) carbohydrate-adjusted fluid diet in improving the metabolism of carbohydrates and lipids in patients with esophageal cancer complicated by diabetes mellitus
    Toshiya Fujiwara
    Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Okayama University, Okayama, Japan
    J Surg Res 138:231-40. 2007
    ....
  85. ncbi request reprint Adenomyoma of the stomach presenting as localized peritonitis
    Shunsuke Kagawa
    Department of Gastroenterological Surgery, Okayama University Hospital, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Dig Dis Sci 52:3184-7. 2007
  86. ncbi request reprint Esophageal cancer exhibits resistance to a novel IGF-1R inhibitor NVP-AEW541 with maintained RAS-MAPK activity
    Xiao Hong Bao
    Department of Gastroenterological Surgery, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Anticancer Res 32:2827-34. 2012
    ..To assess the effects of a novel type 1 insulin-like growth factor receptor (IGF-1R) inhibitor, NVP-AEW541, on cell proliferation and signal transduction of esophageal cancer...
  87. ncbi request reprint The usefulness of pre-radiofrequency ablation SUV(max) in 18F-FDG PET/CT to predict the risk of a local recurrence of malignant lung tumors after lung radiofrequency ablation
    Sosuke Harada
    Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 65:395-402. 2011
    ..67); we thought this was mainly due to selection bias because we excluded tumors less than 10mm in diameter. This study demonstrated the pre-RFA SUV(max) in PET/CT may be a prognostic factor for local recurrence of malignant lung tumors...
  88. ncbi request reprint [Gene therapy for lung cancer]
    Masafumi Kataoka
    Division of Gastroenterological Surgery, Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Nihon Geka Gakkai Zasshi 103:244-9. 2002
    ..Problems encountered and future regimens are also discussed...
  89. ncbi request reprint [Prolonged complete response obtained by radiation and chemotherapy with paclitaxel in a case of recurrent gastric cancer in the rectovesical pouch]
    Nobuhiko Kanaya
    Dept of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    Gan To Kagaku Ryoho 38:2100-2. 2011
    ..Although chemotherapy is of choice for gastric cancer recurrence, in some cases radiotherapy can play an important role in local control even in peritoneal metastasis...
  90. ncbi request reprint [Theranostic application of telomerase-specific oncolytic adenovirus for human cancer]
    Toshiyoshi Fujiwara
    Center for Gene and Cell Therapy, Okayama University Hospital
    Nihon Rinsho 65:1913-22. 2007
    ..This article reviews recent highlights in this rapidly evolving field: cancer therapeutic and cancer diagnostic approaches using the telomerase-specific oncolytic adenoviruses...
  91. pmc Glutamine depletion induces murine neonatal melena with increased apoptosis of the intestinal epithelium
    Takayuki Motoki
    Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 2 5 1, Shikata cho, Okayama, 700 8558, Japan
    World J Gastroenterol 17:717-26. 2011
    ..To investigate the possible biological outcome and effect of glutamine depletion in neonatal mice and rodent intestinal epithelial cells...
  92. ncbi request reprint Leukoencephalopathy syndrome after living-donor liver transplantation
    Yuzo Umeda
    Department of Gastroenterological Transplant Surgery, Surgical Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Exp Clin Transplant 9:139-44. 2011
    ..We determined the incidence and features of leukoencephalopathy syndrome in recipients after living-donor liver transplantations...
  93. doi request reprint Carcinosarcoma of the gallbladder manifesting as cholangitis due to hemobilia
    Hiroshi Sadamori
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata, Okayama, 700 8558, Japan
    J Gastrointest Surg 16:1278-81. 2012
    ..Carcinosarcomas of the gallbladder are rare tumors that are characterized by malignant epithelial and mesenchymal components, and preoperative diagnosis of carcinosarcoma of the gallbladder remains difficult...
  94. ncbi request reprint [Biomarker for colorectal cancer]
    Takeshi Nagasaka
    Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    Nihon Rinsho 70:802-8. 2012
    ..More interestingly, each cell has each promising biological prognostic and/or predictive feature, which will help clinicians to make personalized treatment strategy for each CRC patient...
  95. ncbi request reprint Heparanase expression correlates with invasion and poor prognosis in gastric cancers
    Munenori Takaoka
    Department of First Surgery, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    Lab Invest 83:613-22. 2003
    ..006). In conclusion, our findings suggest that high expression of heparanase in gastric cancer is a strong predictor of poor survival...
  96. doi request reprint MicroRNAs as potential target gene in cancer gene therapy of gastrointestinal tumors
    Hiroshi Tazawa
    Okayama University Hospital, Center for Gene and Cell Therapy, Okayama, Japan
    Expert Opin Biol Ther 11:145-55. 2011
    ....
  97. ncbi request reprint Controlled expansion of human endothelial cell populations by Cre-loxP-based reversible immortalization
    Hirofumi Noguchi
    Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Hum Gene Ther 13:321-34. 2002
    ..This study extends the utility of the reversible immortalization procedure and provides a means to expand primary human ECs of various sources for basic studies and possible cell and gene therapies...
  98. ncbi request reprint Esophageal intramural pseudodiverticulosis with esophageal strictures successfully treated with dilation therapy
    Fuminori Teraishi
    Division of Surgical Oncology, Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Ann Thorac Surg 82:1119-21. 2006
    ..Biopsy specimens showed active chronic inflammatory changes of the mucosa with candidiasis. Dysphagia improved dramatically with esophageal dilation. However, the tiny diverticula did not resolve after treatment...
  99. ncbi request reprint [Oncolytic virotherapy for human solid tumors]
    Toshiyoshi Fujiwara
    Center for Gene and Cell Therapy, Okayama University Hospital, Okayama, Japan
    Gan To Kagaku Ryoho 36:703-9. 2009
    ..This article reviews recent highlights in this rapidly evolving field of cancer therapeutic and diagnostic approaches using telomerase-specific oncolytic adenoviruses...
  100. ncbi request reprint Ataxia-telangiectasia mutated and the Mre11-Rad50-NBS1 complex: promising targets for radiosensitization
    Shinji Kuroda
    Department of Gastroenterological Surgery, Okayama University Graduate School for Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Acta Med Okayama 66:83-92. 2012
    ..In this review, we highlight the great potential of ATM and MRN complex inhibitors, including telomelysin, as radiosensitizing agents...
  101. ncbi request reprint p53 inhibits adriamycin-induced down-regulation of cyclin D1 expression in human cancer cells
    Jianghua Shao
    Division of Surgical Oncology, Okayama University Graduate School of Medicine and Dentistry, Okayama, 700 8558, Japan
    Biochem Biophys Res Commun 290:1101-7. 2002
    ..Our results suggest that ectopic wild-type p53 gene transfer results in increased cyclin D1 expression and, consequently, sensitizes human colorectal cancer cells to chemotherapeutic agents...