Yoshitaka Takahashi

Summary

Affiliation: Okayama Prefectural University
Country: Japan

Publications

  1. doi request reprint Inhibition of leukocyte-type 12-lipoxygenase by guava tea leaves prevents development of atherosclerosis
    Yoshitaka Takahashi
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719 1197, Japan Electronic address
    Food Chem 186:2-5. 2015
  2. ncbi request reprint Essential roles of lipoxygenases in LDL oxidation and development of atherosclerosis
    Yoshitaka Takahashi
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Kuboki 111, Soja, Okayama 719 1197, Japan
    Antioxid Redox Signal 7:425-31. 2005
  3. ncbi request reprint Selective uptake and efflux of cholesteryl linoleate in LDL by macrophages expressing 12/15-lipoxygenase
    Yoshitaka Takahashi
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama 719 1197, Japan
    Biochem Biophys Res Commun 338:128-35. 2005
  4. ncbi request reprint Asymmetric dimethylarginine, an endogenous NOS inhibitor, is actively metabolized in rat erythrocytes
    Miyuki Yokoro
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama, Japan
    Biosci Biotechnol Biochem 76:1334-42. 2012
  5. doi request reprint Neutralization of leukotriene C4 and D4 activity by monoclonal and single-chain antibodies
    Yuki Kawakami
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama 719 1197, Japan
    Biochim Biophys Acta 1840:1625-33. 2014
  6. ncbi request reprint The Y54(L)W mutation of anti-leukotriene C4 single-chain antibody increases affinity to leukotriene E4
    Yuki Kawakami
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719 1197, Japan
    J Biochem . 2016
  7. pmc Activation of AMP-Activated Protein Kinase and Stimulation of Energy Metabolism by Acetic Acid in L6 Myotube Cells
    Hitomi Maruta
    Graduate School of Health and Welfare Science, Okayama Prefectural University, Soja shi, Okayama, Japan
    PLoS ONE 11:e0158055. 2016
  8. ncbi request reprint Development of an enzyme-linked immunosorbent assay system for the determination of asymmetric dimethylarginine using a specific monoclonal antibody
    Miyuki Yokoro
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama, Japan
    Biosci Biotechnol Biochem 76:400-3. 2012
  9. ncbi request reprint Preparation and epitope mapping of a monoclonal antibody against Tri a Bd 27K, a major wheat allergen
    Nobuko Komiyama
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719 1197, Japan
    Biosci Biotechnol Biochem 73:2113-6. 2009
  10. doi request reprint Functional expression of single-chain antibody to leukotriene C(4)
    Yuki Kawakami
    Department of Nutritional Science, Okayama Prefectural University, Okayama 719 1197, Japan
    Biochem Biophys Res Commun 392:421-5. 2010

Collaborators

  • Masumi Kimoto
  • Hiromi Yamashita
  • Shozo Yamamoto
  • Miki Hiemori
  • Tanihiro Yoshimoto
  • Hong Zhu
  • Yutaka Seino
  • Koichiro Yasuda
  • Ataru Taniguchi
  • Junko Tanaka
  • Takashi Izumi
  • Shuh Narumiya
  • Hiromi Daiyasu
  • Yuki Kawakami
  • Hideaki Tsuji
  • Toshiko Suzuki-Yamamoto
  • Miyuki Yokoro
  • Makiko Suzuki
  • Yukihiro Yoshimura
  • Hitomi Maruta
  • Masashi Miyano
  • Mitsuaki Sugahara
  • Sae Aoyama-Sasabe
  • Aya Araki
  • Shiori Hirano
  • Mitsuo Fukushima
  • Mai Kinoshita
  • Kaeko Murota
  • Ayumi Kunimoto
  • Nobuko Komiyama
  • Yeshao Wen
  • Hiroo Kawajiri
  • Takeshi Kurose
  • Wanpeng Xu
  • Nobuya Inagaki
  • Ichika Shimoda
  • Shuji Okochi
  • Tetsuya Hori
  • Xin Xin
  • Hiromichi Saino
  • Keita Kanzaki
  • Daisuke Yabe
  • Yoshiko Mori
  • Yoshikatsu Nakai
  • Rie Mitsui
  • Koji Kishimoto
  • Sae Sasabe
  • Akemi Otsuki
  • Toru Oga
  • Machiko Yatani
  • Chie Otsuka
  • Chikao Yutani
  • Shinobu Doi
  • Rintaro Yamanishi
  • Yoshiko Kashiwase
  • Hiroyuki Toh
  • Yuko Kurahashi
  • Chiaki Yamashita
  • Tomoko Morinaka
  • Noriyuki Kubota
  • Hirofumi F Fujimura
  • Natsuki Ekuni
  • Yoshihiro Miwa
  • Mitsuo Jisaka
  • John Marshall
  • Kevin Aylor
  • Jiali Gu
  • Jerry L Nadler
  • Swarup K Chakrabarti
  • Nobuyuki Hamanaka
  • Yingshi Piao
  • Takashi Murakami
  • Tadao Iwasaki
  • Hiroaki Hattori

Detail Information

Publications20

  1. doi request reprint Inhibition of leukocyte-type 12-lipoxygenase by guava tea leaves prevents development of atherosclerosis
    Yoshitaka Takahashi
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719 1197, Japan Electronic address
    Food Chem 186:2-5. 2015
    ..The anti-atherogenic effect of the tea leaves might be attributed to the inhibition of leukocyte-type 12-lipoxygenase by these components. ..
  2. ncbi request reprint Essential roles of lipoxygenases in LDL oxidation and development of atherosclerosis
    Yoshitaka Takahashi
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Kuboki 111, Soja, Okayama 719 1197, Japan
    Antioxid Redox Signal 7:425-31. 2005
    ..Therefore, the inhibition of these lipoxygenases may be effective in the prevention and treatment of the inflammatory diseases...
  3. ncbi request reprint Selective uptake and efflux of cholesteryl linoleate in LDL by macrophages expressing 12/15-lipoxygenase
    Yoshitaka Takahashi
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama 719 1197, Japan
    Biochem Biophys Res Commun 338:128-35. 2005
    ..These results strongly suggest that LRP contributes to the LDL oxidation by 12/15-LOX in macrophages by selective uptake and efflux of cholesteryl ester in the LDL particle...
  4. ncbi request reprint Asymmetric dimethylarginine, an endogenous NOS inhibitor, is actively metabolized in rat erythrocytes
    Miyuki Yokoro
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama, Japan
    Biosci Biotechnol Biochem 76:1334-42. 2012
    ....
  5. doi request reprint Neutralization of leukotriene C4 and D4 activity by monoclonal and single-chain antibodies
    Yuki Kawakami
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama 719 1197, Japan
    Biochim Biophys Acta 1840:1625-33. 2014
    ....
  6. ncbi request reprint The Y54(L)W mutation of anti-leukotriene C4 single-chain antibody increases affinity to leukotriene E4
    Yuki Kawakami
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719 1197, Japan
    J Biochem . 2016
    ..The results may provide an insight into the molecular basis of specific LT recognition by the antibody...
  7. pmc Activation of AMP-Activated Protein Kinase and Stimulation of Energy Metabolism by Acetic Acid in L6 Myotube Cells
    Hitomi Maruta
    Graduate School of Health and Welfare Science, Okayama Prefectural University, Soja shi, Okayama, Japan
    PLoS ONE 11:e0158055. 2016
    ..These results indicate that acetic acid enhances glucose uptake and fatty acid metabolism through the activation of AMPK, and increases expression of GLUT4 and myoglobin. ..
  8. ncbi request reprint Development of an enzyme-linked immunosorbent assay system for the determination of asymmetric dimethylarginine using a specific monoclonal antibody
    Miyuki Yokoro
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama, Japan
    Biosci Biotechnol Biochem 76:400-3. 2012
    ..The competitive ELISA method using the mAb determined 5 nM-100 nM ADMA, and ADMA levels in human plasma and urine were found to be 0.78 µM and 51.3 µmol/g of creatinine respectively...
  9. ncbi request reprint Preparation and epitope mapping of a monoclonal antibody against Tri a Bd 27K, a major wheat allergen
    Nobuko Komiyama
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719 1197, Japan
    Biosci Biotechnol Biochem 73:2113-6. 2009
    ..Of the amino acid residues on the epitope, the amino acid residues responsible for the binding to the mAb were found to be W156, D160, G161, and P163...
  10. doi request reprint Functional expression of single-chain antibody to leukotriene C(4)
    Yuki Kawakami
    Department of Nutritional Science, Okayama Prefectural University, Okayama 719 1197, Japan
    Biochem Biophys Res Commun 392:421-5. 2010
    ..The scFvLTC also bound to LTD(4) and LTE(4) with 48% and 17% reactivities, respectively, as compared with LTC(4) binding, whereas the antibody showed almost no affinity for LTB(4)...
  11. ncbi request reprint Gastrointestinal digestion and absorption of Pen j 1, a major allergen from Kuruma prawn, Penaeus japonicus
    Ayumi Kunimoto
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Japan
    Biosci Biotechnol Biochem 75:1249-58. 2011
    ..These observations suggest that Pen j 1 may be absorbed via the gastric mucosa prior to its digestion in the intestines...
  12. doi request reprint Molecular cloning of rat acss3 and characterization of mammalian propionyl-CoA synthetase in the liver mitochondrial matrix
    Yukihiro Yoshimura
    Department of Nutritional Science Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja shi, Okayama 719 1197, Japan
    J Biochem . 2016
    ..These results suggested that ACSS3 is a liver mitochondrial matrix enzyme with high affinity to propionic acid, and its expression level is upregulated under ketogenic conditions...
  13. ncbi request reprint Effects of acetate on lipid metabolism in muscles and adipose tissues of type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats
    Hiromi Yamashita
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama, Japan
    Biosci Biotechnol Biochem 73:570-6. 2009
    ..It is possible that acetate has effects on lipid metabolism in the skeletal muscles and the adipose tissues, and has functions that work against obesity and obesity-linked type 2 diabetes...
  14. pmc Insulin Secretory Defect and Insulin Resistance in Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance
    Sae Aoyama-Sasabe
    Division of Clinical Nutrition and Internal Medicine, Okayama Prefectural University, Okayama 719 1197, Japan
    J Diabetes Res 2016:1298601. 2016
    ....
  15. ncbi request reprint Tumor-suppressive lipoxygenases inhibit the expression of c-myc mRNA coding region determinant-binding protein/insulin-like growth factor II mRNA-binding protein 1 in human prostate carcinoma PC-3 cells
    Yuki Kawakami
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Japan
    Biosci Biotechnol Biochem 73:1811-7. 2009
    ..We propose that expression of 8S-LOX and 15S-LOX-2 suppresses CRD-BP/IMP-1 expression, resulting in inhibition of human prostate carcinoma PC-3 cell proliferation...
  16. ncbi request reprint The role of 12/15-lipoxygenase in the expression of interleukin-6 and tumor necrosis factor-alpha in macrophages
    Yeshao Wen
    Diabetes and Hormone Center, University of Virginia, Charlottesville, VA 22908, USA
    Endocrinology 148:1313-22. 2007
    ..These results suggest a potentially important mechanism linking 12/15-LO activation to chronic inflammation and atherosclerosis...
  17. ncbi request reprint LDL receptor-related protein plays an essential role in 12/15-lipoxygenase-mediated LDL oxidation by macrophages
    Wanpeng Xu
    Department of Molecular Pharmacology, Kanazawa University Graduate School of Medical Science, Japan
    Adv Exp Med Biol 525:181-4. 2003
  18. ncbi request reprint Low density lipoprotein receptor-related protein-mediated membrane translocation of 12/15-lipoxygenase is required for oxidation of low density lipoprotein by macrophages
    Hong Zhu
    Department of Molecular Pharmacology, Kanazawa University Graduate School of Medical Science, Kanazawa 920 8640, Japan
    J Biol Chem 278:13350-5. 2003
    ..We propose that cholesterol ester selectively transferred from the LDL particle to the plasma membrane via LRP is oxygenated by 12/15-lipoxygenase translocated to this membrane...
  19. ncbi request reprint Synthesis of 8,9-leukotriene A4 by murine 8-lipoxygenase
    Hiroo Kawajiri
    Department of Molecular Pharmacology, Kanazawa University Graduate School of Medical Science, Kanazawa 920 8640, Japan
    Biochem Biophys Res Commun 338:144-8. 2005
    ..Taken together, 8-lipoxygenase catalyzes both dehydration reaction to yield 8,9-epoxy derivative and oxygenation reaction presumably at 15-position of 8-hydroperoxyeicosa-5,9,11,14-tetraenoic acid...
  20. ncbi request reprint Arachidonate 12-lipoxygenases
    Tanihiro Yoshimoto
    Department of Molecular Pharmacology, Kanazawa University Graduate School of Medicine, Japan
    Prostaglandins Other Lipid Mediat 68:245-62. 2002
    ..There are important roles for the enzymes and their products in several biological systems including those involved in atherosclerosis and neurotransmission...