Research Topics
Genomes and Genes
| Tetsuo OhnishiSummaryAffiliation: RIKEN Brain Science Institute Country: Japan Publications
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Detail Information
Publications
Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1Tetsuo Ohnishi
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
J Biol Chem 282:637-46. 2007..These data suggest that IMPA2 has a separate function in vivo from that of IMPA1...
A spontaneous and novel Pax3 mutant mouse that models Waardenburg syndrome and neural tube defectsTetsuo Ohnishi
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan Electronic address
Gene . 2016....- Human myo-inositol monophosphatase 2 rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genesTetsuo Ohnishi
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan
J Neurochem 124:685-94. 2013..Given the ability of human IMPA2 to rescue the ttx-7 mutant, and its genetic association with multiple neuropsychiatric disorders, close scrutiny of IMPA2 function and the evolutionary origin of IMPase genes is warranted... 
Ablation of Mrds1/Ofcc1 induces hyper-γ-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in miceTetsuo Ohnishi
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan
PLoS ONE 6:e29499. 2011..These results prompt further examination of the gene, including its putative contribution to hyper-γ-glutamyl transpeptidasemia and schizophrenia...- Behavioral analyses of transgenic mice harboring bipolar disorder candidate genes, IMPA1 and IMPA2Tetsuo Ohnishi
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
Neurosci Res 67:86-94. 2010.... - Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjectsMotoko Maekawa
RIKEN Brain Science Institute, Saitama, Japan
J Hum Genet 55:127-30. 2010..Future searches for associated phenotypes with missense SNPs using larger samples are highly warranted... - Population-specific haplotype association of the postsynaptic density gene DLG4 with schizophrenia, in family-based association studiesShabeesh Balan
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
PLoS ONE 8:e70302. 2013..The current study highlights a putative role for DLG4 in schizophrenia pathogenesis, evidenced by haplotype association, and warrants further dense screening for variants within these haplotypes... - Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorderYoshimi Iwayama
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
Am J Med Genet B Neuropsychiatr Genet 153:484-93. 2010..Therefore, future identification of unknown regulatory elements will be necessary to make a more detailed analysis of their genetic contribution to mental illnesses... - A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcriptionTetsuo Ohnishi
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
Neuropsychopharmacology 32:1727-37. 2007..In conclusion, the present study suggests that a promoter haplotype of IMPA2 possibly contributes to risk for bipolar disorder by elevating IMPA2 levels in the brain, albeit the genetic effect varies among populations... - Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophreniaKazuo Yamada
Laboratories for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
Proc Natl Acad Sci U S A 104:2815-20. 2007..These findings support the previous genetic association of altered calcineurin signaling with schizophrenia pathogenesis and identify EGR3 as a compelling susceptibility gene... - Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studiesChie Shimamoto
Department of Biological Sciences, Graduate School of Humanities and Sciences, Ochanomizu University, Tokyo 112 8610, Japan, Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
Hum Mol Genet 23:6495-511. 2014..In conclusion, disturbances in brain-expressed FABPs could represent an underlying disease mechanism in a proportion of schizophrenia and ASD sufferers. .. - Lack of association of EGR2 variants with bipolar disorder in Japanese populationShabeesh Balan
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
Gene 526:246-50. 2013.... - Excessive ingestion of long-chain polyunsaturated fatty acids during developmental stage causes strain- and sex-dependent eye abnormalities in miceMotoko Maekawa
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
Biochem Biophys Res Commun 402:431-7. 2010..These results demonstrate a gene-by-environment (GxE) interaction in eye development in mice. Furthermore, our molecular analysis suggested the potential roles of Pitx3 and Pax6 in the above interaction involving ARA... - Analysis of strain-dependent prepulse inhibition points to a role for Shmt1 (SHMT1) in mice and in schizophreniaMotoko Maekawa
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
J Neurochem 115:1374-85. 2010..We detected a nominal association between SHMT1 and schizophrenia. These results suggest that Shmt1 (SHMT1), but not Srr, is likely to be one of the genetic components regulating PPI in mice and possibly relevant to schizophrenia... - Genome-wide association study of schizophrenia in Japanese populationKazuo Yamada
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
PLoS ONE 6:e20468. 2011..026). The current data in Asian population would be helpful for deciphering ethnic diversity of schizophrenia etiology... - Failure to confirm genetic association of the CHI3L1 gene with schizophrenia in Japanese and Chinese populationsKazuo Yamada
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
Am J Med Genet B Neuropsychiatr Genet 150:508-14. 2009..108) in our sample sets. These results suggest that the genetic contribution of CHI3L1 to schizophrenia is variable, even though it is mechanistically involved in the disease process... - A population-specific uncommon variant in GRIN3A associated with schizophreniaAtsushi Takata
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
Biol Psychiatry 73:532-9. 2013..However, individually, these variants only produce a weak effect. To identify genetic variants with larger effect sizes, increasing attention is now being paid to uncommon and rare variants... - [Analysis of mouse strain-dependent prepulse inhibition points to a role for Shmt1 (SHMT1) in mice and in schizophrenia]Takeo Yoshikawa
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
Nihon Shinkei Seishin Yakurigaku Zasshi 30:197-200. 2010..These results suggest that Shmt1 (SHMT1) is one of the genetic components regulating PPI in mice and is relevant to schizophrenia susceptibility in humans... - Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depressionKazuo Yamada
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Kawaguchi, Saitama, Japan
Biol Psychiatry 60:192-201. 2006..But the polymorphisms highlighted in these reports map to different locations in the two genes, therefore it is unclear which gene exerts a stronger effect on susceptibility... - Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autismMotoko Maekawa
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
Sci Rep 5:16239. 2015.... - Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesisTetsuo Ohnishi
From the Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351 0198
J Biol Chem 289:10785-96. 2014..Furthermore, this mouse model for cellular inositol depletion could be beneficial for understanding the molecular mechanisms underlying the clinical effect of lithium and myo-inositol-mediated skeletal development. .. - Sequencing and expression analyses of the synaptic lipid raft adapter gene PAG1 in schizophreniaShabeesh Balan
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama, 351 0198, Japan
J Neural Transm (Vienna) 122:477-85. 2015..To assess the precise role of PAG1 in schizophrenia, future studies with larger sample sizes are needed... - Association study of the KCNJ3 gene as a susceptibility candidate for schizophrenia in the Chinese populationKazuo Yamada
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
Hum Genet 131:443-51. 2012..These data suggest that the KCNJ3 gene is genetically associated with schizophrenia in Asian populations and add further evidence to the "channelopathy theory of psychiatric illnesses"... - Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbationNoriaki Nakatani
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
Hum Mol Genet 15:1949-62. 2006..Finally, gene network analysis using the currently obtained expression data highlighted cellular growth and nervous system development pathways as potential targets in the molecular pathophysiology of bipolar disorder... - A novel missense mutation (Leu46Val) of PAX6 found in an autistic patientMotoko Maekawa
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
Neurosci Lett 462:267-71. 2009..Our findings suggest the necessity of further studies on the causal relationship between PAX6 and autism... - Utility of Scalp Hair Follicles as a Novel Source of Biomarker Genes for Psychiatric IllnessesMotoko Maekawa
Laboratory of Molecular Psychiatry, RIKEN Brain Science Institute, Saitama
Biol Psychiatry 78:116-25. 2015..Identifying beneficial surrogate genetic markers in psychiatric disorders is crucial but challenging... - Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotypeAkiko Watanabe
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
PLoS Biol 5:e297. 2007..We also discuss the results from the perspective of fetal programming... - Failure to support a genetic contribution of AKT1 polymorphisms and altered AKT signaling in schizophreniaMasayuki Ide
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
J Neurochem 99:277-87. 2006..Collectively, this study failed to support reduced signaling of the AKT-GSK3beta molecular cascade in schizophrenia... - Expression analysis of actin-related genes as an underlying mechanism for mood disordersNoriaki Nakatani
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
Biochem Biophys Res Commun 352:780-6. 2007..These data suggest that the balance of actin dynamics might be altered towards actin depolymerization in mood disorders... - Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levelsKazuo Yamada
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
Biol Psychiatry 57:1493-503. 2005.... - Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7Tetsuo Ohnishi
Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
Mol Cell 12:1187-200. 2003..We propose that sequential phosphorylation and dephosphorylation of hUPF1 by hSMG-1 and PP2A, respectively, contribute to the remodeling of the mRNA surveillance complex... - Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizuresRyoichi Arai
Protein Research Group, RIKEN Genomic Sciences Center, Tsurumi, Yokohama 230 0045, Japan
Proteins 67:732-42. 2007....