T Toyofuku

Summary

Affiliation: Osaka University
Country: Japan

Publications

  1. ncbi Direct association of the gap junction protein connexin-43 with ZO-1 in cardiac myocytes
    T Toyofuku
    Department of Medicine and Pathophysiology, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka 565, Japan
    J Biol Chem 273:12725-31. 1998
  2. ncbi Functional role of c-Src in gap junctions of the cardiomyopathic heart
    T Toyofuku
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Circ Res 85:672-81. 1999
  3. pmc Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex
    T Toyofuku
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Cell Biol 150:225-41. 2000
  4. ncbi c-Src regulates the interaction between connexin-43 and ZO-1 in cardiac myocytes
    T Toyofuku
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Biol Chem 276:1780-8. 2001
  5. ncbi Intercellular calcium signaling via gap junction in connexin-43-transfected cells
    T Toyofuku
    Department of Medicine and Pathophysiology, Osaka University Medical School, Japan
    J Biol Chem 273:1519-28. 1998
  6. ncbi Molecular regulation of phospholamban function and gene expression
    M Tada
    Department of Medicine and Pathophysiology, Osaka University Medical School, Japan
    Ann N Y Acad Sci 853:116-29. 1998
  7. ncbi Identification of Ser38 as the site in cardiac sarcoplasmic reticulum Ca(2+)-ATPase that is phosphorylated by Ca2+/calmodulin-dependent protein kinase
    T Toyofuku
    Banting and Best Department of Medical Research, University of Toronto, C H Best Institute, Ontario, Canada
    J Biol Chem 269:26492-6. 1994
  8. ncbi Shigella protein IpaH(9.8) is secreted from bacteria within mammalian cells and transported to the nucleus
    T Toyotome
    Division of Bacterial Infection, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
    J Biol Chem 276:32071-9. 2001

Collaborators

Detail Information

Publications8

  1. ncbi Direct association of the gap junction protein connexin-43 with ZO-1 in cardiac myocytes
    T Toyofuku
    Department of Medicine and Pathophysiology, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka 565, Japan
    J Biol Chem 273:12725-31. 1998
    ..We therefore conclude that the linkage between connexin-43 and alpha-spectrin, via ZO-1, may serve to localize connexin-43 at the intercalated discs, thereby generating functional gap junctions in cardiac myocytes...
  2. ncbi Functional role of c-Src in gap junctions of the cardiomyopathic heart
    T Toyofuku
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Circ Res 85:672-81. 1999
    ..We, therefore, conclude that during the progression of cardiac dysfunction in the cardiomyopathic heart, gap junctional communication is reduced via c-Src-mediated tyrosine phosphorylation of connexin43...
  3. pmc Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex
    T Toyofuku
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Cell Biol 150:225-41. 2000
    ..These findings suggest that a Wnt-frizzled-2 signaling pathway is centrally involved in the morphological arrangement of cardiac myocytes in neonatal heart through stabilization of complexed cadherin- beta-catenin...
  4. ncbi c-Src regulates the interaction between connexin-43 and ZO-1 in cardiac myocytes
    T Toyofuku
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Biol Chem 276:1780-8. 2001
    ..We therefore conclude that c-Src regulates the interaction between connexin-43 and ZO-1 through tyrosine phosphorylation and through the binding of its SH2 domain to connexin-43...
  5. ncbi Intercellular calcium signaling via gap junction in connexin-43-transfected cells
    T Toyofuku
    Department of Medicine and Pathophysiology, Osaka University Medical School, Japan
    J Biol Chem 273:1519-28. 1998
    ..These results suggest that intercellular Ca2+ signaling takes place in cultured cells expressing connexin-43, leading to their own synchronization and that the extracellular disulfide bonds of connexin-43 are crucial for this process...
  6. ncbi Molecular regulation of phospholamban function and gene expression
    M Tada
    Department of Medicine and Pathophysiology, Osaka University Medical School, Japan
    Ann N Y Acad Sci 853:116-29. 1998
    ..CCAAT-box in the 5'-upstream region was found to be essential for its expression by associating with Y-box binding transcriptional factors...
  7. ncbi Identification of Ser38 as the site in cardiac sarcoplasmic reticulum Ca(2+)-ATPase that is phosphorylated by Ca2+/calmodulin-dependent protein kinase
    T Toyofuku
    Banting and Best Department of Medical Research, University of Toronto, C H Best Institute, Ontario, Canada
    J Biol Chem 269:26492-6. 1994
    ..Thus phosphorylation of Ser38 in SERCA2 results in a unique activation of Vmax for Ca2+ transport, providing a potential regulatory mechanism for Ca2+ removal from cardiac and other tissues in which SERCA2 is expressed...
  8. ncbi Shigella protein IpaH(9.8) is secreted from bacteria within mammalian cells and transported to the nucleus
    T Toyotome
    Division of Bacterial Infection, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
    J Biol Chem 276:32071-9. 2001
    ..The nuclear transport of IpaH(9.8) does not depend on host cytosolic factors but is partially dependent on ATP/GTP, suggesting that, like beta-catenin, IpaH(9.8) secreted from intracellular Shigella can be transported into the nucleus...