Tetsuo Ohnishi

Summary

Affiliation: RIKEN Brain Science Institute
Country: Japan

Publications

  1. ncbi request reprint Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Biol Chem 282:637-46. 2007
  2. doi request reprint A spontaneous and novel Pax3 mutant mouse that models Waardenburg syndrome and neural tube defects
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan Electronic address
    Gene . 2016
  3. doi request reprint Human myo-inositol monophosphatase 2 rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genes
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan
    J Neurochem 124:685-94. 2013
  4. pmc Ablation of Mrds1/Ofcc1 induces hyper-γ-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan
    PLoS ONE 6:e29499. 2011
  5. doi request reprint Behavioral analyses of transgenic mice harboring bipolar disorder candidate genes, IMPA1 and IMPA2
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Neurosci Res 67:86-94. 2010
  6. doi request reprint Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects
    Motoko Maekawa
    RIKEN Brain Science Institute, Saitama, Japan
    J Hum Genet 55:127-30. 2010
  7. pmc Population-specific haplotype association of the postsynaptic density gene DLG4 with schizophrenia, in family-based association studies
    Shabeesh Balan
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    PLoS ONE 8:e70302. 2013
  8. doi request reprint Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder
    Yoshimi Iwayama
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:484-93. 2010
  9. ncbi request reprint A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Neuropsychopharmacology 32:1727-37. 2007
  10. pmc Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia
    Kazuo Yamada
    Laboratories for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 104:2815-20. 2007

Detail Information

Publications32

  1. ncbi request reprint Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Biol Chem 282:637-46. 2007
    ..These data suggest that IMPA2 has a separate function in vivo from that of IMPA1...
  2. doi request reprint A spontaneous and novel Pax3 mutant mouse that models Waardenburg syndrome and neural tube defects
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan Electronic address
    Gene . 2016
    ....
  3. doi request reprint Human myo-inositol monophosphatase 2 rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genes
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan
    J Neurochem 124:685-94. 2013
    ..Given the ability of human IMPA2 to rescue the ttx-7 mutant, and its genetic association with multiple neuropsychiatric disorders, close scrutiny of IMPA2 function and the evolutionary origin of IMPase genes is warranted...
  4. pmc Ablation of Mrds1/Ofcc1 induces hyper-γ-glutamyl transpeptidasemia without abnormal head development and schizophrenia-relevant behaviors in mice
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan
    PLoS ONE 6:e29499. 2011
    ..These results prompt further examination of the gene, including its putative contribution to hyper-γ-glutamyl transpeptidasemia and schizophrenia...
  5. doi request reprint Behavioral analyses of transgenic mice harboring bipolar disorder candidate genes, IMPA1 and IMPA2
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Neurosci Res 67:86-94. 2010
    ....
  6. doi request reprint Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects
    Motoko Maekawa
    RIKEN Brain Science Institute, Saitama, Japan
    J Hum Genet 55:127-30. 2010
    ..Future searches for associated phenotypes with missense SNPs using larger samples are highly warranted...
  7. pmc Population-specific haplotype association of the postsynaptic density gene DLG4 with schizophrenia, in family-based association studies
    Shabeesh Balan
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    PLoS ONE 8:e70302. 2013
    ..The current study highlights a putative role for DLG4 in schizophrenia pathogenesis, evidenced by haplotype association, and warrants further dense screening for variants within these haplotypes...
  8. doi request reprint Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder
    Yoshimi Iwayama
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako City, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:484-93. 2010
    ..Therefore, future identification of unknown regulatory elements will be necessary to make a more detailed analysis of their genetic contribution to mental illnesses...
  9. ncbi request reprint A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Neuropsychopharmacology 32:1727-37. 2007
    ..In conclusion, the present study suggests that a promoter haplotype of IMPA2 possibly contributes to risk for bipolar disorder by elevating IMPA2 levels in the brain, albeit the genetic effect varies among populations...
  10. pmc Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia
    Kazuo Yamada
    Laboratories for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Proc Natl Acad Sci U S A 104:2815-20. 2007
    ..These findings support the previous genetic association of altered calcineurin signaling with schizophrenia pathogenesis and identify EGR3 as a compelling susceptibility gene...
  11. pmc Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies
    Chie Shimamoto
    Department of Biological Sciences, Graduate School of Humanities and Sciences, Ochanomizu University, Tokyo 112 8610, Japan, Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Hum Mol Genet 23:6495-511. 2014
    ..In conclusion, disturbances in brain-expressed FABPs could represent an underlying disease mechanism in a proportion of schizophrenia and ASD sufferers. ..
  12. doi request reprint Lack of association of EGR2 variants with bipolar disorder in Japanese population
    Shabeesh Balan
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Gene 526:246-50. 2013
    ....
  13. doi request reprint Excessive ingestion of long-chain polyunsaturated fatty acids during developmental stage causes strain- and sex-dependent eye abnormalities in mice
    Motoko Maekawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 402:431-7. 2010
    ..These results demonstrate a gene-by-environment (GxE) interaction in eye development in mice. Furthermore, our molecular analysis suggested the potential roles of Pitx3 and Pax6 in the above interaction involving ARA...
  14. doi request reprint Analysis of strain-dependent prepulse inhibition points to a role for Shmt1 (SHMT1) in mice and in schizophrenia
    Motoko Maekawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    J Neurochem 115:1374-85. 2010
    ..We detected a nominal association between SHMT1 and schizophrenia. These results suggest that Shmt1 (SHMT1), but not Srr, is likely to be one of the genetic components regulating PPI in mice and possibly relevant to schizophrenia...
  15. pmc Genome-wide association study of schizophrenia in Japanese population
    Kazuo Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    PLoS ONE 6:e20468. 2011
    ..026). The current data in Asian population would be helpful for deciphering ethnic diversity of schizophrenia etiology...
  16. doi request reprint Failure to confirm genetic association of the CHI3L1 gene with schizophrenia in Japanese and Chinese populations
    Kazuo Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Am J Med Genet B Neuropsychiatr Genet 150:508-14. 2009
    ..108) in our sample sets. These results suggest that the genetic contribution of CHI3L1 to schizophrenia is variable, even though it is mechanistically involved in the disease process...
  17. doi request reprint A population-specific uncommon variant in GRIN3A associated with schizophrenia
    Atsushi Takata
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Biol Psychiatry 73:532-9. 2013
    ..However, individually, these variants only produce a weak effect. To identify genetic variants with larger effect sizes, increasing attention is now being paid to uncommon and rare variants...
  18. ncbi request reprint [Analysis of mouse strain-dependent prepulse inhibition points to a role for Shmt1 (SHMT1) in mice and in schizophrenia]
    Takeo Yoshikawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 30:197-200. 2010
    ..These results suggest that Shmt1 (SHMT1) is one of the genetic components regulating PPI in mice and is relevant to schizophrenia susceptibility in humans...
  19. ncbi request reprint Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression
    Kazuo Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Kawaguchi, Saitama, Japan
    Biol Psychiatry 60:192-201. 2006
    ..But the polymorphisms highlighted in these reports map to different locations in the two genes, therefore it is unclear which gene exerts a stronger effect on susceptibility...
  20. pmc Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism
    Motoko Maekawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Sci Rep 5:16239. 2015
    ....
  21. pmc Defective craniofacial development and brain function in a mouse model for depletion of intracellular inositol synthesis
    Tetsuo Ohnishi
    From the Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351 0198
    J Biol Chem 289:10785-96. 2014
    ..Furthermore, this mouse model for cellular inositol depletion could be beneficial for understanding the molecular mechanisms underlying the clinical effect of lithium and myo-inositol-mediated skeletal development. ..
  22. doi request reprint Sequencing and expression analyses of the synaptic lipid raft adapter gene PAG1 in schizophrenia
    Shabeesh Balan
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama, 351 0198, Japan
    J Neural Transm (Vienna) 122:477-85. 2015
    ..To assess the precise role of PAG1 in schizophrenia, future studies with larger sample sizes are needed...
  23. pmc Association study of the KCNJ3 gene as a susceptibility candidate for schizophrenia in the Chinese population
    Kazuo Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Hum Genet 131:443-51. 2012
    ..These data suggest that the KCNJ3 gene is genetically associated with schizophrenia in Asian populations and add further evidence to the "channelopathy theory of psychiatric illnesses"...
  24. ncbi request reprint Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation
    Noriaki Nakatani
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Hum Mol Genet 15:1949-62. 2006
    ..Finally, gene network analysis using the currently obtained expression data highlighted cellular growth and nervous system development pathways as potential targets in the molecular pathophysiology of bipolar disorder...
  25. doi request reprint A novel missense mutation (Leu46Val) of PAX6 found in an autistic patient
    Motoko Maekawa
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Neurosci Lett 462:267-71. 2009
    ..Our findings suggest the necessity of further studies on the causal relationship between PAX6 and autism...
  26. doi request reprint Utility of Scalp Hair Follicles as a Novel Source of Biomarker Genes for Psychiatric Illnesses
    Motoko Maekawa
    Laboratory of Molecular Psychiatry, RIKEN Brain Science Institute, Saitama
    Biol Psychiatry 78:116-25. 2015
    ..Identifying beneficial surrogate genetic markers in psychiatric disorders is crucial but challenging...
  27. pmc Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype
    Akiko Watanabe
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    PLoS Biol 5:e297. 2007
    ..We also discuss the results from the perspective of fetal programming...
  28. ncbi request reprint Failure to support a genetic contribution of AKT1 polymorphisms and altered AKT signaling in schizophrenia
    Masayuki Ide
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    J Neurochem 99:277-87. 2006
    ..Collectively, this study failed to support reduced signaling of the AKT-GSK3beta molecular cascade in schizophrenia...
  29. ncbi request reprint Expression analysis of actin-related genes as an underlying mechanism for mood disorders
    Noriaki Nakatani
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Biochem Biophys Res Commun 352:780-6. 2007
    ..These data suggest that the balance of actin dynamics might be altered towards actin depolymerization in mood disorders...
  30. ncbi request reprint Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels
    Kazuo Yamada
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Biol Psychiatry 57:1493-503. 2005
    ....
  31. ncbi request reprint Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7
    Tetsuo Ohnishi
    Department of Molecular Biology, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
    Mol Cell 12:1187-200. 2003
    ..We propose that sequential phosphorylation and dephosphorylation of hUPF1 by hSMG-1 and PP2A, respectively, contribute to the remodeling of the mRNA surveillance complex...
  32. ncbi request reprint Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures
    Ryoichi Arai
    Protein Research Group, RIKEN Genomic Sciences Center, Tsurumi, Yokohama 230 0045, Japan
    Proteins 67:732-42. 2007
    ....