Tetsuo Ohnishi

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. request reprint
    Ohnishi T, Ohba H, Seo K, Im J, Sato Y, Iwayama Y, et al. Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. J Biol Chem. 2007;282:637-46 pubmed
    ..These data suggest that IMPA2 has a separate function in vivo from that of IMPA1. ..
  2. Ohnishi T, Watanabe A, Ohba H, Iwayama Y, Maekawa M, Yoshikawa T. Behavioral analyses of transgenic mice harboring bipolar disorder candidate genes, IMPA1 and IMPA2. Neurosci Res. 2010;67:86-94 pubmed publisher
    ....
  3. Ohnishi T, Yamada K, Watanabe A, Ohba H, Sakaguchi T, Honma Y, et al. Ablation of Mrds1/Ofcc1 induces hyper-γ-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice. PLoS ONE. 2011;6:e29499 pubmed publisher
    ..These results prompt further examination of the gene, including its putative contribution to hyper-γ-glutamyl transpeptidasemia and schizophrenia. ..
  4. Ohnishi T, Tanizawa Y, Watanabe A, Nakamura T, Ohba H, Hirata H, et al. Human myo-inositol monophosphatase 2 rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genes. J Neurochem. 2013;124:685-94 pubmed publisher
    ..Given the ability of human IMPA2 to rescue the ttx-7 mutant, and its genetic association with multiple neuropsychiatric disorders, close scrutiny of IMPA2 function and the evolutionary origin of IMPase genes is warranted. ..

Locale

Detail Information

Publications4

  1. request reprint
    Ohnishi T, Ohba H, Seo K, Im J, Sato Y, Iwayama Y, et al. Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. J Biol Chem. 2007;282:637-46 pubmed
    ..These data suggest that IMPA2 has a separate function in vivo from that of IMPA1. ..
  2. Ohnishi T, Watanabe A, Ohba H, Iwayama Y, Maekawa M, Yoshikawa T. Behavioral analyses of transgenic mice harboring bipolar disorder candidate genes, IMPA1 and IMPA2. Neurosci Res. 2010;67:86-94 pubmed publisher
    ....
  3. Ohnishi T, Yamada K, Watanabe A, Ohba H, Sakaguchi T, Honma Y, et al. Ablation of Mrds1/Ofcc1 induces hyper-γ-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice. PLoS ONE. 2011;6:e29499 pubmed publisher
    ..These results prompt further examination of the gene, including its putative contribution to hyper-γ-glutamyl transpeptidasemia and schizophrenia. ..
  4. Ohnishi T, Tanizawa Y, Watanabe A, Nakamura T, Ohba H, Hirata H, et al. Human myo-inositol monophosphatase 2 rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genes. J Neurochem. 2013;124:685-94 pubmed publisher
    ..Given the ability of human IMPA2 to rescue the ttx-7 mutant, and its genetic association with multiple neuropsychiatric disorders, close scrutiny of IMPA2 function and the evolutionary origin of IMPase genes is warranted. ..