Tsuyoshi Saito

Summary

Affiliation: Sapporo Medical University
Country: Japan

Publications

  1. ncbi request reprint Neoadjuvant chemotherapy with cisplatin, aclacinomycin A, and mitomycin C for cervical adenocarcinoma--a preliminary study
    T Saito
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    Int J Gynecol Cancer 14:483-90. 2004
  2. ncbi request reprint Overexpressed progesterone receptor form B inhibit invasive activity suppressing matrix metalloproteinases in endometrial carcinoma cells
    Tsuyoshi Saito
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Cancer Lett 209:237-43. 2004
  3. ncbi request reprint Overexpression of estrogen receptor-alpha gene suppresses gap junctional intercellular communication in endometrial carcinoma cells
    Tsuyoshi Saito
    Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Oncogene 23:1109-16. 2004
  4. ncbi request reprint Correlation between responsiveness of neoadjuvant chemotherapy and apoptosis-associated proteins for cervical adenocarcinoma
    Tsuyoshi Saito
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Gynecol Oncol 92:284-92. 2004
  5. ncbi request reprint Hypermethylation in promoter region of E-cadherin gene is associated with tumor dedifferention and myometrial invasion in endometrial carcinoma
    Tsuyoshi Saito
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer 97:1002-9. 2003
  6. ncbi request reprint Usefulness of silver intensification of immunostaining for cytologic diagnosis of primary melanoma of the female genital organs
    Tsuyoshi Saito
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Acta Cytol 46:1075-80. 2002
  7. ncbi request reprint Suppressed gap junctional intercellular communication in carcinogenesis of endometrium
    T Saito
    Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Japan
    Int J Cancer 93:317-23. 2001
  8. ncbi request reprint Co-ordinated expression of connexins 26 and 32 in human endometrial glandular epithelium during the reproductive cycle and the influence of hormone replacement therapy
    T Saito
    Department of Obstetrics and Gynecology, School of Medicine, Sapporo Medical University, Japan
    Int J Cancer 73:479-85. 1997
  9. ncbi request reprint Expression of uteroglobin in normal and carcinogenic endometrium and influence of hormone replacement therapy
    Ryoichi Tanaka
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Int J Cancer 109:43-8. 2004
  10. doi request reprint Regulation of tight junctions by sex hormones in normal human endometrial epithelial cells and uterus cancer cell line Sawano
    Masayuki Someya
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cell Tissue Res 354:481-94. 2013

Collaborators

Detail Information

Publications104 found, 100 shown here

  1. ncbi request reprint Neoadjuvant chemotherapy with cisplatin, aclacinomycin A, and mitomycin C for cervical adenocarcinoma--a preliminary study
    T Saito
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    Int J Gynecol Cancer 14:483-90. 2004
    ..A prospective-randomized study is needed to assess the value of this approach compared with standard management...
  2. ncbi request reprint Overexpressed progesterone receptor form B inhibit invasive activity suppressing matrix metalloproteinases in endometrial carcinoma cells
    Tsuyoshi Saito
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Cancer Lett 209:237-43. 2004
    ..These results suggest that activation of PR-B by progesterone results in tumor suppression by inhibiting cell growth and invasiveness via suppression of the expression of MMPs...
  3. ncbi request reprint Overexpression of estrogen receptor-alpha gene suppresses gap junctional intercellular communication in endometrial carcinoma cells
    Tsuyoshi Saito
    Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Oncogene 23:1109-16. 2004
    ..These results suggest that activation of ER-alpha by estrogen results in tumor progression by stimulating cell growth and suppressing GJIC via suppression of the expression of Cxs in endometrial carcinogenesis...
  4. ncbi request reprint Correlation between responsiveness of neoadjuvant chemotherapy and apoptosis-associated proteins for cervical adenocarcinoma
    Tsuyoshi Saito
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Gynecol Oncol 92:284-92. 2004
    ..In the present study, 29 patients with locally advanced cervical adenocarcinoma (bulky IB-IVB) were treated with neoadjuvant chemotherapy (NAC) using cisplatin, aclacinomycin-A and mitomycin-C, followed by radical surgery or irradiation...
  5. ncbi request reprint Hypermethylation in promoter region of E-cadherin gene is associated with tumor dedifferention and myometrial invasion in endometrial carcinoma
    Tsuyoshi Saito
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer 97:1002-9. 2003
    ..Loss of E-cadherin expression is associated with aberrant 5' CpG island methylation in various tumors...
  6. ncbi request reprint Usefulness of silver intensification of immunostaining for cytologic diagnosis of primary melanoma of the female genital organs
    Tsuyoshi Saito
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Acta Cytol 46:1075-80. 2002
    ..To improve the procedure for diagnosing vaginal melanoma with cytopathologic analysis of HMB-45...
  7. ncbi request reprint Suppressed gap junctional intercellular communication in carcinogenesis of endometrium
    T Saito
    Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Japan
    Int J Cancer 93:317-23. 2001
    ..Our results indicate that during endometrial carcinogenesis, loss of gap junctional intercellular communication (GJIC) may occur due to the suppressed expression and the aberrant localization of connexin at relatively early stages...
  8. ncbi request reprint Co-ordinated expression of connexins 26 and 32 in human endometrial glandular epithelium during the reproductive cycle and the influence of hormone replacement therapy
    T Saito
    Department of Obstetrics and Gynecology, School of Medicine, Sapporo Medical University, Japan
    Int J Cancer 73:479-85. 1997
    ..They indicate that expression of Cx26 and Cx32 is correlated with cell differentiation and with the glandular function of the endometrial epithelium and suggest that expression of Cxs is controlled by serum progesterone...
  9. ncbi request reprint Expression of uteroglobin in normal and carcinogenic endometrium and influence of hormone replacement therapy
    Ryoichi Tanaka
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Int J Cancer 109:43-8. 2004
    ....
  10. doi request reprint Regulation of tight junctions by sex hormones in normal human endometrial epithelial cells and uterus cancer cell line Sawano
    Masayuki Someya
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cell Tissue Res 354:481-94. 2013
    ..Thus, tight junctions are physiological regulated by sex hormones in normal HEE cells during the menstrual cycle suggesting that safer and more effective therapeutic methods targeting claudins in uterine cancer can be developed. ..
  11. ncbi request reprint Acceleration of invasive activity via matrix metalloproteinases by transfection of the estrogen receptor-alpha gene in endometrial carcinoma cells
    Hisanobu Mizumoto
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Int J Cancer 100:401-6. 2002
    ..These results suggest that activation of ER-alpha by estrogen results in tumor progression by stimulating cell growth and invasiveness via acceleration of the expression of MMPs...
  12. doi request reprint The contributions of resistin and adiponectin gene single nucleotide polymorphisms to the genetic risk for polycystic ovary syndrome in a Japanese population
    Tsuyoshi Baba
    Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Hokkaido, Japan
    Gynecol Endocrinol 25:498-503. 2009
    ..The ADIPOQ SNP at -11377 showed no association with PCOS. We conclude that the RETN G/G at -420 genotype is associated with PCOS in Japanese women...
  13. ncbi request reprint Suppression of gap junctional intercellular communication via 5' CpG island methylation in promoter region of E-cadherin gene in endometrial cancer cells
    Makoto Nishimura
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 0061, Japan
    Carcinogenesis 24:1615-23. 2003
    ..The results indicated that 5' CpG island methylation, which caused loss of E-cadherin expression, indirectly caused the suppression of GJIC by aberrant localization of Cxs in endometrial carcinoma cells...
  14. ncbi request reprint Prediction of histologic type and lymph node metastasis for advanced ovarian cancer on uterine cervical and endometrial cytology
    Miwa Suzuki
    Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Hokkaido, Japan
    Acta Cytol 54:575-81. 2010
    ..To evaluate usefulness of uterine cervical and endometrial cytology for detecting ovarian cancer and predicting histologic type...
  15. doi request reprint Assisted reproductive technique increases the risk of placental polyp
    Tsuyoshi Baba
    Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Hokkaido, Japan
    Gynecol Endocrinol 29:611-4. 2013
    ..Thus, ART-related pregnancies may be a risk factor of placental polyp, and spontaneous drop-off of the polyp is often observed in cases with low blood flow within the mass...
  16. doi request reprint First case of vaginal radical trachelectomy in a pregnant Japanese woman
    Nanako Iwami
    Department of Obstetrics and Gynecology, Sapporo Medical University, Minami 1 jo Nishi 16 chome, Chuo Ku, Sapporo, Hokkaido 064 8453, Japan
    Int J Clin Oncol 16:737-40. 2011
    ..A baby girl was born weighing 2112 g, with Apgar score of 8/9. The mother remains without evidence of recurrence at the time of this report. This is the first case of successful pregnancy and delivery in Japan after vaginal RT...
  17. pmc Remarkable features of ovarian morphology and reproductive hormones in insulin-resistant Zucker fatty (fa/fa) rats
    Hiroyuki Honnma
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, South 1 West 16, Chuo Ku, Sapporo 060 8543, Japan
    Reprod Biol Endocrinol 8:73. 2010
    ....
  18. ncbi request reprint Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells
    Kunihiko Nagasawa
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Cell Physiol 208:123-32. 2006
    ..These findings suggest that Cx40- and/or Cx43-based gap junctions might be required to maintain the endothelial barrier function without altering the expression and localization of the tight-junction components analyzed...
  19. ncbi request reprint Hypermethylation in promoter region of retinoic acid receptor-beta gene and immunohistochemical findings on retinoic acid receptors in carcinogenesis of endometrium
    Rong Li
    Department of Obstetrics and Gynecology, School of Medicine, Sapporo Medical University, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Cancer Lett 219:33-40. 2005
    ..This evidence may point to one of the reasons why endometrial hyperplasia acquires high proliferative capacity without differentiation, and the hypermethylation of RAR-beta2 may occur in the early stage of endometrial carcinogenesis...
  20. doi request reprint Outcomes of planned delivery delay in pregnant patients with invasive gynecologic cancer
    Shin ichi Ishioka
    Department of Obstetrics and Gynecology, Sapporo Medical University, Minami 1 jo, Nishi 16 chome, Chuou ku, Sapporo, Hokkaido, Japan
    Int J Clin Oncol 14:321-5. 2009
    ..If there are no adverse effects from the cancer and there is improvement of neonatal outcomes, this treatment modality might be an option for patients with this condition...
  21. doi request reprint Distinctive features of female-to-male transsexualism and prevalence of gender identity disorder in Japan
    Tsuyoshi Baba
    Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Japan
    J Sex Med 8:1686-93. 2011
    ..Consequently, detection of PCOS is an important part of health care for these individuals...
  22. doi request reprint Difficulty in the management of pregnancy after vaginal radical trachelectomy
    Sakura Takada
    Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, Minami 1 jo, Nishi 16 chome, Chuou ku, Sapporo, Hokkaido, 060 8543, Japan
    Int J Clin Oncol 18:1085-90. 2013
    ..The procedure has a high risk for preterm labor and the subsequent occurrence of preterm premature rupture of membranes (pPROM). We report the present situation and the limits of follow-up of pregnancy after vaginal RT...
  23. doi request reprint Evaluation of cervical conization as a definitive treatment for microinvasive cervical carcinoma and cervical intraepithelial neoplasia grade 3
    Noriko Takeda
    Department of Obstetrics and Gynecology, Sapporo Medical University, South 1 West16 chuo ku, Sapporo, Hokkaido 060 8556, Japan
    Arch Gynecol Obstet 285:453-7. 2012
    ..The aim of the study was to evaluate disease persistence after conization of CIN3 and microinvasive cervical carcinoma...
  24. ncbi request reprint Expression of matrix metalloproteinases in ovarian endometriomas: immunohistochemical study and enzyme immunoassay
    Hisanobu Mizumoto
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 0061, Japan
    Life Sci 71:259-73. 2002
    ..From these results, it was suggested that the destruction of the surrounding matrix by endometriosis might be caused by various MMPs, which are mainly produced in stromal cells...
  25. pmc Matrix metalloproteinase-10 regulates stemness of ovarian cancer stem-like cells by activation of canonical Wnt signaling and can be a target of chemotherapy-resistant ovarian cancer
    Tasuku Mariya
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Oncotarget 7:26806-22. 2016
    ..Therefore, MMP10 is a novel marker for CSCs/CICs in EOC and that targeting MMP10 is a novel promising approach for chemotherapy-resistant CSCs/CICs in EOC. ..
  26. doi request reprint BAG3 increases the invasiveness of uterine corpus carcinoma cells by suppressing miR-29b and enhancing MMP2 expression
    Shutaro Habata
    Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Japan
    Oncol Rep 33:2613-21. 2015
    ..Collectively, our findings indicate that BAG3 enhances MMP2 expression by suppressing miR-29b, thereby increasing the metastatic potential of endometrioid adenocarcinomas...
  27. ncbi request reprint Pregnancy-related complications after vaginal radical trachelectomy for early-stage invasive uterine cervical cancer
    Shin ichi Ishioka
    Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, Minami 1, Nishi 17, Chuou ku, Sapporo, Hokkaido 060 8543, Japan
    Int J Clin Oncol 12:350-5. 2007
    ..The strategy to reduce vaginal RT-related complications during pregnancy is also discussed...
  28. pmc Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells
    Shin ichi Ishioka
    Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, Chuou ku, Sapporo, Japan
    Int J Med Sci 4:36-44. 2006
    ..These findings will contribute to establish new approach to detect hypoxic stress of the placenta, which leads to preeclampsia and other hypoxia-related obstetrics complications...
  29. ncbi request reprint Mutation of beta-catenin gene in endometrial cancer but not in associated hyperplasia
    Koji Ashihara
    Department of Obstetrics and Gynecology, Sapporo Medical University, S 1, W 16, Chuo Ku, Sapporo 060 0061, Japan
    Med Electron Microsc 35:9-15. 2002
    ..The results suggest that molecular alteration of the beta-catenin gene occurs in atypical hyperplasia or cancer, rather than in simple or complex hyperplasia without atypia, during endometrial carcinogenesis...
  30. ncbi request reprint Altered expression of Fas/Fas ligand/caspase 8 and membrane type 1-matrix metalloproteinase in atretic follicles within dehydroepiandrosterone-induced polycystic ovaries in rats
    Hiroyuki Honnma
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, South 1 West 16, Sapporo, 060 8543, Japan
    Apoptosis 11:1525-33. 2006
    ....
  31. ncbi request reprint Polycystic ovary syndrome is associated with genetic polymorphism in the insulin signaling gene IRS-1 but not ENPP1 in a Japanese population
    Tsuyoshi Baba
    Department of Obstetrics and Gynecology, Sapporo Medical University, South 1 West 16, Chu o ku, Sapporo, Hokkaido, 060 8543 Japan
    Life Sci 81:850-4. 2007
    ..We conclude that the IRS-1 Gly972Arg polymorphism is associated with PCOS in the Japanese population...
  32. ncbi request reprint Loss of gamma-Catenin expression in squamous differentiation in endometrial carcinomas
    Koji Ashihara
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Japan
    Int J Gynecol Pathol 21:246-54. 2002
    ..Our results suggest that unique molecular events, i.e., stimulation of beta-catenin and suppression of gamma-catenin expression, occur within endometrial carcinomas with squamous differentiation...
  33. ncbi request reprint Three-dimensional coculture of endometrial cancer cells and fibroblasts in human placenta derived collagen sponges and expression matrix metalloproteinases in these cells
    Ryoichi Tanaka
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 0061, Japan
    Gynecol Oncol 90:297-304. 2003
    ....
  34. doi request reprint Prognostic impact of human leukocyte antigen class I expression and association of platinum resistance with immunologic profiles in epithelial ovarian cancer
    Tasuku Mariya
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Immunol Res 2:1220-9. 2014
    ..77; 95% CI, 1.08-13.12; P = 0.037). Platinum-resistant EOCs show poor immunologic responses. The immune escape system of EOCs may be one of the mechanisms of platinum resistance...
  35. pmc The tight-junction protein claudin-6 induces epithelial differentiation from mouse F9 and embryonic stem cells
    Kotaro Sugimoto
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    PLoS ONE 8:e75106. 2013
    ..Furthermore, similar results were obtained in mouse embryonic stem cells. Thus, we have uncovered that the Cldn6 functions as a novel cue to induce epithelial differentiation. ..
  36. pmc ALDH1-high ovarian cancer stem-like cells can be isolated from serous and clear cell adenocarcinoma cells, and ALDH1 high expression is associated with poor prognosis
    Takafumi Kuroda
    Department of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    PLoS ONE 8:e65158. 2013
    ..Taken together, the results indicate that ALDH1 is a marker for ovarian CSCs/CICs and that the expression level of ALDH1 might be a novel biomarker for prediction of poor prognosis...
  37. doi request reprint Roles of microRNA-34a in the pathogenesis of placenta accreta
    Kota Umemura
    Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Japan
    J Obstet Gynaecol Res 39:67-74. 2013
    ..The trophoblastic cells of placenta accreta invade into the myometrium in a similar way to the invasion of cancers. We studied the roles of miR-34a in the pathogenesis of placenta accreta...
  38. ncbi request reprint Advanced epithelial ovarian carcinoma during pregnancy
    Shin ichi Ishioka
    Department of Obstetrics and Gynecology, School of Medicine, Sapporo Medical University, Minami 1, Nishi 17, Chuou ku, Sapporo, Hokkaido 060 0061, Japan
    Int J Clin Oncol 12:375-8. 2007
    ..To determine a better approach for such patients, multidisciplinary staff meetings, including gynecological oncologists, obstetricians, neonatologists, psychologists, and the patient are important...
  39. doi request reprint Excessive androgen exposure in female-to-male transsexual persons of reproductive age induces hyperplasia of the ovarian cortex and stroma but not polycystic ovary morphology
    Keiko Ikeda
    Department of Obstetrics and Gynecology, Sapporo Medical University, South 1 West 16, Sapporo, Hokkaido 060 8543, Japan
    Hum Reprod 28:453-61. 2013
    ..Does administration of androgen to female-to-male transsexual persons (FTMs) of reproductive age induce polycystic ovary (PCO) morphology?..
  40. pmc Weight reduction and pioglitazone ameliorate polycystic ovary syndrome after removal of a Sertoli-stromal cell tumor
    Tsuyoshi Baba
    Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo
    Int J Womens Health 4:607-11. 2012
    ..However, after losing 12 kg of body weight, the patient's serum androgen levels declined to normal, and spontaneous menstruation became regular. Weight reduction with pioglitazone is an effective means of treating hyperandrogenism...
  41. doi request reprint Simultaneous presentation of tubal and primary abdominal pregnancies following clomiphene citrate treatment
    Tsuyoshi Baba
    Department of Obstetrics and Gynecology, Sapporo Medical University, South 1 West 16, Sapporo, Hokkaido 060 8543, Japan
    Arch Gynecol Obstet 286:395-8. 2012
    ..Concurrent EPs and abdominal pregnancy are very rare. However, it should be noted that reproductive technologies sometimes cause unusual clinical situations. A thorough abdominal inspection is needed...
  42. pmc Continuous follicle-stimulating hormone exposure from pituitary adenoma causes periodic follicle recruitment and atresia, which mimics ovarian hyperstimulation syndrome
    Mika Kanaya
    Mika Ladies Clinic, Sapporo Medical University, School of Medicine, Sapporo, Japan
    Int J Womens Health 4:427-31. 2012
    ..This finding is different from iatrogenic ovarian hyperstimulation syndrome (OHSS), which is associated with extremely high levels of FSH...
  43. doi request reprint BAG3 (BCL2-associated athanogene 3) interacts with MMP-2 to positively regulate invasion by ovarian carcinoma cells
    Miwa Suzuki
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Sapporo 060 8543, Japan
    Cancer Lett 303:65-71. 2011
    ..The incidence of BAG3 positivity was significantly higher at advanced clinical stages of ovarian cancer than at early stages. We suggest that BAG3 binds to MMP2 to positively regulate the process of cell invasion...
  44. doi request reprint Successful uterus-preserving surgery for treatment of chemotherapy-resistant placenta increta
    Toshiaki Endo
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, South 1 West 16, Chuo Ku, Sapporo, Japan endot sapmed ac jp
    Gynecol Obstet Invest 69:112-5. 2010
    ..This approach enabled preservation of the uterus and the patient's fertility. We suggest this procedure could be one of the treatments for patients who have placenta increta and wish to retain their fertility...
  45. pmc Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is involved in cervical cancer stemness and can be a target of immunotherapy
    Takuya Asano
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Oncotarget 7:11223-37. 2016
    ....
  46. doi request reprint BAG3-mediated Mcl-1 stabilization contributes to drug resistance via interaction with USP9X in ovarian cancer
    Shutaro Habata
    Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo 060 8543, Japan
    Int J Oncol 49:402-10. 2016
    ..These results suggest that inhibiting BAG3 in addition to anti-apoptotic Bcl-2 family proteins may be a useful therapeutic strategy for the treatment of chemoresistant ovarian cancers. ..
  47. pmc Preservation of fertility and subsequent childbirth after methotrexate treatment of placenta percreta: a case report
    Masato Tamate
    Department of Obstetrics and Gynecology, Sapporo Medical University Hospital, South 1, West 16, Chuo Ku, Sapporo, Hokkaido, 060 8543, Japan
    J Med Case Rep 9:232. 2015
    ..Here, we present a case of placenta percreta diagnosed by magnetic resonance imaging, and treated with systemic administration of methotrexate...
  48. doi request reprint Palonosetron in combination with 1-day versus 3-day dexamethasone for prevention of nausea and vomiting following paclitaxel and carboplatin in patients with gynecologic cancers: A randomized, multicenter, phase-II trial
    Motoki Matsuura
    Department of Gynecology and Obstetrics, Sapporo Medical University, Sapporo, Japan
    J Obstet Gynaecol Res 41:1607-13. 2015
    ..The purpose of this study was to evaluate palonosetron plus single-dose dexamethasone (DEX) for preventing CINV caused by carboplatin plus paclitaxel combination therapy (TC regimen) in patients with gynecologic cancers...
  49. doi request reprint Importance of uterine cervical cerclage to maintain a successful pregnancy for patients who undergo vaginal radical trachelectomy
    Miseon Kim
    Department of Obstetrics and Gynecology, School of Medicine, Sapporo Medical University, Minami 1 jo, Nishi 16 chome, Chuou ku, Sapporo, Hokkaido, 060 8543, Japan
    Int J Clin Oncol 19:906-11. 2014
    ..We report the significance of transabdominal cerclage in the follow-up of pregnancy after vaginal RT...
  50. pmc Ovarian cancer stem cells are enriched in side population and aldehyde dehydrogenase bright overlapping population
    Kazuyo Yasuda
    Department of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    PLoS ONE 8:e68187. 2013
    ..Taken together, use of the SP and ALDH(Br) overlapping population is a promising approach to isolate highly purified CSCs/CICs and SOX2 might be a novel functional marker for ovarian CSCs/CICs. ..
  51. doi request reprint First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies
    Takashi Yamada
    Department of Obstetrics, Hokkaido University Graduate School of Medicine, Kita ku N14 W6, Sapporo 060 8638, Japan
    Arch Gynecol Obstet 287:9-14. 2013
    ..To determine whether a low serum folate level during the first trimester predicts subsequent late abortion, preterm birth, or fetal growth restriction (FGR)...
  52. pmc Changes of uterine blood flow after vaginal radical trachelectomy (VRT) in patients with early-stage uterine invasive cervical cancer
    Kota Umemura
    Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo Hokkaido, Japan
    Int J Med Sci 7:260-6. 2010
    ..Changes of blood supply to the uterus in two patients who experienced pregnancy and delivery were studied by using 3-D CT scanning. Effects of changes of blood supply to the uterus on the pregnancy courses were also examined...
  53. doi request reprint Spontaneous ovarian hyperstimulation syndrome and pituitary adenoma: incidental pregnancy triggers a catastrophic event
    Tsuyoshi Baba
    Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Hokkaido, Japan
    Fertil Steril 92:390.e1-3. 2009
    ..To report a rare case of spontaneous ovarian hyperstimulation syndrome (OHSS) associated with spontaneous pregnancy and a FSH-secreting pituitary adenoma...
  54. doi request reprint A remarkably easy knot-tying technique for single-incision laparoscopic surgery with the SILS port for gynecologic diseases
    Toshiaki Endo
    Department of Obstetrics and Gynecology, School of Medicine, Sapporo Medical University Hospital, Sapporo, Japan
    J Minim Invasive Gynecol 18:500-2. 2011
    ..The benefit of this technique is that it does not require any special skills; any surgeon able to perform intracorporeal suturing should also be able to easily tie knots during SILS...
  55. ncbi request reprint Statin-mediated reduction of osteopontin expression induces apoptosis and cell growth arrest in ovarian clear cell carcinoma
    Motoki Matsuura
    Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Japan
    Oncol Rep 25:41-7. 2011
    ..In conclusion, simvastatin has anticancer effects in vitro and in vivo. Further confirmation of the anticancer effects of statins in future studies will increase the scope for OCCC treatment...
  56. doi request reprint Osteopontin is a new target molecule for ovarian clear cell carcinoma therapy
    Motoki Matsuura
    Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Japan
    Cancer Sci 101:1828-33. 2010
    ..These results suggest that down- or up-regulation of OPN is involved in carcinoma cell invasion. We thus conclude that OPN regulation could have a crucial role in ovarian clear cell carcinoma therapy...
  57. doi request reprint Possibility of less radical treatment for patients with early invasive uterine cervical cancer
    Miseon Kim
    Department of Obstetrics and Gynecology, Sapporo Medical University, Hokkaido, Japan
    J Obstet Gynaecol Res 42:876-82. 2016
    ..However, pregnancy after RT has high risks of preterm birth. The possibility of more conservative RT and the application of RT for patients with higher clinical stages were studied...
  58. doi request reprint Successful delivery after transabdominal cerclage of uterine cervix for cervical incompetence after radical trachelectomy
    Shinichi Ishioka
    Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Hokkaido
    J Obstet Gynaecol Res 41:1295-9. 2015
    ..TAC is a useful treatment modality to prevent miscarriage for patients who have trouble with cerclage after RT...
  59. doi request reprint BAG3 upregulates Mcl-1 through downregulation of miR-29b to induce anticancer drug resistance in ovarian cancer
    Asuka Sugio
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Sapporo 060 8543, Japan
    Gynecol Oncol 134:615-23. 2014
    ..We identified a set of microRNAs whose expression is altered upon BAG3 knockdown. Our primary objective was to examine the relationships between BAG3, miR-29b and Mcl-1, an antiapoptotic Bcl-2 family protein, in ovarian cancer cells...
  60. doi request reprint Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity
    Kazuyo Yasuda
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Lab Invest 94:1355-69. 2014
    ..Taken together, the results indicate that interaction of fibroblasts with ovarian CSCs/CICs enhanced tumor-initiating capacity and stem-like properties through autocrine and paracrine FGF4-FGFR2 signaling. ..
  61. pmc Long-term treatment with dehydroepiandrosterone may lead to follicular atresia through interaction with anti-Mullerian hormone
    Keiko Ikeda
    Department of Obstetrics and Gynecology, Steel Memorial Muroran Hospital, 1 45, Chiribethutown, Muroran, Hokkaido 050 0076, Japan
    J Ovarian Res 7:46. 2014
    ..We studied how duration of androgen administration affects folliculogenesis and AMH expression...
  62. doi request reprint Low-dose SN-38 with paclitaxel induces lethality in human uterine cervical adenocarcinoma cells by increasing caspase activity
    Mizue Teramoto
    Department of Obstetrics and Gynecology, Sapporo Medical University, S1, W16, Chuo Ku, Sapporo, 060 8543, Japan
    Med Mol Morphol 47:31-7. 2014
    ..In this study, though only a single cell line was used for the experiment and the data are limited, our results suggest that paclitaxel together with low-dose CPT-11 is a promising basis for a new combination cancer chemotherapy. ..
  63. ncbi request reprint The reproducibility of a binary tumor grading system for uterine endometrial endometrioid carcinoma, compared with FIGO system and nuclear grading
    Satoru Sagae
    Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, Sapporo, Japan
    Oncology 67:344-50. 2004
    ..We analyzed this system for predicting the prognosis, with respect to inter- and intraobserver reproducibility and treatment modalities...
  64. ncbi request reprint [Metastasizing mechanisms in endometrial cancer]
    Ryuichi Kudo
    Department of Obstetrics and Gynecology, Sapporo Medical University
    Nihon Rinsho 62:269-72. 2004
  65. doi request reprint p53 negatively regulates the hepatoma growth factor HDGF
    Yasushi Sasaki
    Department of Medical Genome Sciences, Research Institute for Frontier Medicine, Sapporo Medical University, Sapporo, Japan
    Cancer Res 71:7038-47. 2011
    ..Taken together, our results reveal a new pathway in which loss of p53 function contributes to the aggressive pathobiological potential of human cancers by elevating HDGF expression...
  66. ncbi request reprint [A pilot study of combined chemotherapy with paclitaxel, doxorubicin and cisplatin for endometrial cancer]
    Hiroyuki Honma
    Dept of Obstetrics and Gynecology, School of Medicine, Sapporo Medical University
    Gan To Kagaku Ryoho 31:549-53. 2004
    ..0%. We found that TAP therapy was feasible with G-CSF support and shows potential for high efficacy in advanced endometrial cancer...
  67. ncbi request reprint Association between polycystic ovary syndrome and female-to-male transsexuality
    Tsuyoshi Baba
    Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Hokkaido, Japan
    Hum Reprod 22:1011-6. 2007
    ..The aim of this study is to understand the relationship between polycystic ovary syndrome (PCOS), altered hormonal characteristics and insulin resistance in female-to-male (FTM) transsexual patients...
  68. doi request reprint Japan Society of Gynecologic Oncology guidelines 2011 for the treatment of uterine cervical cancer
    Yasuhiko Ebina
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Int J Clin Oncol 20:240-8. 2015
    ..The objective of these guidelines is to update the standard treatment strategies for cervical cancer, thus eliminating unnecessary and insufficient treatment...
  69. pmc Coordinated elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution
    Kengo Manase
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, South 1 West 16, Chuou ku, Sapporo 060 8543, Japan
    Reprod Biol Endocrinol 4:32. 2006
    ..To understand the expression patterns of matrix metalloproteinases (MMPs) in the rat uterus, we analyzed their activities in postpartum uterine involution...
  70. doi request reprint Analgesic efficacy of controlled-release oxycodone in patients with uterine or ovarian cancer
    Takahiro Suzuki
    Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, Sapporo, Japan
    Am J Ther 15:31-5. 2008
    ..In the present study, patients with moderate to severe pain caused by gynecologic cancer could successfully be treated with controlled-release oxycodone...
  71. ncbi request reprint Cytology of vaginal and uterine sarcomas
    Eiki Ito
    Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, Hokkaido, Japan
    Acta Cytol 48:601-7. 2004
    ..To retrospectively review, based on cytologic and histopathologic findings, the diagnoses of 13 patients with uterine sarcoma and 1 with vaginal sarcoma...
  72. doi request reprint Prediction of the therapeutic effect of dienogest in ovarian endometrial cysts using the apparent diffusion coefficient
    Motoki Matsuura
    Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Japan and
    Gynecol Endocrinol 30:597-9. 2014
    ..0x - 0.4y + 0.1z (R: Reduction ratio, x: ADC mean, y: Longest diameter, z: CA125). In conclusion, the ADC mean value is useful for the prediction of the treatment response in ovarian endometrial cyst patients with DNG administration...
  73. doi request reprint Epidermal growth factor modulates claudins and tight junctional functions in ovarian cancer cell lines
    Marie Ogawa
    Department of Gynecology and Obstetrics, Sapporo Medical University School of Medicine, Sapporo, Japan
    Histochem Cell Biol 138:323-38. 2012
    ..These results indicate that EGF may affect claudins and tight junctional functions in ovarian cancer cells during cancer progression...
  74. doi request reprint Novel oligomannose liposome-DNA complex DNA vaccination efficiently evokes anti-HPV E6 and E7 CTL responses
    Masahito Mizuuchi
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
    Exp Mol Pathol 92:185-90. 2012
    ..These results indicate that OML-HPV is a more effective approach than DNA vaccination using standard liposomes, and that a novel HLA-A24-restricted peptide, E6 66-74, might be a suitable target of cervical cancer immunotherapy...
  75. ncbi request reprint Successful delivery after vaginal radical trachelectomy for invasive uterine cervical cancer
    Shin ichi Ishioka
    Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, Minami 1 jo, Nishi 17 chome, Sapporo, Hokkaido 060 8543, Japan
    Int J Clin Oncol 11:146-9. 2006
    ..Both the mother and the baby were discharged without trouble. This is the first successful case in Japan of delivery after vaginal RT for invasive uterine cervical cancer...
  76. ncbi request reprint Identification of SCN3B as a novel p53-inducible proapoptotic gene
    Katsuya Adachi
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, S 1, W 17, Chuo Ku, Sapporo 060 8556, Japan
    Oncogene 23:7791-8. 2004
    ..The results presented here suggest that SCN3B mediates a p53-dependent apoptotic pathway and may be a candidate for gene therapy combined with anticancer drugs...
  77. ncbi request reprint Hyperstimulation and a gonadotropin-releasing hormone agonist modulate ovarian vascular permeability by altering expression of the tight junction protein claudin-5
    Yoshimitsu Kitajima
    Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Japan
    Endocrinology 147:694-9. 2006
    ....
  78. doi request reprint High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by downregulation of antigen presentation pathway
    Kosuke Yoshihara
    Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin Cancer Res 18:1374-85. 2012
    ..Our aim was to establish a novel risk classification system based on a gene expression signature for predicting overall survival, leading to suggesting novel therapeutic strategies for high-risk patients...
  79. ncbi request reprint Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4alpha-induced epithelial polarization
    Seiro Satohisa
    Department of Pathology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Exp Cell Res 310:66-78. 2005
    ....
  80. doi request reprint Evidence-based guidelines for treatment of uterine body neoplasm in Japan: Japan Society of Gynecologic Oncology (JSGO) 2009 edition
    Satoru Nagase
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Int J Clin Oncol 15:531-42. 2010
    ..The treatment recommendations herein are tailored to reflect current Japanese clinical practice and ensure equitable care for all Japanese women diagnosed with endometrial cancer...
  81. doi request reprint Questionnaire survey of the current status of radical trachelectomy in Japan
    Shinya Sato
    Department of Obstetrics and Gynecology, School of Medicine, Tottori University, 36 1 Nishi cho, Yonago, Tottori 683 8504, Japan
    Int J Clin Oncol 16:141-4. 2011
    ..Radical trachelectomy is a potential option for patients who wish to preserve their fertility, but its status is not clear. The present survey was conducted to clarify the status of radical trachelectomy in Japan...
  82. ncbi request reprint Changed expression of heat shock proteins in various pathological findings in placentas with intrauterine fetal growth restriction
    Koya Wataba
    Department of Obstetrics and Gynecology, Sapporo Medical University, S1, W16, Chuo Ku, Sapporo 060 8543, Japan
    Med Electron Microsc 37:170-6. 2004
    ..These results are expected to improve our understanding of the pathological findings of IUGR in placentas, including the quality, damage, and function of the chorionic villi...
  83. doi request reprint Pandemic (H1N1) 2009 in pregnant Japanese women in Hokkaido
    Takahiro Yamada
    Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine Department of Obstetrics and Gynecology, Sapporo, Japan
    J Obstet Gynaecol Res 38:130-6. 2012
    ..This study was performed to investigate how many pregnant women were infected, how many women took antiviral drugs for prophylaxis or treatment, and the rate of vaccination effectiveness...
  84. ncbi request reprint Efficacy of accelerated partial breast irradiation as a neoadjuvant treatment for patients with breast cancer: a pilot study
    Kazuhiko Sato
    Department of Surgery I, Saitama Red Cross Hospital, Saitama, Japan
    Surgery 139:617-23. 2006
    ..Accelerated partial breast irradiation (APBI) is being considered as a possible alternative to WBI. Neoadjuvant APBI might provide more benefit than postsurgical APBI because tumor downstaging will enhance the likelihood of BCT...
  85. ncbi request reprint Nuclear expression of Y-box-binding protein-1 correlates with P-glycoprotein and topoisomerase II alpha expression, and with poor prognosis in synovial sarcoma
    Yoshinao Oda
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pathol 199:251-8. 2003
    ....
  86. ncbi request reprint Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women
    Kimio Ushijima
    Japan Gynecologic Cancer Study Group, Tokyo, Japan
    J Clin Oncol 25:2798-803. 2007
    ..To assess the efficacy of fertility-sparing treatment using medroxyprogesterone acetate (MPA) for endometrial carcinoma (EC) and atypical endometrial hyperplasia (AH) in young women...
  87. ncbi request reprint Possible association between higher beta-catenin mRNA expression and mutated beta-catenin in sporadic desmoid tumors: real-time semiquantitative assay by TaqMan polymerase chain reaction
    Tsuyoshi Saito
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Lab Invest 82:97-103. 2002
    ..This may suggest that the beta-catenin gene may be up-regulated by mutated or continuously elevated beta-catenin protein, that is, the beta-catenin gene may also be one of the targeted genes in the APC-beta-catenin-Tcf pathway...
  88. ncbi request reprint SYT-SSX1 and SYT-SSX2 interfere with repression of E-cadherin by snail and slug: a potential mechanism for aberrant mesenchymal to epithelial transition in human synovial sarcoma
    Tsuyoshi Saito
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 66:6919-27. 2006
    ....
  89. ncbi request reprint E-cadherin mutation and Snail overexpression as alternative mechanisms of E-cadherin inactivation in synovial sarcoma
    Tsuyoshi Saito
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Oncogene 23:8629-38. 2004
    ..Thus, E-cadherin downregulation is associated with the loss or absence of glandular epithelial differentiation in certain SS...
  90. ncbi request reprint beta-Catenin nuclear accumulation in head and neck mucoepidermoid carcinoma: its role in cyclin D1 overexpression and tumor progression
    Hideki Shiratsuchi
    Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Head Neck 29:577-84. 2007
    ..This study investigates abnormalities of beta-catenin and the APC gene in MEC and correlates the patterns of cyclin D1 overexpression and nuclear/cytoplasmic accumulation of beta-catenin with the clinical outcome...
  91. ncbi request reprint Nuclear beta-catenin correlates with cyclin D1 expression in spindle and pleomorphic sarcomas but not in synovial sarcoma
    Tsuyoshi Saito
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hum Pathol 37:689-97. 2006
    ..Thus, cyclin D1 could be considered as one of the targets of the nuclear beta-catenin in spindle cell and pleomorphic sarcomas. A possible association between beta-catenin accumulation and spindle cell morphogenesis may exist in SS...
  92. ncbi request reprint Mutation analysis of human cytokeratin 8 gene in malignant rhabdoid tumor: a possible association with intracytoplasmic inclusion body formation
    Hideki Shiratsuchi
    Department of Anatomic Pathology, Kyushu University, Graduate School of Medical Sciences, Fukuoka, Japan
    Mod Pathol 15:146-53. 2002
    ..In conclusion, mutated codons of CK8 gene in MRT were located in the important region involved in the conformational change of intermediate filament...
  93. ncbi request reprint Death-associated protein kinase (DAP kinase) alteration in soft tissue leiomyosarcoma: Promoter methylation or homozygous deletion is associated with a loss of DAP kinase expression
    Ken Ichi Kawaguchi
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hum Pathol 35:1266-71. 2004
    ..Furthermore, although further detailed analyses are necessary, promoter methylation or homozygous deletion status of DAP kinase may present a major alternative mechanism of a loss of or decrease in DAP kinase expression...
  94. ncbi request reprint Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years
    Ken Ichi Kawaguchi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mod Pathol 15:878-88. 2002
    ..Although the number of patients in this analysis was small, it would appear that MFH-like OS may have some characteristic biologic aspects when compared with osteoblastic OS and MFH of bone in elderly patients...
  95. ncbi request reprint DNA hypermethylation status of multiple genes in soft tissue sarcomas
    Ken Ichi Kawaguchi
    Department of Anatomic Pathology, Pathological Sciences, Kyushu University, Fukuoka, Japan
    Mod Pathol 19:106-14. 2006
    ..Furthermore, MGMT methylation may be associated with tumor aggressiveness and the inactivation of MGMT gene...
  96. ncbi request reprint Beta-catenin accumulation and gene mutation in exon 3 in dedifferentiated liposarcoma and malignant fibrous histiocytoma
    Akio Sakamoto
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Arch Pathol Lab Med 126:1071-8. 2002
    ..beta-Catenin is an adhesion molecule that also plays a role in the Wnt signaling pathway. Objective.-To analyze beta-catenin mutation and accumulation in a series of liposarcomas and malignant fibrous histiocytomas...
  97. ncbi request reprint Genetic and epigenetic alterations of the PTEN gene in soft tissue sarcomas
    Ken Ichi Kawaguchi
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Hum Pathol 36:357-63. 2005
    ..Furthermore, although a further detailed analysis of a larger number of cases is still necessary, the present results suggest that PTEN expression may be a useful indicator of cell proliferation in patients with STS...
  98. ncbi request reprint Prognostic significance of dysadherin expression in epithelioid sarcoma and its diagnostic utility in distinguishing epithelioid sarcoma from malignant rhabdoid tumor
    Teiyu Izumi
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mod Pathol 19:820-31. 2006
    ..However, in malignant rhabdoid tumor, cell growth cycle that is regulated by hSNF5/INI1 gene seems to be critical to lethal biological behavior rather than dysadherin...
  99. ncbi request reprint Possible association between tumor-suppressor gene mutations and hMSH2/hMLH1 inactivation in alveolar soft part sarcoma
    Tsuyoshi Saito
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hum Pathol 34:841-9. 2003
    ..Thus, inactivation of hMSH2/hMLH1 of DNA mismatch repair genes seems to have an important role to play in the mutagenesis of the tumor-suppressor genes in ASPS...
  100. ncbi request reprint Mechanisms of inactivation of the p16INK4a gene in leiomyosarcoma of soft tissue: decreased p16 expression correlates with promoter methylation and poor prognosis
    Ken Ichi Kawaguchi
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pathol 201:487-95. 2003
    ..Furthermore, promoter methylation was more frequent than either homozygous deletion or mutation in this tumour, and promoter methylation was also shown to have a strong association with inactivation of the p16INK4a gene...
  101. ncbi request reprint PTEN and other tumor suppressor gene mutations as secondary genetic alterations in synovial sarcoma
    Tsuyoshi Saito
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Oncol Rep 11:1011-5. 2004
    ..8%), although the mutation status in TSG was not associated with overall survival rate in patients with SS. Secondary genetic alterations in these TSG seem to have a less important prognostic impact on patients with SS...