Ken Ichi Ogawara

Summary

Affiliation: Okayama University
Country: Japan

Publications

  1. ncbi request reprint Involvement of intracellular Ca2+ dynamics in cytoprotective action by amino acids and cytotoxicity by sodium laurate, an absorption enhancer
    Tomoyuki Okuda
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    J Pharm Sci 95:2256-65. 2006
  2. doi request reprint Development of safe and potent O/W emulsion of paclitaxel to treat peritoneal dissemination
    Ken Ichi Ogawara
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700 8530, Japan Electronic address
    J Pharm Sci . 2017
  3. pmc Functional inhibition of NF-kappaB signal transduction in alphavbeta3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IkappaB gene
    Ken Ichi Ogawara
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Arthritis Res Ther 8:R32. 2006
  4. ncbi request reprint Combinatorial use of sodium laurate with taurine or L-glutamine enhances colonic absorption of rebamipide, poorly absorbable antiulcer drug, without any serious histopathological mucosal damages
    Masateru Miyake
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka Okayama 700 8530, Japan
    J Pharm Sci 92:911-21. 2003
  5. ncbi request reprint Important role of serum proteins associated on the surface of particles in their hepatic disposition
    Kentaro Furumoto
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    J Control Release 83:89-96. 2002
  6. ncbi request reprint Pre-coating with serum albumin reduces receptor-mediated hepatic disposition of polystyrene nanosphere: implications for rational design of nanoparticles
    Ken Ichi Ogawara
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    J Control Release 100:451-5. 2004
  7. ncbi request reprint Mechanisms of cytoprotective effect of amino acids on local toxicity caused by sodium laurate, a drug absorption enhancer, in intestinal epithelium
    Yoko Endo
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan
    J Pharm Sci 91:730-43. 2002
  8. ncbi request reprint Development of suppository formulation safely improving rectal absorption of rebamipide, a poorly absorbable drug, by utilizing sodium laurate and taurine
    Masateru Miyake
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka Okayama, Japan
    J Control Release 99:63-71. 2004
  9. ncbi request reprint Prediction of oral absorption of griseofulvin, a BCS class II drug, based on GITA model: utilization of a more suitable medium for in-vitro dissolution study
    Yoshitsugu Fujioka
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    J Control Release 119:222-8. 2007
  10. ncbi request reprint Hepatic uptake of negatively charged particles in rats: possible involvement of serum proteins in recognition by scavenger receptor
    Kentaro Furumoto
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    J Control Release 97:133-41. 2004

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Involvement of intracellular Ca2+ dynamics in cytoprotective action by amino acids and cytotoxicity by sodium laurate, an absorption enhancer
    Tomoyuki Okuda
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    J Pharm Sci 95:2256-65. 2006
    ..These results clearly show that amino acids protect intestinal epithelial cells from being damaged by modulating intracellular Ca2+ dynamics...
  2. doi request reprint Development of safe and potent O/W emulsion of paclitaxel to treat peritoneal dissemination
    Ken Ichi Ogawara
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700 8530, Japan Electronic address
    J Pharm Sci . 2017
    ..These results indicate that the adequately sustained PTX release would lead to potent in vivo anti-tumor activity and that PTX-emulsion B would offer an alternative approach to treat peritoneal dissemination...
  3. pmc Functional inhibition of NF-kappaB signal transduction in alphavbeta3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IkappaB gene
    Ken Ichi Ogawara
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Arthritis Res Ther 8:R32. 2006
    ....
  4. ncbi request reprint Combinatorial use of sodium laurate with taurine or L-glutamine enhances colonic absorption of rebamipide, poorly absorbable antiulcer drug, without any serious histopathological mucosal damages
    Masateru Miyake
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka Okayama 700 8530, Japan
    J Pharm Sci 92:911-21. 2003
    ..5 h after dosing. In conclusion, the combinatorial use of C12 with Tau or L-Gln could lead to a novel formulation improving the bioavailability of poorly absorbable drugs without any serious local damages...
  5. ncbi request reprint Important role of serum proteins associated on the surface of particles in their hepatic disposition
    Kentaro Furumoto
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    J Control Release 83:89-96. 2002
    ....
  6. ncbi request reprint Pre-coating with serum albumin reduces receptor-mediated hepatic disposition of polystyrene nanosphere: implications for rational design of nanoparticles
    Ken Ichi Ogawara
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    J Control Release 100:451-5. 2004
    ..From these findings, pre-coating of nanoparticles with serum albumin could be useful to prevent their rapid clearance by mononuclear phagocyte system in vivo...
  7. ncbi request reprint Mechanisms of cytoprotective effect of amino acids on local toxicity caused by sodium laurate, a drug absorption enhancer, in intestinal epithelium
    Yoko Endo
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan
    J Pharm Sci 91:730-43. 2002
    ....
  8. ncbi request reprint Development of suppository formulation safely improving rectal absorption of rebamipide, a poorly absorbable drug, by utilizing sodium laurate and taurine
    Masateru Miyake
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka Okayama, Japan
    J Control Release 99:63-71. 2004
    ..In conclusion, FB suppository employing the combinatorial use of C12 with Tau could be a promising formulation that is effective and safe enough for poorly absorbable drugs to be practically administered...
  9. ncbi request reprint Prediction of oral absorption of griseofulvin, a BCS class II drug, based on GITA model: utilization of a more suitable medium for in-vitro dissolution study
    Yoshitsugu Fujioka
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    J Control Release 119:222-8. 2007
    ....
  10. ncbi request reprint Hepatic uptake of negatively charged particles in rats: possible involvement of serum proteins in recognition by scavenger receptor
    Kentaro Furumoto
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    J Control Release 97:133-41. 2004
    ..These results indicate that not only the intrinsic negative charge but also serum proteins associated on the surface play an important role in hepatic uptake of negatively charged particles via scavenger receptors...
  11. doi request reprint Determinants for in vivo anti-tumor effects of PEG liposomal doxorubicin: importance of vascular permeability within tumors
    Ken Ichi Ogawara
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    Int J Pharm 359:234-40. 2008
    ..These results indicated that the vascular permeability within the tumor substantially affects the tumor accumulation of PEG liposome and may be one of the important determinants in the in vivo anti-tumor efficacy of PEG liposomal DOX...
  12. doi request reprint Efficient anti-tumor effect of photodynamic treatment with polymeric nanoparticles composed of polyethylene glycol and polylactic acid block copolymer encapsulating hydrophobic porphyrin derivative
    Ken Ichi Ogawara
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Japan
    Eur J Pharm Sci 82:154-60. 2016
    ..These findings indicate the potency of PN-Por for the development of more efficient PDT-based cancer treatments. ..
  13. doi request reprint PEG liposomalization of paclitaxel improved its in vivo disposition and anti-tumor efficacy
    Yuta Yoshizawa
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Kita ku, Okayama 700 8530, Japan
    Int J Pharm 412:132-41. 2011
    ..These results suggest that PEG liposome would serve as a potent PTX delivery vehicle for the future cancer chemotherapy...
  14. ncbi request reprint Time-dependent changes in opsonin amount associated on nanoparticles alter their hepatic uptake characteristics
    Susumu Nagayama
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    Int J Pharm 342:215-21. 2007
    ..These results indicate that the amounts of opsonins associated on nanoparticles would change over time and this process would be substantially reflected in the alteration of their hepatic disposition characteristics...
  15. ncbi request reprint Formulation and evaluation of paclitaxel-loaded polymeric nanoparticles composed of polyethylene glycol and polylactic acid block copolymer
    Tomoya Araki
    Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan
    Biol Pharm Bull 35:1306-13. 2012
    ....
  16. ncbi request reprint Fetuin mediates hepatic uptake of negatively charged nanoparticles via scavenger receptor
    Susumu Nagayama
    Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700 8530, Japan
    Int J Pharm 329:192-8. 2007
    ....
  17. ncbi request reprint In vitro evaluation of the ciliary beat frequency of the rat nasal epithelium using a high-speed digital imaging system
    Daisuke Inoue
    Department of Pharmaceutics, School of Pharmacy, Shujitsu University, Okayama, Japan
    Biol Pharm Bull 36:966-73. 2013
    ..It was found that CBFs were significantly and linearly correlated with MC, indicating that MC is directly regulated by CBF and that this evaluation system allows the quantitative determination of nasal mucociliary function...
  18. ncbi request reprint Evaluation of in vivo dissolution behavior and GI transit of griseofulvin, a BCS class II drug
    Yoshitsugu Fujioka
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    Int J Pharm 352:36-43. 2008
    ....
  19. ncbi request reprint Skin permeation of propranolol from polymeric film containing terpene enhancers for transdermal use
    Chomchan Amnuaikit
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700 8530, Japan
    Int J Pharm 289:167-78. 2005
    ..81+/-11.56 and 54.51+/-0.52 microg/cm2/h, respectively...
  20. ncbi request reprint Regulation of drug absorption from small intestine by enteric nervous system I: a poorly absorbable drug via passive diffusion
    Kazutaka Higaki
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Japan
    Drug Metab Pharmacokinet 19:198-205. 2004
    ....
  21. ncbi request reprint Nanoparticle-based passive drug targeting to tumors: considerations and implications for optimization
    Ken Ichi Ogawara
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700 8530, Japan
    Biol Pharm Bull 36:698-702. 2013
    ....
  22. ncbi request reprint Analysis and prediction of absorption behavior of colon-targeted prodrug in rats by GI-transit-absorption model
    Jun Ichi Yokoe
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Japan
    J Control Release 86:305-13. 2003
    ..330 because of the first-pass elimination through both cecum and liver. In conclusion, the absorption behaviors of a prodrug and its regenerated parent drug can be predicted very well and be clarified successfully using the GITA model...
  23. ncbi request reprint Up-regulation of P-glycoprotein expression in small intestine under chronic serotonin-depleted conditions in rats
    Hideo Hiraoka
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushimanaka, Okayama 700 8530, Japan
    J Pharmacol Exp Ther 312:248-55. 2005
    ....
  24. doi request reprint Amino acids suppress apoptosis induced by sodium laurate, an absorption enhancer
    Chie Takayama
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    J Pharm Sci 98:4629-38. 2009
    ..On the other hand, Tau or L-Gln significantly suppressed the release of cytochrome C from mitochondria and attenuated the activities of both caspases, which could be attributed to the maintenance of Bcl-2 expression...
  25. ncbi request reprint Major determinants in hepatic disposition of polystyrene nanospheres: implication for rational design of particulate drug carriers
    Ken Ichi Ogawara
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Crit Rev Ther Drug Carrier Syst 19:277-306. 2002
    ....
  26. ncbi request reprint Appearance of double peaks in plasma concentration-time profile after oral administration depends on gastric emptying profile and weight function
    Yukiko Metsugi
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama, 700 8530, Japan
    Pharm Res 25:886-95. 2008
    ..The objective of this study was to assess the effect of gastric emptying and a weight function, i.e. pharmacokinetics after reaching the systemic circulation, on the double-peak appearance in plasma concentration profiles...
  27. doi request reprint Prolongation of residence time of liposome by surface-modification with mixture of hydrophilic polymers
    Tamer Shehata
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    Int J Pharm 359:272-9. 2008
    ..The decrease in the adsorbed amount of several opsonins and the increase in the adsorbed dysopsonins would be responsible for its lower affinity to the liver and long residence in the systemic circulation of PEG4%/PVA1% liposome...
  28. ncbi request reprint Effect of coupling of albumin onto surface of PEG liposome on its in vivo disposition
    Kentaro Furumoto
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700 8530, Japan
    Int J Pharm 329:110-6. 2007
    ..From these findings, introduction of serum albumin onto PEG liposome could be useful to develop a new nanoparticulate formulation with a better pharmacokinetic property...
  29. ncbi request reprint Estimation of intradermal disposition kinetics of drugs: II. Factors determining penetration of drugs from viable skin to muscular layer
    Kazutaka Higaki
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    Int J Pharm 239:129-41. 2002
    ....
  30. doi request reprint Quantitative evaluation of PEPT1 contribution to oral absorption of cephalexin in rats
    Takanori Hironaka
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama, 700 8530, Japan
    Pharm Res 26:40-50. 2009
    ..The objective of this study is to quantitatively evaluate the contribution of PEPT1 to oral absorption of cephalexin, a typical substrate for PEPT1, in rats...
  31. doi request reprint Determinants for in vivo antitumor effect of angiogenesis inhibitor SU5416 formulated in PEGylated emulsion
    Ken Ichi Ogawara
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Kita ku, Okayama, 700 8530, Japan
    J Pharm Sci 103:2464-9. 2014
    ....
  32. doi request reprint Deeper penetration into tumor tissues and enhanced in vivo antitumor activity of liposomal paclitaxel by pretreatment with angiogenesis inhibitor SU5416
    Yuta Yoshizawa
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Kita ku, Okayama 700 8530, Japan
    Mol Pharm 9:3486-94. 2012
    ....
  33. ncbi request reprint Evaluation of inhibitory activity of casein on proteases in rat intestine
    Seiji Ohtani
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    Pharm Res 20:611-7. 2003
    ..To investigate the possible use of casein as an adjuvant for oral delivery of peptide drugs, the inhibitory activity of casein on proteases in rat small intestine was examined...
  34. ncbi request reprint Casein enhances stability of peptides in intestinal lumen: role of digested products of casein
    Seiji Ohtani
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    Pharm Res 20:1746-51. 2003
    ..To investigate the inhibitory activity of casein on proteases in detail, the effect of digested products of casein itself on trypsin and chymotrypsin in rat small intestine was examined...
  35. doi request reprint In vivo anti-tumor effect of PEG liposomal doxorubicin (DOX) in DOX-resistant tumor-bearing mice: Involvement of cytotoxic effect on vascular endothelial cells
    Ken Ichi Ogawara
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700 8530, Japan
    J Control Release 133:4-10. 2009
    ..From these results, it was suggested that the cytotoxic effect of DOX on vascular endothelial cells in the tumor would be involved in the in vivo anti-tumor effect of PEG liposomal DOX in C26/DOX-bearing mice...
  36. doi request reprint Sex differences in pharmacokinetics of cilostazol in rats
    Naoki Kamada
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Kita ku, Okayama, Japan
    Xenobiotica 41:903-13. 2011
    ..Our experimental results also suggested that the substantial metabolism of cilostazol in the small intestine and its possible saturation would be responsible for dose-dependent bioavailability in both male and female rats...
  37. doi request reprint Development of transdermal therapeutic formulation of CNS5161, a novel NMDA receptor antagonist, by utilizing pressure-sensitive adhesives II: improved transdermal absorption and evaluation of efficacy and safety
    Mamoru Naruse
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan CMC Control Unit, Teikoku Seiyaku Co, Ltd, Kagawa 769 2695, Japan
    Eur J Pharm Sci 52:86-94. 2014
    ..This formulation caused only slight skin irritation, which indicated that it would be a promising transdermal therapeutic system for CNS5161. ..
  38. doi request reprint Effect of adrenergic stimulation on drug absorption via passive diffusion in Caco-2 cells
    Takahiro Kimoto
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    Int J Pharm 368:31-6. 2009
    ..These results suggest that the decrease in FD-40 transport would be mainly attributed to the decrease in intracellular cAMP and subsequent decrease in PKA activity via alpha(2)-receptor stimulation...
  39. ncbi request reprint Transport of D-glucose across cultured stratified cell layer of human oral mucosal cells
    Toshikiro Kimura
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Japan
    J Pharm Pharmacol 54:213-9. 2002
    ..The results indicate that the sugar transporters function not only to take up D-glucose by the epithelial cells but also to transport the sugar across the stratified epithelial layer...
  40. doi request reprint In-vivo disposition characteristics of PEG niosome and its interaction with serum proteins
    Tamer Shehata
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
    Int J Pharm 512:322-8. 2016
    ....
  41. doi request reprint Augmented EPR effect by photo-triggered tumor vascular treatment improved therapeutic efficacy of liposomal paclitaxel in mice bearing tumors with low permeable vasculature
    Tomoya Araki
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Japan
    J Control Release 200:106-14. 2015
    ..These results clearly indicated that the treatment would have made it possible to provide more efficient extravasation of PL-PTX, leading to its more potent anti-tumor effect. ..
  42. doi request reprint A novel approach to overcome multidrug resistance: utilization of P-gp mediated efflux of paclitaxel to attack neighboring vascular endothelial cells in tumors
    Yuta Yoshizawa
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Kita ku, Okayama 700 8530, Japan
    Eur J Pharm Sci 62:274-80. 2014
    ..These results suggest that the in vivo anti-tumor effect of PL-PTX in C26/PTX-bearing mice would be ascribed to the cytotoxic action of PTX pumped out of tumor cells by overexpressed P-gp to vascular endothelial cells in tumor tissues. ..
  43. ncbi request reprint Development of transdermal therapeutic formulation of CNS5161, a novel N-methyl-D-aspartate receptor antagonist, by utilizing pressure-sensitive adhesives I
    Mamoru Naruse
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, Japan
    Biol Pharm Bull 35:321-8. 2012
    ..These results clearly indicated that silicone PSA would be the most suitable for transdermal delivery of CNS5161 and silicone PSA containing 10% CNS5161 would be suitable for clinical use in humans...
  44. ncbi request reprint In vitro evaluation of nasal mucociliary clearance using excised rat nasal septum
    Daisuke Inoue
    Department of Pharmaceutics, School of Pharmacy, Shujitsu University, Naka ku, Okayama, Japan
    Biol Pharm Bull 35:889-94. 2012
    ....
  45. doi request reprint Improvement of Oral Bioavailability of N-251, a Novel Antimalarial Drug, by Increasing Lymphatic Transport with Long-Chain Fatty Acid-Based Self-Nanoemulsifying Drug Delivery System
    Chikako Imada
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Kita ku, Okayama, 700 8530, Japan
    Pharm Res 32:2595-608. 2015
    ..The objective of this study was to improve the absorption behavior of N-251, a novel antimalarial drug, by preparing an appropriate self-nanoemulsifying drug delivery system (SNEDDS)...
  46. doi request reprint Aminoalkylmethacrylate copolymer E improves oral bioavailability of YM466 by suppressing drug-bile interaction
    Shigeo Takemura
    Pharmaceutical Research and Technology Laboratories, Astellas Pharma Inc, Shizuoka 425 0072, Japan
    J Pharm Sci 102:3128-35. 2013
    ..6-fold of that of YM466 alone. Considering the condition of therapeutic use of YM466 and the maximum tolerated dose of the polymer, the formulation of P-D ratio 3 would be clinically practical and promising from the viewpoint of safety...
  47. doi request reprint Novel oral absorption system containing polyamines and bile salts enhances drug transport via both transcellular and paracellular pathways across Caco-2 cell monolayers
    Fuyuki Mukaizawa
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    Int J Pharm 367:103-8. 2009
    ..Voltage-clamp study clearly showed that their combinatorial use improved rebamipide transport via both paracellular and transcellular pathways, and that the contribution of transcellular route could be larger than paracellular route...
  48. ncbi request reprint A novel strategy to modify adenovirus tropism and enhance transgene delivery to activated vascular endothelial cells in vitro and in vivo
    Ken Ichi Ogawara
    Department of Pharmacokinetics, Groningen University Institute for Drug Exploration, Groningen, The Netherlands
    Hum Gene Ther 15:433-43. 2004
    ....
  49. ncbi request reprint Novel oral formulation safely improving intestinal absorption of poorly absorbable drugs: utilization of polyamines and bile acids
    Masateru Miyake
    BA Project, Formulation Research Institute, Otsuka Pharmaceutical Co, Ltd, 224 18 Ebino, Hiraishi, Kawauchi cho, Tokushima 771 0182, Japan
    J Control Release 111:27-34. 2006
    ..Taken all together, polyamines, especially SPM, and its combinatorial use with STC could improve the absorption of poorly absorbable drugs without any significant changes in gastrointestinal tract after oral administration in rats...
  50. ncbi request reprint Optimization of suppository preparation containing sodium laurate and taurine that can safely improve rectal absorption of rebamipide
    Masateru Miyake
    Formulation Development 1, Formulation Research Institute, Otsuka Pharmaceutical Co Ltd, 224 18 Ebino, Hiraishi, Kawauchi cho, Tokushima 771 0182, Japan
    Biol Pharm Bull 29:330-5. 2006
    ..Considering the balance between efficacy and safety, the suppository containing 10- or 20-mg C12 with 30-mg Tau is better than C10 suppositories as commercial products and could be promising for practical use in human...
  51. ncbi request reprint Importance of bile acids for novel oral absorption system containing polyamines to improve intestinal absorption
    Masateru Miyake
    Bioavailability Research Project, Formulation Research Institute, Otsuka Pharmaceutical Co, Ltd, 224 18 Ebino, Hiraishi, Kawauchi cho, Tokushima 771 0182, Japan
    J Control Release 115:130-3. 2006
    ..These results indicate that bile acids are indispensable for the novel formulation containing SPM to improve the absorption of rebamipide after oral administration...
  52. ncbi request reprint Albumin-conjugated PEG liposome enhances tumor distribution of liposomal doxorubicin in rats
    Jun Ichi Yokoe
    Pharmaceutical Research Division, Nipro Corporation, Shiga, Japan
    Int J Pharm 353:28-34. 2008
    ..These results clearly indicate that rHSA-conjugation onto the surface of PEG liposome would be a useful approach to increase the effectiveness and safety of PEG liposomal DXR...