Motoko Maekawa

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. doi request reprint Excessive ingestion of long-chain polyunsaturated fatty acids during developmental stage causes strain- and sex-dependent eye abnormalities in mice
    Motoko Maekawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 402:431-7. 2010
  2. doi request reprint A novel missense mutation (Leu46Val) of PAX6 found in an autistic patient
    Motoko Maekawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Neurosci Lett 462:267-71. 2009
  3. doi request reprint Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects
    Motoko Maekawa
    RIKEN Brain Science Institute, Saitama, Japan
    J Hum Genet 55:127-30. 2010
  4. doi request reprint Analysis of strain-dependent prepulse inhibition points to a role for Shmt1 (SHMT1) in mice and in schizophrenia
    Motoko Maekawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    J Neurochem 115:1374-85. 2010
  5. pmc Giant subependymoma developed in a patient with aniridia: analyses of PAX6 and tumor-relevant genes
    Motoko Maekawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
    Brain Pathol 20:1033-41. 2010
  6. pmc Population-specific haplotype association of the postsynaptic density gene DLG4 with schizophrenia, in family-based association studies
    Shabeesh Balan
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    PLoS ONE 8:e70302. 2013
  7. doi request reprint Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder
    Yoshimi Iwayama
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:484-93. 2010
  8. pmc Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies
    Chie Shimamoto
    Department of Biological Sciences, Graduate School of Humanities and Sciences, Ochanomizu University, Tokyo 112 8610, Japan, Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Hum Mol Genet 23:6495-511. 2014
  9. doi request reprint A population-specific uncommon variant in GRIN3A associated with schizophrenia
    Atsushi Takata
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Biol Psychiatry 73:532-9. 2013
  10. doi request reprint Lack of association of EGR2 variants with bipolar disorder in Japanese population
    Shabeesh Balan
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Gene 526:246-50. 2013

Collaborators

Detail Information

Publications27

  1. doi request reprint Excessive ingestion of long-chain polyunsaturated fatty acids during developmental stage causes strain- and sex-dependent eye abnormalities in mice
    Motoko Maekawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 402:431-7. 2010
    ..These results demonstrate a gene-by-environment (GxE) interaction in eye development in mice. Furthermore, our molecular analysis suggested the potential roles of Pitx3 and Pax6 in the above interaction involving ARA...
  2. doi request reprint A novel missense mutation (Leu46Val) of PAX6 found in an autistic patient
    Motoko Maekawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Neurosci Lett 462:267-71. 2009
    ..Our findings suggest the necessity of further studies on the causal relationship between PAX6 and autism...
  3. doi request reprint Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects
    Motoko Maekawa
    RIKEN Brain Science Institute, Saitama, Japan
    J Hum Genet 55:127-30. 2010
    ..Future searches for associated phenotypes with missense SNPs using larger samples are highly warranted...
  4. doi request reprint Analysis of strain-dependent prepulse inhibition points to a role for Shmt1 (SHMT1) in mice and in schizophrenia
    Motoko Maekawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    J Neurochem 115:1374-85. 2010
    ..We detected a nominal association between SHMT1 and schizophrenia. These results suggest that Shmt1 (SHMT1), but not Srr, is likely to be one of the genetic components regulating PPI in mice and possibly relevant to schizophrenia...
  5. pmc Giant subependymoma developed in a patient with aniridia: analyses of PAX6 and tumor-relevant genes
    Motoko Maekawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
    Brain Pathol 20:1033-41. 2010
    ..Collectively, we speculate that the defect in PAX6 may have contributed to the extremely large size of the subependymoma, due to a loss of tumor suppressor activity in glial cell lineage...
  6. pmc Population-specific haplotype association of the postsynaptic density gene DLG4 with schizophrenia, in family-based association studies
    Shabeesh Balan
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    PLoS ONE 8:e70302. 2013
    ..The current study highlights a putative role for DLG4 in schizophrenia pathogenesis, evidenced by haplotype association, and warrants further dense screening for variants within these haplotypes...
  7. doi request reprint Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder
    Yoshimi Iwayama
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:484-93. 2010
    ..Therefore, future identification of unknown regulatory elements will be necessary to make a more detailed analysis of their genetic contribution to mental illnesses...
  8. pmc Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies
    Chie Shimamoto
    Department of Biological Sciences, Graduate School of Humanities and Sciences, Ochanomizu University, Tokyo 112 8610, Japan, Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Hum Mol Genet 23:6495-511. 2014
    ..In conclusion, disturbances in brain-expressed FABPs could represent an underlying disease mechanism in a proportion of schizophrenia and ASD sufferers. ..
  9. doi request reprint A population-specific uncommon variant in GRIN3A associated with schizophrenia
    Atsushi Takata
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Biol Psychiatry 73:532-9. 2013
    ..However, individually, these variants only produce a weak effect. To identify genetic variants with larger effect sizes, increasing attention is now being paid to uncommon and rare variants...
  10. doi request reprint Lack of association of EGR2 variants with bipolar disorder in Japanese population
    Shabeesh Balan
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Gene 526:246-50. 2013
    ....
  11. pmc Genome-wide association study of schizophrenia in Japanese population
    Kazuo Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    PLoS ONE 6:e20468. 2011
    ..026). The current data in Asian population would be helpful for deciphering ethnic diversity of schizophrenia etiology...
  12. pmc Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism
    Motoko Maekawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Sci Rep 5:16239. 2015
    ....
  13. pmc Ablation of Mrds1/Ofcc1 induces hyper-γ-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan
    PLoS ONE 6:e29499. 2011
    ..These results prompt further examination of the gene, including its putative contribution to hyper-γ-glutamyl transpeptidasemia and schizophrenia...
  14. pmc Association study of the KCNJ3 gene as a susceptibility candidate for schizophrenia in the Chinese population
    Kazuo Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Hum Genet 131:443-51. 2012
    ..These data suggest that the KCNJ3 gene is genetically associated with schizophrenia in Asian populations and add further evidence to the "channelopathy theory of psychiatric illnesses"...
  15. doi request reprint Association study of Nogo-related genes with schizophrenia in a Japanese case-control sample
    Daisuke Jitoku
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 156:581-92. 2011
    ....
  16. ncbi request reprint [Analysis of mouse strain-dependent prepulse inhibition points to a role for Shmt1 (SHMT1) in mice and in schizophrenia]
    Takeo Yoshikawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 30:197-200. 2010
    ..These results suggest that Shmt1 (SHMT1) is one of the genetic components regulating PPI in mice and is relevant to schizophrenia susceptibility in humans...
  17. doi request reprint Utility of Scalp Hair Follicles as a Novel Source of Biomarker Genes for Psychiatric Illnesses
    Motoko Maekawa
    Laboratory of Molecular Psychiatry, RIKEN Brain Science Institute, Saitama
    Biol Psychiatry 78:116-25. 2015
    ..Identifying beneficial surrogate genetic markers in psychiatric disorders is crucial but challenging...
  18. doi request reprint Sequencing and expression analyses of the synaptic lipid raft adapter gene PAG1 in schizophrenia
    Shabeesh Balan
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama, 351 0198, Japan
    J Neural Transm (Vienna) 122:477-85. 2015
    ..To assess the precise role of PAG1 in schizophrenia, future studies with larger sample sizes are needed...
  19. pmc Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype
    Akiko Watanabe
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    PLoS Biol 5:e297. 2007
    ..We also discuss the results from the perspective of fetal programming...
  20. doi request reprint Behavioral analyses of transgenic mice harboring bipolar disorder candidate genes, IMPA1 and IMPA2
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Neurosci Res 67:86-94. 2010
    ....
  21. doi request reprint Fatty acid composition and fatty acid binding protein expression in the postmortem frontal cortex of patients with schizophrenia: A case-control study
    Kei Hamazaki
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan Department of Public Health, Faculty of Medicine, University of Toyama, Toyama City, Toyama 9300194, Japan Electronic address
    Schizophr Res 171:225-32. 2016
    ..Altered mRNA expression of fatty acid binding protein (FABP) 5 and FABP7 has likewise been reported...
  22. doi request reprint Analysis of a t(18;21)(p11.1;p11.1) translocation in a family with schizophrenia
    Joanne M A Meerabux
    Laboratory for Molecular Psychiatry, RIKEN, Brain Science Institute, Saitama, Japan
    J Hum Genet 54:386-91. 2009
    ....
  23. doi request reprint Comprehensive association analysis of 27 genes from the GABAergic system in Japanese individuals affected with schizophrenia
    Shabeesh Balan
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Schizophr Res . 2017
    ..These results warrant further investigations to replicate the association of GABRA1 and GPHN with schizophrenia and to discern the precise mechanisms of disease pathophysiology...
  24. doi request reprint Fatty acid composition of the postmortem prefrontal cortex of patients with schizophrenia, bipolar disorder, and major depressive disorder
    Kei Hamazaki
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan Department of Public Health, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama City, Toyama 930 0194, Japan Electronic address
    Psychiatry Res 227:353-9. 2015
    ..These psychiatric disorders might be characterized by very specific fatty acid compositions in certain areas of the brain, and BA8 might not be involved in abnormalities of PUFA metabolism. ..
  25. ncbi request reprint Role of polyunsaturated fatty acids and fatty acid binding protein in the pathogenesis of schizophrenia
    Motoko Maekawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Curr Pharm Des 17:168-75. 2011
    ....
  26. doi request reprint Ceramide galactosyltransferase expression is regulated positively by Nkx2.2 and negatively by OLIG2
    Kyohei Okahara
    Disease Glycomics Team, Systems Glycobiology Research Group, RIKEN Max Planck Joint Research Center, Global Research Cluster, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Glycobiology 24:926-34. 2014
    ..2, providing new insights into how expression of GalCer is tightly regulated in cell-type- and stage-specific manners. ..
  27. doi request reprint Schizophrenia with the 22q11.2 deletion and additional genetic defects: case history
    M Toyosima
    Laboratory for Molecular Psychiatry RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    Br J Psychiatry 199:245-6. 2011
    ..We propose that the combination of these genetic defects may have exceeded the threshold for the manifestation of schizophrenia...