Yasutaka Azuma

Summary

Affiliation: Osaka Dental University
Country: Japan

Publications

  1. ncbi Possible interaction between new quinolones and immune functions in macrophages
    Y Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Gen Pharmacol 32:609-14. 1999
  2. ncbi Histamine inhibits chemotaxis, phagocytosis, superoxide anion production, and the production of TNFalpha and IL-12 by macrophages via H2-receptors
    Y Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Int Immunopharmacol 1:1867-75. 2001
  3. ncbi 15-Deoxy-delta(12,14)-prostaglandin J2 is a negative regulator of macrophage functions
    Y Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Int Immunopharmacol 1:2101-8. 2001
  4. ncbi Endomorphins delay constitutive apoptosis and alter the innate host defense functions of neutrophils
    Yasutaka Azuma
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, Osaka 573 1121, Japan
    Immunol Lett 81:31-40. 2002
  5. ncbi Endomorphins 1 and 2 inhibit IL-10 and IL-12 production and innate immune functions, and potentiate NF-kappaB DNA binding in THP-1 differentiated to macrophage-like cells
    Y Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Osaka, Japan
    Scand J Immunol 56:260-9. 2002
  6. ncbi Endomorphin-2 modulates productions of TNF-alpha, IL-1beta, IL-10, and IL-12, and alters functions related to innate immune of macrophages
    Yasutaka Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Inflammation 26:223-32. 2002
  7. ncbi Alteration of constitutive apoptosis in neutrophils by quinolones
    Yasutaka Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Osaka, Japan
    Inflammation 27:115-22. 2003
  8. ncbi Immunological modulation by lidocaine-epinephrine and prilocaine-felypressin on the functions related to natural immunity in neutrophils and macrophages
    Yasutaka Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Osaka 573 1121, Japan
    Curr Drug Targets Immune Endocr Metabol Disord 4:29-36. 2004
  9. ncbi Possible involvement of p38 in mechanisms underlying acceleration of proliferation by 15-deoxy-Delta(12,14)-prostaglandin J2 and the precursors in leukemia cell line THP-1
    Yasutaka Azuma
    Department of Pharmacology, Osaka Dental University, Japan
    J Pharmacol Sci 94:261-70. 2004
  10. ncbi Endomorphins 1 and 2 modulate chemotaxis, phagocytosis and superoxide anion production by microglia
    Y Azuma
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Osaka 573 1121, Hirakata, Japan
    J Neuroimmunol 119:51-6. 2001

Detail Information

Publications28

  1. ncbi Possible interaction between new quinolones and immune functions in macrophages
    Y Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Gen Pharmacol 32:609-14. 1999
    ..Moreover, the new quinolones at a dose of 0.5 microg/ml were effective in markedly potentiating the generation of superoxide anion. These results indicate that the new quinolones may modulate immune functions in rat macrophages...
  2. ncbi Histamine inhibits chemotaxis, phagocytosis, superoxide anion production, and the production of TNFalpha and IL-12 by macrophages via H2-receptors
    Y Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Int Immunopharmacol 1:1867-75. 2001
    ..These results suggest that histamine and dimaprit may inhibit chemotaxis, phagocytosis, superoxide anion production, and the production of TNFalpha and IL-12 by macrophages via H2-histamine receptors. reserved...
  3. ncbi 15-Deoxy-delta(12,14)-prostaglandin J2 is a negative regulator of macrophage functions
    Y Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Int Immunopharmacol 1:2101-8. 2001
    ..Similarly, dPGJ2 inhibited the production of hydrogen peroxide when macrophages were stimulated with either PMA or OPZ. These studies suggest that dPGJ2 may be a negative regulator of macrophage functions...
  4. ncbi Endomorphins delay constitutive apoptosis and alter the innate host defense functions of neutrophils
    Yasutaka Azuma
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, Osaka 573 1121, Japan
    Immunol Lett 81:31-40. 2002
    ..However, endomorphins 1 and 2 did not alter phagocytosis of Escherichia coli by neutrophils. These results suggest that endomorphins 1 and 2 may act to delay neutrophil apoptosis and alter the natural immune functions of neutrophils...
  5. ncbi Endomorphins 1 and 2 inhibit IL-10 and IL-12 production and innate immune functions, and potentiate NF-kappaB DNA binding in THP-1 differentiated to macrophage-like cells
    Y Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Osaka, Japan
    Scand J Immunol 56:260-9. 2002
    ..These results suggest that endomorphins 1 and 2 may inhibit THP-1 functions, such as cytokine production and functions related to innate immune, and potentiate NF-kappaB DNA binding in THP-1...
  6. ncbi Endomorphin-2 modulates productions of TNF-alpha, IL-1beta, IL-10, and IL-12, and alters functions related to innate immune of macrophages
    Yasutaka Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Inflammation 26:223-32. 2002
    ..These results suggest that endomorphin-2 may alter macrophage functions such as cytokine productions and functions related to innate immune...
  7. ncbi Alteration of constitutive apoptosis in neutrophils by quinolones
    Yasutaka Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Osaka, Japan
    Inflammation 27:115-22. 2003
    ..These results suggest that tosufloxacin may delay neutrophil apoptosis via activation of PI3K/Akt and/or p38 MAPK, and the other quinolones may promote neutrophil death without affecting their apoptosis...
  8. ncbi Immunological modulation by lidocaine-epinephrine and prilocaine-felypressin on the functions related to natural immunity in neutrophils and macrophages
    Yasutaka Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Osaka 573 1121, Japan
    Curr Drug Targets Immune Endocr Metabol Disord 4:29-36. 2004
    ..In addition, lidocaine with epinephrine evidently differs from prilocaine with felypressine regarding the molecular mechanisms underlying the modulation of superoxide anion production by neutrophils and macrophages...
  9. ncbi Possible involvement of p38 in mechanisms underlying acceleration of proliferation by 15-deoxy-Delta(12,14)-prostaglandin J2 and the precursors in leukemia cell line THP-1
    Yasutaka Azuma
    Department of Pharmacology, Osaka Dental University, Japan
    J Pharmacol Sci 94:261-70. 2004
    ..These results suggest that 15dPGJ2 and PGD2 may, through inactivation of the p38 mitogen-activated protein kinase pathway, inhibit the expression of Cdk inhibitors, leading to acceleration of the THP-1 proliferation...
  10. ncbi Endomorphins 1 and 2 modulate chemotaxis, phagocytosis and superoxide anion production by microglia
    Y Azuma
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Osaka 573 1121, Hirakata, Japan
    J Neuroimmunol 119:51-6. 2001
    ..These results suggest that endomorphins 1 and 2 modulate phagocytosis, chemotaxis and superoxide anion production by microglia...
  11. ncbi Differentiation by in vitro treatment of lidocaine-epinephrine and prilocaine-felypressine in neutrophils
    Y Azuma
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, 573 1121, Osaka, Japan
    Immunol Lett 77:151-8. 2001
    ....
  12. ncbi Comparison of the effect of lidocaine-epinephrine and prilocaine-felypressine to alter macrophage functions
    Y Azuma
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, Osaka 573 1121, Japan
    Int Immunopharmacol 1:911-23. 2001
    ..In addition, lidocaine-epinephrine evidently differs from prilocaine-felypressine regarding the molecular mechanisms underlying the modulation of superoxide anion production by macrophages...
  13. ncbi Comparative studies of modulatory effect to the function of rat peritoneal neutrophils treated with new quinolones
    Y Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Immunol Lett 69:321-7. 1999
    ..These results suggest that the new quinolones at a therapeutic concentration may affect functions such as phagocytosis, and production of superoxide anion in neutrophils...
  14. ncbi Quinolones alter defense reactions mediated by macrophages
    Y Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Int Immunopharmacol 1:179-87. 2001
    ..These results suggest that the quinolones at a therapeutic concentration differentially affect phagocytosis, adhesion, and the production of hydrogen peroxide by macrophages...
  15. ncbi 15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-10 and IL-12 production by macrophages
    Y Azuma
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Osaka, Hirakata, 573 1121, Japan
    Biochem Biophys Res Commun 283:344-6. 2001
    ..Further, dPGJ(2) did not appear to act through the PGD(2) receptor. These results suggest that dPGJ(2) may inhibit LPS-induced IL-10 and IL-12 production by macrophages through PPARgamma...
  16. ncbi Immunomodulation of the neutrophil respiratory burst by endomorphins 1 and 2
    Y Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Immunol Lett 75:55-9. 2000
    ..These results suggest that the endogenous opioid peptides endomorphins 1 and 2 may modulate the production of superoxide anions in neutrophils via mu-opioid receptors...
  17. ncbi Comparison of inhibitory effects of local anesthetics on immune functions of neutrophils
    Y Azuma
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, 573 1121, Osaka, Japan
    Int J Immunopharmacol 22:789-96. 2000
    ..These results suggest that the local anesthetics may affect adhesion, phagocytosis, and the production of superoxide anion and hydrogen peroxide by neutrophils...
  18. pmc Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling
    Takashi Fujita
    Department of Pharmacology, Setsunan University, Hirakata, Japan
    J Cell Biol 166:85-95. 2004
    ..These findings demonstrate that Runx2 and PI3K-Akt signaling are mutually dependent on each other in the regulation of osteoblast and chondrocyte differentiation and their migration...
  19. ncbi Induction of proliferation by 15-deoxy-delta12,14-prostaglandin J2 and the precursors in monocytic leukemia U937
    Yasutaka Azuma
    Department of Pharmacology, Osaka Dental University, Hirakata, Osaka, Japan
    Pharmacology 71:181-91. 2004
    ..These results suggest that 15dPGJ2 and PGD2 may, through inactivation of the p38 MAPK pathway, inhibit the expression of Cdk inhibitors, leading to acceleration of proliferation...
  20. ncbi Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling
    Ryo Fukuyama
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata 573 0101, Japan
    Biochem Biophys Res Commun 315:636-42. 2004
    ....
  21. ncbi Differential alteration of functions of rat peritoneal macrophages responsive to endogenous opioid peptide endomorphin-1
    Yoshiro Inui
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Int Immunopharmacol 2:1133-42. 2002
    ..These results suggest that endomorphin-1 may alter macrophage functions such as cytokine productions and functions related to natural host defense...
  22. ncbi Toll-like receptor 4-mediated signal pathway induced by Porphyromonas gingivalis lipopolysaccharide in human gingival fibroblasts
    P L Wang
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho Hirakata, Osaka, 573 1121, Japan
    Biochem Biophys Res Commun 273:1161-7. 2000
    ..Our findings suggest that the binding of P. gingivalis LPS to TLR4 on HGFs activates various second messenger systems...
  23. ncbi Heterogeneous expression of Toll-like receptor 4 and downregulation of Toll-like receptor 4 expression on human gingival fibroblasts by Porphyromonas gingivalis lipopolysaccharide
    P L Wang
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, 573 1121, Japan
    Biochem Biophys Res Commun 288:863-7. 2001
    ..gingivalis LPS downregulates TLR4 expression on HGFs. These findings may be used to control inflammatory and immune responses in periodontal disease...
  24. ncbi IL-10 inhibits Porphyromonas gingivalis LPS-stimulated human gingival fibroblasts production of IL-6
    P L Wang
    Department of Pharmacology, Department of Pediatric Dentistry, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, 573 1121, Japan
    Biochem Biophys Res Commun 263:372-7. 1999
    ..These results suggest that IL-10 inhibits the inflammatory response via the IL-10 receptor in P. gingivalis LPS-initiated periodontal diseases...
  25. ncbi Effect of Actinobacillus actinomycetemcomitans protease on the proliferation of gingival epithelial cells
    P L Wang
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Oral Dis 7:233-7. 2001
    ..The aim of this report is to examine the effect of in vitro application of A. actinomycetemcomitans protease on the cell growth, DNA synthesis, and fibronectin level of human gingival epithelial cells...
  26. ncbi Effect of anti-CD14 antibody on experimental periodontitis induced by Porphyromonas gingivalis lipopolysaccharide
    Pao Li Wang
    Department of Pharmacology, Osaka Dental University, Hirakata, Japan
    Jpn J Pharmacol 89:176-83. 2002
    ..This result suggests that anti-CD14 antibody may be usable as a prototype for the development of drugs for the treatment of periodontal disease...
  27. ncbi Photodynamic therapy for human oral squamous cell carcinoma and xenografts using a new photosensitizer, PAD-S31
    Masataka Date
    Department of Pharmacology, Osaka Dental University, Hirakata 573 1121, Japan
    Lasers Surg Med 33:57-63. 2003
    ..We examined the effect of PDT using a new photosensitizer, PAD-S31, and the 670-nm diode laser in human oral squamous cell carcinomas (SCC)...
  28. ncbi Apoptosis in human oral squamous cell carcinomas is induced by 15-deoxy-delta 12,14-prostaglandin J2 but not by troglitazone
    K Fukuchi
    First Department of Oral and Maxillofacial Surgery, Osaka Dental University, Hirakata, Japan
    J Dent Res 82:802-6. 2003
    ..Our study demonstrates that treatment with 15-d-PGJ(2), but not troglitazone, induces apoptosis in human SCC cell lines, and 15-d-PGJ(2) appears to work through cytochrome c release and caspase activation...